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Journal of Drug Targeting Volume 11, 2003 - Issue 1
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Research Article

The Pharmacokinetic and Biological Activity Profile of Dexamethasone Targeted to Sinusoidal Endothelial and Kupffer Cells

Barbro N. Melgert Department of Pharmacokinetics and Drug Delivery, Groningen University Institute for Drug Exploration (GUIDE), University of Groningen, AV, 9713, Groningen, The NetherlandsCorrespondence[email protected]
,
Betty Weert Department of Pharmacokinetics and Drug Delivery, Groningen University Institute for Drug Exploration (GUIDE), University of Groningen, AV, 9713, Groningen, The Netherlands
,
Huub Schellekens Central Laboratory Animal Institute, University of Utrecht, TD, 3508, Utrecht, The Netherlands
,
Dirk K.F. Meijer Department of Pharmacokinetics and Drug Delivery, Groningen University Institute for Drug Exploration (GUIDE), University of Groningen, AV, 9713, Groningen, The Netherlands
&
Klaas Poelstra Department of Pharmacokinetics and Drug Delivery, Groningen University Institute for Drug Exploration (GUIDE), University of Groningen, AV, 9713, Groningen, The Netherlands
Pages 1-10 | Published online: 03 Oct 2008

Citations (14)

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Jeong-Hun Kang, Riki Toita & Masaharu Murata. (2016) Liver cell-targeted delivery of therapeutic molecules. Critical Reviews in Biotechnology 36:1, pages 132-143.
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Elena Neumann, Eva Frei, Dorothee Funk, Matthias D Becker, Hans-Hermann Schrenk, Ulf Müller-Ladner & Christoph Fiehn. (2010) Native albumin for targeted drug delivery. Expert Opinion on Drug Delivery 7:8, pages 915-925.
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Feng Li & Ji-yao Wang. (2009) Targeted delivery of drugs for liver fibrosis. Expert Opinion on Drug Delivery 6:5, pages 531-541.
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Articles from other publishers (11)

Anna Salvati & Klaas Poelstra. (2022) Drug Targeting and Nanomedicine: Lessons Learned from Liver Targeting and Opportunities for Drug Innovation. Pharmaceutics 14:1, pages 217.
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Qian Tang, Yu-Wen Su, Chia-Ming Fan, Rosa Chung, Mohammadhossein Hassanshahi, Yaser Peymanfar & Cory J Xian. (2019) Release of CXCL12 From Apoptotic Skeletal Cells Contributes to Bone Growth Defects Following Dexamethasone Therapy in Rats. Journal of Bone and Mineral Research 34:2, pages 310-326.
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Hui Yi Xue, Shimeng Liu & Ho Lun Wong. (2014) Nanotoxicity: a key obstacle to clinical translation of siRNA-based nanomedicine. Nanomedicine 9:2, pages 295-312.
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Klaas Poelstra, Jai Prakash & Leonie Beljaars. (2012) Drug targeting to the diseased liver. Journal of Controlled Release 161:2, pages 188-197.
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Christopher S. Muratore, Mark W. Harty, Elaine F. Papa & Thomas F. TracyJr.Jr.. (2009) Dexamethasone Alters the Hepatic Inflammatory Cellular Profile Without Changes in Matrix Degradation During Liver Repair Following Biliary Decompression. Journal of Surgical Research 156:2, pages 231-239.
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Irena Musik, Małgorzata Kiełczykowska, Anna Hordyjewska & Kazimierz Pasternak. (2009) Influence of different forms of selenium supplementation on superoxide dismutase activity and total antioxidant status in ratsWpływ suplementacji różnymi związkami selenu na aktywność dysmutazy ponadtlenkowej i całkowity status antyoksydacyjny u szczurów. Annales UMCS, Pharmacia 22:1, pages 95-101.
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O. P. Makarova, D. D. Tsyrendorjiev & V. A. Shkurupiy. (2009) Lipid Peroxidation in the Liver of Mice during Development of Granulomatous Inflammation after Combined Infection with C. albicans and M. tuberculosis. Bulletin of Experimental Biology and Medicine 146:5, pages 569-572.
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Chi Wei Lee, Jiin Haur Chuang, Pei Wen Wang, Nyuk Kong Chang, Hsiu Chuan Wang, Chao Cheng Huang, Mao Meng Tiao & Sing Kai Lo. (2006) Effect of Glucocorticoid Pretreatment on Oxidative Liver Injury and Survival in Jaundiced Rats with Endotoxin Cholangitis. World Journal of Surgery 30:12, pages 2217-2226.
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Chih-Sung Hsieh, Pei-Wen Wang, Shin-Ye Lee, Chao-Cheng Huang, Nyuk-Kong Chang, Ching-Mei Chen, Chia-Ling Wu, Hsiu-Chuan Wang & Jiin-Haur Chuang. (2006) Glucocorticoid pretreatment suppresses chemokine expression and inflammatory cell infiltration in cholestatic rats receiving biliary intervention. Journal of Pediatric Surgery 41:10, pages 1669-1675.
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Halil Eken. (2006) Dose-related effects of dexamethasone on liver damage due to bile duct ligation in rats. World Journal of Gastroenterology 12:33, pages 5379.
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Costas Xidakis, Dushanka Ljumovic, Pinelopi Manousou, George Notas, Vassilis Valatas, George Kolios & Elias Kouroumalis. (2005) Production of Pro- and Anti-fibrotic Agents by Rat Kupffer Cells; The Effect of Octreotide. Digestive Diseases and Sciences 50:5, pages 935-941.
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