194
Views
50
CrossRef citations to date
0
Altmetric
Original

Effect of a conjugated quercetin metabolite, quercetin 3-glucuronide, on lipid hydroperoxide-dependent formation of reactive oxygen species in differentiated PC-12 cells

, , , , , , , , , , & show all
Pages 1047-1053 | Received 28 Mar 2006, Published online: 07 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Hande Gül Ulusoy & Nevin Sanlier. (2020) A minireview of quercetin: from its metabolism to possible mechanisms of its biological activities. Critical Reviews in Food Science and Nutrition 60:19, pages 3290-3303.
Read now
Rie Mukai, Kyuichi Kawabata, Seiko Otsuka, Akari Ishisaka, Yoshichika Kawai, Zai-Si Ji, Hiroshi Tsuboi & Junji Terao. (2012) Effect of quercetin and its glucuronide metabolite upon 6-hydorxydopamine-induced oxidative damage in Neuro-2a cells. Free Radical Research 46:8, pages 1019-1028.
Read now
Bernardino Ossola, Tiina M Kääriäinen & Pekka T Männistö. (2009) The multiple faces of quercetin in neuroprotection. Expert Opinion on Drug Safety 8:4, pages 397-409.
Read now

Articles from other publishers (47)

Anh Thu Ha, Laily Rahmawati, Long You, Mohammad Amjad Hossain, Jong-Hoon Kim & Jae Youl Cho. (2021) Anti-Inflammatory, Antioxidant, Moisturizing, and Antimelanogenesis Effects of Quercetin 3-O-β-D-Glucuronide in Human Keratinocytes and Melanoma Cells via Activation of NF-κB and AP-1 Pathways. International Journal of Molecular Sciences 23:1, pages 433.
Crossref
Thaneeya Hawiset, Napatr Sriraksa, Ratchaniporn Kongsui, Utcharaporn Kamsrijai, Keerati Wanchai & Prachak Inkaew. (2021) Azadirachta indica A. Juss flower extract attenuates memory deficit - induced by restraint stress in male rats. Physiology and Pharmacology 1:inpress, pages 0-0.
Crossref
Singeun Kim, Ki-Bae Hong, Kyungae Jo & Hyung Joo Suh. (2021) Quercetin-3-O-glucuronide in the Ethanol Extract of Lotus Leaf (Nelumbo nucifera) Enhances Sleep Quantity and Quality in a Rodent Model via a GABAergic Mechanism. Molecules 26:10, pages 3023.
Crossref
Ramesh C. Gupta & Lucio G. Costa. 2021. Nutraceuticals. Nutraceuticals 3 15 .
Asma Vafadar, Zahra Shabaninejad, Ahmad Movahedpour, Farzaneh Fallahi, Mona Taghavipour, Younes Ghasemi, Maryam Akbari, Alimohammad Shafiee, Sarah Hajighadimi, Sanaz Moradizarmehri, Ebrahim Razi, Amir Savardashtaki & Hamed Mirzaei. (2020) Quercetin and cancer: new insights into its therapeutic effects on ovarian cancer cells. Cell & Bioscience 10:1.
Crossref
Junyu Liu, Yuanlian Zeng, Guojuan Sun, Shaopeng Yu, Yi Xu, Chao He, Zulun Li, Shenrui Jin & Xuhua Qin. (2020) Polygonumperfoliatum L., an Excellent Herbal Medicine Widely Used in China: A Review. Frontiers in Pharmacology 11.
Crossref
Lili Gan, Jiating Ma, Guoquan You, Jinxia Mai, Zhaoyu Wang, Ruopeng Yang, Cong Xie, Jingrao Fei, Lan Tang, Jie Zhao, Zheng Cai & Ling Ye. (2020) Glucuronidation and its effect on the bioactivity of amentoflavone, a biflavonoid from Ginkgo biloba leaves . Journal of Pharmacy and Pharmacology 72:12, pages 1840-1853.
Crossref
Nahide Ekici-Günay. 2020. Pathology. Pathology 235 245 .
Shirin Kahremany, Ilana Babaev, Raanan Gvirtz, Navit Ogen-Stern, Salome Azoulay-Ginsburg, Hanoch Senderowitz, Guy Cohen & Arie Gruzman. (2019) Nrf2 Activation by SK-119 Attenuates Oxidative Stress, UVB, and LPS-Induced Damage. Skin Pharmacology and Physiology 32:4, pages 173-181.
Crossref
Mario Dell’Agli, Chiara Di Lorenzo, Enrico Sangiovanni, Gary Williamson, Paolo Meoni, Patrizia Restani & Raymond Pieters. 2018. Food Supplements Containing Botanicals: Benefits, Side Effects and Regulatory Aspects. Food Supplements Containing Botanicals: Benefits, Side Effects and Regulatory Aspects 117 139 .
Domenico Iacopetta, Fedora Grande, Anna Caruso, Roberta Alessandra Mordocco, Maria Rosaria Plutino, Luca Scrivano, Jessica Ceramella, Noemi Muià, Carmela Saturnino, Francesco Puoci, Camillo Rosano & Maria Stefania Sinicropi. (2017) New insights for the use of quercetin analogs in cancer treatment. Future Medicinal Chemistry 9:17, pages 2011-2028.
Crossref
Abdelkarim Guaâdaoui. 2017. Fruit and Vegetable Phytochemicals. Fruit and Vegetable Phytochemicals 541 594 .
Piotr Michel, Aleksandra Owczarek, Martyna Kosno, Daniel Gontarek, Magdalena Matczak & Monika A. Olszewska. (2017) Variation in polyphenolic profile and in vitro antioxidant activity of eastern teaberry ( Gaultheria procumbens L.) leaves following foliar development. Phytochemistry Letters 20, pages 356-364.
Crossref
Samrat Baral, Ramesh Pariyar, Jaehyo Kim, Ho-Sub Lee & Jungwon Seo. (2017) Quercetin-3-O-glucuronide promotes the proliferation and migration of neural stem cells. Neurobiology of Aging 52, pages 39-52.
Crossref
Chenlin Shen, Zhengyue Qian, Ruonan Chen, Xiaoming Meng, Tingting Hu, Zhaolin Chen, Yangyang Li, Cheng Huang, Chaojie Hu & Jun Li. (2015) Single Dose Oral and Intravenous Pharmacokinetics and Tissue Distribution of a Novel Hesperetin Derivative MTBH in Rats. European Journal of Drug Metabolism and Pharmacokinetics 41:6, pages 675-688.
Crossref
Lucio G. Costa, Jacqueline M. Garrick, Pamela J. Roquè & Claudia Pellacani. (2016) Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More. Oxidative Medicine and Cellular Longevity 2016, pages 1-10.
Crossref
Lucio G. Costa, Jacqueline Garrick, Pamela J. Roque & Claudia Pellacani. 2016. Nutraceuticals. Nutraceuticals 3 13 .
B. Anu Monisha, Niraj Kumar & Ashu Bhan Tiku. 2016. Anti-inflammatory Nutraceuticals and Chronic Diseases. Anti-inflammatory Nutraceuticals and Chronic Diseases 47 73 .
Wiesław Wiczkowski, Janina Skipor, Tomasz Misztal, Dorota Szawara-Nowak, Joanna Topolska & Mariusz K. Piskula. (2015) Quercetin and isorhamnetin aglycones are the main metabolites of dietary quercetin in cerebrospinal fluid. Molecular Nutrition & Food Research 59:6, pages 1088-1094.
Crossref
Kyuichi Kawabata, Rie Mukai & Akari Ishisaka. (2015) Quercetin and related polyphenols: new insights and implications for their bioactivity and bioavailability. Food & Function 6:5, pages 1399-1417.
Crossref
Akari Ishisaka, Rie Mukai, Junji Terao, Noriyuki Shibata & Yoshichika Kawai. (2014) Specific localization of quercetin-3-O-glucuronide in human brain. Archives of Biochemistry and Biophysics 557, pages 11-17.
Crossref
Yoshichika Kawai. (2014) β-Glucuronidase activity and mitochondrial dysfunction: the sites where flavonoid glucuronides act as anti-inflammatory agents. Journal of Clinical Biochemistry and Nutrition 54:3, pages 145-150.
Crossref
Periasamy Ramyaa & Viswanadha Vijaya Padma. (2013) Ochratoxin-induced toxicity, oxidative stress and apoptosis ameliorated by quercetin – Modulation by Nrf2. Food and Chemical Toxicology 62, pages 205-216.
Crossref
Akari Ishisaka, Kyuichi Kawabata, Satomi Miki, Yuko Shiba, Shoko Minekawa, Tomomi Nishikawa, Rie Mukai, Junji Terao & Yoshichika Kawai. (2013) Mitochondrial Dysfunction Leads to Deconjugation of Quercetin Glucuronides in Inflammatory Macrophages. PLoS ONE 8:11, pages e80843.
Crossref
Yue Ding, Ming Peng, Tong Zhang, Jian-Sheng Tao, Zhen-Zhen Cai & Yong Zhang. (2013) Quantification of conjugated metabolites of drugs in biological matrices after the hydrolysis with β -glucuronidase and sufatase: a review of bio-analytical methods . Biomedical Chromatography 27:10, pages 1280-1295.
Crossref
Shiuan-Pey Lin, Pei-Ming Chu, Shang-Yuan Tsai, Meng-Hao Wu & Yu-Chi Hou. (2012) Pharmacokinetics and tissue distribution of resveratrol, emodin and their metabolites after intake of Polygonum cuspidatum in rats. Journal of Ethnopharmacology 144:3, pages 671-676.
Crossref
Pamela Bulzomi, Paola Galluzzo, Alessandro Bolli, Stefano Leone, Filippo Acconcia & Maria Marino. (2012) The pro-apoptotic effect of quercetin in cancer cell lines requires ERβ-dependent signals. Journal of Cellular Physiology 227:5, pages 1891-1898.
Crossref
Nataraj Loganayaki, Nandhagopalan Suganya & Sellamuthu Manian. (2012) Evaluation of edible flowers of agathi (Sesbania grandiflora L. Fabaceae) for in vivo anti-inflammatory and analgesic, and in vitro antioxidant potential. Food Science and Biotechnology 21:2, pages 509-517.
Crossref
Aristidis S. Veskoukis, Antonios Kyparos, Michalis G. Nikolaidis, Dimitrios Stagos, Nektarios Aligiannis, Maria Halabalaki, Konstantinos Chronis, Nikolaos Goutzourelas, Leandros Skaltsounis & Dimitrios Kouretas. (2012) The Antioxidant Effects of a Polyphenol-Rich Grape Pomace Extract In Vitro Do Not Correspond In Vivo Using Exercise as an Oxidant Stimulus . Oxidative Medicine and Cellular Longevity 2012, pages 1-14.
Crossref
Karsten Beekmann, Lucas Actis-Goretta, Peter J. van Bladeren, Fabiola Dionisi, Frederic Destaillats & Ivonne M. C. M. Rietjens. (2012) A state-of-the-art overview of the effect of metabolic conjugation on the biological activity of flavonoids. Food & Function 3:10, pages 1008.
Crossref
Aristidis S. Veskoukis, Aristidis M. Tsatsakis & Dimitrios Kouretas. (2011) Dietary oxidative stress and antioxidant defense with an emphasis on plant extract administration. Cell Stress and Chaperones 17:1, pages 11-21.
Crossref
Akari Ishisaka, Satomi Ichikawa, Hiroyuki Sakakibara, Mariusz K. Piskula, Toshiyuki Nakamura, Yoji Kato, Mikiko Ito, Ken-ichi Miyamoto, Akira Tsuji, Yoshichika Kawai & Junji Terao. (2011) Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats. Free Radical Biology and Medicine 51:7, pages 1329-1336.
Crossref
Dongsheng Fan, Xin Zhou, Chao Zhao, Huaguo Chen, Yang Zhao & Xiaojian Gong. (2011) Anti-inflammatory, antiviral and quantitative study of quercetin-3-O-β-D-glucuronide in Polygonum perfoliatum L.. Fitoterapia 82:6, pages 805-810.
Crossref
Silvina B. Lotito, Wei-Jian Zhang, Chung S. Yang, Alan Crozier & Balz Frei. (2011) Metabolic conversion of dietary flavonoids alters their anti-inflammatory and antioxidant properties. Free Radical Biology and Medicine 51:2, pages 454-463.
Crossref
Junji Terao, Kaeko Murota & Yoshichika Kawai. (2011) Conjugated quercetin glucuronides as bioactive metabolites and precursors of aglyconein vivo. Food Funct. 2:1, pages 11-17.
Crossref
Junji Terao, Kaeko Murota & Yoshichika Kawai. 2010. Recent Advances in Polyphenol Research. Recent Advances in Polyphenol Research 299 318 .
Kyuichi Kawabata, Yoshichika Kawai & Junji Terao. (2010) Suppressive effect of quercetin on acute stress-induced hypothalamic-pituitary-adrenal axis response in Wistar rats. The Journal of Nutritional Biochemistry 21:5, pages 374-380.
Crossref
Rongliang Zheng, Yimin Shi, Zhongjian Jia, Chenyang Zhao, Qi Zhang & Xiaorong Tan. (2010) Fast repair of DNA radicals. Chemical Society Reviews 39:8, pages 2827.
Crossref
Sanja Pavlica & Rolf Gebhardt. (2010) Protective effects of flavonoids and two metabolites against oxidative stress in neuronal PC12 cells. Life Sciences 86:3-4, pages 79-86.
Crossref
Gary Williamson, Helmut Sies, David Heber, Carl L Keen, Ian A Macdonald, Lucas Actis-Gorreta, Tony Y Momma, Javier I Ottaviani, Roberta R Holt, Hagen Schroeter & Christian Heiss. (2009) Functional foods for health promotion: state-of-the-science on dietary flavonoids�Extended abstracts from the 12 th Annual Conference on Functional Foods for Health Promotion, April 2009 . Nutrition Reviews 67:12, pages 736-743.
Crossref
Maria Traka & Richard F. Mithen. 2009. Plant-derived Natural Products. Plant-derived Natural Products 385 403 .
Tiny Kgomotso, Francis Chiu & Ken Ng. (2008) Genistein‐ and daidzein 7‐O‐β‐ D ‐glucuronic acid retain the ability to inhibit copper‐mediated lipid oxidation of low density lipoprotein . Molecular Nutrition & Food Research 52:12, pages 1457-1466.
Crossref
Akira Murakami, Hitoshi Ashida & Junji Terao. (2008) Multitargeted cancer prevention by quercetin. Cancer Letters 269:2, pages 315-325.
Crossref
Barry Halliwell. (2008) Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies?. Archives of Biochemistry and Biophysics 476:2, pages 107-112.
Crossref
Kousuke Ishino, Takahiro Shibata, Takeshi Ishii, Yu-Ting Liu, Shinya Toyokuni, Xiaochun Zhu, Lawrence M. Sayre & Koji Uchida. (2008) Protein N -Acylation: H 2 O 2 -Mediated Covalent Modification of Protein by Lipid Peroxidation-Derived Saturated Aldehydes . Chemical Research in Toxicology 21:6, pages 1261-1270.
Crossref
Masumi Sasaki, Hiroyuki Nakamura, Shizuko Tsuchiya, Syunji Horie, Makoto Kashiwayanagi, Takeshi Saito & Toshihiko Murayama. (2007) Quercetin-Induced PC12 Cell Death Accompanied by Caspase-Mediated DNA Fragmentation. Biological and Pharmaceutical Bulletin 30:4, pages 682-686.
Crossref
Chooi Yeng Lee, Hwee Ming Cheng & Si Mui Sim. (2007) Mulberry leaves protect rat tissues from immobilization stress-induced inflammation. BioFactors 31:1, pages 25-33.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.