88
Views
35
CrossRef citations to date
0
Altmetric
Original Article

Antioxidants Inhibit Angiogenesis In Vivo through Down-regulation of Nitric Oxide Synthase Expression and Activity

&
Pages 501-508 | Received 19 Dec 2003, Published online: 07 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Silvia Anna Ciafrè, Francesco Niola, Ezio Giorda, Maria Giulia Farace & Daniela Caporossi. (2007) CoCl2-simulated hypoxia in skeletal muscle cell lines: Role of free radicals in gene up-regulation and induction of apoptosis. Free Radical Research 41:4, pages 391-401.
Read now

Articles from other publishers (33)

Eleanor Star, Megan Stevens, Clare Gooding, Christopher W. J. Smith, Ling Li, Monica Lamici Ayine, Steve J. Harper, David O. Bates & Sebastian Oltean. (2021) A drug-repositioning screen using splicing-sensitive fluorescent reporters identifies novel modulators of VEGF-A splicing with anti-angiogenic properties. Oncogenesis 10:5.
Crossref
Babita Shashni, Yuji Nishikawa & Yukio Nagasaki. (2021) Management of tumor growth and angiogenesis in triple-negative breast cancer by using redox nanoparticles. Biomaterials 269, pages 120645.
Crossref
Ting-Ting Chang & Jaw-Wen Chen. (2020) Hydralazine improves ischemia-induced neovasculogenesis via xanthine-oxidase inhibition in chronic renal insufficiency. Pharmacological Research 151, pages 104509.
Crossref
Dominik André-Lévigne, Ali Modarressi, Michael Pepper & Brigitte Pittet-Cuénod. (2017) Reactive Oxygen Species and NOX Enzymes Are Emerging as Key Players in Cutaneous Wound Repair. International Journal of Molecular Sciences 18:10, pages 2149.
Crossref
Daniel D. Shill, W. Michael Southern, T. Bradley Willingham, Kasey A. Lansford, Kevin K. McCully & Nathan T. Jenkins. (2016) Mitochondria-specific antioxidant supplementation does not influence endurance exercise training-induced adaptations in circulating angiogenic cells, skeletal muscle oxidative capacity or maximal oxygen uptake. The Journal of Physiology 594:23, pages 7005-7014.
Crossref
Sotiria Tsirmoula, Margarita Lamprou, Maria Hatziapostolou, Nelly Kieffer & Evangelia Papadimitriou. (2015) Pleiotrophin-induced endothelial cell migration is regulated by xanthine oxidase-mediated generation of reactive oxygen species. Microvascular Research 98, pages 74-81.
Crossref
Sophie Réhault-Godbert, Karlheinz Mann, Marie Bourin, Aurélien Brionne & Yves Nys. (2014) Effect of Embryonic Development on the Chicken Egg Yolk Plasma Proteome after 12 Days of Incubation. Journal of Agricultural and Food Chemistry 62:12, pages 2531-2540.
Crossref
Vasiliki K. Katsi, Costas T. Psarros, Marios G. Krokidis, Georgia D. Vamvakou, Dimitris Tousoulis, Christodoulos I. Stefanadis & Ioannis E. Kallikazaros. 2014. Anti-Angiogenesis Drug Discovery and Development. Anti-Angiogenesis Drug Discovery and Development 268 308 .
Abdelhadi Rebbaa, Ghanshyam Patil, Murat Yalcin, Thangirala Sudha & Shaker A. Mousa. (2013) OT-404, multi-targeted anti-cancer agent affecting tumor proliferation, chemo-resistance, and angiogenesis. Cancer Letters 332:1, pages 55-62.
Crossref
Li Liu, Xiaoping Qi, Zhijuan Chen, Lynn Shaw, Jun Cai, Layton H. Smith, Maria B. Grant & Michael E. Boulton. (2013) Targeting the IRE1α/XBP1 and ATF6 Arms of the Unfolded Protein Response Enhances VEGF Blockade to Prevent Retinal and Choroidal Neovascularization. The American Journal of Pathology 182:4, pages 1412-1424.
Crossref
Ya-hong Jiang, Yan Shi, Ya-ping He, Jing Du, Run-sheng Li, Hui-juan Shi, Zhao-gui Sun & Jian Wang. (2011) Serine protease inhibitor 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride (AEBSF) inhibits the rat embryo implantation in vivo and interferes with cell adhesion in vitro. Contraception 84:6, pages 642-648.
Crossref
Michael E. Andrades & Rodrigo Lorenzi. 2011. Oxidative Stress in Vertebrates and Invertebrates. Oxidative Stress in Vertebrates and Invertebrates 153 166 .
Víctor H. Parraguez, Miljenko Atlagich, Oscar Araneda, Carlos García, Andrés Muñoz, Mónica De los Reyes & Bessie Urquieta. (2011) Effects of antioxidant vitamins on newborn and placental traits in gestations at high altitude: comparative study in high and low altitude native sheep. Reproduction, Fertility and Development 23:2, pages 285.
Crossref
Ping Mu, Qing Liu & Rongliang Zheng. (2013) Biphasic regulation of H 2 O 2 on angiogenesis implicated NADPH oxidase . Cell Biology International 34:10, pages 1013-1020.
Crossref
Manjari Tandon, Sourabh Dutta, Mangat R Dogra & Amod Gupta. (2010) Oral D-penicillamine for the prevention of retinopathy of prematurity in very low birth weight infants: a randomized, placebo-controlled trial. Acta Paediatrica 99:9, pages 1324-1328.
Crossref
Masuko Ushio-FukaiNorifumi Urao. (2009) Novel Role of NADPH Oxidase in Angiogenesis and Stem/Progenitor Cell Function. Antioxidants & Redox Signaling 11:10, pages 2517-2533.
Crossref
Ryan Reed, Barry Potter, Erika Smith, Rashmi Jadhav, Patricia Villalta, Hanjoong Jo & Petra Rocic. (2009) Redox-sensitive Akt and Src regulate coronary collateral growth in metabolic syndrome. American Journal of Physiology-Heart and Circulatory Physiology 296:6, pages H1811-H1821.
Crossref
Christos Polytarchou, Maria Hatziapostolou, Evangelia Poimenidi, Constantinos Mikelis, Ariadni Papadopoulou, Anastasia Parthymou & Evangelia Papadimitriou. (2009) Nitric oxide stimulates migration of human endothelial and prostate cancer cells through up-regulation of pleiotrophin expression and its receptor protein tyrosine phosphatase β/ζ. International Journal of Cancer 124:8, pages 1785-1793.
Crossref
Chandan K. Sen & Sashwati Roy. (2008) Redox signals in wound healing. Biochimica et Biophysica Acta (BBA) - General Subjects 1780:11, pages 1348-1361.
Crossref
Masuko Ushio-Fukai & Yoshimasa Nakamura. (2008) Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy. Cancer Letters 266:1, pages 37-52.
Crossref
Marcus KochJop Mostert, Alexander Arutjunyan, Michael Stepanov, Albert Teelken, Dorothea Heersema & Jacques De Keyser. (2007) Peripheral blood leukocyte NO production and oxidative stress in multiple sclerosis. Multiple Sclerosis Journal 14:2, pages 159-165.
Crossref
Sashwati Roy, Savita Khanna & Chandan K. Sen. (2008) Redox regulation of the VEGF signaling path and tissue vascularization: Hydrogen peroxide, the common link between physical exercise and cutaneous wound healing. Free Radical Biology and Medicine 44:2, pages 180-192.
Crossref
Zhao-gui Sun, Hui-juan Shi, Zheng Gu, Jian Wang & Qing-xiang Shen. (2007) A single intrauterine injection of the serine protease inhibitor 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride reversibly inhibits embryo implantation in mice. Contraception 76:3, pages 250-255.
Crossref
R D Christensen, S C Alder, S C Richards, D K Lambert, N Schmutz, S E Wiedmeier, J Burnett, V L Baer, J T Horn, M Richards & J Barraza. (2007) D-Penicillamine administration and the incidence of retinopathy of prematurity. Journal of Perinatology 27:2, pages 103-111.
Crossref
Anastasia Pyriochou, Dimitris Beis, Vasiliki Koika, Christos Potytarchou, Evangelia Papadimitriou, Zongmin Zhou & Andreas Papapetropoulos. (2006) Soluble Guanylyl Cyclase Activation Promotes Angiogenesis. Journal of Pharmacology and Experimental Therapeutics 319:2, pages 663-671.
Crossref
Didier Laurent. 2006. In Vivo MR Techniques in Drug Discovery and Development. In Vivo MR Techniques in Drug Discovery and Development 437 463 .
James R. StoneSuping Yang. (2006) Hydrogen Peroxide: A Signaling Messenger. Antioxidants & Redox Signaling 8:3-4, pages 243-270.
Crossref
R D Christensen, S C Alder, S C Richards, J T Horn, D K Lambert & V L Baer. (2006) A pilot trial testing the feasibility of administering D-penicillamine to extremely low birth weight neonates. Journal of Perinatology 26:2, pages 120-124.
Crossref
Károly Palatka. (2006) Effect of IBD sera on expression of inducible and endothelial nitric oxide synthase in human umbilical vein endothelial cells. World Journal of Gastroenterology 12:11, pages 1730.
Crossref
Yi-Tai Wu, Zhao-Long Wu, Xiao-Feng Jiang, Su Li & Fang-Qiang Zhou. (2005) Pyruvate Improves Neutrophilic Nitric Oxide Generation in Peritoneal Dialysis Solutions.. Artificial Organs 29:12, pages 976-980.
Crossref
Christos Polytarchou, Maria Hatziapostolou & Evangelia Papadimitriou. (2005) Hydrogen Peroxide Stimulates Proliferation and Migration of Human Prostate Cancer Cells through Activation of Activator Protein-1 and Up-regulation of the Heparin Affin Regulatory Peptide Gene. Journal of Biological Chemistry 280:49, pages 40428-40435.
Crossref
Sophie Lanone, Sébastien Bloc, Roberta Foresti, Abdelhamid Almolki, Camille Taillé, Jacques Callebert, Marc Conti, Delphine Goven, Michel Aubier, Bertrand Dureuil, Jamel El‐Benna, Roberto Mottierlini & Jorge Boczkowski. (2005) Bilirubin decreases NOS2 expression via inhibition of NAD(P)H oxidase: implications for protection against endotoxic shock in rats. The FASEB Journal 19:13, pages 1890-1892.
Crossref
Christos Polytarchou & Evangelia Papadimitriou. (2005) Antioxidants inhibit human endothelial cell functions through down-regulation of endothelial nitric oxide synthase activity. European Journal of Pharmacology 510:1-2, pages 31-38.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.