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Original Article

Glutathione loading prevents free radical injury in red blood cells after storage

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Pages 517-529 | Received 07 Mar 2000, Published online: 07 Jul 2009

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Read on this site (2)

Kamila Czubak, Adam Antosik, Natalia Cichon & Halina Malgorzata Zbikowska. (2017) Vitamin C and Trolox decrease oxidative stress and hemolysis in cold-stored human red blood cells. Redox Report 22:6, pages 445-450.
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Florian Lang, Kashif Jilani & Elisabeth Lang. (2015) Therapeutic potential of manipulating suicidal erythrocyte death. Expert Opinion on Therapeutic Targets 19:9, pages 1219-1227.
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Articles from other publishers (49)

Alkmini T. Anastasiadi, Konstantinos Stamoulis, Effie G. Papageorgiou, Veronica Lelli, Sara Rinalducci, Issidora S. Papassideri, Anastasios G. Kriebardis, Marianna H. Antonelou & Vassilis L. Tzounakas. (2023) The time-course linkage between hemolysis, redox, and metabolic parameters during red blood cell storage with or without uric acid and ascorbic acid supplementation. Frontiers in Aging 4.
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Masannagari Pallavi & Vani Rajashekaraiah. (2023) Synergistic activity of vitamin-C and vitamin-E to ameliorate the efficacy of stored erythrocytes. Transfusion Clinique et Biologique 30:1, pages 87-95.
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Vassilis L. Tzounakas, Alkmini T. Anastasiadi, Vasiliki-Zoi Arvaniti, Veronica Lelli, Giuseppina Fanelli, Efthymios C. Paronis, Anastasia C. Apostolidou, Evangelos G. Balafas, Nikolaos G. Kostomitsopoulos, Effie G. Papageorgiou, Issidora S. Papassideri, Konstantinos Stamoulis, Anastasios G. Kriebardis, Sara Rinalducci & Marianna H. Antonelou. (2022) Supplementation with uric and ascorbic acid protects stored red blood cells through enhancement of non-enzymatic antioxidant activity and metabolic rewiring. Redox Biology 57, pages 102477.
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S. Li, L. Zhang, H. Yuan, L. Yang, F. Song, H. Liu, C. Wei, H. Ding, Q. Ma & Y. Su. (2022) Effect of low concentration of melatonin on the quality of stored red blood cells <em>in vitro</em>. Russian journal of hematology and transfusiology 67:1, pages 62-73.
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Paweł Kowalczyk, Dorota Sulejczak, Patrycja Kleczkowska, Iwona Bukowska-Ośko, Marzena Kucia, Marta Popiel, Ewa Wietrak, Karol Kramkowski, Karol Wrzosek & Katarzyna Kaczyńska. (2021) Mitochondrial Oxidative Stress—A Causative Factor and Therapeutic Target in Many Diseases. International Journal of Molecular Sciences 22:24, pages 13384.
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Leonid Livshits, Gregory Barshtein, Dan Arbell, Alexander Gural, Carina Levin & Hélène Guizouarn. (2021) Do We Store Packed Red Blood Cells under “Quasi-Diabetic” Conditions?. Biomolecules 11:7, pages 992.
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Irina Kumukova, Pavel Trakhtman, Nicolay Starostin, Daria Borsakova, Anastasia Ignatova & Yana Bayzyanova. (2020) Quality assessment of red blood cell suspensions derived from pathogen‐reduced whole blood. Vox Sanguinis 116:5, pages 547-556.
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Marcelo David, Evgeniya Levy, Gregory Barshtein, Leonid Livshits, Dan Arbell, Paul Ben Ishai & Yuri Feldman. (2020) The dielectric spectroscopy of human red blood cells during 37-day storage: β-dispersion parameterization. Biochimica et Biophysica Acta (BBA) - Biomembranes 1862:11, pages 183410.
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Larisa Latypova, Gregory Barshtein, Dan Arbell & Yuri Feldman. (2020) The Contribution of Storage Medium and Membranes in the Microwave Dielectric Response of Packed Red Blood Cells Suspension. Applied Sciences 10:5, pages 1702.
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Qiang Meng, Xiaowu Peng, Shuming Zhao, Ting Xu, Shichun Wang, Qi Liu, Ruili Cai & Yahan Fan. (2019) Hypoxic storage of erythrocytes slows down storage lesions and prolongs shelf‐life. Journal of Cellular Physiology 234:12, pages 22833-22844.
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Gregory Barshtein, Dan Arbell, Leonid Livshits & Alexander Gural. (2018) Is It Possible to Reverse the Storage-Induced Lesion of Red Blood Cells?. Frontiers in Physiology 9.
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Marcelo David, Evgeniya Levy, Yuri Feldman, Paul Ben Ishai, Orly Zelig, Saul Yedgar & Gregory Barshtein. (2017) The dielectric spectroscopy of human red blood cells: the differentiation of old from fresh cells. Physiological Measurement 38:7, pages 1335-1348.
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Shaohan Zhang, Shizhu Chen, Chunyue Gao, Yi Jin, Guang Jia, Zhenhua Li, Dandan Liu, Xingjie Liang, Xinjian Yang & Jinchao Zhang. (2016) Apoptosis induced by NaYF4:Eu3+ nanoparticles in liver cells via mitochondria damage dependent pathway. Science China Chemistry 60:1, pages 122-129.
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Michel Prudent, Frédéric Stauber, Alexis Rapin, Sonia Hallen, Nicole Pham, Mélanie Abonnenc, Laure Marvin, Bertrand Rochat, Jean-Daniel Tissot & Niels Lion. (2016) Small-Scale Perfusion Bioreactor of Red Blood Cells for Dynamic Studies of Cellular Pathways: Proof-of-Concept. Frontiers in Molecular Biosciences 3.
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Anna L. Peters, Robin van Bruggen, Dirk de Korte, Cornelis J.F. Van Noorden & Alexander P.J. Vlaar. (2016) Glucose-6-phosphate dehydrogenase activity decreases during storage of leukoreduced red blood cells. Transfusion 56:2, pages 427-432.
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Zübeyir Huyut, Mehmet Ramazan Şekeroğlu, Ragıp Balahoroğlu, Tahsin Karakoyun & Erdem Çokluk. (2016) The Relationship of Oxidation Sensitivity of Red Blood Cells and Carbonic Anhydrase Activity in Stored Human Blood: Effect of Certain Phenolic Compounds. BioMed Research International 2016, pages 1-8.
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Simone B. Bayer, Mark B. Hampton & Christine C. Winterbourn. (2015) Accumulation of oxidized peroxiredoxin 2 in red blood cells and its prevention. Transfusion 55:8, pages 1909-1918.
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Adam Antosik, Kamila Czubak, Arkadiusz Gajek, Agnieszka Marczak, Rafal Glowacki, Kamila Borowczyk & Halina Malgorzata Zbikowska. (2015) Influence of Pre-Storage Irradiation on the Oxidative Stress Markers, Membrane Integrity, Size and Shape of the Cold Stored Red Blood Cells. Transfusion Medicine and Hemotherapy 42:3, pages 140-148.
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Elisabeth Lang & Florian Lang. (2015) Triggers, Inhibitors, Mechanisms, and Significance of Eryptosis: The Suicidal Erythrocyte Death. BioMed Research International 2015, pages 1-16.
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Thomas J. van ‘t Erve, Claire M. Doskey, Brett A. Wagner, John R. Hess, Benjamin W. Darbro, Kelli K. Ryckman, Jeffrey C. Murray, Thomas J. Raife & Garry R. Buettner. (2014) Heritability of glutathione and related metabolites in stored red blood cells. Free Radical Biology and Medicine 76, pages 107-113.
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Kelly M. Winter, Lacey Johnson, Matthew Kwok, Diana Vidovic, Ryan A. Hyland, Nina Mufti, Anna Erickson & Denese C. Marks. (2014) Red blood cell in vitro quality and function is maintained after S-303 pathogen inactivation treatment. Transfusion 54:7, pages 1798-1807.
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Florian LangMajed AbedElisabeth LangMichael Föller. (2014) Oxidative Stress and Suicidal Erythrocyte Death. Antioxidants & Redox Signaling 21:1, pages 138-153.
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Gregory Barshtein, Alexander Gural, Noga Manny, Orly Zelig, Saul Yedgar & Dan Arbell. (2014) Storage-Induced Damage to Red Blood Cell Mechanical Properties Can Be Only Partially Reversed by Rejuvenation. Transfusion Medicine and Hemotherapy 41:3, pages 197-204.
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James C. Zimring, Nicole Smith, Sean R. Stowell, Jill M. Johnsen, Lauren N. Bell, Richard O. Francis, Eldad A. Hod, Jeanne E. Hendrickson, John D. Roback & Steven L. Spitalnik. (2014) Strain-specific red blood cell storage, metabolism, and eicosanoid generation in a mouse model. Transfusion 54:1, pages 137-148.
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J. S. Raval, J. Fontes, U. Banerjee, M. H. Yazer, E. Mank & A. F. Palmer. (2013) Ascorbic acid improves membrane fragility and decreases haemolysis during red blood cell storage. Transfusion Medicine 23:2, pages 87-93.
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Matthew D. Neal, Jay S. Raval, Darrell J. Triulzi & Richard L. Simmons. (2013) Innate Immune Activation After Transfusion of Stored Red Blood Cells. Transfusion Medicine Reviews 27:2, pages 113-118.
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Jean-Daniel Tissot, Giorgia Canellini, Olivier Rubin, Anne Angelillo-Scherrer, Julien Delobel, Michel Prudent & Niels Lion. (2013) Blood microvesicles: From proteomics to physiology. Translational Proteomics 1:1, pages 38-52.
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Gamaleldin I. Harisa, Mohamed F. Ibrahim & Fars K. Alanazi. (2012) Erythrocyte-mediated delivery of pravastatin: In Vitro study of effect of hypotonic lysis on biochemical parameters and loading efficiency. Archives of Pharmacal Research 35:8, pages 1431-1439.
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Mehmet Ramazan Şekeroğlu, Zübeyr Huyut & Aydın Him. (2012) The susceptibility of erythrocytes to oxidation during storage of blood: Effects of melatonin and propofol. Clinical Biochemistry 45:4-5, pages 315-319.
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Ryan Stapley, Dario A. Vitturi & Rakesh P. Patel. 2011. Chemistry and Biochemistry of Oxygen Therapeutics. Chemistry and Biochemistry of Oxygen Therapeutics 231 241 .
Stephney Whillier, Julia E. Raftos, Rosemary L. Sparrow & Philip W. Kuchel. (2011) The effects of long-term storage of human red blood cells on the glutathione synthesis rate and steady-state concentration. Transfusion 51:7, pages 1450-1459.
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Sara Rinalducci, Gian Maria D’Amici, Barbara Blasi & Lello Zolla. (2011) Oxidative stress-dependent oligomeric status of erythrocyte peroxiredoxin II (PrxII) during storage under standard blood banking conditions. Biochimie 93:5, pages 845-853.
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Nilam S. Mangalmurti, Shampa Chatterjee, Guanjun Cheng, Emily Andersen, Aishat Mohammed, Donald L. Siegel, Ann Marie Schmidt, Steven M. Albelda & Janet S. Lee. (2010) Advanced glycation end products on stored red blood cells increase endothelial reactive oxygen species generation through interaction with receptor for advanced glycation end products. Transfusion 50:11, pages 2353-2361.
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John R. Hess. (2010) Red cell changes during storage. Transfusion and Apheresis Science 43:1, pages 51-59.
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Tamir Kanias & Jason P. Acker. (2010) Biopreservation of red blood cells – the struggle with hemoglobin oxidation. The FEBS Journal 277:2, pages 343-356.
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Alexander Koshkaryev, Orly Zelig, Noga Manny, Saul Yedgar & Gregory Barshtein. (2009) Rejuvenation treatment of stored red blood cells reverses storage-induced adhesion to vascular endothelial cells. Transfusion 49:10, pages 2136-2143.
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Hanna Relevy, Alexander Koshkaryev, Noga Manny, Saul Yedgar & Gregory Barshtein. (2007) Blood banking–induced alteration of red blood cell flow properties. Transfusion 0:0, pages 071005074756002-???.
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Gian Maria D'Amici, Sara Rinalducci & Lello Zolla. (2007) Proteomic Analysis of RBC Membrane Protein Degradation during Blood Storage. Journal of Proteome Research 6:8, pages 3242-3255.
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Florian LangKarl S. LangPhilipp A. LangStephan M. HuberThomas Wieder. (2006) Mechanisms and Significance of Eryptosis. Antioxidants & Redox Signaling 8:7-8, pages 1183-1192.
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Fausta Omodeo-Sale, Anna Motti, Arjen Dondorp, Nicholas J. White & Donatella Taramelli. (2005) Destabilisation and subsequent lysis of human erythrocytes induced by Plasmodium falciparum haem products. European Journal of Haematology 74:4, pages 324-332.
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U. J. DumaswalaL. ZhuoS. MahajanP. N. M. NairH. G. Shertzer, P. Dibello & D. W. Jacobsen. (2001) Glutathione protects chemokine-scavenging and antioxidative defense functions in human RBCs. American Journal of Physiology-Cell Physiology 280:4, pages C867-C873.
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