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Research Article

GPCR-Kir Channel Signaling Complexes: Defining Rules of Engagement

Pages 83-91 | Published online: 10 Oct 2008

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Peter Zylbergold, Nitya Ramakrishnan & Terry Hébert. (2010) The role of G proteins in assembly and function of Kir3 inwardly rectifying potassium channels . Channels 4:5, pages 411-421.
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Haichang Luo, Ezequiel Marron Fernandez de Velasco & Kevin Wickman. (2022) Neuronal G protein-gated K + channels . American Journal of Physiology-Cell Physiology 323:2, pages C439-C460.
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Shai Berlin, Etay Artzy, Reem Handklo-Jamal, Uri Kahanovitch, Hanna Parnas, Nathan Dascal & Daniel Yakubovich. (2020) A Collision Coupling Model Governs the Activation of Neuronal GIRK1/2 Channels by Muscarinic-2 Receptors. Frontiers in Pharmacology 11.
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Victoria A. Baronas, Runying Y. Yang, Luis Carlos Morales, Simonetta Sipione & Harley T. Kurata. (2018) Slc7a5 regulates Kv1.2 channels and modifies functional outcomes of epilepsy-linked channel mutations. Nature Communications 9:1.
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David A. Brown. (2018) Regulation of neural ion channels by muscarinic receptors. Neuropharmacology 136, pages 383-400.
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Jana Fischer, Gunnar Kleinau, Claudia Rutz, Denise Zwanziger, Noushafarin Khajavi, Anne Müller, Maren Rehders, Klaudia Brix, Catherine L. Worth, Dagmar Führer, Heiko Krude, Burkhard Wiesner, Ralf Schülein & Heike Biebermann. (2017) Evidence of G-protein-coupled receptor and substrate transporter heteromerization at a single molecule level. Cellular and Molecular Life Sciences 75:12, pages 2227-2239.
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G. Kleinau, N. Khajavi, J. Köhrle & H. Biebermann. 2016. Trace Amines and Neurological Disorders. Trace Amines and Neurological Disorders 63 81 .
Daniel Yakubovich, Shai Berlin, Uri Kahanovitch, Moran Rubinstein, Isabella Farhy-Tselnicker, Boaz Styr, Tal Keren-Raifman, Carmen W. Dessauer & Nathan Dascal. (2015) A Quantitative Model of the GIRK1/2 Channel Reveals That Its Basal and Evoked Activities Are Controlled by Unequal Stoichiometry of Gα and Gβγ. PLOS Computational Biology 11:11, pages e1004598.
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Helton Estrela Ramos, Magnus Régios Dias da Silva, Aurore Carré, Joaquim Custódio Silva Jr.Rolf Matias Paninka, Taise Lima Oliveira, Elodie Tron, Mireille Castanet & Michel Polak. (2015) Molecular Insights into the Possible Role of Kir4.1 and Kir5.1 in Thyroid Hormone Biosynthesis. Hormone Research in Paediatrics 83:2, pages 141-147.
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Nathan Dascal & Uri Kahanovitch. 2015. Structure to Function of G Protein-Gated Inwardly Rectifying (GIRK) Channels. Structure to Function of G Protein-Gated Inwardly Rectifying (GIRK) Channels 27 85 .
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Uri Kahanovitch, Vladimir Tsemakhovich, Shai Berlin, Moran Rubinstein, Boaz Styr, Ruth Castel, Sagit Peleg, Galit Tabak, Carmen W. Dessauer, Tatiana Ivanina & Nathan Dascal. (2014) Recruitment of Gβγ controls the basal activity of G‐protein coupled inwardly rectifying potassium (GIRK) channels: crucial role of distal C terminus of GIRK1. The Journal of Physiology 592:24, pages 5373-5390.
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K. Ukhanov, Y. Bobkov, E.A. Corey & B.W. Ache. (2014) Ligand-selective activation of heterologously-expressed mammalian olfactory receptor. Cell Calcium 56:4, pages 245-256.
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Marie-Cécile Kienitz, Elisa Mintert-Jancke, Fabian Hertel & Lutz Pott. (2014) Differential effects of genetically-encoded Gβγ scavengers on receptor-activated and basal Kir3.1/Kir3.4 channel current in rat atrial myocytes. Cellular Signalling 26:6, pages 1182-1192.
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Peter Zylbergold, Rory Sleno, Shahriar M. Khan, Ashley M. Jacobi, Mark A. Belhke & Terence E. Hébert. (2014) Kir3 channel ontogeny – the role of Gβγ subunits in channel assembly and trafficking. Frontiers in Cellular Neuroscience 8.
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Rafael Luján, Ezequiel Marron Fernandez de Velasco, Carolina Aguado & Kevin Wickman. (2014) New insights into the therapeutic potential of Girk channels. Trends in Neurosciences 37:1, pages 20-29.
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Christophe Altier. 2012. GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity. GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity 241 262 .
Lydia N. Caro, Christophe J. Moreau, Jean Revilloud & Michel Vivaudou. (2011) β2-Adrenergic Ion-Channel Coupled Receptors as Conformational Motion Detectors. PLoS ONE 6:3, pages e18226.
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Laura K.K. Pacey, Lilian Doss, Carlo Cifelli, Derek van der Kooy, Scott P. Heximer & David R. Hampson. (2011) Genetic deletion of regulator of G-protein signaling 4 (RGS4) rescues a subset of fragile X related phenotypes in the FMR1 knockout mouse. Molecular and Cellular Neuroscience 46:3, pages 563-572.
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Aparna Renigunta, Kerim Mutig, Kathrin Rottermann, Günter Schlichthörl, Regina Preisig-Müller, Jürgen Daut, Siegfried Waldegger & Vijay Renigunta. (2011) The Glycolytic Enzymes Glyceraldehyde 3-Phosphate Dehydrogenase and Enolase Interact with the Renal Epithelial K<sup>+</sup> Channel ROMK2 and Regulate its Function. Cellular Physiology and Biochemistry 28:4, pages 663-672.
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Christoph Littwitz, Mathias Timpert, Kirsten Bender, Lutz Pott & Marie-Cécile Kienitz. (2010) Autocrine signaling via A1 adenosine receptors causes downregulation of M2 receptors in adult rat atrial myocytes in vitro. Pflügers Archiv - European Journal of Physiology 461:1, pages 165-176.
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Adi Raveh, Ayelet Cooper, Liora Guy-David & Eitan Reuveny. (2010) Nonenzymatic Rapid Control of GIRK Channel Function by a G Protein-Coupled Receptor Kinase. Cell 143:5, pages 750-760.
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Shai Berlin, Tal Keren-Raifman, Ruth Castel, Moran Rubinstein, Carmen W. Dessauer, Tatiana Ivanina & Nathan Dascal. (2010) Gαi and Gβγ Jointly Regulate the Conformations of a Gβγ Effector, the Neuronal G Protein-activated K+ Channel (GIRK). Journal of Biological Chemistry 285:9, pages 6179-6185.
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Rafael Luján, James Maylie & John P. Adelman. (2009) New sites of action for GIRK and SK channels. Nature Reviews Neuroscience 10:7, pages 475-480.
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Mélanie Robitaille, Nitya Ramakrishnan, Alessandra Baragli & Terence E. Hébert. (2009) Intracellular trafficking and assembly of specific Kir3 channel/G protein complexes. Cellular Signalling 21:4, pages 488-501.
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Marta Lomazzi, Paul A. Slesinger & Christian Lüscher. (2008) Addictive drugs modulate GIRK-channel signaling by regulating RGS proteins. Trends in Pharmacological Sciences 29:11, pages 544-549.
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