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Free Radical Research Volume 39, 2005 - Issue 3
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Original Article

Cross-regulation between Egr-1 and APE/Ref-1 during early response to oxidative stress in the human osteoblastic HOBIT cell line: Evidence for an autoregulatory loop

Alex Pines Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, University of Trieste, via Giorgieri 1, 34127, Trieste, Italy
,
Nicoletta Bivi Dipartimento di Scienze e Tecnologie Biomediche, University of Udine, Italy
,
Milena Romanello Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, University of Trieste, via Giorgieri 1, 34127, Trieste, Italy
,
Giuseppe Damante Dipartimento di Scienze e Tecnologie Biomediche, University of Udine, Italy
,
Mark R. Kelley Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA
,
Eileen D. Adamson The Burnham Institute, La Jolla, CA, USA
,
Paola D'Andrea Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, University of Trieste, via Giorgieri 1, 34127, Trieste, Italy
,
Franco Quadrifoglio Dipartimento di Scienze e Tecnologie Biomediche, University of Udine, Italy
,
Luigi Moro Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, University of Trieste, via Giorgieri 1, 34127, Trieste, Italy
&
Gianluca Tell Dipartimento di Scienze e Tecnologie Biomediche, University of Udine, Italy
 show all
Pages 269-281 | Received 02 Jul 2004, Published online: 07 Jul 2009

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Damiano Fantini, Damiano Fantini, Carlo Vascotto, Marta Deganuto, Nicoletta Bivi, Stefano Gustincich, Gabriella Marcon, Franco Quadrifoglio, Giuseppe Damante, Kishor K. Bhakat, Sankar Mitra & Gianluca Tell. (2008) APE1/Ref-1 regulates PTEN expression mediated by Egr-1. Free Radical Research 42:1, pages 20-29.
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Articles from other publishers (40)

Guiming Deng, Hao Sun, Rong Huang, Hongming Pan, Yanjiao Zuo, Ruihu Zhao, Zhongze Du, Yingwei Xue & Hongjiang Song. (2023) An oxidative stress biomarkers predict prognosis in gastric cancer patients receiving immune checkpoint inhibitor. Frontiers in Oncology 13.
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Caitlin M. Woodson & Kylene Kehn-Hall. (2022) Examining the role of EGR1 during viral infections. Frontiers in Microbiology 13.
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Yuhan Zhou, Hector M. Arredondo & Ning Wang. (2022) P2Y Receptors in Bone - Anabolic, Catabolic, or Both?. Frontiers in Endocrinology 12.
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Thais Teixeira Oliveira, Fabrícia Lima Fontes-Dantas, Rayssa Karla de Medeiros Oliveira, Daniele Maria Lopes Pinheiro, Leonam Gomes Coutinho, Vandeclecio Lira da Silva, Sandro José de Souza & Lucymara Fassarella Agnez-Lima. (2021) Chemical Inhibition of Apurinic-Apyrimidinic Endonuclease 1 Redox and DNA Repair Functions Affects the Inflammatory Response via Different but Overlapping Mechanisms. Frontiers in Cell and Developmental Biology 9.
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Sergio Rius-PérezSalvador PérezPablo Martí-AndrésMaría MonsalveJuan Sastre. (2020) Nuclear Factor Kappa B Signaling Complexes in Acute Inflammation. Antioxidants & Redox Signaling 33:3, pages 145-165.
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S. Udhaya Kumar, D. Thirumal Kumar, R. Siva, C. George Priya Doss, Salma Younes, Nadin Younes, Mariem Sidenna & Hatem Zayed. (2020) Dysregulation of Signaling Pathways Due to Differentially Expressed Genes From the B-Cell Transcriptomes of Systemic Lupus Erythematosus Patients – A Bioinformatics Approach. Frontiers in Bioengineering and Biotechnology 8.
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Emmanuelle Havis & Delphine Duprez. (2020) EGR1 Transcription Factor is a Multifaceted Regulator of Matrix Production in Tendons and Other Connective Tissues. International Journal of Molecular Sciences 21:5, pages 1664.
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Renata Alleva, Andrea Tognù, Marco Tomasetti, Maria Serena Benassi, Laura Pazzaglia, Hanna van Oven, Ettore Viganò, Nicola De Simone, Ilaria Pacini, Sandra Giannone, Sanjin Gagic, Raffaele Borghi, Sara Picone & Battista Borghi. (2019) Effect of different anaesthetic techniques on gene expression profiles in patients who underwent hip arthroplasty. PLOS ONE 14:7, pages e0219113.
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Gábor Erdős, Bálint Mészáros, Dana Reichmann & Zsuzsanna Dosztányi. (2019) Large‐Scale Analysis of Redox‐Sensitive Conditionally Disordered Protein Regions Reveals Their Widespread Nature and Key Roles in High‐Level Eukaryotic Processes. PROTEOMICS 19:6, pages 1800070.
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A. L. Zakharenko, N. A. Lebedeva & O. I. Lavrik. (2018) DNA Repair Enzymes as Promising Targets in Oncotherapy. Russian Journal of Bioorganic Chemistry 44:1, pages 1-18.
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Patrícia S. Guerreiro, Eduardo Corvacho, João G. Costa, Nuno Saraiva, Ana S. Fernandes, Matilde Castro, Joana P. Miranda & Nuno G. Oliveira. (2017) The APE1 redox inhibitor E3330 reduces collective cell migration of human breast cancer cells and decreases chemoinvasion and colony formation when combined with docetaxel. Chemical Biology & Drug Design 90:4, pages 561-571.
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Isabel R Orriss, Dilek Guneri, Mark O R Hajjawi, Kristy Shaw, Jessal J Patel & Timothy R Arnett. (2017) Activation of the P2Y2 receptor regulates bone cell function by enhancing ATP release. Journal of Endocrinology 233:3, pages 341-356.
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Je-won Ryu, Sung Sik Choe, Seung-Hee Ryu, Eun-Young Park, Byoung Wook Lee, Tae Keun Kim, Chang Hoon Ha & Sang-wook Lee. (2016) Paradoxical induction of growth arrest and apoptosis by EGF via the up-regulation of PTEN by activating Redox factor-1/Egr-1 in human lung cancer cells. Oncotarget 8:3, pages 4181-4195.
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Yan-Ming Yang, Fang Fang, Xin Li, Lei Yu & Zhi-Cheng Wang. (2017) TRAIL overexpression co-regulated by Egr1 and HRE enhances radiosensitivity of hypoxic A549 cells depending on its apoptosis inducing role. Oncology Reports 37:1, pages 533-539.
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Isabel R. Orriss. (2015) The role of purinergic signalling in the musculoskeletal system. Autonomic Neuroscience 191, pages 124-134.
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Shweta Thakur, Bibekananda Sarkar, Ravi P Cholia, Nandini Gautam, Monisha Dhiman & Anil K Mantha. (2014) APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functions. Experimental & Molecular Medicine 46:7, pages e106-e106.
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Asima Bhattacharyya, Ranajoy Chattopadhyay, Sankar Mitra & Sheila E. Crowe. (2014) Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases. Physiological Reviews 94:2, pages 329-354.
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Inn H. Yuk, Jitao David Zhang, Martin Ebeling, Marco Berrera, Natalia Gomez, Silke Werz, Christoph Meiringer, Zhixin Shao, Jeffrey C. Swanberg, Kelvin H. Lee, Jun Luo & Berthold Szperalski. (2014) Effects of copper on CHO cells: Insights from gene expression analyses. Biotechnology Progress 30:2, pages 429-442.
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Hye-Jin Kim Hawkes, Therese C. Karlenius & Kathryn F. Tonissen. (2014) Regulation of the human thioredoxin gene promoter and its key substrates: A study of functional and putative regulatory elements. Biochimica et Biophysica Acta (BBA) - General Subjects 1840:1, pages 303-314.
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Jun Zhang, Meihua Luo, Daniela Marasco, Derek Logsdon, Kaice A. LaFavers, Qiujia Chen, April Reed, Mark R. Kelley, Michael L. Gross & Millie M. Georgiadis. (2013) Inhibition of Apurinic/Apyrimidinic Endonuclease I’s Redox Activity Revisited. Biochemistry 52:17, pages 2955-2966.
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Daniel G. Sedding, Rebecca Widmer-Teske, Andreas Mueller, Philipp Stieger, Jan-Marcus Daniel, Dursun Gündüz, Soni Pullamsetti, Holger Nef, Helge Moellmann, Christian Troidl, Christian Hamm & Rüdiger Braun-Dullaeus. (2013) Role of the Phosphatase PTEN in Early Vascular Remodeling. PLoS ONE 8:3, pages e55445.
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Isabel R. Orriss & Timothy R. Arnett. (2012) P2Y receptors in bone. Wiley Interdisciplinary Reviews: Membrane Transport and Signaling 1:6, pages 805-814.
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Lisa Lirussi, Giulia Antoniali, Carlo Vascotto, Chiara D'Ambrosio, Mattia Poletto, Milena Romanello, Daniela Marasco, Marilisa Leone, Franco Quadrifoglio, Kishor K. Bhakat, Andrea Scaloni & Gianluca Tell. (2012) Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells. Molecular Biology of the Cell 23:20, pages 4079-4096.
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Judith-Irina Pagel & Elisabeth Deindl. (2012) Disease Progression Mediated by Egr-1 Associated Signaling in Response to Oxidative Stress. International Journal of Molecular Sciences 13:12, pages 13104-13117.
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M Ding, E Zhang, R He, X Wang, R Li, W Wang & Q Yi. (2012) The radiation dose-regulated AND gate genetic circuit, a novel targeted and real-time monitoring strategy for cancer gene therapy. Cancer Gene Therapy 19:6, pages 382-392.
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María del R. Castro, Edu Suarez, Edmundo Kraiselburd, Angel Isidro, José Paz, León Ferder & Sylvette Ayala-Torres. (2012) Aging increases mitochondrial DNA damage and oxidative stress in liver of rhesus monkeys. Experimental Gerontology 47:1, pages 29-37.
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Michael F. Ritchie, Yandong Zhou & Jonathan Soboloff. (2011) Transcriptional mechanisms regulating Ca2+ homeostasis. Cell Calcium 49:5, pages 314-321.
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De-Sheng Pei, Xiao-Jie Yang, Wei Liu, Jeroen E. J. Guikema, Carol E. Schrader & Phyllis R. Strauss. (2011) A novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase β. Nucleic Acids Research 39:8, pages 3156-3165.
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Gianluca Tell, Damiano Fantini & Franco Quadrifoglio. (2010) Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment. Cellular and Molecular Life Sciences 67:21, pages 3589-3608.
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Aditi BapatMelissa L. FishelMark R. Kelley. (2009) Going Ape as an Approach to Cancer Therapeutics. Antioxidants & Redox Signaling 11:3, pages 651-667.
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Kishor K. BhakatAnil K. ManthaSankar Mitra. (2009) Transcriptional Regulatory Functions of Mammalian AP-Endonuclease (APE1/Ref-1), an Essential Multifunctional Protein. Antioxidants & Redox Signaling 11:3, pages 621-637.
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Gianluca TellFranco QuadrifoglioClaudio TiribelliMark R. Kelley. (2009) The Many Functions of APE1/Ref-1: Not Only a DNA Repair Enzyme. Antioxidants & Redox Signaling 11:3, pages 601-619.
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Carlo Vascotto, Laura Cesaratto, Leo A. H. Zeef, Marta Deganuto, Chiara D'Ambrosio, Andrea Scaloni, Milena Romanello, Giuseppe Damante, Giulio Taglialatela, Daniela Delneri, Mark R. Kelley, Sankar Mitra, Franco Quadrifoglio & Gianluca Tell. (2009) Genome‐wide analysis and proteomic studies reveal APE1/Ref‐1 multifunctional role in mammalian cells. PROTEOMICS 9:4, pages 1058-1074.
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Cecilia C. Low Wang. 2009. Insulin Resistance. Insulin Resistance 207 228 .
Yanlin Jiang, Chunlu Guo, Michael R. Vasko & Mark R. Kelley. (2008) Implications of Apurinic/Apyrimidinic Endonuclease in Reactive Oxygen Signaling Response after Cisplatin Treatment of Dorsal Root Ganglion Neurons. Cancer Research 68:15, pages 6425-6434.
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Laura Cesaratto, Sebastian D. Calligaris, Carlo Vascotto, Marta Deganuto, Cristina Bellarosa, Franco Quadrifoglio, J. Donald Ostrow, Claudio Tiribelli & Gianluca Tell. (2007) Bilirubin-induced cell toxicity involves PTEN activation through an APE1/Ref-1-dependent pathway. Journal of Molecular Medicine 85:10, pages 1099-1112.
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Kayo SUMIDAKoichi SAITOKenji OEDAYoshikuni YAKABE, Masanori OTSUKA, Hiroshi MATSUMOTO, Masaru SEKIJIMAKoji NAKAYAMAYukiko KAWANOTomoyuki SHIRAI. (2007) A COMPARATIVE STUDY OF GENE EXPRESSION PROFILES IN RAT LIVER AFTER ADMINISTRATION OF ALPHA-HEXACHLOROCYCLOHEXANE AND LINDANE. The Journal of Toxicological Sciences 32:3, pages 261-288.
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Irina Korichneva. (2006) Zinc Dynamics in the Myocardial Redox Signaling Network. Antioxidants & Redox Signaling 8:9-10, pages 1707-1721.
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Wei-dong Wang, Rong Li, Zheng-tang Chen, De-zhi Li, Yu-zhong Duan & Zheng-huai Cao. (2005) Cisplatin-controlled p53 gene therapy for human non-small cell lung cancer xenografts in athymic nude mice via the CArG elements. Cancer Science 96:10, pages 706-712.
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