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Free Radical Research Volume 43, 2009 - Issue 10
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Original

Nitroindazole compounds inhibit the oxidative activation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to neurotoxic pyridinium cations by human monoamine oxidase (MAO)

Tomás Herraiz Instituto de Fermentaciones IndustrialesCorrespondence[email protected]
,
Vicente J. Arán Instituto de Química Médica, Spanish Council for Scientific Research, CSIC, Juan de la Cierva, 3, 28006, Madrid, Spain
&
Hugo Guillén Instituto de Fermentaciones Industriales
Pages 975-984 | Received 21 May 2009, Published online: 15 Sep 2009

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Tomás Herraiz. (2012) Evaluation of the oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to toxic pyridinium cations by monoamine oxidase (MAO) enzymes and its use to search for new MAO inhibitors and protective agents. Journal of Enzyme Inhibition and Medicinal Chemistry 27:6, pages 810-817.
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Articles from other publishers (13)

Tomás Herraiz. (2023) β-Carboline Alkaloids in Soy Sauce and Inhibition of Monoamine Oxidase (MAO). Molecules 28:6, pages 2723.
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Tomás Herraiz. 2023. Monoamine Oxidase. Monoamine Oxidase 97 114 .
Dilipkumar Pal & Pooja Sahu. (2022) Importance of Indazole against Neurological Disorders. Current Topics in Medicinal Chemistry 22:14, pages 1136-1151.
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I.N. Tyurenkov, T.A. Popova, V.N. Perfilova, I.I. Prokofiev, A.V. Borisov, M.V. Kustova, G.I. Zaypullaev & O.V. Ostrovskij. (2017) Protective effects of a new glutamic acid derivative against stress after nNOS blockade. Biomeditsinskaya Khimiya 63:1, pages 47-55.
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Tomás Herraiz. (2016) N-methyltetrahydropyridines and pyridinium cations as toxins and comparison with naturally-occurring alkaloids. Food and Chemical Toxicology 97, pages 23-39.
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T. Bohnert, A. Patel, I. Templeton, Y. Chen, C. Lu, G. Lai, L. Leung, S. Tse, H. J. Einolf, Y.-H. Wang, M. Sinz, R. Stearns, R. Walsky, W. Geng, S. Sudsakorn, D. Moore, L. He, J. Wahlstrom, J. Keirns, R. Narayanan, D. Lang & X. Yang. (2016) Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions--an Industry Perspective. Drug Metabolism and Disposition 44:8, pages 1399-1423.
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Nikolay T. Tzvetkov, Sonja Hinz, Petra Küppers, Marcus Gastreich & Christa E. Müller. (2014) Indazole- and Indole-5-carboxamides: Selective and Reversible Monoamine Oxidase B Inhibitors with Subnanomolar Potency. Journal of Medicinal Chemistry 57:15, pages 6679-6703.
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Jacques Joubert, Jacobus P. Petzer, Louis H.A. Prins, Benjamin P. Repsold & Sarel F. Malan. 2014. Drug Design and Discovery in Alzheimer's Disease. Drug Design and Discovery in Alzheimer's Disease 291 365 .
K.S. Madathil, S.S. Karuppagounder, R. Haobam, M. Varghese, U. Rajamma & K.P. Mohanakumar. (2013) Nitric oxide synthase inhibitors protect against rotenone-induced, oxidative stress mediated parkinsonism in rats. Neurochemistry International 62:5, pages 674-683.
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Wei Cui, Zaijun Zhang, Wenming Li, Shengquan Hu, Shinghung Mak, Huan Zhang, Renwen Han, Shuai Yuan, Sai Li, Fei Sa, Daping Xu, Zhixiu Lin, Zhong Zuo, Jianhui Rong, Edmond Dik-Lung Ma, Tony Chunglit Choi, Simon MY Lee & Yifan Han. (2013) The anti-cancer agent SU4312 unexpectedly protects against MPP + -induced neurotoxicity via selective and direct inhibition of neuronal NOS . British Journal of Pharmacology 168:5, pages 1201-1214.
Crossref
Tomás Herraiz. 2012. Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants. Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants 77 103 .
Tomás Herraiz & Hugo Guillén. (2011) Inhibition of the bioactivation of the neurotoxin MPTP by antioxidants, redox agents and monoamine oxidase inhibitors. Food and Chemical Toxicology 49:8, pages 1773-1781.
Crossref
T. Herraiz, D. González, C. Ancín-Azpilicueta, V.J. Arán & H. Guillén. (2010) β-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO). Food and Chemical Toxicology 48:3, pages 839-845.
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