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Free Radical Research Volume 41, 2007 - Issue 3
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The flavonoid quercetin induces hypoxia-inducible factor-1α (HIF-1α) and inhibits cell proliferation by depleting intracellular iron

Anastasia Triantafyllou Laboratory of Biochemistry, Department of Medicine, School of Health Sciences, University of Thessaly, 22 Papakyriazi Street, 41222, Larissa, Greece
,
Panagiotis Liakos Laboratory of Biochemistry, Department of Medicine, School of Health Sciences, University of Thessaly, 22 Papakyriazi Street, 41222, Larissa, Greece
,
Andreas Tsakalof Laboratory of Biochemistry, Department of Medicine, School of Health Sciences, University of Thessaly, 22 Papakyriazi Street, 41222, Larissa, Greece
,
Georgia Chachami Laboratory of Physiology, Department of Medicine, School of Health Sciences, University of Thessaly, 22 Papakyriazi Street, 41222, Larissa, Greece
,
Efrosyni Paraskeva Laboratory of Physiology, Department of Medicine, School of Health Sciences, University of Thessaly, 22 Papakyriazi Street, 41222, Larissa, Greece
,
Pashalis-Adam Molyvdas Laboratory of Physiology, Department of Medicine, School of Health Sciences, University of Thessaly, 22 Papakyriazi Street, 41222, Larissa, Greece
,
Elena Georgatsou Laboratory of Biochemistry, Department of Medicine, School of Health Sciences, University of Thessaly, 22 Papakyriazi Street, 41222, Larissa, Greece
,
George Simos Laboratory of Biochemistry, Department of Medicine, School of Health Sciences, University of Thessaly, 22 Papakyriazi Street, 41222, Larissa, Greece
&
Sophia Bonanou Laboratory of Biochemistry, Department of Medicine, School of Health Sciences, University of Thessaly, 22 Papakyriazi Street, 41222, Larissa, GreeceCorrespondence[email protected]
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Pages 342-356 | Received 03 Jun 2006, Published online: 07 Jul 2009

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Mingming Yin, Yongping Liu & Yi Chen. (2021) Iron metabolism: an emerging therapeutic target underlying the anti-cancer effect of quercetin. Free Radical Research 55:3, pages 296-303.
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Articles from other publishers (35)

V. Cardozo, L. Vaamonde, A. Parodi-Talice, M.J. Zuluaga, D. Agrati, M. Portela, A. Lima, F. Blasina, F. Dajas & G. Bedó. (2021) Multitarget neuroprotection by quercetin: Changes in gene expression in two perinatal asphyxia models. Neurochemistry International 147, pages 105064.
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Lin Xiao, Gang Luo, Yuhan Tang & Ping Yao. (2018) Quercetin and iron metabolism: What we know and what we need to know. Food and Chemical Toxicology 114, pages 190-203.
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Geir Bjørklund & Salvatore Chirumbolo. (2017) Role of oxidative stress and antioxidants in daily nutrition and human health. Nutrition 33, pages 311-321.
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Samie Salehi, Amir Shokooh Saljooghi & Mohammad Izadyar. (2016) A theoretical study on the electronic structures and equilibrium constants evaluation of Deferasirox iron complexes. Computational Biology and Chemistry 64, pages 99-106.
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Sarah L Miles, Margaret McFarland & Richard M Niles. (2014) Molecular and physiological actions of quercetin: need for clinical trials to assess its benefits in human disease. Nutrition Reviews 72:11, pages 720-734.
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Francisco Javier Rodríguez-Jiménez & Victoria Moreno-Manzano. (2011) Modulation of hypoxia-inducible factors (HIF) from an integrative pharmacological perspective. Cellular and Molecular Life Sciences 69:4, pages 519-534.
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Jong Gwon ChoiJung-Lim KimJoohee ParkSoonwook LeeSeh Jong ParkJun Suk KimChul Won Choi. (2012) Effects of oral iron chelator deferasirox on human malignant lymphoma cells. The Korean Journal of Hematology 47:3, pages 194.
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Achillia Lakka, Ilias Mylonis, Sophia Bonanou, George Simos & Andreas Tsakalof. (2010) Isolation of hypoxia-inducible factor 1 (HIF-1) inhibitors from frankincense using a molecularly imprinted polymer. Investigational New Drugs 29:5, pages 1081-1089.
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Orly WeinrebTamar AmitSilvia MandelLana KupershmidtMoussa B.H. Youdim. (2010) Neuroprotective Multifunctional Iron Chelators: From Redox-Sensitive Process to Novel Therapeutic Opportunities. Antioxidants & Redox Signaling 13:6, pages 919-949.
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Aline BachJulia Bender–SigelDieter SchrenkDaniela FlügelThomas Kietzmann. (2010) The Antioxidant Quercetin Inhibits Cellular Proliferation via HIF-1-Dependent Induction of p21WAF . Antioxidants & Redox Signaling 13:4, pages 437-448.
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Elena Ansó, Alicia Zuazo, Marta Irigoyen, María C. Urdaci, Ana Rouzaut & Juan J. Martínez-Irujo. (2010) Flavonoids inhibit hypoxia-induced vascular endothelial growth factor expression by a HIF-1 independent mechanism. Biochemical Pharmacology 79:11, pages 1600-1609.
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Mikko Nikinmaa. 2012. Respiratory Physiology of Vertebrates. Respiratory Physiology of Vertebrates 14 48 .
Gangjun Du, Haihong Lin, Mei Wang, Shuo Zhang, Xianchuang Wu, Linlin Lu, Liyan Ji & Lijuan Yu. (2009) Quercetin greatly improved therapeutic index of doxorubicin against 4T1 breast cancer by its opposing effects on HIF-1α in tumor and normal cells. Cancer Chemotherapy and Pharmacology 65:2, pages 277-287.
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Heather C Hatcher, Ravi N Singh, Frank M TortiSuzy V Torti. (2009) Synthetic and natural iron chelators: therapeutic potential and clinical use. Future Medicinal Chemistry 1:9, pages 1643-1670.
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Pauline Radreau, Jeremy D. Rhodes, Richard F. Mithen, Paul A. Kroon & Julie Sanderson. (2009) Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells. Experimental Eye Research 89:6, pages 995-1002.
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Bogdan Manolescu, Eliza Oprea, Carmina Busu & Cornelia Cercasov. (2009) Natural compounds and the hypoxia-inducible factor (HIF) signalling pathway. Biochimie 91:11-12, pages 1347-1358.
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Junko H. Ohyashiki, Chiaki Kobayashi, Ryoko Hamamura, Seiichi Okabe, Tetsuzo Tauchi & Kazuma Ohyashiki. (2009) The oral iron chelator deferasirox represses signaling through the mTOR in myeloid leukemia cells by enhancing expression of REDD1. Cancer Science 100:5, pages 970-977.
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Thilakavathy Thangasamy, Sivanandane Sittadjody & Randy Burd. 2009. Complementary and Alternative Therapies and the Aging Population. Complementary and Alternative Therapies and the Aging Population 563 584 .
Jae-Hoon Jeong, Jee Young An, Yong Tae Kwon, Lu-Yuan Li & Yong J. Lee. (2008) Quercetin-induced ubiquitination and down-regulation of Her-2/ neu . Journal of Cellular Biochemistry 105:2, pages 585-595.
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Rebecca P. Dearlove, Phillip Greenspan, Diane K. Hartle, Ruthann B. Swanson & James L. Hargrove. (2008) Inhibition of Protein Glycation by Extracts of Culinary Herbs and Spices. Journal of Medicinal Food 11:2, pages 275-281.
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Sung‐Soo Park, Insoo Bae & Yong J. Lee. (2007) Flavonoids‐induced accumulation of hypoxia‐inducible factor (HIF)‐1α/2α is mediated through chelation of iron. Journal of Cellular Biochemistry 103:6, pages 1989-1998.
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Anastasia Triantafyllou, Ilias Mylonis, George Simos, Sophia Bonanou & Andreas Tsakalof. (2008) Flavonoids induce HIF-1α but impair its nuclear accumulation and activity. Free Radical Biology and Medicine 44:4, pages 657-670.
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Benoit M. Lienard, Ana Conejo-García, Ineke Stolze, Christoph Loenarz, Neil J. Oldham, Peter J. Ratcliffe & Christopher J. Schofield. (2008) Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases. Chemical Communications:47, pages 6393.
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