3,360
Views
62
CrossRef citations to date
0
Altmetric
Review Article

Drug metabolism and pharmacokinetics

, , , , , , & show all
Pages 344-390 | Received 27 Feb 2009, Accepted 12 Mar 2009, Published online: 15 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Ziwei Yu, Ziqiang Chen, Qijuan Li, Ke Yang, Zecheng Huang, Wenjun Wang, Siyu Zhao & Huiling Hu. (2021) What dominates the changeable pharmacokinetics of natural sesquiterpene lactones and diterpene lactones: a review focusing on absorption and metabolism. Drug Metabolism Reviews 53:1, pages 122-140.
Read now
Mojtaba Abbasian, Parisa Hasanzadeh, Farideh Mahmoodzadeh & Roya Salehi. (2020) Novel cationic cellulose-based nanocomposites for targeted delivery of methotrexate to breast cancer cells. Journal of Macromolecular Science, Part A 57:2, pages 99-115.
Read now
Osama Y. Alshogran. (2017) Pharmacogenetics of aldo-keto reductase 1C (AKR1C) enzymes. Expert Opinion on Drug Metabolism & Toxicology 13:10, pages 1063-1073.
Read now
A. V. Rudik, A. V. Dmitriev, V. M. Bezhentsev, A. A. Lagunin, D. A. Filimonov & V. V. Poroikov. (2017) Prediction of metabolites of epoxidation reaction in MetaTox. SAR and QSAR in Environmental Research 28:10, pages 833-842.
Read now
Mei Zeng, Lan Yang, Dan He, Yao Li, Mingxin Shi & Jingqing Zhang. (2017) Metabolic pathways and pharmacokinetics of natural medicines with low permeability. Drug Metabolism Reviews 49:4, pages 464-476.
Read now

Articles from other publishers (57)

Sadaf Ejaz, Syed Muhammad Afroz Ali, Bina Zarif, Ramla Shahid, Ayesha Ihsan, Tayyaba Noor & Muhammad Imran. (2023) Surface engineering of chitosan nanosystems and the impact of functionalized groups on the permeability of model drug across intestinal tissue. International Journal of Biological Macromolecules 242, pages 124777.
Crossref
Xinyi Wu, Jie En Valerie Sia, Min Hai, Xuan Lai, Haiyan Li, Cheng Cui & Dongyang Liu. (2023) Physiologically Based Pharmacokinetic Model for Older Adults and Its Application in Geriatric Drug Research. Current Drug Metabolism 24:3, pages 211-222.
Crossref
Zhenxu Yang, Xiaochen Liu, Elise M. Cribbin, Alice M. Kim, Jiao Jiao Li & Ken-Tye Yong. (2022) Liver-on-a-chip: Considerations, advances, and beyond. Biomicrofluidics 16:6.
Crossref
Prakriti Diwan, Rajendra Jangde, Sulekha Khunte, Harish Bhardwaj & Preeti K. Suresh. 2022. Drug Development Life Cycle. Drug Development Life Cycle.
Charbel Fadel, Beata Łebkowska‐Wieruszewska, Irene Sartini, Andrzej Lisowski, Amnart Poapolathep & Mario Giorgi. (2022) Robenacoxib pharmacokinetics in sheep following oral, subcutaneous, and intravenous administration. Journal of Veterinary Pharmacology and Therapeutics 45:6, pages 550-557.
Crossref
Omar Abdulhameed Almazroo, Imam H Shaik, Christopher B Hughes, Abhinav Humar & Raman Venkataramanan. (2022) Treprostinil Supplementation Ameliorates Hepatic Ischemia Reperfusion Injury and Regulates Expression of Hepatic Drug Transporters: An Isolated Perfused Rat Liver (IPRL) Study. Pharmaceutical Research 39:11, pages 2979-2990.
Crossref
F A Dain Md Opo, Saleh Alkarim, Ghadeer I. Alrefaei, Mohammad Habibur Rahman Molla, Nouf H. Alsubhi, Faisal Alzahrani & Foysal Ahammad. (2022) Pharmacophore-Model-Based Virtual-Screening Approaches Identified Novel Natural Molecular Candidates for Treating Human Neuroblastoma. Current Issues in Molecular Biology 44:10, pages 4838-4858.
Crossref
Xiaomei Liu, Wenfang Li, Han Zhang, Xiaoming Wang, Yuhong Huang, Yuhong Li & Guixiang Pan. (2022) Biodistribution and pharmacokinetic profile of berberine and its metabolites in hepatocytes. Phytomedicine 104, pages 154288.
Crossref
Yang Hu, Jingxin Ding, Zhiwei Sun, Zheng Zong, Hui Song, Xiangming Sun, Beilei Xu, Zheng Qi, Bing Liu & Wenlan Li. (2022) Identification and analysis of chemical constituents of total glycosides of Cistanche deserticola YC Ma in rat hepatic metabolism by ultra performance liquid chromatography-quadrupole/time-of-flight mass spectrometry (UPLC-Q-TOF-MS) . Materials Express 12:8, pages 1059-1071.
Crossref
Daniel Porat, Oleg Dukhno, Ella Vainer, Sandra Cvijić & Arik Dahan. (2022) Antiallergic Treatment of Bariatric Patients: Potentially Hampered Solubility/Dissolution and Bioavailability of Loratadine, but Not Desloratadine, Post-Bariatric Surgery. Molecular Pharmaceutics 19:8, pages 2922-2936.
Crossref
Andrew Lofts, Fahed Abu-Hijleh, Nicolette Rigg, Ram K. Mishra & Todd Hoare. (2022) Using the Intranasal Route to Administer Drugs to Treat Neurological and Psychiatric Illnesses: Rationale, Successes, and Future Needs. CNS Drugs 36:7, pages 739-770.
Crossref
Siyao Shao, Ruonan Zheng, Xi Cheng, Sufen Zhang, Zhiyang Yu, Xingyan Pang, Jiaoyang Li, Haiyan Wang & Qingfu Ye. (2022) Diverse positional 14C labeling-assisted metabolic analysis of pesticides in rats: The case of vanisulfane, a novel vanillin-derived pesticide. Science of The Total Environment 826, pages 153920.
Crossref
Margarida L. F. Martins, Paniz Heydari, Wenlong Li, Alejandra Martínez-Chávez, Nikkie Venekamp, Maria C. Lebre, Luc Lucas, Jos H. Beijnen & Alfred H. Schinkel. (2022) Drug Transporters ABCB1 (P-gp) and OATP, but not Drug-Metabolizing Enzyme CYP3A4, Affect the Pharmacokinetics of the Psychoactive Alkaloid Ibogaine and its Metabolites. Frontiers in Pharmacology 13.
Crossref
Jingyu Lee, Myeong-Sang Yu & Dokyun Na. (2022) DILI-Stk: An Ensemble Model for the Prediction of Drug-induced Liver Injury of Drug Candidates. Current Bioinformatics 17:3, pages 296-303.
Crossref
Ales Sorf, Dimitrios Vagiannis, Fahda Ahmed, Jakub Hofman & Martina Ceckova. (2022) Dabrafenib inhibits ABCG2 and cytochrome P450 isoenzymes; potential implications for combination anticancer therapy. Toxicology and Applied Pharmacology 434, pages 115797.
Crossref
Tanshi Mehrotra & Subir Kumar Maulik. 2022. Human Microbiome in Health and Disease - Part A. Human Microbiome in Health and Disease - Part A 207 228 .
Yasra Sayyed, Kanwal Rehman, Muhammad Sajid Hamid Akash, Sairah Hafeez Kamran & Mohammad Badran. 2022. Biochemistry of Drug Metabolizing Enzymes. Biochemistry of Drug Metabolizing Enzymes 305 321 .
Christoph Wenzel, Marek Drozdzik & Stefan Oswald. (2021) Mass spectrometry-based targeted proteomics method for the quantification of clinically relevant drug metabolizing enzymes in human specimens. Journal of Chromatography B 1180, pages 122891.
Crossref
Sin-Eun Kim, Hyung-Ju Seo, Yeojin Jeong, Gyung-Min Lee, Seung-Bae Ji, So-Young Park, Zhexue Wu, Sangkyu Lee, Sunghwan Kim & Kwang-Hyeon Liu. (2021) In Vitro Metabolism of Donepezil in Liver Microsomes Using Non-Targeted Metabolomics. Pharmaceutics 13:7, pages 936.
Crossref
Arastou Raoufi, Mahmoud Ebrahimi & Mohammad Reza Bozorgmehr. (2021) Determination of Thermodynamics Constant of Interaction among of Atenolol and Metoprolol with Human Serum Albumin: Spectroscopic and Molecular Modeling Approaches. Russian Journal of Physical Chemistry A 95:6, pages 1269-1276.
Crossref
Maria Bialik, Marzena Kuras, Marcin Sobczak & Ewa Oledzka. (2021) Achievements in Thermosensitive Gelling Systems for Rectal Administration. International Journal of Molecular Sciences 22:11, pages 5500.
Crossref
Joana Santos, Luísa Lobato & Nuno Vale. (2021) Clinical pharmacokinetic study of latrepirdine via in silico sublingual administration. In Silico Pharmacology 9:1.
Crossref
Herana Kamal SeneviratneJoseph TillotsonJulie M. LadeLinda-Gail BekkerSue LiSubash PathakJessica JustmanNyaradzo MgodiShobha SwaminathanNirupama SistaJennifer FarriorPaul RichardsonCraig W. HendrixNamandje N. Bumpus. (2021) Metabolism of Long-Acting Rilpivirine After Intramuscular Injection: HIV Prevention Trials Network Study 076 (HPTN 076). AIDS Research and Human Retroviruses 37:3, pages 173-183.
Crossref
Mavara AzmiImam Pasha SyedAnupama Koneru. (2021) In Silico Docking Analysis and Admet Prediction of Thymoquinone Derivatives Against Ovarian Cancer. Oriental Journal Of Chemistry 37:1, pages 221-228.
Crossref
Dimitrios Vagiannis, Zhang Yu, Eva Novotna, Anselm Morell & Jakub Hofman. (2020) Entrectinib reverses cytostatic resistance through the inhibition of ABCB1 efflux transporter, but not the CYP3A4 drug-metabolizing enzyme. Biochemical Pharmacology 178, pages 114061.
Crossref
Jiajing Hu, Yingchun Cai, Weihua Li, Guixia Liu & Yun Tang. (2020) In Silico Prediction of Metabolic Epoxidation for Drug‐like Molecules via Machine Learning Methods . Molecular Informatics 39:8.
Crossref
Saied M. Abd El‐atty. (2020) Health monitoring scheme‐based Forster resonance energy transfer nanocommunications in the Internet of Biological Nanothings. International Journal of Communication Systems 33:11.
Crossref
Danyi Lu, Mengjing Zhao, Min Chen & Baojian Wu. (2020) Circadian Clock–Controlled Drug Metabolism: Implications for Chronotherapeutics. Drug Metabolism and Disposition 48:5, pages 395-406.
Crossref
Anowarul Islam, Md Sadikul Islam, Md Nazim Uddin, Mir Md Iqbal Hasan & Md Rashedunnabi Akanda. (2020) The potential health benefits of the isoflavone glycoside genistin. Archives of Pharmacal Research 43:4, pages 395-408.
Crossref
Dimitrios Vagiannis, Eva Novotna, Adam Skarka, Sarah Kammerer, Jan-Heiner Küpper, Si Chen, Lei Guo, Frantisek Staud & Jakub Hofman. (2020) Ensartinib (X-396) Effectively Modulates Pharmacokinetic Resistance Mediated by ABCB1 and ABCG2 Drug Efflux Transporters and CYP3A4 Biotransformation Enzyme. Cancers 12:4, pages 813.
Crossref
Mengjing Zhao, Yi Wang, Min Chen & Baojian Wu. 2020. Circadian Pharmacokinetics. Circadian Pharmacokinetics 23 40 .
Maciej Gawlik, Jakub Trawiński & Robert Skibiński. (2019) Simulation of phase I metabolism reactions of selected calcium channel blockers by human liver microsomes and photochemical methods with the use of Q-TOF LC/MS. Journal of Pharmaceutical and Biomedical Analysis 175, pages 112776.
Crossref
A. V. Rudik, A. V. Dmitriev, A. A. Lagunin, S. M. Ivanov, D. A. Filimonov & V. V. Poroikov. (2019) Computer-Aided Xenobiotic Toxicity Prediction Taking into Account their Metabolism in the Human Body. Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry 13:3, pages 228-236.
Crossref
Dolores Camacho-Muñoz, Bruce Petrie, Luigi Lopardo, Kathryn Proctor, Jack Rice, Jane Youdan, Ruth Barden & Barbara Kasprzyk-Hordern. (2019) Stereoisomeric profiling of chiral pharmaceutically active compounds in wastewaters and the receiving environment – A catchment-scale and a laboratory study. Environment International 127, pages 558-572.
Crossref
Ružena Čižmáriková, Ladislav Habala, Jindra Valentová & Mário Markuliak. (2019) Survey of Pharmacological Activity and Pharmacokinetics of Selected β-Adrenergic Blockers in Regard to Their Stereochemistry. Applied Sciences 9:4, pages 625.
Crossref
A.V. Rudik, A.V. Dmitriev, A.A. Lagunin, S.M. Ivanov, D.A. Filimonov & V.V. Poroikov. (2019) Xenobiotic toxicity prediction combined with xenobiotic metabolism prediction in the human body. Biomeditsinskaya Khimiya 65:2, pages 114-122.
Crossref
Anastasiya Rudik, Vladislav Bezhentsev, Alexander Dmitriev, Alexey Lagunin, Dmitry Filimonov & Vladimir Poroikov. (2019) Metatox - Web application for generation of metabolic pathways and toxicity estimation. Journal of Bioinformatics and Computational Biology 17:01, pages 1940001.
Crossref
Lieke Lamont, Gert B. Eijkel, Emrys A. Jones, Bryn Flinders, Shane R. Ellis, Tiffany Porta Siegel, Ron M.A. Heeren & Rob J. Vreeken. (2018) Targeted Drug and Metabolite Imaging: Desorption Electrospray Ionization Combined with Triple Quadrupole Mass Spectrometry. Analytical Chemistry 90:22, pages 13229-13235.
Crossref
Dominik Hlaváč, Diana Klushina & Jonáš Tokarský. (2018) Interaction of antitumoral drug erlotinib with biodegradable triblock copolymers: a molecular modeling study. Chemical Papers 72:8, pages 2023-2034.
Crossref
Fabio Bachmann, Urs Duthaler, Deborah Rudin, Stephan Krähenbühl & Manuel Haschke. (2018) N-demethylation of N-methyl-4-aminoantipyrine, the main metabolite of metamizole. European Journal of Pharmaceutical Sciences 120, pages 172-180.
Crossref
Anne M. Dolberg & Stephan Reichl. (2017) Activity of Multidrug Resistance-Associated Proteins 1–5 (MRP1–5) in the RPMI 2650 Cell Line and Explants of Human Nasal Turbinate. Molecular Pharmaceutics 14:5, pages 1577-1590.
Crossref
Omar Abdulhameed Almazroo, Mohammad Kowser Miah & Raman Venkataramanan. (2017) Drug Metabolism in the Liver. Clinics in Liver Disease 21:1, pages 1-20.
Crossref
E. Sánchez-López, M. Espina, S. Doktorovova, E.B. Souto & M.L. García. (2017) Lipid nanoparticles (SLN, NLC): Overcoming the anatomical and physiological barriers of the eye – Part I – Barriers and determining factors in ocular delivery. European Journal of Pharmaceutics and Biopharmaceutics 110, pages 70-75.
Crossref
Vibhuti Agrahari, Abhirup Mandal, Vivek Agrahari, Hoang M. Trinh, Mary Joseph, Animikh Ray, Hicheme Hadji, Ranjana Mitra, Dhananjay Pal & Ashim K. Mitra. (2016) A comprehensive insight on ocular pharmacokinetics. Drug Delivery and Translational Research 6:6, pages 735-754.
Crossref
Marci L. Chew, Joyce Mordenti, Thean Yeoh, Gautam Ranade, Ruolun Qiu, Juanzhi Fang, Yali Liang & Brian Corrigan. (2016) Minimization of CYP2D6 Polymorphic Differences and Improved Bioavailability via Transdermal Administration: Latrepirdine Example. Pharmaceutical Research 33:8, pages 1873-1880.
Crossref
Maria Luisa Sardu, Giuseppe De Nicolao & Italo Poggesi. 2015. New Horizons in Predictive Drug Metabolism and Pharmacokinetics. New Horizons in Predictive Drug Metabolism and Pharmacokinetics 391 413 .
Marta Sánchez-González, Glòria Lozano-Mena, Andrés Parra, M. Emília Juan & Joana M. Planas. (2015) Identification in Rat Plasma and Urine by Linear Trap Quadrupole–Orbitrap Mass Spectrometry of the Metabolites of Maslinic Acid, a Triterpene from Olives. Journal of Agricultural and Food Chemistry 63:4, pages 1126-1132.
Crossref
Dong Ki Kim, Jay Wook Lee, Kwang-Hee Shin, Sejoong Kim, Kook-Hwan Oh, Myounghee Kim, Kyung-Sang Yu, Jung Pyo Lee, Chun-Soo Lim, Yon Su Kim & Kwon Wook Joo. (2014) Dose selection method for pharmacokinetic study in hemodialysis patients using a subpharmacological dose: oseltamivir as a model drug. BMC Nephrology 15:1.
Crossref
Thomas Kampe, Anna König, Hendrik Schroeder, Jan G. Hengstler & Christof M. Niemeyer. (2014) Modular Microfluidic System for Emulation of Human Phase I/Phase II Metabolism. Analytical Chemistry 86:6, pages 3068-3074.
Crossref
Peter Eichhorn. 2013. Analysis, Removal, Effects and Risk of Pharmaceuticals in the Water Cycle - Occurrence and Transformation in the Environment. Analysis, Removal, Effects and Risk of Pharmaceuticals in the Water Cycle - Occurrence and Transformation in the Environment 1 36 .
Poonam R. Velagaleti & Michael H. Buonarati. 2014. Ocular Pharmacology and Toxicology. Ocular Pharmacology and Toxicology 33 52 .
Yinying Zhang, Kuan Shi, Jun Wen, Guorong Fan, Yifeng Chai & Zhanying Hong. (2012) Chiral hplc determination and stereoselective pharmacokinetics of tetrahydroberberine enantiomers in rats. Chirality 24:3, pages 239-244.
Crossref
David J. Kopsky & Jan M. Keppel Hesselink. (2011) High Doses of Topical Amitriptyline in Neuropathic Pain: Two Cases and Literature Review. Pain Practice 12:2, pages 148-153.
Crossref
Peter Eichhorn, Sandra Pérez & Damià Barceló. 2012. TOF-MS within Food and Environmental Analysis - Comprehensive Analytical Chemistry. TOF-MS within Food and Environmental Analysis - Comprehensive Analytical Chemistry 217 272 .
Christoph Hiemke, Pierre Baumann & Julia Stingl. 2012. Handbuch der Psychopharmakotherapie. Handbuch der Psychopharmakotherapie 441 464 .
Danyel G.J. Jennen, Stan Gaj, Pieter J. Giesbertz, Joost H.M. van Delft, Chris T. Evelo & Jos C.S. Kleinjans. (2010) Biotransformation pathway maps in WikiPathways enable direct visualization of drug metabolism related expression changes. Drug Discovery Today 15:19-20, pages 851-858.
Crossref
Yung-Jen Tsai, Lie-Chwen Lin & Tung-Hu Tsai. (2010) Pharmacokinetics of Adenosine and Cordycepin, a Bioactive Constituent of Cordyceps sinensis in Rat . Journal of Agricultural and Food Chemistry 58:8, pages 4638-4643.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.