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Research Article

Mitochondrial Superoxide Radical Formation is Controlled by Electron Bifurcation to the High and Low Potential Pathways

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Pages 381-387 | Published online: 07 Jul 2009

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Sergey I. Dikalov, Igor A. Kirilyuk, Maxim Voinov & Igor A. Grigor'ev. (2011) EPR detection of cellular and mitochondrial superoxide using cyclic hydroxylamines. Free Radical Research 45:4, pages 417-430.
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Lizette Gil, Daniel Pérez, Rolando Tápanes, Jorge Pérez & Tilman Grune. (2005) Does mitochondrial dysfunction during antiretroviral therapy in human immunodeficiency virus infection suggest antioxidant supplementation as a beneficial option?. Redox Report 10:3, pages 113-119.
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Sabari Dutta, Ratnamala Bendre, Subhash Padhye, Fakhara Ahmed & Fazlul Sarkar. (2005) Synthesis, Antioxidant Properties and Antiproliferative Activities of Tetrameric Copper and Copper‐Zinc Metal Complexes of Catecholamine Schiff Base Ligand. Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry 35:1, pages 3-10.
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Hans Nohl, Lars Gille, Andrey Kozlov & Katrin Staniek. (2003) Are mitochondria a spontaneous and permanent source of reactive oxygen species?. Redox Report 8:3, pages 135-141.
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Romana Fato, Christian Bergamini, Serena Leoni & Giorgio Lenaz. (2008) Mitochondrial production of reactive oxygen species: Role of Complex I and quinone analogues. BioFactors 32:1-4, pages 31-39.
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LOTHAR ESSER, LINDA YU, CHANG-AN YU & DI XIA. (2011) INSIGHTS INTO THE MECHANISMS OF QUINOL OXIDATION IN CYTOCHROME bc 1 IN LIGHT OF THE STRUCTURE OF THE BACTERIAL COMPLEX . Biophysical Reviews and Letters 02:03n04, pages 229-257.
Crossref
T Kanome, N Itoh, F Ishikawa, K Mori, J-R Kim-Kaneyama, K Nose & M Shibanuma. (2007) Characterization of Jumping translocation breakpoint (JTB) gene product isolated as a TGF-β1-inducible clone involved in regulation of mitochondrial function, cell growth and cell death. Oncogene 26:41, pages 5991-6001.
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Lan Yan, Jun-Dong Zhang, Yong-Bing Cao, Ping-Hui Gao & Yuan-Ying Jiang. (2007) Proteomic Analysis Reveals a Metabolism Shift in a Laboratory Fluconazole-Resistant Candida albicans Strain . Journal of Proteome Research 6:6, pages 2248-2256.
Crossref
Hirokazu Fukui & Carlos T. Moraes. (2007) Extended polyglutamine repeats trigger a feedback loop involving the mitochondrial complex III, the proteasome and huntingtin aggregates. Human Molecular Genetics 16:7, pages 783-797.
Crossref
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Gregory A. Dement, Scott C. Maloney & Raymond Reeves. (2007) Nuclear HMGA1 nonhistone chromatin proteins directly influence mitochondrial transcription, maintenance, and function. Experimental Cell Research 313:1, pages 77-87.
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Marcelo P. Barros, Orlando NecchiJr.Jr., Pio Colepicolo & Marianne Pedersén. (2006) Kinetic study of the plastoquinone pool availability correlated with H2O2 release in seawater and antioxidant responses in the red alga Kappaphycus alvarezii exposed to single or combined high light, chilling and chemical stresses. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1757:11, pages 1520-1528.
Crossref
Lothar Esser, Xing Gong, Shaoqing Yang, Linda Yu, Chang-An Yu & Di Xia. (2006) Surface-modulated motion switch: Capture and release of iron–sulfur protein in the cytochrome bc 1 complex . Proceedings of the National Academy of Sciences 103:35, pages 13045-13050.
Crossref
S.L. Prior, A.P. Griffiths, J.M. Baxter, P.W. Baxter, S.C. Hodder, K.C. Silvester & P.D. Lewis. (2006) Mitochondrial DNA mutations in oral squamous cell carcinoma. Carcinogenesis 27:5, pages 945-950.
Crossref
Geetha Achanta, Ryohei Sasaki, Li Feng, Jennifer S Carew, Weiqin Lu, Helene Pelicano, Michael J Keating & Peng Huang. (2005) Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol γ. The EMBO Journal 24:19, pages 3482-3492.
Crossref
Andrey V. Kozlov, Laszlo Szalay, Fraz Umar, Karl Kropik, Katrin Staniek, Hans Niedermüller, Soheyl Bahrami & Hans Nohl. (2005) Skeletal muscles, heart, and lung are the main sources of oxygen radicals in old rats. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1740:3, pages 382-389.
Crossref
Evgeny Denisov & Igor Afanas’ev. 2005. Oxidation and Antioxidants in Organic Chemistry and Biology. Oxidation and Antioxidants in Organic Chemistry and Biology 1 284 .
Xing Gong, Linda Yu, Di Xia & Chang-An Yu. (2005) Evidence for Electron Equilibrium between the Two Hemes bL in the Dimeric Cytochrome bc1 Complex. Journal of Biological Chemistry 280:10, pages 9251-9257.
Crossref
Paul S. Brookes. (2005) Mitochondrial H+ leak and ROS generation: An odd couple. Free Radical Biology and Medicine 38:1, pages 12-23.
Crossref
Travis W. Young, Fang C. Mei, Gong Yang, Jennifer A. Thompson-Lanza, Jinsong Liu & Xiaodong Cheng. (2004) Activation of Antioxidant Pathways in Ras-Mediated Oncogenic Transformation of Human Surface Ovarian Epithelial Cells Revealed by Functional Proteomics and Mass Spectrometry. Cancer Research 64:13, pages 4577-4584.
Crossref
Olivier Baud, Robin F. Haynes, Hong Wang, Rebecca D. Folkerth, Jianrong Li, Joseph J. Volpe & Paul A. Rosenberg. (2004) Developmental up-regulation of MnSOD in rat oligodendrocytes confers protection against oxidative injury. European Journal of Neuroscience 20:1, pages 29-40.
Crossref
Young Ik Lee, Jung Me Hwang, Jee Hye Im, Yoon Ik Lee, Nam Soon Kim, Dae Gon Kim, Dae Yeul Yu, Hyung Bae Moon & Sook Kyung Park. (2004) Human Hepatitis B Virus-X Protein Alters Mitochondrial Function and Physiology in Human Liver Cells. Journal of Biological Chemistry 279:15, pages 15460-15471.
Crossref
Helene Pelicano, Dennis Carney & Peng Huang. (2004) ROS stress in cancer cells and therapeutic implications. Drug Resistance Updates 7:2, pages 97-110.
Crossref
Ashish Mehta & Chandrima Shaha. (2004) Apoptotic Death in Leishmania donovani Promastigotes in Response to Respiratory Chain Inhibition. Journal of Biological Chemistry 279:12, pages 11798-11813.
Crossref
Masayoshi Horimoto, Péter Fülöp, Zoltán Derdák, Jack R. Wands & György Baffy. (2004) Uncoupling protein-2 deficiency promotes oxidant stress and delays liver regeneration in mice. Hepatology 39:2, pages 386-392.
Crossref
Rosario Rizzuto, Paolo Pinton, Davide Ferrari, Mounia Chami, György Szabadkai, Paulo J Magalhães, Francesco Di Virgilio & Tullio Pozzan. (2003) Calcium and apoptosis: facts and hypotheses. Oncogene 22:53, pages 8619-8627.
Crossref
Hélène Pelicano, Li Feng, Yan Zhou, Jennifer S. Carew, Elizabeth O. Hileman, William Plunkett, Michael J. Keating & Peng Huang. (2003) Inhibition of Mitochondrial Respiration. Journal of Biological Chemistry 278:39, pages 37832-37839.
Crossref
Yan ZhouElizabeth O. HilemanWilliam PlunkettMichael J. KeatingPeng Huang. (2003) Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer agents. Blood 101:10, pages 4098-4104.
Crossref
Keita Odani, Toshihiro Kobayashi, Yasuhiro Ogawa, Shoji Yoshida & Harumichi Seguchi. (2003) ML-7 inhibits exocytosis of superoxide-producing intracellular compartments in human neutrophils stimulated with phorbol myristate acetate in a myosin light chain kinase-independent manner. Histochemistry and Cell Biology 119:5, pages 363-370.
Crossref
Donald D Newmeyer & Shelagh Ferguson-Miller. (2003) Mitochondria. Cell 112:4, pages 481-490.
Crossref
John R. Speakman. 2003. Energy Metabolism and Lifespan Determination. Energy Metabolism and Lifespan Determination 35 68 .
Hans Nohl, Katrin Staniek, Andrey V. Kozlov & Lars Gille. (2003) The biomolecule ubiquinone exerts a variety of biological functions. BioFactors 18:1-4, pages 23-31.
Crossref

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