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Research Article

An Investigation on Liver-Targeting Microemulsions of Norcantharidin

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Pages 289-295 | Received 22 Jan 2005, Accepted 25 Feb 2005, Published online: 10 Oct 2008

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Read on this site (5)

Benjian Gao, Jia Luo, Ying Liu, Song Su, Shaozhi Fu, Xiaoli Yang & Bo Li. (2021) Intratumoral Administration of Thermosensitive Hydrogel Co-Loaded with Norcantharidin Nanoparticles and Doxorubicin for the Treatment of Hepatocellular Carcinoma. International Journal of Nanomedicine 16, pages 4073-4085.
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Zhenghai Zhang, Lei Yang, Jian Hou, Xiaojing Xia, Jing Wang, Qing Ning & Shulong Jiang. (2018) Promising positive liver targeting delivery system based on arabinogalactan-anchored polymeric micelles of norcantharidin. Artificial Cells, Nanomedicine, and Biotechnology 46:sup3, pages 630-640.
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Min-Chen Liu, Lin Liu, Xia-Rong Wang, Wu-Ping Shuai, Ying Hu, Min Han & Jian-Qing Gao. (2016) Folate receptor-targeted liposomes loaded with a diacid metabolite of norcantharidin enhance antitumor potency for H22 hepatocellular carcinoma both in vitro and in vivo. International Journal of Nanomedicine 11, pages 1395-1412.
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Mingna Li, Xiaofen Xu, Fei Lu & Shengrong Guo. (2014) Primary in vitro and in vivo evaluation of norcantharidin-chitosan/poly (vinyl alcohol) for cancer treatment. Drug Delivery 21:4, pages 293-301.
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Xia Lin, Bo Zhang, Keru Zhang, Yu Zhang, Juan Wang, Na Qi, Shenshen Yang, Haibing He & Xing Tang. (2012) Preclinical evaluations of norcantharidin-loaded intravenous lipid microspheres with low toxicity. Expert Opinion on Drug Delivery 9:12, pages 1449-1462.
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Bing-Tao Zhai, Jing Sun, Ya-Jun Shi, Xiao-Fei Zhang, Jun-Bo Zou, Jiang-Xue Cheng, Yu Fan, Dong-Yan Guo & Huan Tian. (2022) Review targeted drug delivery systems for norcantharidin in cancer therapy. Journal of Nanobiotechnology 20:1.
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Saman Sargazi, Mohammad Reza Hajinezhad, Mahmood Barani, Abbas Rahdar, Sheida Shahraki, Pouya Karimi, Magali Cucchiarini, Mehrdad Khatami & Sadanand Pandey. (2021) Synthesis, characterization, toxicity and morphology assessments of newly prepared microemulsion systems for delivery of valproic acid. Journal of Molecular Liquids 338, pages 116625.
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Ioanna Theochari, Aristotelis Xenakis & Vassiliki Papadimitriou. 2020. Smart Nanocontainers. Smart Nanocontainers 315 341 .
Zhe Ma, Bing Zhang, Yuqi Fan, Meng Wang, Dereje Kebebe, Jiawei Li & Zhidong Liu. (2019) Traditional Chinese medicine combined with hepatic targeted drug delivery systems: A new strategy for the treatment of liver diseases. Biomedicine & Pharmacotherapy 117, pages 109128.
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Shulong Jiang, Mengying Li, Ying Hu, Zhenhai Zhang & Huixia Lv. (2018) Multifunctional self-assembled micelles of galactosamine-hyaluronic acid-vitamin E succinate for targeting delivery of norcantharidin to hepatic carcinoma. Carbohydrate Polymers 197, pages 194-203.
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Xiaolin Liu, Xiaoguang Tao, Qi Zheng, Hang Xu, Yu Zhang, Tian Lei, Tian Yin, Haibing He & Xing Tang. (2017) Development and validation of an LC-ESI-MS/MS approach to determine a highly hydrophobic drug, norcantharidin palmitate, and apply to a preliminary pharmacokinetic study in rats. Biomedical Chromatography 31:12, pages e4010.
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Sanju Singh, Poonam Parashar, Jovita Kanoujia, Indu Singh, Sudipta Saha & Shubhini A. Saraf. (2017) Transdermal potential and anti-gout efficacy of Febuxostat from niosomal gel. Journal of Drug Delivery Science and Technology 39, pages 348-361.
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Hiroyuki OhshimaSoumik Bardhan, Kaushik Kundu, Gulmi Chakraborty, Bidyut K. Paul, Satya P. Moulik & Swapan K. Saha. 2016. Encyclopedia of Biocolloid and Biointerface Science 2V Set. Encyclopedia of Biocolloid and Biointerface Science 2V Set 122 144 .
Ming-Che Chang, Jin-Yi Wu, Hui-Fen Liao, Yu-Jen Chen & Cheng-Deng Kuo. (2016) Comparative assessment of therapeutic safety of norcantharidin, N-farnesyloxy-norcantharimide, and N-farnesyl-norcantharimide against Jurkat T cells relative to human normal lymphoblast. Medicine 95:31, pages e4467.
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Cheng Peng, Zequn Li, Zhengchuan Niu, Wei Niu, Zongquan Xu, Huijie Gao, Weibo Niu, JiaYong Wang, Zhaobin He, Chao Gao, Pengfei Lin, Michael Agrez, Zongli Zhang & Jun Niu. (2016) Norcantharidin Suppresses Colon Cancer Cell Epithelial-Mesenchymal Transition by Inhibiting the αvβ6-ERK-Ets1 Signaling Pathway. Scientific Reports 6:1.
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Ming-Che Chang, Jin-Yi Wu, Hui-Fen Liao, Yu-Jen Chen & Cheng-Deng Kuo. (2015) N-Farnesyloxy-norcantharimide inhibits progression of human leukemic Jurkat T cells through regulation of mitogen-activated protein kinase and interleukin-2 production. Anti-Cancer Drugs 26:10, pages 1034-1042.
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Gurpreet Kaur, S.K. Mehta, Sandeep Kumar, Gaurav Bhanjana & Neeraj Dilbaghi. (2015) Coencapsulation of Hydrophobic and Hydrophilic Antituberculosis Drugs in Synergistic Brij 96 Microemulsions: A Biophysical Characterization. Journal of Pharmaceutical Sciences 104:7, pages 2203-2212.
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Ming-Che Chang, En-Tung Tsai, Jin-Yi Wu, Hui-Fen Liao, Yu-Jen Chen & Cheng-Deng Kuo. (2015) N-Farnesyloxy-norcantharimide and N-farnesyl-norcantharimide inhibit the progression of leukemia and increase survival days in a syngeneic mouse leukemia model. Anti-Cancer Drugs 26:5, pages 508-517.
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Neha Jindal & S.K. Mehta. (2015) Nevirapine loaded Poloxamer 407/Pluronic P123 mixed micelles: Optimization of formulation and in vitro evaluation. Colloids and Surfaces B: Biointerfaces 129, pages 100-106.
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S. K. Mehta & Neha Jindal. (2014) Tyloxapol Niosomes as Prospective Drug Delivery Module for Antiretroviral Drug Nevirapine. AAPS PharmSciTech 16:1, pages 67-75.
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Maung Win, Paul Lang, Manu Vashishtha & Dinesh Shah. 2014. Surfactant Science and Technology. Surfactant Science and Technology 377 398 .
S.K. Mehta & Neha Jindal. (2013) Mixed micelles of Lecithin–Tyloxapol as pharmaceutical nanocarriers for anti-tubercular drug delivery. Colloids and Surfaces B: Biointerfaces 110, pages 419-425.
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X.Q. Wang & Q. Zhang. 2013. Drug Delivery Strategies for Poorly Water-Soluble Drugs. Drug Delivery Strategies for Poorly Water-Soluble Drugs 287 323 .
S.K. Mehta & Neha Jindal. (2013) Formulation of Tyloxapol niosomes for encapsulation, stabilization and dissolution of anti-tubercular drugs. Colloids and Surfaces B: Biointerfaces 101, pages 434-441.
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Min Guan, Yi Zhou, Qiao-Ling Zhu, Yang Liu, Yong-Yan Bei, Xue-Nong Zhang & Qiang Zhang. (2012) N-trimethyl chitosan nanoparticle-encapsulated lactosyl-norcantharidin for liver cancer therapy with high targeting efficacy. Nanomedicine: Nanotechnology, Biology and Medicine 8:7, pages 1172-1181.
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Kedong Lu, Mingzhuo Cao, Weiwei Mao, Xuanrong Sun, Jianbin Tang, Youqing Shen & Meihua Sui. (2012) Targeted acid-labile conjugates of norcantharidin for cancer chemotherapy. Journal of Materials Chemistry 22:31, pages 15804.
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Flora Cimmino, Maria Nunzia Scoppettuolo, Marianeve Carotenuto, Pasqualino De Antonellis, Valeria Di Dato, Gennaro De Vita & Massimo Zollo. (2011) Norcantharidin impairs medulloblastoma growth by inhibition of Wnt/β-catenin signaling. Journal of Neuro-Oncology 106:1, pages 59-70.
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Ranajay Saha, Pramod Kumar Verma, Rajib Kumar Mitra & Samir Kumar Pal. (2011) Structural and dynamical characterization of unilamellar AOT vesicles in aqueous solutions and their efficacy as potential drug delivery vehicle. Colloids and Surfaces B: Biointerfaces 88:1, pages 345-353.
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Surinder K. Mehta, Neha Jindal & Gurpreet Kaur. (2011) Quantitative investigation, stability and in vitro release studies of anti-TB drugs in Triton niosomes. Colloids and Surfaces B: Biointerfaces 87:1, pages 173-179.
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Qin Wang, Liang Zhang, Wei Hu, Zhan-Hong Hu, Yong-Yan Bei, Jing-Yu Xu, Wen-Juan Wang, Xue-Nong Zhang & Qiang Zhang. (2010) Norcantharidin-associated galactosylated chitosan nanoparticles for hepatocyte-targeted delivery. Nanomedicine: Nanotechnology, Biology and Medicine 6:2, pages 371-381.
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S.K. Mehta, Gurpreet Kaur & K.K. Bhasin. (2010) Entrapment of multiple anti‐Tb drugs in microemulsion system: Quantitative analysis, stability, and in vitro release studies. Journal of Pharmaceutical Sciences 99:4, pages 1896-1911.
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S. K. Mehta, Gurpreet Kaur & K. K. Bhasin. (2010) Tween-Embedded Microemulsions—Physicochemical and Spectroscopic Analysis for Antitubercular Drugs. AAPS PharmSciTech 11:1, pages 143-153.
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Cheng Peng, Xiangqun Liu, Enyu Liu, Kesen Xu, Weibo Niu, Rong Chen, Jiayong Wang, Zhaoyang Zhang, Pengfei Lin, Jian Wang, Michael Agrez & Jun Niu. (2009) Norcantharidin induces HT‐29 colon cancer cell apoptosis through the αvβ6–extracellular signal‐related kinase signaling pathway. Cancer Science 100:12, pages 2302-2308.
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Yu-Jen Chen, Cheng-Deng Kuo, Yin-Meng Tsai, Chih-Chia Yu, Guang-Sheng Wang & Hui-Fen Liao. (2008) Norcantharidin induces anoikis through Jun-N-terminal kinase activation in CT26 colorectal cancer cells. Anti-Cancer Drugs 19:1, pages 55-64.
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S. K. Mehta, Gurpreet Kaur & K. K. Bhasin. (2007) Incorporation of Antitubercular Drug Isoniazid in Pharmaceutically Accepted Microemulsion: Effect on Microstructure and Physical Parameters. Pharmaceutical Research 25:1, pages 227-236.
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Syamasri Gupta & S.P. Moulik. (2008) Biocompatible Microemulsions and Their Prospective Uses in Drug Delivery. Journal of Pharmaceutical Sciences 97:1, pages 22-45.
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S.K. Mehta, Gurpreet Kaur & K.K. Bhasin. (2007) Analysis of Tween based microemulsion in the presence of TB drug rifampicin. Colloids and Surfaces B: Biointerfaces 60:1, pages 95-104.
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