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Original Article

Can oxidative DNA damage be used as a biomarker of cancer risk in humans? Problems, resolutions and preliminary results from nutritional supplementation studies

Pages 469-486 | Received 01 Sep 1998, Published online: 07 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (13)

Benjamin Kendzia, Beate Pesch, Boleslaw Marczynski, Anne Lotz, Peter Welge, Hans-Peter Rihs, Thomas Brüning & Monika Raulf-Heimsoth. (2012) Pre- and Postshift Levels of Inflammatory Biomarkers and Dna Damage in Non-Bitumen-Exposed Construction Workers—Subpopulation of the German Human Bitumen Study. Journal of Toxicology and Environmental Health, Part A 75:8-10, pages 533-543.
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AmyC. Butalla, TracyE. Crane, Bhimanagouda Patil, BetsyC. Wertheim, Patricia Thompson & CynthiaA. Thomson. (2012) Effects of a Carrot Juice Intervention on Plasma Carotenoids, Oxidative Stress, and Inflammation in Overweight Breast Cancer Survivors. Nutrition and Cancer 64:2, pages 331-341.
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ATHANASIOS VALAVANIDIS, THOMAIS VLACHOGIANNI & CONSTANTINOS FIOTAKIS. (2009) 8-hydroxy-2′ -deoxyguanosine (8-OHdG): A Critical Biomarker of Oxidative Stress and Carcinogenesis. Journal of Environmental Science and Health, Part C 27:2, pages 120-139.
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Ingrid Kiefer, Peter Prock, Catherine Lawrence, John Wise, Wilfried Bieger, Peter Bayer, Theres Rathmanner, Michael Kunze & Anita Rieder. (2004) Supplementation with Mixed Fruit and Vegetable Juice Concentrates Increased Serum Antioxidants and Folate in Healthy Adults. Journal of the American College of Nutrition 23:3, pages 205-211.
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Gunther Guetens, Gert De Boeck, Martin Highley, Allan T. van Oosterom & Ernst A. de Bruijn. (2002) Oxidative DNA Damage: Biological Significance and Methods of Analysis. Critical Reviews in Clinical Laboratory Sciences 39:4-5, pages 331-457.
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S-K. Lim, B. Ferraro, K. Moore & B. Halliwell. (2001) Role of haptoglobin in free hemoglobin metabolism. Redox Report 6:4, pages 219-227.
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Martalena br Purba, Antigone Kouris-Blazos, Naiyana Wattanapenpaiboon, Widjaja Lukito, Elizabet M Rothenberg, Bertil C. Steen & Mark L. Wahlqvist. (2001) Skin Wrinkling: Can Food Make a Difference?. Journal of the American College of Nutrition 20:1, pages 71-80.
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P. Duez, M. Helson, T.I. Some, J. Dubois & M. Hanocq. (2000) Chromatographic determination of 8-oxo-7,8-dihydro-2′-deoxyguanosine in cellular DNA: A validation study. Free Radical Research 33:3, pages 243-260.
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Barry Halliwell, Kaicun Zhao & Matthew Whiteman. (2000) The gastrointestinal tract: A major site of antioxidant action?. Free Radical Research 33:6, pages 819-830.
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Timothy England, Emily Beatty, Almas Rehman, Jaffar Nourooz-Zadeh, Paulo Pereira, James O'Reilly, Helen Wiseman, Catherine Geissler & Barry Halliwell. (2000) The steady-state levels of oxidative DNA damage and of lipid peroxidation (F2-isoprostanes) are not correlated in healthy human subjects. Free Radical Research 32:4, pages 355-362.
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Barry Halliwell. (1999) Antioxidant defence mechanisms: From the beginning to the end (of the beginning). Free Radical Research 31:4, pages 261-272.
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Almas Rehman, Jaffar Nourooz-Zadeh, Wenke Möller, Hans Tritschler, Paulo Pereira & Barry Halliwell. (1999) Increased oxidative damage to all DNA bases in patients with type II diabetes mellitus. FEBS Letters 448:1, pages 120-122.
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