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Artificial Cells, Blood Substitutes, and Biotechnology Volume 35, 2007 - Issue 1
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Development of Zero-Link Polymers of Hemoglobin, Which do not Extravasate and do not Induce Pressure Increases upon Infusion

Enrico Bucci Department of Biochemistry and Molecular Biology, University of Maryland Medical School, Baltimore, Maryland, USACorrespondence[email protected]
,
Herman Kwansa Department of Biochemistry and Molecular Biology, University of Maryland Medical School, Baltimore, Maryland, USA
,
Raymond C. Koehler Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institute, Baltimore, Maryland, USA
&
Barbara Matheson Department of Biomedical Science, University of Maryland Dental School, Baltimore, Maryland, USA
Pages 11-18 | Published online: 24 Aug 2009

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Huifang Liu, Chengbin Yan, Kunping Yan, Wenjin Zhu, Yuesheng Shen, Bo Yang, Chao Chen & Hongli Zhu. (2017) Study of the effects of polymerized porcine hemoglobin (pPolyHb) in an acute anemia rat model. Artificial Cells, Nanomedicine, and Biotechnology 45:4, pages 694-700.
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John P. Harrington, Kseniya Orlig, Samantha L. Zito, Jacek Wollocko & Hanna Wollocko. (2010) Structural and Redox Behavior of OxyVita™, a Zero-linked Polymeric Hemoglobin: Comparison with Natural Acellular Polymeric Hemoglobins. Artificial Cells, Blood Substitutes, and Biotechnology 38:2, pages 64-68.
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Articles from other publishers (21)

Alisyn Greenfield, Derek R. Lamb, Xiangming Gu, Kiruphagaran Thangaraju, Saini Setua, Ahmad Yahya, Amid Vahedi, Mohd. Asim Khan, Qihong Wang, Paul W. Buehler & Andre F. Palmer. (2023) Biophysical Analysis and Preclinical Pharmacokinetics–Pharmacodynamics of Tangential Flow Filtration Fractionated Polymerized Human Hemoglobin as a Red Blood Cell Substitute. Biomacromolecules 24:4, pages 1855-1870.
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Clayton T. Cuddington, Savannah R. Wolfe, Donald A. Belcher, Megan Allyn, Alisyn Greenfield, Xiangming Gu, Richard Hickey, Shuwei Lu, Tanmay Salvi & Andre F. Palmer. (2022) Pilot scale production and characterization of next generation high molecular weight and tense quaternary state polymerized human hemoglobin. Biotechnology and Bioengineering 119:12, pages 3447-3461.
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Takashi Matsuhira & Hiromi Sakai. (2022) Artificial oxygen carriers, from nanometer- to micrometer-sized particles, made of hemoglobin composites substituting for red blood cells. Particuology 64, pages 43-55.
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Hanna Wollocko, Jacek Wollocko, Jonathan S. Jahr & Kenneth Steier. 2022. Blood Substitutes and Oxygen Biotherapeutics. Blood Substitutes and Oxygen Biotherapeutics 267 276 .
Jonathan S. Jahr, Kimia Roghani, Yll Buqa, Allen Rojhani, Preya Jhita & Hae Won Kim. 2022. Blood Substitutes and Oxygen Biotherapeutics. Blood Substitutes and Oxygen Biotherapeutics 131 148 .
Letian Wang, Matthew Eliceiri, Yang Deng, Yoonsoo Rho, Wan Shou, Heng Pan, Jie Yao & Costas P. Grigoropoulos. (2020) Fast Reversible Phase Change Silicon for Visible Active Photonics. Advanced Functional Materials 30:17, pages 1910784.
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Aizhou Wang & Ronald Kluger. (2016) Enhanced Nitrite Reductase Activity and Its Correlation with Oxygen Affinity in Hemoglobin Bis-Tetramers. Biochemistry 55:33, pages 4688-4696.
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Amy E. Schmidt, Majed A. Refaai & Neil Blumberg. (2016) Past, present and forecast of transfusion medicine: What has changed and what is expected to change?. La Presse Médicale 45:7-8, pages e253-e272.
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Colin F. Mackenzie, Arkadiy N. Pitman, R. Eric Hodgson, Martin J. Sussman, Lewis J. Levien, Jonathan S. Jahr & A. Gerson Greenburg. (2015) Are Hemoglobin-Based Oxygen Carriers Being Withheld Because of Regulatory Requirement for Equivalence to Packed Red Blood Cells?. American Journal of Therapeutics 22:4, pages e115-e121.
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Andre F. PalmerMarcos Intaglietta. (2014) Blood Substitutes. Annual Review of Biomedical Engineering 16:1, pages 77-101.
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Pedro Cabrales & Marcos Intaglietta. (2013) Blood Substitutes. ASAIO Journal 59:4, pages 337-354.
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Brian M. Belcik & Andre F. Palmer. 2013. Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics. Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics 693 711 .
Hae Won Kim. 2013. Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics. Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics 587 620 .
John P. Harrington & Hanna Wollocko. 2013. Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics. Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics 283 297 .
Magnus G. OlssonMaria AllhornLeif BülowStefan R. HanssonDavid LeyMartin L. OlssonArtur SchmidtchenBo Åkerström. (2012) Pathological Conditions Involving Extracellular Hemoglobin: Molecular Mechanisms, Clinical Significance, and Novel Therapeutic Opportunities for α 1 -Microglobulin . Antioxidants & Redox Signaling 17:5, pages 813-846.
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John P. Harrington & Hanna Wollocko. (2011) Molecular Design Properties of OxyVita Hemoglobin, a New Generation Therapeutic Oxygen Carrier: A Review. Journal of Functional Biomaterials 2:4, pages 414-424.
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Kenneth W. Olsen & Eugene Tarasov. 2011. Chemistry and Biochemistry of Oxygen Therapeutics. Chemistry and Biochemistry of Oxygen Therapeutics 327 344 .
A.G. Greenburg, W.R. Light & G.P. Dubé. (2010) Reconstructing hemoglobin-based oxygen carriers. Transfusion 50:12, pages 2764-2767.
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Ronald Kluger, Jonathan S. Foot & Adelle A. Vandersteen. (2010) Protein–protein coupling and its application to functional red cell substitutes. Chemical Communications 46:8, pages 1194.
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Yiping Jia & Abdu I. Alayash. (2009) Effects of cross-linking and zero-link polymerization on oxygen transport and redox chemistry of bovine hemoglobin. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1794:8, pages 1234-1242.
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PEDRO CABRALES & JOEL M. FRIEDMAN. (2007) Pegylated hemoglobins mechanisms to avoid vasoconstriction and maintain perfusion. Transfusion Alternatives in Transfusion Medicine 9:4, pages 281-293.
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