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Original Article

Retinol supplementation induces DNA damage and modulates iron turnover in rat Sertoli cells

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Pages 677-687 | Received 25 Apr 2000, Published online: 07 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Ricardo F. da Rocha, Marcos Roberto de Oliveira, Patrícia Schonhofen, Carlos Eduardo Schnorr, Felipe Dal Pizzol & José Cláudio F. Moreira. (2010) Long-term vitamin A supplementation at therapeutic doses induces mitochondrial electrons transfer chain (METC) impairment and increased mitochondrial membrane-enriched fraction (MMEF) 3-nitrotyrosine on rat heart. Free Radical Research 44:5, pages 505-512.
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Matheus A. B. Pasquali, Daniel P. Gelain, Marcos R. Oliveira, Guilherme A. Behr, Leonardo L. Motta, Ricardo F. Rocha, Fábio Klamt & José C. F. Moreira. (2009) VITAMIN A SUPPLEMENTATION INDUCES OXIDATIVE STRESS AND DECREASES THE IMMUNOCONTENT OF CATALASE AND SUPEROXIDE DISMUTASE IN RAT LUNGS. Experimental Lung Research 35:5, pages 427-438.
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Alfeu Zanotto-Filho, Rafael Schröder & José Cláudio F. Moreira. (2008) Differential effects of retinol and retinoic acid on cell proliferation: A role for reactive species and redox-dependent mechanisms in retinol supplementation. Free Radical Research 42:9, pages 778-788.
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Alfeu Zanotto-Filho, Rafael Schröder & José Cláudio F. Moreira. (2008) Xanthine oxidase-dependent ROS production mediates vitamin A pro-oxidant effects in cultured Sertoli cells. Free Radical Research 42:6, pages 593-601.
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Rodrigo J. S. Dalmolin, Alfeu Zanotto-filho, Ramatis B. De oliveira, Roxane F. Duarte, Matheus A. B. Pasquali & José C. F. Moreira. (2007) Retinol and retinoic acid increase MMP-2 activity by different pathways in cultured Sertoli cells. Free Radical Research 41:12, pages 1338-1347.
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Mário Luiz Conte da Frota, Fábio Klamt, Felipe Dal-Pizzol, Marion Schiengold & José Cláudio Fonseca Moreira. (2004) Retinol-induced mdr1 and mdr3 modulation in cultured rat Sertoli cells is attenuated by free radical scavengers. Redox Report 9:3, pages 161-165.
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Felipe Dal-Pizzol, Fábio Klamt, Rodrigo J.S. Dalmolin, Elena A. Bernard & José Cláudio F. Moreira. (2001) Mitogenic signaling mediated by oxidants in retinol treated sertoli cells. Free Radical Research 35:6, pages 749-755.
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Felipe Dal-Pizzol, Fábio Klamt, Mara S. Benfato, Elena A. Bernard & José Cláudio F. Moreira. (2001) Retinol supplementation induces oxidative stress and modulates antioxidant enzyme activities in rat Sertoli cells. Free Radical Research 34:4, pages 395-404.
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Robert van Lith, Xuesong Wang & Guillermo Ameer. (2016) Biodegradable Elastomers with Antioxidant and Retinoid-like Properties. ACS Biomaterials Science & Engineering 2:2, pages 268-277.
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Daniel Pens Gelain, Matheus Augusto de Bittencourt Pasquali, Fernanda Freitas Caregnato, Mauro Antonio Alves Castro & José Claudio Fonseca Moreira. (2012) Retinol induces morphological alterations and proliferative focus formation through free radical-mediated activation of multiple signaling pathways. Acta Pharmacologica Sinica 33:4, pages 558-567.
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Matheus Augusto de Bittencourt Pasquali, Marcos Roberto de Oliveira, Marco Antônio De Bastiani, Ricardo Fagundes da Rocha, Carlos Eduardo Schnorr, Juciano Gasparotto, Daniel Pens Gelain & José Cláudio Fonseca Moreira. (2011) L‐NAME co‐treatment prevent oxidative damage in the lung of adult Wistar rats treated with vitamin A supplementation. Cell Biochemistry and Function 30:3, pages 256-263.
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Thallita Kelly Rabelo, Fares Zeidán-Chuliá, Laura Milán Vasques, João Paulo Almeida dos Santos, Ricardo Fagundes da Rocha, Matheus Augusto de Bittencourt Pasquali, José Luiz Rybarczyk-Filho, Adriano Antunes Souza Araújo, José Claudio Fonseca Moreira & Daniel Pens Gelain. (2012) Redox characterization of usnic acid and its cytotoxic effect on human neuron-like cells (SH-SY5Y). Toxicology in Vitro 26:2, pages 304-314.
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Ramatis B. de Oliveira, Fernanda S. Gravina, Rebecca Lim, Alan M. Brichta, Robert J. Callister & Dirk F. van Helden. (2012) Heterogeneous Responses to Antioxidants in Noradrenergic Neurons of the Locus Coeruleus Indicate Differing Susceptibility to Free Radical Content. Oxidative Medicine and Cellular Longevity 2012, pages 1-10.
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Daniel Pens Gelain, Matheus Augusto de Bittencourt Pasquali, Fernanda Freitas Caregnato & José Claudio Fonseca Moreira. (2011) Vitamin A (retinol) up-regulates the receptor for advanced glycation endproducts (RAGE) through p38 and Akt oxidant-dependent activation. Toxicology 289:1, pages 38-44.
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Marcelia Garcez Dória Melo, João Paulo Almeida dos Santos, Mairim Russo Serafini, Fernanda Freitas Caregnato, Matheus Augusto de Bittencourt Pasquali, Thallita Kelly Rabelo, Ricardo Fagundes da Rocha, Lucindo QuintansJr.Jr., Adriano Antunes de Souza Araújo, Francilene Amaral da Silva, José Cláudio Fonseca Moreira & Daniel Pens Gelain. (2011) Redox properties and cytoprotective actions of atranorin, a lichen secondary metabolite. Toxicology in Vitro 25:2, pages 462-468.
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Carlos Eduardo Schnorr, Maurílio da Silva Morrone, André Simões-Pires, Ricardo Fagundes da Rocha, Guilherme Antônio Behr & José Cláudio Fonseca Moreira. (2011) Vitamin A supplementation in rats under pregnancy and nursing induces behavioral changes and oxidative stress upon striatum and hippocampus of dams and their offspring. Brain Research 1369, pages 60-73.
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Ricardo Fagundes da Rocha, Marcos Roberto de Oliveira, Patrícia Schonhofen, Marco Antônio De Bastiani, Carlos Eduardo Schnorr, Fábio Klamt, Felipe Dal Pizzol & José Claudio Fonseca Moreira. (2010) Vitamin A supplementation for different periods alters rat vascular redox parameters. Journal of Physiology and Biochemistry 66:4, pages 351-357.
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Matheus Augusto de Bittencourt Pasquali, Carlos Eduardo Schnorr, Lucas Brambilla Hilbig Feistauer, Daniel Pens Gelain & José Cláudio Fonseca Moreira. (2010) Vitamin A supplementation to pregnant and breastfeeding female rats induces oxidative stress in the neonatal lung. Reproductive Toxicology 30:3, pages 452-456.
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Matheus Augusto de Bittencourt Pasquali, Daniel Pens Gelain, Marcos Roberto de Oliveira, Guilherme Antônio Behr, Leonardo Lisbôa da Motta, Ricardo Fagundes da Rocha, Fábio Klamt & José Cláudio Fonseca Moreira. (2009) Vitamin A Supplementation for Different Periods Alters Oxidative Parameters in Lungs of Rats. Journal of Medicinal Food 12:6, pages 1375-1380.
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Marcos Roberto de Oliveira, Max William Soares Oliveira, Rodrigo Lorenzi, Ricardo Fagundes da Rocha & José Cláudio Fonseca Moreira. (2008) Short-term vitamin A supplementation at therapeutic doses induces a pro-oxidative state in the hepatic environment and facilitates calcium-ion-induced oxidative stress in rat liver mitochondria independently from permeability transition pore formation. Cell Biology and Toxicology 25:6, pages 545-560.
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Marcos Roberto De Oliveira, Max William Soares Oliveira, Ricardo Fagundes Da Rocha & José Cláudio Fonseca Moreira. (2009) Vitamin A supplementation at pharmacological doses induces nitrosative stress on the hypothalamus of adult Wistar rats. Chemico-Biological Interactions 180:3, pages 407-413.
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Marcos Roberto de Oliveira, Max William Soares Oliveira, Guilherme Antônio Behr, Matheus Augusto de Bittencourt Pasquali & José Cláudio Fonseca Moreira. (2009) Increased Receptor for Advanced Glycation Endproducts Immunocontent in the Cerebral Cortex of Vitamin A-Treated Rats. Neurochemical Research 34:8, pages 1410-1416.
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Miguel Roehrs, Juliana Valentini, Rachel Bulcão, José Cláudio Moreira, Hanz Biesalski, Renata P. Limberger, Tilman Grune & Solange Cristina Garcia. (2009) The plasma retinol levels as pro-oxidant/oxidant agents in haemodialysis patients. Nephrology Dialysis Transplantation 24:7, pages 2212-2218.
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Marcos Roberto de Oliveira, Max William Soares Oliveira, Guilherme Antônio Behr, Mariana Leivas Muller Hoff, Ricardo Fagundes da Rocha & José Cláudio Fonseca Moreira. (2009) Evaluation of the effects of vitamin A supplementation on adult rat substantia nigra and striatum redox and bioenergetic states: Mitochondrial impairment, increased 3-nitrotyrosine and α-synuclein, but decreased D2 receptor contents. Progress in Neuro-Psychopharmacology and Biological Psychiatry 33:2, pages 353-362.
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Matheus A.B. Pasquali, Daniel P. Gelain, Alfeu Zanotto-Filho, Luiz F. de Souza, Ramatis B. de Oliveira, Fabio Klamt & Jose C.F. Moreira. (2008) Retinol and retinoic acid modulate catalase activity in Sertoli cells by distinct and gene expression-independent mechanisms. Toxicology in Vitro 22:5, pages 1177-1183.
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Daniel Pens Gelain, Matheus Augusto de Bittencourt Pasquali, Fernanda Freitas Caregnato, Alfeu Zanotto-Filho & José Cláudio Fonseca Moreira. (2008) Retinol up-regulates the receptor for advanced glycation endproducts (RAGE) by increasing intracellular reactive species. Toxicology in Vitro 22:5, pages 1123-1127.
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Marcos Roberto de Oliveira & José Cláudio Fonseca Moreira. (2007) Acute and chronic vitamin A supplementation at therapeutic doses induces oxidative stress in submitochondrial particles isolated from cerebral cortex and cerebellum of adult rats. Toxicology Letters 173:3, pages 145-150.
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Marcos Roberto de Oliveira, Matheus Augusto de Bittencourt Pasquali, Roberta Bristot Silvestrin, Tadeu Mello e Souza & José Cláudio Fonseca Moreira. (2007) Vitamin A supplementation induces a prooxidative state in the striatum and impairs locomotory and exploratory activity of adult rats. Brain Research 1169, pages 112-119.
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Mario Luiz Conte da FrotaJr.Jr., Evandro Gomes Da Silva, Guilherme Antônio Behr, Marcos Roberto De Oliveira, Felipe Dal-Pizzol, Fábio Klamt & José Cláudio Fonseca Moreira. (2006) All-trans retinoic acid induces free radical generation and modulate antioxidant enzyme activities in rat sertoli cells. Molecular and Cellular Biochemistry 285:1-2, pages 173-179.
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David D. Kitts. 2005. Bailey's Industrial Oil and Fat Products. Bailey's Industrial Oil and Fat Products.
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Ramatis Birnfeld Oliveira, F�bio Klamt, Mauro A. A. Castro, Manuela Polydoro, Alfeu Zanotto Filho, Daniel Pens Gelain, Felipe Dal-Pizzol1 & Jos� Cl�udio Fonseca Moreira1. (2005) Morphological and oxidative alterations on Sertoli cells cytoskeleton due to retinol-induced reactive oxygen species. Molecular and Cellular Biochemistry 271:1-2, pages 189-196.
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Fábio Klamt, Felipe Dal-Pizzol, Elena Aida Bernard & José Cláudio Fonseca Moreira. (2003) Enhanced UV-mediated free radical generation; DNA and mitochondrial damage caused by retinol supplementation. Photochemical & Photobiological Sciences 2:8, pages 856-860.
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