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Original

Cytoprotective effects of the antioxidant phytochemical indicaxanthin in β-thalassemia red blood cells

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Pages 753-761 | Received 14 Nov 2005, Published online: 07 Jul 2009

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Davi Vieira Teixeira da Silva, Diego dos Santos Baião, Vitor Francisco Ferreira & Vania Margaret Flosi Paschoalin. (2022) Betanin as a multipath oxidative stress and inflammation modulator: a beetroot pigment with protective effects on cardiovascular disease pathogenesis. Critical Reviews in Food Science and Nutrition 62:2, pages 539-554.
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Sara T Olalla-Saad. (2010) Fermented papaya preparation for β-thalassemia?. Expert Review of Hematology 3:3, pages 265-268.
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L. Tesoriere, M. Allegra, C. Gentile & M. A. Livrea. (2009) Betacyanins as phenol antioxidants. Chemistry and mechanistic aspects of the lipoperoxyl radical-scavenging activity in solution and liposomes. Free Radical Research 43:8, pages 706-717.
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Ashutosh Lal, Wafa Atamna, David W. Killilea, Jung H. Suh & Bruce N. Ames. (2008) Lipoic acid and acetyl-carnitine reverse iron-induced oxidative stress in human fibroblasts. Redox Report 13:1, pages 2-10.
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L. Tesoriere, M. Allegra, D. Butera, C. Gentile & M. A. Livrea. (2007) Kinetics of the lipoperoxyl radical-scavenging activity of indicaxanthin in solution and unilamellar liposomes. Free Radical Research 41:2, pages 226-233.
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Juanjuan He, Farhan Siddique, Hans Lischka, Frank H. Quina & Adelia J. A. Aquino. (2020) Conical intersections and the weak fluorescence of betalains. Photochemical & Photobiological Sciences 18:8, pages 1972-1981.
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Alessandro Attanzio, Luisa Tesoriere, Sonya Vasto, Anna Maria Pintaudi, Maria A. Livrea & Mario Allegra. (2018) Short-term cactus pear [Opuntia ficus-indica (L.) Mill] fruit supplementation ameliorates the inflammatory profile and is associated with improved antioxidant status among healthy humans. Food & Nutrition Research 62:0.
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Giuditta Gambino, Mario Allegra, Pierangelo Sardo, Alessandro Attanzio, Luisa Tesoriere, Maria A. Livrea, Giuseppe Ferraro & Fabio Carletti. (2018) Brain Distribution and Modulation of Neuronal Excitability by Indicaxanthin From Opuntia Ficus Indica Administered at Nutritionally-Relevant Amounts. Frontiers in Aging Neuroscience 10.
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Amira A. Adly & Eman A. Ismail. (2018) Management of Children With β-Thalassemia Intermedia: Overview, Recent Advances, and Treatment Challenges. Journal of Pediatric Hematology/Oncology 40:4, pages 253-268.
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Erum Akbar Hussain, Zubi Sadiq & Muhammad Zia-Ul-HaqErum Akbar Hussain, Zubi Sadiq & Muhammad Zia-Ul-Haq. 2018. Betalains: Biomolecular Aspects. Betalains: Biomolecular Aspects 109 124 .
Antonio Cilla, Amparo Alegría, Alessandro Attanzio, Guadalupe Garcia-Llatas, Luisa Tesoriere & Maria A. Livrea. (2017) Dietary phytochemicals in the protection against oxysterol-induced damage. Chemistry and Physics of Lipids 207, pages 192-205.
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Mario Allegra, Fabio Carletti, Giuditta Gambino, Marco Tutone, Alessandro Attanzio, Luisa Tesoriere, Giuseppe Ferraro, Pierangelo Sardo, Anna Maria Almerico & Maria Antonia Livrea. (2015) Indicaxanthin from Opuntia ficus-indica Crosses the Blood–Brain Barrier and Modulates Neuronal Bioelectric Activity in Rat Hippocampus at Dietary-Consistent Amounts . Journal of Agricultural and Food Chemistry 63:33, pages 7353-7360.
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Luisa Tesoriere, Alessandro Attanzio, Mario Allegra & Maria A. Livrea. (2015) Dietary indicaxanthin from cactus pear ( Opuntia ficus-indica L. Mill) fruit prevents eryptosis induced by oxysterols in a hypercholesterolaemia-relevant proportion and adhesion of human erythrocytes to endothelial cell layers . British Journal of Nutrition 114:3, pages 368-375.
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Renata M. Martinez, Daniela T. Longhi-Balbinot, Ana C. Zarpelon, Larissa Staurengo-Ferrari, Marcela M. Baracat, Sandra R. Georgetti, Rogério C. Sassonia, Waldiceu A. VerriJr.Jr. & Rubia Casagrande. (2014) Anti-inflammatory activity of betalain-rich dye of Beta vulgaris: effect on edema, leukocyte recruitment, superoxide anion and cytokine production. Archives of Pharmacal Research 38:4, pages 494-504.
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J. Chandrasekhar, G. Sonika, M.C. Madhusudhan & K.S.M.S. Raghavarao. (2015) Differential partitioning of betacyanins and betaxanthins employing aqueous two phase extraction. Journal of Food Engineering 144, pages 156-163.
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Mario Allegra, Angela Ianaro, Mariaroberta Tersigni, Elisabetta Panza, Luisa Tesoriere & Maria Antonia Livrea. (2014) Indicaxanthin from Cactus Pear Fruit Exerts Anti-Inflammatory Effects in Carrageenin-Induced Rat Pleurisy. The Journal of Nutrition 144:2, pages 185-192.
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M. Allegra, F. D’Acquisto, L. Tesoriere, A. Attanzio & M.A. Livrea. (2014) Pro-oxidant activity of indicaxanthin from Opuntia ficus indica modulates arachidonate metabolism and prostaglandin synthesis through lipid peroxide production in LPS-stimulated RAW 264.7 macrophages. Redox Biology 2, pages 892-900.
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Luisa Tesoriere, Alessandro Attanzio, Mario Allegra, Carla Gentile & Maria A. Livrea. (2012) Phytochemical indicaxanthin suppresses 7-ketocholesterol-induced THP-1 cell apoptosis by preventing cytosolic Ca 2+ increase and oxidative stress . British Journal of Nutrition 110:2, pages 230-240.
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L. Tesoriere, C. Gentile, F. Angileri, A. Attanzio, M. Tutone, M. Allegra & M. A. Livrea. (2012) Trans-epithelial transport of the betalain pigments indicaxanthin and betanin across Caco-2 cell monolayers and influence of food matrix. European Journal of Nutrition 52:3, pages 1077-1087.
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Samir Awadallah. 2013. 85 128 .
Sara Baldassano, Alessandra Rotondo, Rosa Serio, Maria Antonietta Livrea, Luisa Tesoriere & Flavia Mulè. (2011) Inhibitory effects of indicaxanthin on mouse ileal contractility: Analysis of the mechanism of action. European Journal of Pharmacology 658:2-3, pages 200-205.
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Ali T. Taher, Khaled M. Musallam, Maria Domenica Cappellini & David J. Weatherall. (2011) Optimal management of β thalassaemia intermedia. British Journal of Haematology 152:5, pages 512-523.
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Eitan Fibach, Ee‐Shien Tan, Saumya Jamuar, Ivy Ng, Johnny Amer & Eliezer A. Rachmilewitz. (2010) Amelioration of oxidative stress in red blood cells from patients with β‐thalassemia major and intermedia and E‐β‐thalassemia following administration of a fermented papaya preparation. Phytotherapy Research 24:9, pages 1334-1338.
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S. Baldassano, L. Tesoriere, A. Rotondo, R. Serio, M. A. Livrea & F. Mulè. (2010) Inhibition of the Mechanical Activity of Mouse Ileum by Cactus Pear ( Opuntia Ficus Indica , L, Mill.) Fruit Extract and Its Pigment Indicaxanthin . Journal of Agricultural and Food Chemistry 58:13, pages 7565-7571.
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Jean‐François Bisson, Stéphanie Daubié, Sophie Hidalgo, Damien Guillemet & Elodie Linarés. (2009) Diuretic and antioxidant effects of Cacti‐Nea ® , a dehydrated water extract from prickly pear fruit, in rats . Phytotherapy Research 24:4, pages 587-594.
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Maria Liria Turco Liveri, Luciana Sciascia, Mario Allegra, Luisa Tesoriere & Maria A. Livrea. (2009) Partition of Indicaxanthin in Membrane Biomimetic Systems. A Kinetic and Modeling Approach. Journal of Agricultural and Food Chemistry 57:22, pages 10959-10963.
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Luisa Tesoriere, Marco Fazzari, Francesa Angileri, Carla Gentile & Maria A. Livrea. (2008) In Vitro Digestion of Betalainic Foods. Stability and Bioaccessibility of Betaxanthins and Betacyanins and Antioxidative Potential of Food Digesta. Journal of Agricultural and Food Chemistry 56:22, pages 10487-10492.
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Diego A. Moreno, Cristina García-Viguera, José I. Gil & Angel Gil-Izquierdo. (2008) Betalains in the era of global agri-food science, technology and nutritional health. Phytochemistry Reviews 7:2, pages 261-280.
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Johnny Amer, Ada Goldfarb, Eliezer A. Rachmilewitz & Eitan Fibach. (2008) Fermented papaya preparation as redox regulator in blood cells of β ‐thalassemic mice and patients . Phytotherapy Research 22:6, pages 820-828.
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Caterina Borgna‐Pignatti. (2007) Modern treatment of thalassaemia intermedia. British Journal of Haematology 138:3, pages 291-304.
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