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Research Article

THE MOUSE EAR MODEL OF CUTANEOUS SULFUR MUSTARD INJURY

Pages 381-397 | Published online: 30 Sep 2008

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Read on this site (6)

Hemanta C. Rao Tumu, Benedette J. Cuffari, Maria A. Pino, Jerzy Palus, Magdalena Piętka-Ottlik & Blase Billack. (2020) Ebselen oxide attenuates mechlorethamine dermatotoxicity in the mouse ear vesicant model. Drug and Chemical Toxicology 43:4, pages 335-346.
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James V. Rogers, Jonathon W. Kohne, Timothy L. Hayes, Frances M. Reid & John S. Graham. (2005) Measuring Liquid Sulfur Mustard Recovery to Characterize a Weanling Swine Skin Short-Term Exposure Model. Cutaneous and Ocular Toxicology 24:3, pages 177-185.
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Carol L. K. Sabourin, James V. Rogers, Mindy K. Stonerock, Nancy A. Niemuth, Robyn C. Kiser, Stacy L. Casbohm, Michael C. Babin, John J. Schlager & Robert P. Casillas. (2004) Alterations of Gene Expression in Sulfur Mustard‐Exposed Skin Topically Treated with Vanilloids. Journal of Toxicology: Cutaneous and Ocular Toxicology 23:4, pages 321-328.
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Michael C. Babin, Karen M. Ricketts, Robyn C. Kiser, Michelle Y. Gazaway, Nathaniel Krogel, Larry W. Mitcheltree, D. Marie Moore, Kristen Skvorak, Richard E. Sweeney, Irwin Koplovitz & Robert P. Casillas. (2003) A 7‐Day Mouse Model to Assess Protection from Sulfur Mustard (SM) Skin Injury. Journal of Toxicology: Cutaneous and Ocular Toxicology 22:4, pages 231-242.
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Carol L. K. Sabourin, Michele M. Danne, Kristi L. Buxton, James V. Rogers, Nancy A. Niemuth, James A. Blank, Michael C. Babin & Robert P. Casillas. (2003) Modulation Of Sulfur Mustard-induced Inflammation And Gene Expression By Olvanil In The Hairless Mouse Vesicant Model. Journal of Toxicology: Cutaneous and Ocular Toxicology 22:3, pages 125-136.
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Thomas P. Logan, Michael Shutz, Susan M. Schulz, Roy Railer, Karen M. Ricketts & Robert P. Casillas. (2002) APPLICATION AND DETECTION OF 14C-HD IN TWO MOUSE MODELS. Toxicology Mechanisms and Methods 12:4, pages 293-300.
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Articles from other publishers (32)

Trishaal Janardhanam Raghavendra Rao, Ganming Mao, Benedette J. Cuffari & Blase Billack. (2023) Dysregulation of the mTOR pathway by mechlorethamine. Toxicology 486, pages 153434.
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Tomas L. Roldan, Shike Li, Jeffrey D. Laskin, Dayuan Gao & Patrick J. Sinko. (2023) Depilatory double‐disc mouse model for evaluation of vesicant dermal injury pharmacotherapy countermeasures. Animal Models and Experimental Medicine 6:1, pages 57-65.
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Jeffrey D. Laskin, Kevin Ozkuyumcu, Peihong Zhou, Claire R. Croutch, Diane E. Heck, Debra L. Laskin & Laurie B. Joseph. (2023) Skin Models Used to Define Mechanisms of Action of Sulfur Mustard. Disaster Medicine and Public Health Preparedness 17.
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Hemanta C Rao Tumu, Benedette J. Cuffari & Blase Billack. (2021) Combination of ebselen and hydrocortisone substantially reduces nitrogen mustard-induced cutaneous injury. Current Research in Toxicology 2, pages 375-385.
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Yoke-Chen Chang, Rita A. Hahn, Marion K. Gordon, Jeffrey D. Laskin & Donald R. Gerecke. (2020) A type IV collagenase inhibitor, N-hydroxy-3-phenyl-2-(4-phenylbenzenesulfonamido) propanamide (BiPS), suppresses skin injury induced by sulfur mustard. Toxicology and Applied Pharmacology 401, pages 115078.
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Yoke‐Chen Chang, James D. Wang, Hui‐Ying Chang, Peihong Zhou, Rita A. Hahn, Marion K. Gordon, Jeffrey D. Laskin & Donald R. Gerecke. (2020) Expression of Laminin γ2 Proteolytic Fragments in Murine Skin Following Exposure to Sulfur Mustard. The Anatomical Record 303:6, pages 1642-1652.
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Joshua P. Gray, Michael P. Shakarjian, Donald R. Gerecke & Robert P. Casillas. 2020. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents 613 639 .
Benedette J. Cuffari, Hemanta C Rao Tumu, Maria A. Pino & Blase Billack. (2018) Assessment of the time-dependent dermatotoxicity of mechlorethamine using the mouse ear vesicant model. Interdisciplinary Toxicology 11:4, pages 255-266.
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Yoke-Chen Chang, Melannie Soriano, Rita A. Hahn, Robert P. Casillas, Marion K. Gordon, Jeffrey D. Laskin & Donald R. Gerecke. (2018) Expression of cytokines and chemokines in mouse skin treated with sulfur mustard. Toxicology and Applied Pharmacology 355, pages 52-59.
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Joshua P. Gray, Michael P. Shakarjian, Donald R. Gerecke & Robert P. Casillas. 2015. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents 557 576 .
Anju Lulla, Sandra Reznik, Louis Trombetta & Blase Billack. (2014) Use of the mouse ear vesicant model to evaluate the effectiveness of ebselen as a countermeasure to the nitrogen mustard mechlorethamine. Journal of Applied Toxicology 34:12, pages 1373-1378.
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Yoke-Chen Chang, James D. Wang, Kathy K. Svoboda, Robert P. Casillas, Jeffrey D. Laskin, Marion K. Gordon & Donald R. Gerecke. (2013) Sulfur mustard induces an endoplasmic reticulum stress response in the mouse ear vesicant model. Toxicology and Applied Pharmacology 268:2, pages 178-187.
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Stephen Boulware, Tammy Fields, Elizabeth McIvor, K. Leslie Powell, Erika L. Abel, Karen M. Vasquez & Michael C. MacLeod. (2012) 2,6-Dithiopurine, a nucleophilic scavenger, protects against mutagenesis in mouse skin treated in vivo with 2-(chloroethyl) ethyl sulfide, a mustard gas analog. Toxicology and Applied Pharmacology 263:2, pages 203-209.
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Michael P. Shakarjian, Diane E. Heck, Joshua P. Gray, Patrick J. Sinko, Marion K. Gordon, Robert P. Casillas, Ned D. Heindel, Donald R. Gerecke, Debra L. Laskin & Jeffrey D. Laskin. (2010) Mechanisms Mediating the Vesicant Actions of Sulfur Mustard after Cutaneous Exposure. Toxicological Sciences 114:1, pages 5-19.
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Shlomit Dachir, Maayan Cohen, Eliezer Fishbeine, Rita Sahar, Rachel Brandies, Vered Horwitz & Tamar Kadar. (2010) Characterization of acute and long-term sulfur mustard-induced skin injuries in hairless guinea-pigs using non-invasive methods. Skin Research and Technology 16:1, pages 114-124.
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Nahum Allon, Adina Amir, Eliau Manisterski, Ishay Rabinovitz, Shlomit Dachir & Tamar Kadar. (2009) Inhalation exposure to sulfur mustard in the guinea pig model: Clinical, biochemical and histopathological characterization of respiratory injuries. Toxicology and Applied Pharmacology 241:2, pages 154-162.
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William J. Smith. (2009) Therapeutic options to treat sulfur mustard poisoning—The road ahead. Toxicology 263:1, pages 70-73.
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Michael P. Shakarjian, Pinaki Bhatt, Marion K. Gordon, Yoke-Chen Chang, Stacy L. Casbohm, Thomas L. Rudge, Robyn C. Kiser, Carol L. Sabourin, Robert P. Casillas, Pamela Ohman-Strickland, David J. Riley & Donald R. Gerecke. (2006) Preferential expression of matrix metalloproteinase-9 in mouse skin after sulfur mustard exposure. Journal of Applied Toxicology 26:3, pages 239-246.
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James F. DillmanIIIIII, Alison I. Hege, Christopher S. Phillips, Linda D. Orzolek, Albert J. Sylvester, Carol Bossone, Claudia Henemyre-Harris, Robyn C. Kiser, Young W. Choi, John J. Schlager & Carol L. Sabourin. (2006) Microarray Analysis of Mouse Ear Tissue Exposed to Bis-(2-chloroethyl) Sulfide: Gene Expression Profiles Correlate with Treatment Efficacy and An Established Clinical Endpoint. Journal of Pharmacology and Experimental Therapeutics 317:1, pages 76-87.
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Carol L. K. Sabourin, James V. Rogers, Young W. Choi, Robyn C. Kiser, Robert P. Casillas, Michael C. Babin & John J. Schlager. (2005) Time- and dose-dependent analysis of gene expression using microarrays in sulfur mustard-exposed mice. Journal of Biochemical and Molecular Toxicology 18:6, pages 300-312.
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James V. Rogers, Young W. Choi, Robyn C. Kiser, Michael C. Babin, Robert P. Casillas, John J. Schlager & Carol L. K. Sabourin. (2005) Microarray analysis of gene expression in murine skin exposed to sulfur mustard. Journal of Biochemical and Molecular Toxicology 18:6, pages 289-299.
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Stacy L. Casbohm, James V. Rogers, Mindy K. Stonerock, Jamie L. Martin, Karen M. Ricketts-Kaminsky, Michael C. Babin, Robert P. Casillas & Carol L.K. Sabourin. (2004) Localization of substance P gene expression for evaluating protective countermeasures against sulfur mustard. Toxicology 204:2-3, pages 229-239.
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Shlomit Dachir, Eliezer Fishbeine, Yakov Meshulam, Rita Sahar, Shira Chapman, Adina Amir & Tamar Kadar. (2004) Amelioration of sulfur mustard skin injury following a topical treatment with a mixture of a steroid and a NSAID. Journal of Applied Toxicology 24:2, pages 107-113.
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William Smith, Michael Babin, Robyn Kiser & Robert Casillas. 2003. Alternative Toxicological Methods. Alternative Toxicological Methods.
Carol L. K. Sabourin, Michele M. Danne, Kristi L. Buxton, Robert P. Casillas & John J. Schlager. (2002) Cytokine, chemokine, and matrix metalloproteinase response after sulfur mustard injury to weanling pig skin. Journal of Biochemical and Molecular Toxicology 16:6, pages 263-272.
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S DachirE Fishbeine, Y Meshulam, R Sahar, A Amir & T Kadar. (2016) Potential anti-inflammatory treatments against cutaneous sulfur mustard injury using the mouse ear vesicant model. Human & Experimental Toxicology 21:4, pages 197-203.
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K. M. Ricketts, C. T. Santai, J. A. France, A. M. Graziosi, T. D. Doyel, M. Y. Gazaway & R. P. Casillas. (2001) Inflammatory cytokine response in sulfur mustard-exposed mouse skin†‡. Journal of Applied Toxicology 20:S1, pages S73-S76.
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James C. Powers, Chih-Min Kam, Karen M. Ricketts & Robert P. Casillas. (2001) Cutaneous protease activity in the mouse ear vesicant model†. Journal of Applied Toxicology 20:S1, pages S177-S182.
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M. C. Babin, K. Ricketts, J. P. Skvorak, M. Gazaway, L. W. Mitcheltree & R. P. Casillas. (2001) Systemic administration of candidate antivesicants to protect against topically applied sulfur mustard in the mouse ear vesicant model (MEVM)‡**. Journal of Applied Toxicology 20:S1, pages S141-S144.
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Robert P. Casillas, Robyn C. Kiser, Jean A. Truxall, Al W. Singer, Shawn M. Shumaker, Nancy A. Niemuth, Karen M. Ricketts, Larry W. Mitcheltree, Lilia R. Castrejon & James A. Blank. (2001) Therapeutic approaches to dermatotoxicity by sulfur mustard I. Modulation of sulfur mustard-induced cutaneous injury in the mouse ear vesicant model†**. Journal of Applied Toxicology 20:S1, pages S145-S151.
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Carol L. K. Sabourin, John P. Petrali & Robert P. Casillas. (2000) Alterations in inflammatory cytokine gene expression in sulfur mustard-exposed mouse skin. Journal of Biochemical and Molecular Toxicology 14:6, pages 291-302.
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Nancy A. Monteiro-Riviere, Alfred O. Inman, Michael C. Babin & Robert P. Casillas. (1999) Immunohistochemical characterization of the basement membrane epitopes in bis(2-chloroethyl) sulfide-induced toxicity in mouse ear skin. Journal of Applied Toxicology 19:5, pages 313-328.
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