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Original

Protection against in vivo focal myocardial ischemia/reperfusion injury-induced arrhythmias and apoptosis by Hesperidin

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Pages 817-827 | Received 07 Apr 2009, Published online: 01 Sep 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Chaoyun Li & Hermann Schluesener. (2017) Health-promoting effects of the citrus flavanone hesperidin. Critical Reviews in Food Science and Nutrition 57:3, pages 613-631.
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Rajesh Maheshwari, Ramachandran Balaraman, Ashim Kumar Sen, Disha Shukla & Avinash Seth. (2017) Effect of concomitant administration of coenzyme Q10 with sitagliptin on experimentally induced diabetic nephropathy in rats. Renal Failure 39:1, pages 130-139.
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Ussama Z. Said, Helen N. Saada, Mohga S. Abd-Alla, Mahdy E. Elsayed & Alshimaa M. Amin. (2012) Hesperidin attenuates brain biochemical changes of irradiated rats. International Journal of Radiation Biology 88:8, pages 613-618.
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Articles from other publishers (27)

Rohit Tayal, Kavita Munjal, Vinod Kumar Gauttam, Pankaj Popli, Loveleen Khurana & Neeraj Choudhary. (2023) Potential role of hesperidin in lifestyle disorders: A scoping review. South African Journal of Botany 161, pages 542-554.
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Jiami Zou, Jiaojiao Wang, Weile Ye, Jing Lu, Chengzhi Li, Dongmei Zhang, Wencai Ye, Suowen Xu, Chunbo Chen, Peiqing Liu & Zhiping Liu. (2022) Citri Reticulatae Pericarpium (Chenpi): A multi-efficacy pericarp in treating cardiovascular diseases. Biomedicine & Pharmacotherapy 154, pages 113626.
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Danesh Soltani, Bayan Azizi, Roja Rahimi, Azita H. Talasaz, Hossein Rezaeizadeh & Ali Vasheghani-Farahani. (2022) Mechanism-based targeting of cardiac arrhythmias by phytochemicals and medicinal herbs: A comprehensive review of preclinical and clinical evidence. Frontiers in Cardiovascular Medicine 9.
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Cong Chen, Lin-Tong Yu, Bai-Ru Cheng, Jiang-Lin Xu, Yun Cai, Jia-Lin Jin, Ru-Li Feng, Long Xie, Xin-Yan Qu, Dong Li, Jing Liu, Yan Li, Xiao-Yun Cui, Jin-Jin Lu, Kun Zhou, Qian Lin & Jie Wan. (2022) Promising Therapeutic Candidate for Myocardial Ischemia/Reperfusion Injury: What Are the Possible Mechanisms and Roles of Phytochemicals?. Frontiers in Cardiovascular Medicine 8.
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Jun-ying Jia, Er-huan Zang, Li-juan Lv, Qin-yu Li, Chun-hua Zhang, Ying Xia, Lei Zhang, Lian-sheng Dang & Min-hui Li. (2021) Flavonoids in myocardial ischemia-reperfusion injury: Therapeutic effects and mechanisms. Chinese Herbal Medicines 13:1, pages 49-63.
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Ramachandran Balaraman, G Parmar, Rajesh A. Maheshwari & Sugreev Dwivedi Anuj. (2020) A Review on the Biological Effects of some Natural Products. Journal of Natural Remedies 20:3, pages 117-127.
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Amira R. Amin, Rami B. Kassab, Ahmed E. Abdel Moneim & Hatem K. Amin. (2020) Comparison Among Garlic, Berberine, Resveratrol, Hibiscus sabdariffa , Genus Zizyphus , Hesperidin, Red Beetroot, Catha edulis , Portulaca oleracea , and Mulberry Leaves in the Treatment of Hypertension and Type 2 DM: A Comprehensive Review . Natural Product Communications 15:4, pages 1934578X2092162.
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Won Seo Park, Min Su Park, Sang Wook Kang, Seul A. Jin, Youngchul Jeon, Jeikiun Hwang & Su Kang Kim. (2019) Hesperidin Shows Protective Effects on Renal Function in Ischemia-induced Acute Kidney Injury (Sprague-Dawley Rats). Transplantation Proceedings 51:8, pages 2838-2841.
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Daniela Gentile, Matteo Fornai, Carolina Pellegrini, Rocchina Colucci, Corrado Blandizzi & Luca Antonioli. (2018) Dietary flavonoids as a potential intervention to improve redox balance in obesity and related co-morbidities: a review. Nutrition Research Reviews 31:2, pages 239-247.
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Xuefei Li, Xiaorong Hu, Jichun Wang, Weipan Xu, Chunfeng Yi, Ruisong Ma & Hong Jiang. (2018) Inhibition of autophagy via activation of PI3K/Akt/mTOR pathway contributes to the protection of hesperidin against myocardial ischemia/reperfusion injury. International Journal of Molecular Medicine.
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Rosanna Mattera, Monica Benvenuto, Maria Giganti, Ilaria Tresoldi, Francesca Pluchinotta, Sonia Bergante, Guido Tettamanti, Laura Masuelli, Vittorio Manzari, Andrea Modesti & Roberto Bei. (2017) Effects of Polyphenols on Oxidative Stress-Mediated Injury in Cardiomyocytes. Nutrients 9:5, pages 523.
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Mahdieh Pashai, Seyedeh Negisa Seyed Toutounchi, Maryam Rameshrad, Haleh Vaez, Fatemeh Fathiazad & Alireza Garjani. (2016) The Effects of Hesperidin on Ischemia/Reperfusion Induced Arrhythmias and Infarct Size in Isolated Rat Heart. Pharmaceutical Sciences 22:2, pages 68-75.
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Eman Taha Mohamed & Ghada Mohamed Safwat. (2016) Evaluation of cardioprotective activity of Lepidium sativum seed powder in albino rats treated with 5-fluorouracil. Beni-Suef University Journal of Basic and Applied Sciences 5:2, pages 208-215.
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Emily F Warner, Qingzhi Zhang, K Saki Raheem, David O’Hagan, Maria A O’Connell & Colin D Kay. (2016) Common Phenolic Metabolites of Flavonoids, but Not Their Unmetabolized Precursors, Reduce the Secretion of Vascular Cellular Adhesion Molecules by Human Endothelial Cells. The Journal of Nutrition 146:3, pages 465-473.
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Daisuke Maruyama, Naoyuki Hirata, Yasuyuki Tokinaga, Ryoichi Kawaguchi & Michiaki Yamakage. (2016) Nitrite Reduces Ischemia-Induced Ventricular Arrhythmias by Attenuating Connexin 43 Dephosphorylation in Rats. Anesthesia & Analgesia 122:2, pages 410-417.
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Zhifeng Zhang, Yuan Liu, Xuecong Ren, Hua Zhou, Kaishun Wang, Hao Zhang & Pei Luo. (2016) Caffeoylquinic Acid Derivatives Extract of Erigeron multiradiatus Alleviated Acute Myocardial Ischemia Reperfusion Injury in Rats through Inhibiting NF-KappaB and JNK Activations . Mediators of Inflammation 2016, pages 1-11.
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Mahesh Gupta, Pallavi Sharma, Arindam Ghosh Mazumder, Vikram Patial & Damanpreet Singh. (2015) Dwindling of cardio damaging effect of isoproterenol by Punica granatum L. peel extract involve activation of nitric oxide-mediated Nrf2/ARE signaling pathway and apoptosis inhibition. Nitric Oxide 50, pages 105-113.
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Ali Roohbakhsh, Hamideh Parhiz, Fatemeh Soltani, Ramin Rezaee & Mehrdad Iranshahi. (2015) Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases. Life Sciences 124, pages 64-74.
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Naglaa A. Bayomy, Saad H. Elshafey, Reda H. ElBakary & Eman Z. Abdelaziz. (2014) Protective effect of hesperidin against lung injury induced by intestinal ischemia/reperfusion in adult albino rats: Histological, immunohistochemical and biochemical study. Tissue and Cell 46:5, pages 304-310.
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M. Namik Oztanir, Osman Ciftci, Aslı Cetin & M. Arif Aladag. (2014) Hesperidin attenuates oxidative and neuronal damage caused by global cerebral ischemia/reperfusion in a C57BL/J6 mouse model. Neurological Sciences 35:9, pages 1393-1399.
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Yogeeta O. Agrawal, Pankaj Kumar Sharma, Birendra Shrivastava, Dharamvir Singh Arya & Sameer N. Goyal. (2014) Hesperidin blunts streptozotocin-isoproternol induced myocardial toxicity in rats by altering of PPAR-γ receptor. Chemico-Biological Interactions 219, pages 211-220.
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M. Akhlaghi & B. Bandy. 2013. Bioactive Food as Dietary Interventions for Cardiovascular Disease. Bioactive Food as Dietary Interventions for Cardiovascular Disease 415 429 .
Ramesh SrirangamKetan HippalgaonkarBharathi AvulaIkhlas A. KhanSoumyajit Majumdar. (2012) Evaluation of the Intravenous and Topical Routes for Ocular Delivery of Hesperidin and Hesperetin. Journal of Ocular Pharmacology and Therapeutics 28:6, pages 618-627.
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Julia J Peterson, Johanna T Dwyer, Paul F Jacques & Marjorie L McCullough. (2012) Associations between flavonoids and cardiovascular disease incidence or mortality in European and US populations. Nutrition Reviews 70:9, pages 491-508.
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Ramesh Srirangam, Ketan Hippalgaonkar & Soumyajit Majumdar. (2012) Intravitreal Kinetics of Hesperidin, Hesperetin, and Hesperidin G: Effect of Dose and Physicochemical Properties. Journal of Pharmaceutical Sciences 101:4, pages 1631-1638.
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Yu-Rim Lee, Ji-Hye Jung & Hyun-Sook Kim. (2011) Hesperidin Partially Restores Impaired Immune and Nutritional Function in Irradiated Mice. Journal of Medicinal Food 14:5, pages 475-482.
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Vaibhav Patel, Aman Upaganlawar, Rishit Zalawadia & R. Balaraman. (2010) Cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats: A biochemical, electrocardiographic and histoarchitectural evaluation. European Journal of Pharmacology 644:1-3, pages 160-168.
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