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Free Radical Research Volume 35, 2001 - Issue 6
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Original Article

Oxidation of melatonin by oxoferryl hemoglobin: A mechanistic study

Luisa Tesoriere Department of Pharmaceutical Toxicological and Biological Chemistry, c/o Dipartimento di Scienze Farmacologiche, University of Palermo, Via Carlo Forlanini, 1, 90134, Palermo, Italy
,
Giuseppe Avellone Department of Pharmaceutical Chemistry and Technology, University of Palermo, Palermo, Italy
,
Leopoldo Ceraulo Department of Pharmaceutical Toxicological and Biological Chemistry, c/o Dipartimento di Scienze Farmacologiche, University of Palermo, Via Carlo Forlanini, 1, 90134, Palermo, Italy
,
Daniele D'Arpa Department of Pharmaceutical Chemistry and Technology, University of Palermo, Palermo, Italy
,
Mario Allegra Department of Pharmaceutical Toxicological and Biological Chemistry, c/o Dipartimento di Scienze Farmacologiche, University of Palermo, Via Carlo Forlanini, 1, 90134, Palermo, Italy
&
Maria A. Livrea Department of Pharmaceutical Chemistry and Technology, University of Palermo, Palermo, Italy
Pages 633-642 | Received 16 Feb 2001, Published online: 07 Jul 2009

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Russel J. Reiter, Sergio D. Paredes, Lucien C. Manchester & Dan-Xian Tan. (2009) Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin. Critical Reviews in Biochemistry and Molecular Biology 44:4, pages 175-200.
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Articles from other publishers (25)

Zhenguo Hu, Luya Feng, Qian Jiang, Wenliang Wang, Bi'e Tan, Xiongzhuo Tang & Yulong Yin. (2023) Intestinal tryptophan metabolism in disease prevention and swine production. Animal Nutrition 15, pages 364-374.
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Chenlu Zhang, Yaxin Guo, Yan Yang, Zhaojin Du, Yunhui Fan, Yin Zhao & Suzhen Yuan. (2023) Oxidative stress on vessels at the maternal-fetal interface for female reproductive system disorders: Update. Frontiers in Endocrinology 14.
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Jiancheng Yang, Qinghua Tang & Yuhong Zeng. (2022) Melatonin: Potential avenue for treating iron overload disorders. Ageing Research Reviews 81, pages 101717.
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Wei Yong, Haiying Ma, Man Na, Teng Gao, Ye Zhang, Liying Hao, Hang Yu, Huazhe Yang & Xin Deng. (2021) Roles of melatonin in the field of reproductive medicine. Biomedicine & Pharmacotherapy 144, pages 112001.
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Igor R. Ilyasov, Vladimir L. Beloborodov, Irina A. Selivanova & Roman P. Terekhov. (2020) ABTS/PP Decolorization Assay of Antioxidant Capacity Reaction Pathways. International Journal of Molecular Sciences 21:3, pages 1131.
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Annia Galano & Russel J. Reiter. (2018) Melatonin and its metabolites vs oxidative stress: From individual actions to collective protection. Journal of Pineal Research 65:1, pages e12514.
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Dun-Xian Tan, Lucien Manchester, Eduardo Esteban-Zubero, Zhou Zhou & Russel Reiter. (2015) Melatonin as a Potent and Inducible Endogenous Antioxidant: Synthesis and Metabolism. Molecules 20:10, pages 18886-18906.
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Annia Galano, Dun Xian Tan & Russel J. Reiter. (2014) Cyclic 3-hydroxymelatonin, a key metabolite enhancing the peroxyl radical scavenging activity of melatonin. RSC Advances 4:10, pages 5220.
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Dhiman Maitra, Ibrahim Abdulhamid, Michael P. Diamond, Ghassan M. Saed & Husam M. Abu‐Soud. (2012) Melatonin attenuates hypochlorous acid‐mediated heme destruction, free iron release, and protein aggregation in hemoglobin. Journal of Pineal Research 53:2, pages 198-205.
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María Eugenia Letelier, José Jara-Sandoval, Alfredo Molina-Berríos, Mario Faúndez, Paula Aracena-Parks & Felipe Aguilera. (2010) Melatonin protects the cytochrome P450 system through a novel antioxidant mechanism. Chemico-Biological Interactions 185:3, pages 208-214.
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Debasri Mukherjee, Sreerupa Ghose Roy, Arun Bandyopadhyay, Aindrila Chattopadhyay, Anjali Basu, Elina Mitra, Arnab Kr. Ghosh, Russel J. Reiter & Debasish Bandyopadhyay. (2010) Melatonin protects against isoproterenol‐induced myocardial injury in the rat: antioxidative mechanisms. Journal of Pineal Research 48:3, pages 251-262.
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Rüdiger Hardeland, Dun‐Xian Tan & Russel J. Reiter. (2009) Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines. Journal of Pineal Research 47:2, pages 109-126.
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Igor Semak, Elena Korik, Maria Antonova, Jacobo Wortsman & Andrzej Slominski. (2008) Metabolism of melatonin by cytochrome P450s in rat liver mitochondria and microsomes. Journal of Pineal Research 45:4, pages 515-523.
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Tobias W. Fischer, Andrzej Slominski, Desmond J. Tobin & Ralf Paus. (2007) Melatonin and the hair follicle. Journal of Pineal Research 0:0, pages 071027134919001-???.
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Dun-Xian Tan, Lucien C. Manchester, Maria P. Terron, Luis J. Flores & Russel J. Reiter. (2007) One molecule, many derivatives: A never-ending interaction of melatonin with reactive oxygen and nitrogen species?. Journal of Pineal Research 42:1, pages 28-42.
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Aleksandra Kowalczyk, Mieczysław Puchała, Katarzyna Wesołowska & Eligiusz Serafin. (2007) Inactivation of alcohol dehydrogenase (ADH) by ferryl derivatives of human hemoglobin. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1774:1, pages 86-92.
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Tobias W. Fischer, Trevor W. Sweatman, Igor Semak, Robert M. Sayre, Jacobo Wortsman, Andrƶej Slominski, Tobias W. Fischer, Trevor W. Sweatman, Igor Semak, Robert M. Sayre, Jacobo Wortsman & Andrzej Slominski. (2006) Constitutive and UV‐induced metabolism of melatonin in keratinocytes and cell‐free systems. The FASEB Journal 20:9, pages 1564-1566.
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Rüdiger Hardeland & SR Pandi-Perumal. (2005) Melatonin, a potent agent in antioxidative defense: Actions as a natural food constituent, gastrointestinal factor, drug and prodrug. Nutrition & Metabolism 2:1.
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Dun-Xian Tan, Lucien C. Manchester, Rosa M. Sainz, Juan C. Mayo, Josefa Leon, Ruediger Hardeland, Burkhard Poeggeler & Russel J. Reiter. (2005) Interactions between melatonin and nicotinamide nucleotide: NADH preservation in cells and in cell-free systems by melatonin. Journal of Pineal Research 39:2, pages 185-194.
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Andrzej Slominski, Jacobo Wortsman & Desmond J. Tobin. (2005) The cutaneous serotoninergic/melatoninergic system: securing a place under the sun. The FASEB Journal 19:2, pages 176-194.
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Pasquale Agozzino, Giuseppe Avellone, David Bongiorno, Leopoldo Ceraulo, Felice Filizzola, Maria C. Natoli, Maria A. Livrea & Luisa Tesoriere. (2003) Melatonin: structural characterization of its non-enzymatic mono-oxygenate metabolite. Journal of Pineal Research 35:4, pages 269-275.
Crossref
Dun-xian Tan, Rüdiger Hardeland, Lucien C. Manchester, Burkhard Poeggeler, Silvia Lopez-Burillo, Juan C. Mayo, Rosa M. Sainz & Russel J. Reiter. (2003) Mechanistic and comparative studies of melatonin and classic antioxidants in terms of their interactions with the ABTS cation radical. Journal of Pineal Research 34:4, pages 249-259.
Crossref
M. Allegra, R.J. Reiter, D.-X. Tan, C. Gentile, L. Tesoriere & M.A. Livrea. (2003) The chemistry of melatonin's interaction with reactive species. Journal of Pineal Research 34:1, pages 1-10.
Crossref
M. Allegra, C. Gentile, L. Tesoriere & M. A. Livrea. (2002) Protective effect of melatonin against cytotoxic actions of malondialdehyde: an in vitro study on human erythrocytes. Journal of Pineal Research 32:3, pages 187-193.
Crossref
Mario Allegra, Paul Georg Furtmüller, Günther Regelsberger, Maria L. Turco-Liveri, Luisa Tesoriere, Mauro Perretti, Maria A. Livrea & Christian Obinger. (2001) Mechanism of Reaction of Melatonin with Human Myeloperoxidase. Biochemical and Biophysical Research Communications 282:2, pages 380-386.
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