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Bertrand Lebouché, Alexis Yero, Tao Shi, Omar Farnos, Joel Singer, Ido Kema, Cecilia T. Costiniuk, Réjean Thomas, Marie-Josée Brouillette, Kim Engler, Jean-Pierre Routy & Mohammad-Ali Jenabian. (2020) Impact of extended-release niacin on immune activation in HIV-infected immunological non-responders on effective antiretroviral therapy. HIV Research & Clinical Practice 21:6, pages 182-190.
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Kira Bensimon, Nathan Herrmann, Walter Swardfager, Hao Yi, Sandra E Black, Fu-Qiang Gao, Abraham Snaiderman & Krista L Lanctôt. (2014) Kynurenine and depressive symptoms in a poststroke population. Neuropsychiatric Disease and Treatment 10, pages 1827-1835.
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Articles from other publishers (63)
Gal Levin & Tsachi Ein-Dor. (2023) A unified model of the biology of peripartum depression. Translational Psychiatry 13:1.
Crossref
Crossref
Teodor T. Postolache, Sanjaya K. Upadhyaya, Anna M. Spector, Iqra Mohyuddin, Niel Constantine, Robert K. Ernst, Abhishek Wadhawan, Samia Valeria Ozorio Dutra, Aline Dagdag, Hina Makkar, Christopher A. Lowry, Faisal Akram, Dietmar Fuchs, Lisa A. BrennerMaureen W. Groer & Mark A. Reynolds. (2022)
Decreasing Tryptophan and Increasing Neopterin Plasma Levels During
Pregnancy are Associated with High First Trimester
Porphyromonas gingivalis
K-Serotype IgG Serointensity in a Cohort of Hispanic Women
. Current Topics in Medicinal Chemistry 22:25, pages 2126-2144.
Crossref
Crossref
Laiba Jamshed, Amrita Debnath, Shanza Jamshed, Jade V. Wish, Jason C. Raine, Gregg T. Tomy, Philippe J. Thomas & Alison C. Holloway. (2022) An Emerging Cross-Species Marker for Organismal Health: Tryptophan-Kynurenine Pathway. International Journal of Molecular Sciences 23:11, pages 6300.
Crossref
Crossref
Zhandong Yang, Xuzi Cai, Xiaoxia Xu, Zengmei Xu, Simin Ye, Yan Wang, Yanjun Hong, Baochun Shen, Qiongfeng Liao, Zhiyong Xie & Xuefeng Wang. (2022) Urinary metabolomics identified metabolic disturbance associated with polycystic ovary syndrome. Analytical Biochemistry 647, pages 114665.
Crossref
Crossref
Michelle Broekhuizen, A. H. Jan Danser, Irwin K. M. Reiss & Daphne Merkus. (2021) The Function of the Kynurenine Pathway in the Placenta: A Novel Pharmacotherapeutic Target?. International Journal of Environmental Research and Public Health 18:21, pages 11545.
Crossref
Crossref
Kyaimon Myint, Kelly Jacobs, Aye-Mu Myint, Sau Kuen Lam, Yvonne Ai-Lian Lim, Christopher Chiong-Meng Boey, See Ziau Hoe & Gilles J. Guillemin. (2021) Psychological Stresses in Children Trigger Cytokine- and Kynurenine Metabolite-Mediated Abdominal Pain and Proinflammatory Changes. Frontiers in Immunology 12.
Crossref
Crossref
Chien-Ning Hsu & You-Lin Tain. (2020) Developmental Programming and Reprogramming of Hypertension and Kidney Disease: Impact of Tryptophan Metabolism. International Journal of Molecular Sciences 21:22, pages 8705.
Crossref
Crossref
Zhipeng Wang, Panpan Zhao, Yuanyuan Zhang, Shan Shi & Xiaohui Chen. (2020) The hepatoprotective effect and mechanism of lotus leaf on liver injury induced by Genkwa Flos. Journal of Pharmacy and Pharmacology 72:12, pages 1909-1920.
Crossref
Crossref
Martin Hajsl, Alzbeta Hlavackova, Karolina Broulikova, Martin Sramek, Martin Maly, Jan E. Dyr & Jiri Suttnar. (2020) Tryptophan Metabolism, Inflammation, and Oxidative Stress in Patients with Neurovascular Disease. Metabolites 10:5, pages 208.
Crossref
Crossref
Mohammad Fayiz AbuMoh’dLaila Matalqah & Zainalabidden Al-Abdulla. (2020) Effects of Oral Branched‐Chain Amino Acids (BCAAs) Intake on Muscular and Central Fatigue During an Incremental Exercise. Journal of Human Kinetics 72:1, pages 69-78.
Crossref
Crossref
Homère J. Alves Monteiro, Chloé Brahmi, Anderson B. Mayfield, Jérémie Vidal‐Dupiol, Bruno Lapeyre & Jérémy Le Luyer. (2019) Molecular mechanisms of acclimation to long‐term elevated temperature exposure in marine symbioses. Global Change Biology 26:3, pages 1271-1284.
Crossref
Crossref
Rafael Marins Rezende, Maria do Carmo Gouveia Pelúzio, Franciany de Jesus Silva, Emanuel Mattos Della Lucia, Lukiya Silva Campos Favarato, Hercia Stampini Duarte Martino & Antônio José Natali. (2019) Does aerobic exercise associated with tryptophan supplementation attenuates hyperalgesia and inflammation in female rats with experimental fibromyalgia?. PLOS ONE 14:2, pages e0211824.
Crossref
Crossref
Efstathia Papada, Alastair Forbes, Charalampia Amerikanou, Ljilja Torović, Nick Kalogeropoulos, Chara Tzavara, John Triantafillidis & Andriana Kaliora. (2018) Antioxidative Efficacy of a Pistacia Lentiscus Supplement and Its Effect on the Plasma Amino Acid Profile in Inflammatory Bowel Disease: A Randomised, Double-Blind, Placebo-Controlled Trial. Nutrients 10:11, pages 1779.
Crossref
Crossref
Lívea Maria Gomes, Gabriela de Mello Miassi, Luan Sousa dos Santos, Mayra Anton Dib Saleh, José Roberto Sartori, Marcos Lívio Panhoza Tse & Dirlei Antonio Berto. (2018) Impact of two light programs and two levels of dietary tryptophan for weanling piglets. Livestock Science 216, pages 191-196.
Crossref
Crossref
Kelly Doolin, Leonardo Tozzi, Johann Steiner & Thomas Frodl. 2018. Inflammation and Immunity in Depression. Inflammation and Immunity in Depression
267
285
.
Rita Azeredo, Marina Machado, António Afonso, Camino Fierro-Castro, Felipe E. Reyes-López, Lluis Tort, Manuel Gesto, Marta Conde-Sieira, Jesús M. Míguez, José L. Soengas, Eva Kreuz, Sven Wuertz, Helena Peres, Aires Oliva-Teles & Benjamin Costas. (2017) Neuroendocrine and Immune Responses Undertake Different Fates following Tryptophan or Methionine Dietary Treatment: Tales from a Teleost Model. Frontiers in Immunology 8.
Crossref
Crossref
Ji Sun Oh, Hong Seong Seo, Kyoung Heon Kim, Heesoo Pyo, Bong Chul Chung & Jeongae Lee. (2017) Urinary profiling of tryptophan and its related metabolites in patients with metabolic syndrome by liquid chromatography-electrospray ionization/mass spectrometry. Analytical and Bioanalytical Chemistry 409:23, pages 5501-5512.
Crossref
Crossref
Kang Xu, Hongnan Liu, Miaomiao Bai, Jing Gao, Xin Wu & Yulong Yin. (2017) Redox Properties of Tryptophan Metabolism and the Concept of Tryptophan Use in Pregnancy. International Journal of Molecular Sciences 18:7, pages 1595.
Crossref
Crossref
Tobias V. Lanz, Simon Becker, Soumya R. Mohapatra, Christiane A. Opitz, Wolfgang Wick & Michael Platten. (2017) Suppression of Th1 differentiation by tryptophan supplementation in vivo. Amino Acids 49:7, pages 1169-1175.
Crossref
Crossref
Katherine O'Farrell & Andrew Harkin. (2017) Stress-related regulation of the kynurenine pathway: Relevance to neuropsychiatric and degenerative disorders. Neuropharmacology 112, pages 307-323.
Crossref
Crossref
Paul B. Larkin, Korrapati V. Sathyasaikumar, Francesca M. Notarangelo, Hiroshi Funakoshi, Toshikazu Nakamura, Robert Schwarcz & Paul J. Muchowski. (2016) Tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase 1 make separate, tissue-specific contributions to basal and inflammation-induced kynurenine pathway metabolism in mice. Biochimica et Biophysica Acta (BBA) - General Subjects 1860:11, pages 2345-2354.
Crossref
Crossref
Alexander V. Ivanov, Vladimir T. Valuev-Elliston, Olga N. Ivanova, Sergey N. Kochetkov, Elizaveta S. Starodubova, Birke Bartosch & Maria G. Isaguliants. (2016) Oxidative Stress during HIV Infection: Mechanisms and Consequences. Oxidative Medicine and Cellular Longevity 2016, pages 1-18.
Crossref
Crossref
Thomas Frodl. 2016. Systems Neuroscience in Depression. Systems Neuroscience in Depression
xvii
xxxvi
.
Marie Favennec, Benjamin Hennart, Robert Caiazzo, Audrey Leloire, Loïc Yengo, Marie Verbanck, Abdelilah Arredouani, Michel Marre, Marie Pigeyre, Alban Bessede, Gilles J. Guillemin, Giulia Chinetti, Bart Staels, François Pattou, Beverley Balkau, Delphine Allorge, Philippe FroguelOdile Poulain-Godefroy. (2015) The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation. Obesity 23:10, pages 2066-2074.
Crossref
Crossref
Bertrand Lebouché, Mohammad-Ali Jenabian, Joel Singer, Gina M Graziani, Kim Engler, Benoit Trottier, Réjean Thomas, Marie-Josée Brouillette & Jean-Pierre Routy. (2014) The role of extended-release niacin on immune activation and neurocognition in HIV-infected patients treated with antiretroviral therapy – CTN PT006: study protocol for a randomized controlled trial. Trials 15:1.
Crossref
Crossref
S. Klinkenberg, C.J.H. van den Borne, M.W. Aalbers, P. Verschuure, A.G. Kessels, L. Leenen, K. Rijkers, A.P. Aldenkamp, J.S.H. Vles & H.J.M. Majoie. (2014) The effects of vagus nerve stimulation on tryptophan metabolites in children with intractable epilepsy. Epilepsy & Behavior 37, pages 133-138.
Crossref
Crossref
Lay Khoon Too, James A. McQuillan, Helen J. Ball, Masaaki Kanai, Toshikazu Nakamura, Hiroshi Funakoshi, Iain S. McGregor & Nicholas H. Hunt. (2014) The kynurenine pathway contributes to long-term neuropsychological changes in experimental pneumococcal meningitis. Behavioural Brain Research 270, pages 179-195.
Crossref
Crossref
Thomas Frodl & Francesco Amico. (2014) Is there an association between peripheral immune markers and structural/functional neuroimaging findings?. Progress in Neuro-Psychopharmacology and Biological Psychiatry 48, pages 295-303.
Crossref
Crossref
Longfei Du, Hong Wang, Wei Xu, Yan Zeng, Yurong Hou, Yuqiu Zhang, Xiujuan Zhao & Changhao Sun. (2013) Application of Ultraperformance Liquid Chromatography/Mass Spectrometry–Based Metabonomic Techniques to Analyze the Joint Toxic Action of Long-term Low-Level Exposure to a Mixture of Organophosphate Pesticides on Rat Urine Profile. Toxicological Sciences 134:1, pages 195-206.
Crossref
Crossref
D Theofylaktopoulou, Ø Midttun, A Ulvik, P M Ueland, G S Tell, S E Vollset, O Nygård & S J P M Eussen. (2013) A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study. Clinical and Experimental Immunology 173:1, pages 121-130.
Crossref
Crossref
Prasun Patra, Shouvik Mitra, Nitai Debnath & Arunava Goswami. (2012) Biochemical-, Biophysical-, and Microarray-Based Antifungal Evaluation of the Buffer-Mediated Synthesized Nano Zinc Oxide: An in Vivo and in Vitro Toxicity Study. Langmuir 28:49, pages 16966-16978.
Crossref
Crossref
Marisa Möller, Jan L. Du Preez & Brian H. Harvey. (2012) Development and validation of a single analytical method for the determination of tryptophan, and its kynurenine metabolites in rat plasma. Journal of Chromatography B 898, pages 121-129.
Crossref
Crossref
Vivian Strassburger Andrade, Denise Bertin Rojas, Lenise Oliveira, Mychely Lopes Nunes, Fernanda Luz de Castro, Cristina Garcia, Tanise Gemelli, Rodrigo Binkowski de Andrade & Clóvis Milton Duval Wannmacher. (2011) Creatine and pyruvate prevent behavioral and oxidative stress alterations caused by hypertryptophanemia in rats. Molecular and Cellular Biochemistry 362:1-2, pages 225-232.
Crossref
Crossref
Trevor W. Stone, Caroline M. Forrest, Nicholas Stoy & L. Gail Darlington. (2011) Involvement of kynurenines in Huntington’s disease and stroke-induced brain damage. Journal of Neural Transmission 119:2, pages 261-274.
Crossref
Crossref
Diba SheipouriNady BraidyGilles J. Guillemin. (2012) Kynurenine Pathway in Skin Cells: Implications for UV-Induced Skin Damage. International Journal of Tryptophan Research 5, pages IJTR.S9835.
Crossref
Crossref
Takanobu Yamamoto, Hirotsugu Azechi & Mary Board. (2014) Essential Role of Excessive Tryptophan and its Neurometabolites in Fatigue. Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 39:1, pages 40-47.
Crossref
Crossref
Allison B Gold, Nathan Herrmann, Walter Swardfager, Sandra E Black, Richard I Aviv, Gayla Tennen, Alexander Kiss & Krista L Lanctôt. (2011) The relationship between indoleamine 2,3-dioxygenase activity and post-stroke cognitive impairment. Journal of Neuroinflammation 8:1.
Crossref
Crossref
Nathalie Le Floc’h, Winfried Otten & Elodie Merlot. (2010) Tryptophan metabolism, from nutrition to potential therapeutic applications. Amino Acids 41:5, pages 1195-1205.
Crossref
Crossref
Caroline M. Forrest, Gillian M. Mackay, Lynn Oxford, Keith Millar, L. Gail Darlington, Michael J. Higgins & Trevor W. Stone. (2011) Kynurenine metabolism predicts cognitive function in patients following cardiac bypass and thoracic surgery. Journal of Neurochemistry 119:1, pages 136-152.
Crossref
Crossref
Yosuke Osawa, Hiromitsu Kanamori, Ekihiro Seki, Masato Hoshi, Hirofumi Ohtaki, Yoichi Yasuda, Hiroyasu Ito, Atsushi Suetsugu, Masahito Nagaki, Hisataka Moriwaki, Kuniaki Saito & Mitsuru Seishima. (2011) l-Tryptophan-mediated Enhancement of Susceptibility to Nonalcoholic Fatty Liver Disease Is Dependent on the Mammalian Target of Rapamycin. Journal of Biological Chemistry 286:40, pages 34800-34808.
Crossref
Crossref
R.S. Richards, E.U. Nwose & P. Bwititi. (2011) Biochemical basis of circadian rhythms and diseases: With emphasis on post-traumatic stress disorder. Medical Hypotheses 77:4, pages 605-609.
Crossref
Crossref
M. Maes, B.E. Leonard, A.M. Myint, M. Kubera & R. Verkerk. (2011) The new ‘5-HT’ hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry 35:3, pages 702-721.
Crossref
Crossref
Nerissa L. Soh & Garry Walter. (2014) Tryptophan and depression: can diet alone be the answer?. Acta Neuropsychiatrica 23:1, pages 3-11.
Crossref
Crossref
Y. G. Grigoriev, V. F. Mikhailov, A. A. Ivanov, V. N. Maltsev, A. M. Ulanova, N. M. Stavrakova, I. A. Nikolaeva & O. A. Grigoriev. (2011) Autoimmune processes after long-term low-level exposure to electromagnetic fields part 4. Oxidative intracellular stress response to the long-term rat exposure to nonthermal RF EMF. Biophysics 55:6, pages 1054-1058.
Crossref
Crossref
Raf Brouns, Robert Verkerk, Tony Aerts, Didier De Surgeloose, Annick Wauters, Simon Scharpé & Peter P. De Deyn. (2010) The Role of Tryptophan Catabolism along the Kynurenine Pathway in Acute Ischemic Stroke. Neurochemical Research 35:9, pages 1315-1322.
Crossref
Crossref
Yiquan Chen, Roger Stankovic, Karen M. Cullen, Vincent Meininger, Brett Garner, Sarah Coggan, Ross Grant, Bruce J. Brew & Gilles J. Guillemin. (2009) The Kynurenine Pathway and Inflammation in Amyotrophic Lateral Sclerosis. Neurotoxicity Research 18:2, pages 132-142.
Crossref
Crossref
Michael F. Murray. (2010) Insights into Therapy: Tryptophan Oxidation and HIV Infection. Science Translational Medicine 2:32.
Crossref
Crossref
André L. G. Vieira & Suely L. Gomes. (2010) Global Gene Expression Analysis during Sporulation of the Aquatic Fungus Blastocladiella emersonii. Eukaryotic Cell 9:3, pages 415-423.
Crossref
Crossref
Abdulla A-B BadawyChristopher J Morgan. (2010) Rapid Isocratic Liquid Chromatographic Separation and Quantification of Tryptophan and Six kynurenine Metabolites in Biological Samples with Ultraviolet and Fluorimetric Detection. International Journal of Tryptophan Research 3, pages IJTR.S6225.
Crossref
Crossref
Walter Swardfager, Nathan Herrmann, Yekta Dowlati, Paul I. Oh, Alexander Kiss, Scott E. Walker & Krista L. Lanctôt. (2009) Indoleamine 2,3-dioxygenase activation and depressive symptoms in patients with coronary artery disease. Psychoneuroendocrinology 34:10, pages 1560-1566.
Crossref
Crossref
Krystyna Pawlak, Janina Tankiewicz, Michal Mysliwiec & Dariusz Pawlak. (2009) Tissue factor/its pathway inhibitor system and kynurenines in chronic kidney disease patients on conservative treatment. Blood Coagulation & Fibrinolysis 20:7, pages 590-594.
Crossref
Crossref
Krystyna Pawlak, Tomasz Domaniewski, Michal Mysliwiec & Dariusz Pawlak. (2009) The kynurenines are associated with oxidative stress, inflammation and the prevalence of cardiovascular disease in patients with end-stage renal disease. Atherosclerosis 204:1, pages 309-314.
Crossref
Crossref
Luciane Rosa Feksa, Alexandra Latini, Virgínia Cielo Rech, Patrícia Bartels Feksa, Gustavo Duarte Waltereith Koch, Maria Fernanda Arevalo Amaral, Guilhian Leipnitz, Carlos Severo Dutra-Filho, Moacir Wajner & Clóvis Milton Duval Wannmacher. (2008) Tryptophan administration induces oxidative stress in brain cortex of rats. Metabolic Brain Disease 23:2, pages 221-233.
Crossref
Crossref
S. Duleu, A. Mangas, F. Poulletier de Gannes, M.-C. Tranchant & M. Geffard. (2008) Circulating antibodies to conjugated tryptophan derivatives of the IDO pathway in amyotrophic lateral sclerosis, Alzheimer's, Parkinson's and multiple sclerosis patients. Immuno-analyse & Biologie Spécialisée 23:1, pages 27-34.
Crossref
Crossref
GREGORY F. OXENKRUG. (2007) Genetic and Hormonal Regulation of Tryptophan-Kynurenine Metabolism. Annals of the New York Academy of Sciences 1122:1, pages 35-49.
Crossref
Crossref
Abdulla A.-B. Badawy, Christopher J. Morgan, Jennifer A. Turner, Donald M. Dougherty, Dawn M. Marsh, Charles W. Mathias, Meredith A. Addicott & Ashley A. Jagar. (2007) Assessment of the kynurenine pathway in humans: I. Normal plasma values, ethnic differences and their clinical implications. International Congress Series 1304, pages 335-343.
Crossref
Crossref
L. G. Darlington, G. M. Mackay, C. M. Forrest, N. Stoy, C. George & T. W. Stone. (2007) Altered kynurenine metabolism correlates with infarct volume in stroke. European Journal of Neuroscience 26:8, pages 2211-2221.
Crossref
Crossref
Caroline M. Forrest, Gillian M. Mackay, Nicholas Stoy, Trevor W. Stone & L. Gail Darlington. (2007) Inflammatory status and kynurenine metabolism in rheumatoid arthritis treated with melatonin. British Journal of Clinical Pharmacology 64:4, pages 517-526.
Crossref
Crossref
Alessandro Laviano, Michael M Meguid, Isabella Preziosa & Filippo Rossi Fanelli. (2007) Oxidative stress and wasting in cancer. Current Opinion in Clinical Nutrition and Metabolic Care 10:4, pages 449-456.
Crossref
Crossref
A. S. Ptolemy, R. Lee & P. Britz-McKibbin. (2007) Strategies for comprehensive analysis of amino acid biomarkers of oxidative stress. Amino Acids 33:1, pages 3-18.
Crossref
Crossref
Joseph Prandota. (2007) Recurrent Headache as the Main Symptom of Acquired Cerebral Toxoplasmosis in Nonhuman Immunodeficiency Virus-infected Subjects With no Lymphadenopathy. American Journal of Therapeutics 14:1, pages 63-105.
Crossref
Crossref
Keiko Murakami, Miyako Haneda & Masataka Yoshino. (2006) Prooxidant action of xanthurenic acid and quinoline compounds: Role of transition metals in the generation of reactive oxygen species and enhanced formation of 8-hydroxy-2′-deoxyguanosine in DNA†. BioMetals 19:4, pages 429-435.
Crossref
Crossref
Luciane Rosa Feksa, Alexandra Latini, Virgínia Cielo Rech, Moacir Wajner, Carlos Severo Dutra-Filho, Angela Terezinha de Souza Wyse & Clovis Milton Duval Wannmacher. (2006) Promotion of oxidative stress by l-tryptophan in cerebral cortex of rats. Neurochemistry International 49:1, pages 87-93.
Crossref
Crossref