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Free Radical Research Volume 36, 2002 - Issue 4
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Research Article

Mitochondrial Dysfunction in Friedreich's Ataxia: From Pathogenesis to Treatment Perspectives

R. Lodi Dipartimento di Medicina Clinica e Biotecnologia Applicata, Universita' di Bologna, Policlinico S. Orsola, Via Massareti 9, 40138 Bologna, Italy
,
B. Rajagopalan MRC Biochemical and Clinical Magnetic Resonance Unit, Department of Biochemistry, University of Oxford and Oxford Radcliffe Hospital, Oxford, UK
,
J.L. Bradley University Department of Clinical Neurosciences, Royal Free and University College Medical School, London, UK
,
D.J. Taylor MRC Biochemical and Clinical Magnetic Resonance Unit, Department of Biochemistry, University of Oxford and Oxford Radcliffe Hospital, Oxford, UK
,
J.G. Crilley MRC Biochemical and Clinical Magnetic Resonance Unit, Department of Biochemistry, University of Oxford and Oxford Radcliffe Hospital, Oxford, UK
,
P.E. Hart University Department of Clinical Neurosciences, Royal Free and University College Medical School, London, UK
,
A.M. Blamire MRC Biochemical and Clinical Magnetic Resonance Unit, Department of Biochemistry, University of Oxford and Oxford Radcliffe Hospital, Oxford, UK
,
D. Manners MRC Biochemical and Clinical Magnetic Resonance Unit, Department of Biochemistry, University of Oxford and Oxford Radcliffe Hospital, Oxford, UK
,
P. Styles MRC Biochemical and Clinical Magnetic Resonance Unit, Department of Biochemistry, University of Oxford and Oxford Radcliffe Hospital, Oxford, UK
,
A.H.V. Schapira Dipartimento di Medicina Clinica e Biotecnologia Applicata, Universita' di Bologna, Policlinico S. Orsola, Via Massareti 9, 40138 Bologna, Italy; Institute of Neurology, University College, London, UK
&
J.M. Cooper University Department of Clinical Neurosciences, Royal Free and University College Medical School, London, UK
 show all
Pages 461-466 | Published online: 07 Jul 2009

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Meredith Spindler, M Flint Beal & Claire Henchcliffe. (2009) Coenzyme Q10 effects in neurodegenerative disease. Neuropsychiatric Disease and Treatment 5, pages 597-610.
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HASMET AYHAN HANAGASI, DILEK AYRIBAS, KEMAL BAYSAL & MURAT EMRE. (2005) MITOCHONDRIAL COMPLEX I, II/III, AND IV ACTIVITIES IN FAMILIAL AND SPORADIC PARKINSON'S DISEASE. International Journal of Neuroscience 115:4, pages 479-493.
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Articles from other publishers (20)

XinPing Cheng, Andrey Y. Vinokurov, Evgeniy A. Zherebtsov, Olga A. Stelmashchuk, Plamena R. Angelova, Noemi Esteras & Andrey Y. Abramov. (2020) Variability of mitochondrial energy balance across brain regions. Journal of Neurochemistry 157:4, pages 1234-1243.
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Massimo Pandolfo. 2020. Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease. Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease 99 112 .
Kazumasa Yamagishi, Ai Ikeda, Yuri Moriyama, Choy-Lye Chei, Hiroyuki Noda, Mitsumasa Umesawa, Renzhe Cui, Masanori Nagao, Akihiko Kitamura, Yorihiro Yamamoto, Takashi Asada & Hiroyasu Iso. (2014) Serum coenzyme Q10 and risk of disabling dementia: The Circulatory Risk in Communities Study (CIRCS). Atherosclerosis 237:2, pages 400-403.
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Jennifer LeightonJason HowardRon El-Hawary. (2013) Posterior Spinal Fusion for Friedreich Ataxia-Related Scoliosis in Twin Girls. JBJS Case Connector 3:2, pages e39.
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Young Geol Yoon, Sun Hee Park, Jee Suk Lee, Chunlan Yan, Chan Bae Park, Michael D. Koob & Young Hyun Yoo. (2013) Synthesis of frataxin genes by direct assembly of serial deoxyoligonucleotide primers and its expression in Escherichia coli. Biotechnology and Bioprocess Engineering 18:2, pages 382-389.
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Josef Finsterer. (2010) Treatment of mitochondrial disorders. European Journal of Paediatric Neurology 14:1, pages 29-44.
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Alison La Pean, Neal Jeffries, Chelsea Grow, Bernard Ravina & Nicholas A. Di Prospero. (2008) Predictors of progression in patients with Friedreich ataxia. Movement Disorders 23:14, pages 2026-2032.
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V. Calabrese, D. A. Butterfield & A. M. Giuffrida Stella. 2008. Handbook of Neurochemistry and Molecular Neurobiology. Handbook of Neurochemistry and Molecular Neurobiology 103 146 .
A. Joyce Young, Stephanie Johnson, David C. Steffens & P. Murali Doraiswamy. (2014) Coenzyme Q10: A Review of Its Promise as a Neuroprotectant . CNS Spectrums 12:1, pages 62-68.
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Nicole von Wurmb-Schwark. 2007. Oxidative Stress and Neurodegenerative Disorders. Oxidative Stress and Neurodegenerative Disorders 59 87 .
Megan Whitnall & Des R. Richardson. (2006) Iron: A New Target for Pharmacological Intervention in Neurodegenerative Diseases. Seminars in Pediatric Neurology 13:3, pages 186-197.
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Josef Finsterer, Claudia Stöllberger & Gerhard Blazek. (2006) Neuromuscular implications in left ventricular hypertrabeculation/noncompaction. International Journal of Cardiology 110:3, pages 288-300.
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Vittorio CalabreseD. Allan ButterfieldGiovanni ScapagniniA.M. Giuffrida StellaMahin D. Maines. (2006) Redox Regulation of Heat Shock Protein Expression by Signaling Involving Nitric Oxide and Carbon Monoxide: Relevance to Brain Aging, Neurodegenerative Disorders, and Longevity. Antioxidants & Redox Signaling 8:3-4, pages 444-477.
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Danuta S. Kalinowski & Des R. Richardson. (2005) The Evolution of Iron Chelators for the Treatment of Iron Overload Disease and Cancer. Pharmacological Reviews 57:4, pages 547-583.
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Vittorio Calabrese, Raffaele Lodi, Caterina Tonon, Velia D'Agata, Maria Sapienza, Giovanni Scapagnini, Andrea Mangiameli, Giovanni Pennisi, A.M. Giuffrida Stella & D. Allan Butterfield. (2005) Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich's ataxia. Journal of the Neurological Sciences 233:1-2, pages 145-162.
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Hemmi N. Bhagavan & Raj K. Chopra. (2005) Potential role of ubiquinone (coenzyme Q10) in pediatric cardiomyopathy. Clinical Nutrition 24:3, pages 331-338.
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HYMAN M. SCHIPPER. (2004) Redox Neurology: Visions of an Emerging Subspecialty. Annals of the New York Academy of Sciences 1012:1, pages 342-355.
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J. Finsterer. (2004) Mitochondriopathies. European Journal of Neurology 11:3, pages 163-186.
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Paul E. Hart & Anthony H.V. Schapira. 2004. Encyclopedia of Biological Chemistry. Encyclopedia of Biological Chemistry 143 145 .
Gulay Alper & Vinodh Narayanan. (2003) Friedreich’s ataxia. Pediatric Neurology 28:5, pages 335-341.
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