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Original

Natural vitamin E α-tocotrienol: Retention in vital organs in response to long-term oral supplementation and withdrawal

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Pages 763-771 | Received 01 Feb 2006, Published online: 07 Jul 2009

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Thuhairah Abdul Rahman, Noor Faezah Hassim, Nurmazni Zulkafli, Suhaila Muid, Noor Kaslina Kornain & Hapizah Nawawi. (2016) Atheroprotective effects of pure tocotrienol supplementation in the treatment of rabbits with experimentally induced early and established atherosclerosis. Food & Nutrition Research 60:1.
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Chandan K Sen, Cameron Rink & Savita Khanna. (2010) Palm Oil–Derived Natural Vitamin E α-Tocotrienol in Brain Health and Disease. Journal of the American College of Nutrition 29:sup3, pages 314S-323S.
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Piek Ngoh Chang, Wei Ney Yap, Davy Tak Wing Lee, M.T. Ling, Y.C. Wong & Yee Leng Yap. (2009) Evidence of γ-Tocotrienol as an Apoptosis-Inducing, Invasion-Suppressing, and Chemotherapy Drug-Sensitizing Agent in Human Melanoma Cells. Nutrition and Cancer 61:3, pages 357-366.
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Articles from other publishers (28)

Ranmali Ranasinghe, Michael Mathai & Anthony Zulli. (2022) Revisiting the therapeutic potential of tocotrienol. BioFactors 48:4, pages 813-856.
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Kacper Szewczyk, Aleksandra Chojnacka & Magdalena Górnicka. (2021) Tocopherols and Tocotrienols—Bioactive Dietary Compounds; What Is Certain, What Is Doubt?. International Journal of Molecular Sciences 22:12, pages 6222.
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Shi Wei Tan, Daud Ahmad bin Israf Ali, Huzwah Khaza'ai, Jia Woei Wong & Sharmili Vidyadaran. (2020) Cellular uptake and anti-inflammatory effects of palm oil-derived delta (δ)-tocotrienol in microglia. Cellular Immunology 357, pages 104200.
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Maret G. Traber & Richard S. Bruno. 2020. Present Knowledge in Nutrition. Present Knowledge in Nutrition 115 136 .
Gerald Chen Jie Tan, Suzanne May Quinn Tan, Sonia Chew Wen Phang, Yeek Tat Ng, En Yng Ng, Badariah Ahmad, Uma Devi M. Palamisamy & Khalid Abdul Kadir. (2019) Tocotrienol-rich vitamin E improves diabetic nephropathy and persists 6–9 months after washout: a phase IIa randomized controlled trial. Therapeutic Advances in Endocrinology and Metabolism 10, pages 204201881989546.
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Nukhet Aykin-Burns, Rupak Pathak, Marjan Boerma, Thomas Kim & Martin Hauer-Jensen. (2019) Utilization of Vitamin E Analogs to Protect Normal Tissues While Enhancing Antitumor Effects. Seminars in Radiation Oncology 29:1, pages 55-61.
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Monice M. Fiume, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. MarksJrJr, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen & Bart Heldreth. (2018) Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics. International Journal of Toxicology 37:2_suppl, pages 61S-94S.
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Raffaella Comitato, Roberto Ambra & Fabio Virgili. (2017) Tocotrienols: A Family of Molecules with Specific Biological Activities. Antioxidants 6:4, pages 93.
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Zein E. Obagi. 2014. The Art of Skin Health Restoration and Rejuvenation. The Art of Skin Health Restoration and Rejuvenation 288 313 .
Gowri Nagapan, Yong Meng Goh, Intan Shameha Abdul Razak, Kalanithi Nesaretnam & Mahdi Ebrahimi. (2013) The effects of prenatal and early postnatal tocotrienol-rich fraction supplementation on cognitive function development in male offspring rats. BMC Neuroscience 14:1.
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Maret G. Traber. (2013) Mechanisms for the prevention of vitamin E excess. Journal of Lipid Research 54:9, pages 2295-2306.
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Weng-Yew Wong, Hemant Poudyal, Leigh C. Ward & Lindsay Brown. (2012) Tocotrienols Reverse Cardiovascular, Metabolic and Liver Changes in High Carbohydrate, High Fat Diet-Fed Rats. Nutrients 4:10, pages 1527-1541.
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Maret G. Traber. 2012. Present Knowledge in Nutrition. Present Knowledge in Nutrition 214 229 .
Viren Patel, Cameron Rink, Gayle M. Gordillo, Savita Khanna, Urmila Gnyawali, Sashwati Roy, Bassel Shneker, Kasturi Ganesh, Gary Phillips, J. Layne More, Atom Sarkar, Robert Kirkpatrick, Elmahdi A. Elkhammas, Emily Klatte, Michael Miller, Michael S. Firstenberg, E. Antonio Chiocca, Kalanithi Nesaretnam & Chandan K. Sen. (2012) Oral Tocotrienols Are Transported to Human Tissues and Delay the Progression of the Model for End-Stage Liver Disease Score in Patients4. The Journal of Nutrition 142:3, pages 513-519.
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Eva C. Vaquero & Xavier Molero. 2012. Natural compounds as inducers of cell death. Natural compounds as inducers of cell death 477 489 .
Merriline M. Satyamitra, Shilpa Kulkarni, Sanchita P. Ghosh, Conor P. Mullaney, Donald Condliffe & Venkataraman Srinivasan. (2011) Hematopoietic Recovery and Amelioration of Radiation-Induced Lethality by the Vitamin E Isoform δ-Tocotrienol. Radiation Research 175:6, pages 736-745.
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Shi Wei Tan, Rajesh Ramasamy, Maha Abdullah & Sharmili Vidyadaran. (2011) Inhibitory effects of palm α-, γ- and δ-tocotrienol on lipopolysaccharide-induced nitric oxide production in BV2 microglia. Cellular Immunology 271:2, pages 205-209.
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Leucio D. Vieira-Filho, Lucienne S. Lara, Paulo A. Silva, Felipe T.J. Santos, Ricardo Luzardo, Fabiana S.T. Oliveira, Ana D.O. Paixão & Adalberto Vieyra. (2011) Placental malnutrition changes the regulatory network of renal Na-ATPase in adult rat progeny: Reprogramming by maternal α-tocopherol during lactation. Archives of Biochemistry and Biophysics 505:1, pages 91-97.
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Cameron Rink, Savita Khanna & Chandan K. Sen. 2011. Studies on Experimental Models. Studies on Experimental Models 63 90 .
Wei Ney Yap, Norazean Zaiden, Yee Ling Tan, Chang Piek Ngoh, Xue Wu Zhang, Y.C. Wong, M.T. Ling & Yee Leng Yap. (2010) Id1, inhibitor of differentiation, is a key protein mediating anti-tumor responses of gamma-tocotrienol in breast cancer cells. Cancer Letters 291:2, pages 187-199.
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Maret G. Traber. (2010) Regulation of xenobiotic metabolism, the only signaling function of α-tocopherol?. Molecular Nutrition & Food Research 54:5, pages 661-668.
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Yuhei Hiura, Hirofumi Tachibana, Ryo Arakawa, Natsuki Aoyama, Masaaki Okabe, Midori Sakai & Koji Yamada. (2009) Specific accumulation of γ- and δ-tocotrienols in tumor and their antitumor effect in vivo. The Journal of Nutritional Biochemistry 20:8, pages 607-613.
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W N Yap, P N Chang, H Y Han, D T W Lee, M T Ling, Y C Wong & Y L Yap. (2008) γ-Tocotrienol suppresses prostate cancer cell proliferation and invasion through multiple-signalling pathways. British Journal of Cancer 99:11, pages 1832-1841.
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Stephan Ohnmacht, Phillip Nava, Ryan West, Robert Parker & Jeffrey Atkinson. (2008) Inhibition of oxidative metabolism of tocopherols with ω-N-heterocyclic derivatives of vitamin E. Bioorganic & Medicinal Chemistry 16:16, pages 7631-7638.
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Shu-Jing Wu, Po-Len Liu & Lean-Teik Ng. (2008) Tocotrienol-rich fraction of palm oil exhibits anti-inflammatory property by suppressing the expression of inflammatory mediators in human monocytic cells. Molecular Nutrition & Food Research 52:8, pages 921-929.
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Yasushi YAMADA, Mariko OBAYASHI, Tomoko ISHIKAWA, Yoshinobu KISO, Yoshiko ONO & Kanae YAMASHITA. (2008) Dietary Tocotrienol Reduces UVB-induced Skin Damage and Sesamin Enhances Tocotrienol Effects in Hairless Mice. Journal of Nutritional Science and Vitaminology 54:2, pages 117-123.
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Yasukazu Yoshida, Yoshiro Saito, Leslie Sargent Jones & Yasushi Shigeri. (2007) Chemical Reactivities and Physical Effects in Comparison between Tocopherols and Tocotrienols: Physiological Significance and Prospects as Antioxidants. Journal of Bioscience and Bioengineering 104:6, pages 439-445.
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Mariana Rickmann, Eva C. Vaquero, Juan Ramón Malagelada & Xavier Molero. (2007) Tocotrienols Induce Apoptosis and Autophagy in Rat Pancreatic Stellate Cells Through the Mitochondrial Death Pathway. Gastroenterology 132:7, pages 2518-2532.
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