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Journal of Receptors and Signal Transduction Volume 26, 2006 - Issue 5-6
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Research Article

Global Down-Regulation of Gene Expression in the Brain Using RNA Interference, with Emphasis on Monoamine Transporters and GPCRs: Implications for Target Characterization in Psychiatric and Neurological Disorders

DANIEL HOYER Psychiatry Program, Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland; The Harold L. Dorris Neurological Research Center, MIND, The Scripps Research Institute, La Jolla, California, USA
,
DEEPAK R. THAKKER Biosciences R&D, Medtronic, Inc., Minneapolis, Minnesota, USA
,
FRANÇOIS NATT Genome and Proteome Sciences, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
,
RAINER MAIER Psychiatry Program, Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
,
DIETER HUESKEN Genome and Proteome Sciences, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
,
MATTHIAS MÜLLER Model of Disease Center, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
,
PETER FLOR Psychiatry Program, Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
,
HERMAN VAN DER PUTTEN Psychiatry Program, Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
,
MARKUS SCHMUTZ Psychiatry Program, Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
,
GRAEME BILBE Psychiatry Program, Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
&
JOHN F. CRYAN Department of Pharmacology, School of Pharmacy, University College Cork, Cork, Ireland
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Pages 527-547 | Published online: 10 Oct 2008

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Andrew S. Gibbons, Daniel Hoyer & Brian Dean. (2021) SMAD4 protein is decreased in the dorsolateral prefrontal and anterior cingulate cortices in schizophrenia. The World Journal of Biological Psychiatry 22:1, pages 70-77.
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Evgeniya V. Efimova, Raul R. Gainetdinov, Evgeny A. Budygin & Tatyana D. Sotnikova. (2016) Dopamine transporter mutant animals: a translational perspective. Journal of Neurogenetics 30:1, pages 5-15.
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Katelin F Hansen & Karl Obrietan. (2013) MicroRNA as therapeutic targets for treatment of depression. Neuropsychiatric Disease and Treatment 9, pages 1011-1021.
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Articles from other publishers (14)

Ryan J. Keenan, Sara Oberrauch, Romke Bron, Cameron J. Nowell, Leesa M. Challis, Daniel Hoyer & Laura H. Jacobson. (2021) Decreased Orexin Receptor 1 mRNA Expression in the Locus Coeruleus in Both Tau Transgenic rTg4510 and Tau Knockout Mice and Accompanying Ascending Arousal System Tau Invasion in rTg4510. Journal of Alzheimer's Disease 79:2, pages 693-708.
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Takayoshi Ubuka, Takanobu Mizuno, Yujiro Fukuda, George E. Bentley, John C. Wingfield & Kazuyoshi Tsutsui. (2013) RNA interference of gonadotropin-inhibitory hormone gene induces aggressive and sexual behaviors in birds. General and Comparative Endocrinology 181, pages 179-186.
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Inga D. Neumann & Peter J. Flor. 2010. Encyclopedia of Psychopharmacology. Encyclopedia of Psychopharmacology 1 7 .
Daniel Hoyer & Tamas Bartfai. (2012) Neuropeptides and Neuropeptide Receptors: Drug Targets, and Peptide and Non-Peptide Ligands: a Tribute to Prof. Dieter Seebach . Chemistry & Biodiversity 9:11, pages 2367-2387.
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R M O'Connor, T G Dinan & J F Cryan. (2011) Little things on which happiness depends: microRNAs as novel therapeutic targets for the treatment of anxiety and depression. Molecular Psychiatry 17:4, pages 359-376.
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Takayoshi Ubuka, Motoko Mukai, Jordan Wolfe, Ryan Beverly, Sarah Clegg, Ariel Wang, Serena Hsia, Molly Li, Jesse S. Krause, Takanobu Mizuno, Yujiro Fukuda, Kazuyoshi Tsutsui, George E. Bentley & John C. Wingfield. (2012) RNA Interference of Gonadotropin-Inhibitory Hormone Gene Induces Arousal in Songbirds. PLoS ONE 7:1, pages e30202.
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Melissa D. Krebs & Eben Alsberg. (2011) Localized, Targeted, and Sustained siRNA Delivery. Chemistry – A European Journal 17:11, pages 3054-3062.
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Philippe Sarret, Louis Doré-Savard, Pascal Tétreault, Valérie Bégin-Lavallée, Marc-André Dansereau & Nicolas Beaudet. 2011. Methods for the Discovery and Characterization of G Protein-Coupled Receptors. Methods for the Discovery and Characterization of G Protein-Coupled Receptors 379 402 .
Richard M. O'Connor, Beate C. Finger, Peter J. Flor & John F. Cryan. (2010) Metabotropic glutamate receptor 7: At the interface of cognition and emotion. European Journal of Pharmacology 639:1-3, pages 123-131.
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Y. Zhang, M. Landthaler, S.D. Schlussman, V. Yuferov, A. Ho, T. Tuschl & M.J. Kreek. (2009) Mu opioid receptor knockdown in the substantia nigra/ventral tegmental area by synthetic small interfering RNA blocks the rewarding and locomotor effects of heroin. Neuroscience 158:2, pages 474-483.
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Hamid Mostafavi Abdolmaleky, Jin-Rong ZhouSam Thiagalingam & Cassandra L Smith. (2008) Epigenetic and pharmacoepigenomic studies of major psychoses and potentials for therapeutics. Pharmacogenomics 9:12, pages 1809-1823.
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Louis Doré-Savard, Geneviève Roussy, Marc-André Dansereau, Michael A Collingwood, Kim A Lennox, Scott D Rose, Nicolas Beaudet, Mark A Behlke & Philippe Sarret. (2008) Central Delivery of Dicer-substrate siRNA: A Direct Application for Pain Research. Molecular Therapy 16:7, pages 1331-1339.
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Priti Kumar, Haoquan Wu, Jodi L. McBride, Kyeong-Eun Jung, Moon Hee Kim, Beverly L. Davidson, Sang Kyung Lee, Premlata Shankar & N. Manjunath. (2007) Transvascular delivery of small interfering RNA to the central nervous system. Nature 448:7149, pages 39-43.
Crossref
Daniel Hoyer & Kumlesh K. Dev. (2006) RNA interference as a therapeutic strategy for treating CNS disorders. Drug Discovery Today: Therapeutic Strategies 3:4, pages 451-456.
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