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Journal of Drug Targeting Volume 17, 2009 - Issue 6
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Research Article

Sulfate-conjugated methylprednisolone as a colon-targeted methylprednisolone prodrug with improved therapeutic properties against rat colitis

Hyesik KongUrologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
,
Younghyun LeeLaboratory of Biomedicinal/Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan, Republic of Korea
,
Sungchae HongLaboratory of Biomedicinal/Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan, Republic of Korea
,
Jeongoh HanLaboratory of Biomedicinal/Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan, Republic of Korea
,
Biom ChoiLaboratory of Biomedicinal/Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan, Republic of Korea
,
Yunjin JungLaboratory of Biomedicinal/Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan, Republic of KoreaCorrespondence[email protected]
&
Young Mi KimLaboratory of Biomedicinal/Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan, Republic of Korea
 show all
Pages 450-458 | Received 21 Feb 2009, Accepted 16 Apr 2009, Published online: 18 May 2009

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Kohei Mizuno, Yuri Ikeuchi-Takahashi, Yoshiyuki Hattori & Hiraku Onishi. (2021) Preparation and evaluation of conjugate nanogels of glycyl-prednisolone with natural anionic polysaccharides as anti-arthritic delivery systems. Drug Delivery 28:1, pages 136-144.
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Hiraku Onishi, Hisashi Kikuchi & Yoshiharu Machida. (2012) Comparison of simple Eudragit microparticles loaded with prednisolone and Eudragit-coated chitosan-succinyl-prednisolone conjugate microparticles: Part I. Particle characteristics and in vitro evaluation as a colonic delivery system. Drug Development and Industrial Pharmacy 38:7, pages 800-807.
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Yunjin Jung & Young Mi Kim. (2010) What should be considered on design of a colon-specific prodrug?. Expert Opinion on Drug Delivery 7:2, pages 245-258.
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Articles from other publishers (7)

Shujing Yan, Yuexuan Cheng, Liangyun Li, Chunhong Zhong, Chunli Chen & Xiaoli Gao. (2023) Lipid-based formulations: A promising approach for poorly soluble drug delivery via the intestinal lymphatic system. Journal of Drug Delivery Science and Technology 87, pages 104770.
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Ryo Tabuchi, Makoto Anraku, Daisuke Iohara, Takako Ishiguro, Shinsuke Ifuku, Tomone Nagae, Kaneto Uekama, Shoko Okazaki, Keizo Takeshita, Masaki Otagiri & Fumitoshi Hirayama. (2017) Surface-deacetylated chitin nanofibers reinforced with a sulfobutyl ether β-cyclodextrin gel loaded with prednisolone as potential therapy for inflammatory bowel disease. Carbohydrate Polymers 174, pages 1087-1094.
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Tatiana G. Volova, Yuri S. Vinnik, Ekaterina I. Shishatskaya, Nadejda M. Markelova & Gennady E. Zaikov. 2017. Natural-Based Polymers for Biomedical Applications. Natural-Based Polymers for Biomedical Applications 209 275 .
Hiraku Onishi & Hisashi Kikuchi. (2015) Comparison of Simple Eudragit Microparticles Loaded with Prednisolone and Eudragit-Coated Chitosan-Succinyl-Prednisolone Conjugate Microparticles: Part II. In Vivo Evaluation of Efficacy, Toxicity, and Biodisposition Characteristics. International Journal of Molecular Sciences 16:11, pages 26125-26136.
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Sofie Vandevyver, Lien Dejager & Claude Libert. (2014) Comprehensive Overview of the Structure and Regulation of the Glucocorticoid Receptor. Endocrine Reviews 35:4, pages 671-693.
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Gopabandhu Jena & Priyanka P. Trivedi. (2014) A Review of the Use of Melatonin in Ulcerative Colitis. Inflammatory Bowel Diseases 20:3, pages 553-563.
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Yonghyun Lee, Seongkeun Jeong, Wooseong Kim, Hyunjeong Kim, Jeong-Hyun Yoon, Seong Hoon Jeong & Yunjin Jung. (2012) Glycyrrhizin Enhances Therapeutic Activity of a Colon-Specific Methylprednisolone Prodrug Against Experimental Colitis. Digestive Diseases and Sciences 58:5, pages 1226-1234.
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