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Drug Delivery Volume 29, 2022 - Issue 1
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Research Articles

Enhanced oral absorption of insulin: hydrophobic ion pairing and a self-microemulsifying drug delivery system using a D-optimal mixture design

Yoon Tae Gooa College of Pharmacy, Chung-Ang University, Seoul, Republic of KoreaView further author information
,
Sangkil Leeb College of Pharmacy, Keimyung University, Daegu, Republic of KoreaORCID Iconhttps://orcid.org/0000-0002-8216-6076View further author information
ORCID Icon,
Ji Yeh Choic Department of Psychology, York University, Toronto, Ontario, CanadaORCID Iconhttps://orcid.org/0000-0002-0134-9963View further author information
ORCID Icon,
Min Song Kima College of Pharmacy, Chung-Ang University, Seoul, Republic of KoreaView further author information
,
Gi Hyeong Sina College of Pharmacy, Chung-Ang University, Seoul, Republic of KoreaView further author information
,
Sun Ho Honga College of Pharmacy, Chung-Ang University, Seoul, Republic of KoreaView further author information
,
Chang Hyun Kima College of Pharmacy, Chung-Ang University, Seoul, Republic of KoreaView further author information
,
Seh Hyon Songd College of Pharmacy, Kyungsung University, Busan, Republic of KoreaView further author information
&
Young Wook Choia College of Pharmacy, Chung-Ang University, Seoul, Republic of KoreaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2431-3995View further author information
ORCID Icon show all
Pages 2831-2845 | Received 06 Jul 2022, Accepted 15 Aug 2022, Published online: 01 Sep 2022

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Melbha Starlin Chellathurai, Syed Mahmood, Zarif Mohamed Sofian, Cheng Wan Hee, Ramkanth Sundarapandian, Haja Nazeer Ahamed, C. S. Kandasamy, Ayah R. Hilles, Najihah Mohd Hashim & Ashok Kumar Janakiraman. (2024) Biodegradable polymeric insulin microneedles – a design and materials perspective review. Drug Delivery 31:1.
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Sheetal S. Buddhadev, Kevinkumar C. Garala, Saisivam S, Mohamed Rahamathulla, Mohammed Muqtader Ahmed, Syeda Ayesha Farhana & Ismail Pasha. (2024) Quality by design aided self-nano emulsifying drug delivery systems development for the oral delivery of Benidipine: Improvement of biopharmaceutical performance. Drug Delivery 31:1.
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Yoon Tae Goo, Min Song Kim, Ji Yeh Choi, Gi Hyeong Sin, Sun Ho Hong, Chang Hyun Kim & Young Wook Choi. (2024) A cochleate formulation optimized by D-optimal mixture design enhances oral bioavailability of Revaprazan. Journal of Liposome Research 34:1, pages 31-43.
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Articles from other publishers (10)

Bingwen Ding, Zhu Zhu, Cong Guo, Jiaxin Li, Yong Gan & Miaorong Yu. (2024) Oral peptide therapeutics for diabetes treatment: State-of-the-art and future perspectives. Acta Pharmaceutica Sinica B 14:5, pages 2006-2025.
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Liknaw Workie Limenh. (2024) A review on oral novel delivery systems of insulin through the novel delivery system formulations: A review. SAGE Open Medicine 12.
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Hong-Yan Sun & Xiao-Yan Lin. (2023) Genetic perspectives on childhood monogenic diabetes: Diagnosis, management, and future directions. World Journal of Diabetes 14:12, pages 1738-1753.
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Arne Matteo Jörgensen, Christian Steinbring, Daniel Stengel, Dennis To, Pascal Schmid & Andreas Bernkop‐Schnürch. (2023) Self‐Emulsifying Drug Delivery Systems (SEDDS) Containing Reverse Micelles: Advanced Oral Formulations for Therapeutic Peptides. Advanced Healthcare Materials 12:31.
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Jahanzeb Mudassir, Afsheen Raza, Mahtab Ahmad Khan, Huma Hameed, Gamal A. Shazly, Ali Irfan, Sadia Jafar Rana, Khizar Abbas, Muhammad Sohail Arshad, Sajjad Muhammad & Yousef A. Bin Jardan. (2023) Design and Evaluation of Hydrophobic Ion Paired Insulin Loaded Self Micro-Emulsifying Drug Delivery System for Oral Delivery. Pharmaceutics 15:7, pages 1973.
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S. Spoorthi Shetty, Praveen Halagali, Asha P. Johnson, K.M. Asha Spandana & H.V. Gangadharappa. (2023) Oral insulin delivery: Barriers, strategies, and formulation approaches: A comprehensive review. International Journal of Biological Macromolecules 242, pages 125114.
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Priyanka Agarwal & Ilva D. Rupenthal. (2023) Non-aqueous formulations in topical ocular drug delivery – A paradigm shift?. Advanced Drug Delivery Reviews 198, pages 114867.
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Victor Claus, Helen Spleis, Christoph Federer, Katrin Zöller, Richard Wibel, Flavia Laffleur, Camille Dumont, Philippe Caisse & Andreas Bernkop-Schnürch. (2023) Self-emulsifying drug delivery systems (SEDDS): In vivo-proof of concept for oral delivery of insulin glargine. International Journal of Pharmaceutics 639, pages 122964.
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Chien-Ming Hsieh, Ting-Lun Yang, Athika Darumas Putri & Chin-Tin Chen. (2023) Application of Design of Experiments in the Development of Self-Microemulsifying Drug Delivery Systems. Pharmaceuticals 16:2, pages 283.
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Richard Wibel, Arne Matteo Jörgensen, Flavia Laffleur, Helen Spleis, Victor Claus & Andreas Bernkop-Schnürch. (2023) Oral delivery of calcitonin-ion pairs: In vivo proof of concept for a highly lipophilic counterion. International Journal of Pharmaceutics 631, pages 122476.
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