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Research Article

Determination of the Relative Toxicity of Amphotericin B Formulations: A Red Blood Cell Potassium Release Assay

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Pages 81-88 | Published online: 29 Sep 2008

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Read on this site (7)

Gerard M. Jensen. (2017) The care and feeding of a commercial liposomal product: liposomal amphotericin B (AmBisome®). Journal of Liposome Research 27:3, pages 173-179.
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J. P. Adler-Moore, R. T. Proffitt, J. A. Olson & G. M. Jensen. (2017) Tissue pharmacokinetics and pharmacodynamics of AmBisome® (L-AmBis) in uninfected and infected animals and their effects on dosing regimens. Journal of Liposome Research 27:3, pages 195-209.
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Qamar Zia, Aijaz Ahmed Khan, Zubair Swaleha & Mohammad Owais. (2015) Self-assembled amphotericin B-loaded polyglutamic acid nanoparticles: preparation, characterization and in vitro potential against Candida albicans. International Journal of Nanomedicine 10, pages 1769-1790.
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Angela S Loo, Saif A Muhsin & Thomas J Walsh. (2013) Toxicokinetic and mechanistic basis for the safety and tolerability of liposomal amphotericin B . Expert Opinion on Drug Safety 12:6, pages 881-895.
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J.-U. Junghanns, I. Buttle, R.H. Müller, I.B. Araújo, A.K.A. Silva, E.S.T. Egito & B.P.G.L. Damasceno. (2007) SolEmuls® Technology: A Way to Overcome the Drawback of Parenteral Administration of Insoluble Drugs. Pharmaceutical Development and Technology 12:5, pages 437-445.
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Gerard M. Jensen & Tarquinus H. Bunch. (2007) Conventional Liposome Performance and Evaluation: Lessons from the Development of Vescan. Journal of Liposome Research 17:3-4, pages 121-137.
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Theodore F. Taraschi & Joseph M. Beggs. (2000) Letters. Journal of Liposome Research 10:1, pages 96-98.
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Articles from other publishers (28)

R J Brüggemann, G M Jensen & C Lass-Flörl. (2022) Liposomal amphotericin B—the past. Journal of Antimicrobial Chemotherapy 77:Supplement_2, pages ii3-ii10.
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Richard Marx, Jaeweon Lee, Yuri Svirkin, Seongkyu Yoon, Nelson Landrau, Md Abul Kaisar, Bin Qin, Jin H. Park, Khondoker Alam, Darby Kozak, Yan Wang, Xiaoming Xu, Jiwen Zheng & Benjamin Rivnay. (2022) Physicochemical surrogates for in vitro toxicity assessment of liposomal amphotericin B. International Journal of Pharmaceutics 628, pages 122273.
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Yuri Svirkin, Jaeweon Lee, Richard Marx, Seongkyu Yoon, Nelson Landrau, Md Abul Kaisar, Bin Qin, Jin H. Park, Khondoker Alam, Darby Kozak, Yan Wang, Xiaoming Xu, Jiwen Zheng & Benjamin Rivnay. (2022) Amphotericin B release rate is the link between drug status in the liposomal bilayer and toxicity. Asian Journal of Pharmaceutical Sciences 17:4, pages 544-556.
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Jayesh A. Kulkarni, Sam Chen & Yuen Yi C. Tam. (2021) Scalable Production of Lipid Nanoparticles Containing Amphotericin B. Langmuir 37:24, pages 7312-7319.
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Elsa R. Arias, Vivian Angarita-Villamizar, Yolima Baena, Claudia Parra-Giraldo & Leon D. Perez. (2021) Phospholipid-Conjugated PEG-b-PCL Copolymers as Precursors of Micellar Vehicles for Amphotericin B. Polymers 13:11, pages 1747.
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Angie V. Angarita-Villamizar, Elsa R. Arias, Ivonne L. Diaz & Leon D. Perez. (2021) Amphiphilic copolymers modified with oleic acid and cholesterol by combining ring opening polymerization and click chemistry with improved amphotericin B loading capacity. Journal of Polymer Research 28:1.
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Yayuan Liu, Zihan Mei, Ling Mei, Jie Tang, Wenmin Yuan, Santhanakrishnan Srinivasan, Rose Ackermann & Anna S. Schwendeman. (2020) Analytical method development and comparability study for AmBisome® and generic Amphotericin B liposomal products. European Journal of Pharmaceutics and Biopharmaceutics 157, pages 241-249.
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Huolong Liu, Benjamin Rivnay, Ken Avery, Ja Hye Myung, Darby Kozak, Nelson Landrau, Alex Nivorozhkin, Muhammad Ashraf & Seongkyu Yoon. (2020) Optimization of the manufacturing process of a complex amphotericin B liposomal formulation using quality by design approach. International Journal of Pharmaceutics 585, pages 119473.
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Yeimy J. Rodriguez, Luis F. Quejada, Jean C. Villamil, Yolima Baena, Claudia M. Parra-Giraldo & Leon D. Perez. (2020) Development of Amphotericin B Micellar Formulations Based on Copolymers of Poly(ethylene glycol) and Poly(ε-caprolactone) Conjugated with Retinol. Pharmaceutics 12:3, pages 196.
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Kaushik Thanki, Tushar Date & Sanyog Jain. (2019) Improved Oral Bioavailability and Gastrointestinal Stability of Amphotericin B through Fatty Acid Conjugation Approach. Molecular Pharmaceutics 16:11, pages 4519-4529.
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Rosa M. Reguera, Yolanda Pérez-Pertejo, Camino Gutiérrez-Corbo, Bárbara Domínguez-Asenjo, César Ordóñez, Carlos García-Estrada, María Martínez-Valladares & Rafael Balaña-Fouce. (2019) Current and promising novel drug candidates against visceral leishmaniasis. Pure and Applied Chemistry 91:8, pages 1385-1404.
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Benjamin Rivnay, Joseph Wakim, Ken Avery, Peter Petrochenko, Ja Hye Myung, Darby Kozak, Seongkyu Yoon, Nelson Landrau & Alex Nivorozhkin. (2019) Critical process parameters in manufacturing of liposomal formulations of amphotericin B. International Journal of Pharmaceutics 565, pages 447-457.
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Louise Walker, Prashant Sood, Megan D. Lenardon, Gillian Milne, Jon Olson, Gerard Jensen, Julie Wolf, Arturo Casadevall, Jill Adler-Moore & Neil A. R. Gow. (2018) The Viscoelastic Properties of the Fungal Cell Wall Allow Traffic of AmBisome as Intact Liposome Vesicles. mBio 9:1.
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Maryam Iman, Zhaohua Huang, Seyedeh Hoda Alavizadeh, Francis C. SzokaJr.Jr. & Mahmoud R. Jaafari. (2017) Biodistribution and In Vivo Antileishmanial Activity of 1,2-Distigmasterylhemisuccinoyl- sn -Glycero-3-Phosphocholine Liposome-Intercalated Amphotericin B . Antimicrobial Agents and Chemotherapy 61:9.
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Jill P Adler-Moore, Jean-Pierre Gangneux & Peter G Pappas. (2016) Comparison between liposomal formulations of amphotericin B. Medical Mycology 54:3, pages 223-231.
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J. A. Olson, J. A. Schwartz, D. Hahka, N. Nguyen, T. Bunch, G. M. Jensen & J. P. Adler-Moore. (2014) Toxicity and efficacy differences between liposomal amphotericin B formulations in uninfected and Aspergillus fumigatus infected mice. Medical Mycology 53:2, pages 107-118.
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Maryam Iman, Zhaohua Huang, Francis C. SzokaJr.Jr. & Mahmoud R. Jaafari. (2011) Characterization of the colloidal properties, in vitro antifungal activity, antileishmanial activity and toxicity in mice of a distigmasterylhemisuccinoyl-glycero-phosphocholine liposome-intercalated amphotericin B. International Journal of Pharmaceutics 408:1-2, pages 163-172.
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Jodi M. Lestner, Susan J. Howard, Joanne Goodwin, Lea Gregson, Jayesh Majithiya, Thomas J. Walsh, Gerard M. Jensen & William W. Hope. (2010) Pharmacokinetics and Pharmacodynamics of Amphotericin B Deoxycholate, Liposomal Amphotericin B, and Amphotericin B Lipid Complex in an In Vitro Model of Invasive Pulmonary Aspergillosis . Antimicrobial Agents and Chemotherapy 54:8, pages 3432-3441.
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J.P. Adler-Moore & R.T. Proffitt. (2008) Amphotericin B lipid preparations: what are the differences?. Clinical Microbiology and Infection 14, pages 25-36.
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Jon A. Olson, Jill P. Adler-Moore, Gerard M. Jensen, Julie Schwartz, M. Cecilia Dignani & Richard T. Proffitt. (2008) Comparison of the Physicochemical, Antifungal, and Toxic Properties of Two Liposomal Amphotericin B Products. Antimicrobial Agents and Chemotherapy 52:1, pages 259-268.
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G. M. Jensen, C. S. Ashvar, S. W. Bunte, C. D. Barzak, T. H. Bunch, R. L. Fahrner, N. Hu, J. Kennavane, H. Pham, C. Skenes & S. Yang. (2007) A liposomal dispersion formulation of propofol: formulation, pharmacokinetics, stability, and identification of an oxidative degradant. Theoretical Chemistry Accounts 119:1-3, pages 291-296.
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Gerard Jensen, Tarquinus Bunch, Ning Hu & Crispin Eley. 2006. Liposome Technology, Volume I. Liposome Technology, Volume I 297 310 .
Jon A. Olson, Jill P. Adler-Moore, Julie Schwartz, Gerard M. Jensen & Richard T. Proffitt. (2006) Comparative Efficacies, Toxicities, and Tissue Concentrations of Amphotericin B Lipid Formulations in a Murine Pulmonary Aspergillosis Model. Antimicrobial Agents and Chemotherapy 50:6, pages 2122-2131.
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Richard Proffitt & Jill Adler-Moore. 2005. Injectable Dispersed Systems. Injectable Dispersed Systems 481 525 .
Ivonete Batista Araújo, C. Ramon N. Brito, Isabel A. Urbano, Victor A. Dominici, Miguel A. Silva Filho, Walteçá L. L. Silveira, Bolívar P. G. L. Damasceno, Aldo Cunha Medeiros & E. Sócrates T. Egito. (2005) Similarity between the in vitro activity and toxicity of two different fungizone™ / lipofundin™ admixtures. Acta Cirurgica Brasileira 20:suppl 1, pages 129-133.
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Lloyd W. Turtinen, David N. Prall, Lindsay A. Bremer, Rachel E. Nauss & Scott C. Hartsel. (2004) Antibody Array-Generated Profiles of Cytokine Release from THP-1 Leukemic Monocytes Exposed to Different Amphotericin B Formulations. Antimicrobial Agents and Chemotherapy 48:2, pages 396-403.
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J. P. Adler-Moore & R. T. Proffitt. 2004. Human Fungal Pathogens. Human Fungal Pathogens 339 362 .
E.Sócrates T. Egito, Ivonete B. Araújo, Bolivar P.G.L. Damasceno & James C. Price. (2002) Amphotericin B/Emulsion Admixture Interactions: An Approach Concerning the Reduction of Amphotericin B Toxicity. Journal of Pharmaceutical Sciences 91:11, pages 2354-2366.
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