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Original Article

Endogenous nitric oxide synthesis: Biological functions and pathophysiology

Pages 577-596 | Received 07 Apr 1999, Published online: 07 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (24)

Juliano Casonatto & João Vagner Cavalari. (2023) A Single Dosage of l-Arginine Oral Supplementation Induced Post-Aerobic Exercise Hypotension in Hypertensive Patients. Journal of Dietary Supplements 20:5, pages 735-748.
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Xiaowen Jiang, Xinxin Feng, Hui Huang, Lin Liu, Lu Qiao, Binqing Zhang & Wenhui Yu. (2017) The effects of rotenone-induced toxicity via the NF-κB–iNOS pathway in rat liver. Toxicology Mechanisms and Methods 27:4, pages 318-325.
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D. Tripathy, J. Chakraborty & K. P. Mohanakumar. (2015) Antagonistic pleiotropic effects of nitric oxide in the pathophysiology of Parkinson's disease. Free Radical Research 49:9, pages 1129-1139.
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Bawneet K. Narang, Subhajit Roy, Rajiv Sharma, Virender Singh & Ravindra K. Rawal. (2015) Riociguat as a treatment regime for pulmonary arterial hypertension: a review. Clinical and Experimental Hypertension 37:4, pages 323-331.
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Linghe Zang, Hao He, Yuanchao Ye, Weiwei Liu, Simiao Fan, Shin-Ichi Tashiro, Satoshi Onodera & Takashi Ikejima. (2012) Nitric oxide augments oridonin-induced efferocytosis by human histocytic lymphoma U937 cells via autophagy and the NF-κB-COX-2-IL-1β pathway. Free Radical Research 46:10, pages 1207-1219.
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Margarita C. Currás-Collazo. (2011) Nitric Oxide Signaling as a Common Target of Organohalogens and Other Neuroendocrine Disruptors. Journal of Toxicology and Environmental Health, Part B 14:5-7, pages 495-536.
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Shingo Kaida, Yoshiji Ohta, Yoichiro Imai & Minoru Kawanishi. (2010) Protective effect of L-ascorbic acid against oxidative damage in the liver of rats with water-immersion restraint stress. Redox Report 15:1, pages 11-19.
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Jia Yang, Li-Jun Wu, Shin-Ichi Tashiro, Satoshi Onodera & Takashi Ikejima. (2008) Nitric oxide activated by p38 and NF-κB facilitates apoptosis and cell cycle arrest under oxidative stress in evodiamine-treated human melanoma A375-S2 cells. Free Radical Research 42:1, pages 1-11.
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Yoshiji Ohta, Sayaka Chiba, Masayo Tada, Yoichiro Imai & Akira Kitagawa. (2007) Development of oxidative stress and cell damage in the liver of rats with water-immersion restraint stress. Redox Report 12:3, pages 139-147.
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Chiwaka Kimura, Masahiro Oike, Michi Watanabe & Yushi Ito. (2007) Proapoptotic Nitric Oxide Production in Amyloid β Protein-Treated Cerebral Microvascular Endothelial Cells. Microcirculation 14:2, pages 89-97.
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Katia Aquilano, Giuseppe Filomeni, Livia di Renzo, Maura di Vito, Carla di Stefano, Paola Sinibaldi Salimei, Maria R. Ciriolo & Gabriella Marfè. (2007) Reactive oxygen and nitrogen species are involved in sorbitol-induced apoptosis of human erithroleukaemia cells K562. Free Radical Research 41:4, pages 452-460.
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Graciela Beatriz Garcia, Maria Eugenia Biancardi & Ariel Dario Quiroga. (2005) Vanadium (V)-Induced Neurotoxicity in the Rat Central Nervous System: A Histo-Immunohistochemical Study. Drug and Chemical Toxicology 28:3, pages 329-344.
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HALIL DUZOVA, HANDAN IŞIN ÖZIŞIK, ALAADIN POLAT, M. HANIFI EMRE & ESIN GULLU. (2005) CORRELATIONS BETWEEN EVENT-RELATED POTENTIAL COMPONENTS AND NITRIC OXIDE IN MAXIMAL ANAEROBIC EXERCISE AMONG SPORTSMEN TRAINED AT VARIOUS LEVELS. International Journal of Neuroscience 115:10, pages 1353-1373.
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Takashi Togo, Omi Katsuse & Eizo Iseki. (2004) Nitric oxide pathways in Alzheimer's disease and other neurodegenerative dementias. Neurological Research 26:5, pages 563-566.
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Yvonne Mei Sian Tay, Kok Seong Lim, Fwu-Shan Sheu, Andrew Jenner, Matthew Whiteman, Kim Ping Wong & Barry Halliwell. (2004) Do Mitochondria make Nitric Oxide? No?. Free Radical Research 38:6, pages 591-599.
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Valérie Collot, Jana Sopkova-de Oliveira Santos, Pascale Schumann-Bard, Nathalie Colloc'h, Eric T. MacKenzie & Sylvain Rault. (2003) Synthesis, Pharmacological Study and Modeling of 7-Methoxyindazole and Related Substituted Indazoles as Neuronal Nitric Oxide Synthase Inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 18:2, pages 195-199.
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MR Willmot & PMW Bath. (2003) The potential of nitric oxide therapeutics in stroke. Expert Opinion on Investigational Drugs 12:3, pages 455-470.
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Adam J Janczuk, Qiang Jia, Ming Xian, Zhong Wen, Peng George Wang & Tingwei Cai. (2002) NO donors with anticancer activity. Expert Opinion on Therapeutic Patents 12:6, pages 819-826.
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