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Original Articles

Mode of Action Frameworks: A Critical Analysis

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Pages 16-31 | Published online: 04 Jan 2008

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M. E. (Bette) Meek, Sir Colin Berry, AlanR. Boobis, SamuelM. Cohen, Margaret Hartley, Sharon Munn, Stephen Olin, Josef Schlatter & Carolyn Vickers. (2008) Re: Guyton, Kathryn Z., Barone, Stanley, Jr., Brown, Rebecca C., Euling, Susan Y., Jinot, Jennifer, Makris, Susan (2008). Mode of Action Frameworks: A Critical Analysis. Journal of Toxicology and Environmental Health, Part B, 11(1): 16–31. Journal of Toxicology and Environmental Health, Part B 11:8, pages 681-685.
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Joanna Klapacz & B. Bhaskar Gollapudi. (2019) Considerations for the Use of Mutation as a Regulatory Endpoint in Risk Assessment. Environmental and Molecular Mutagenesis 61:1, pages 84-93.
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Claire Beausoleil, Elodie Pasquier, Christophe Rousselle & Cécile Michel. (2018) Special issue: Is BPA an ED?. Molecular and Cellular Endocrinology 475, pages 1-3.
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Lynn S. McCarty & Christopher J. Borgert. (2017) Comment on “Mode of Action (MOA) Assignment Classifications for Ecotoxicology: An Evaluation of Approaches”. Environmental Science & Technology 51:22, pages 13509-13510.
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M.E. (Bette) Meek. (2017) AOPs in hazard characterization for human health. Current Opinion in Toxicology 3, pages 80-86.
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M.E. Bette Meek. 2015. Hamilton & Hardy's Industrial Toxicology. Hamilton & Hardy's Industrial Toxicology 1129 1134 .
M. E. (Bette) Meek, Christine M. Palermo, Ammie N. Bachman, Colin M. North & R. Jeffrey Lewis. (2014) Mode of action human relevance (species concordance) framework: Evolution of the Bradford Hill considerations and comparative analysis of weight of evidence. Journal of Applied Toxicology 34:6, pages 595-606.
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Palma Ann Marone, William C. Hall & A. Wallace Hayes. (2014) Reassessing the two-year rodent carcinogenicity bioassay: A review of the applicability to human risk and current perspectives. Regulatory Toxicology and Pharmacology 68:1, pages 108-118.
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Mary E. Kushman, Andrew D. Kraft, Kathryn Z. Guyton, Weihsueh A. Chiu, Susan L. Makris & Ivan Rusyn. (2013) A systematic approach for identifying and presenting mechanistic evidence in human health assessments. Regulatory Toxicology and Pharmacology 67:2, pages 266-277.
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Holly M. Mortensen & Susan Y. Euling. (2013) Integrating mechanistic and polymorphism data to characterize human genetic susceptibility for environmental chemical risk assessment in the 21st century. Toxicology and Applied Pharmacology 271:3, pages 395-404.
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Mosé Casalegno & Guido Sello. (2013) Determination of Toxicant Mode of Action by Augmented Top Priority Fragment Class. Journal of Chemical Information and Modeling 53:5, pages 1113-1126.
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Alan Poole & Shakil A. Saghir. (2012) Diiodomethyl-p-tolylsulfone: Evaluation of the mode of action for reproductive toxicity. Regulatory Toxicology and Pharmacology 62:3, pages 504-512.
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Maureen R. Gwinn, Danielle DeVoney, Annie M. Jarabek, Babasaheb Sonawane, John Wheeler, David N. Weissman, Scott Masten & Claudia Thompson. (2011) Meeting Report: Mode(s) of Action of Asbestos and Related Mineral Fibers. Environmental Health Perspectives 119:12, pages 1806-1810.
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P. Marx-Stoelting, R. Pfeil, R. Solecki, B. Ulbrich, K. Grote, V. Ritz, U. Banasiak, B. Heinrich-Hirsch, T. Moeller, I. Chahoud & K.I. Hirsch-Ernst. (2011) Assessment strategies and decision criteria for pesticides with endocrine disrupting properties relevant to humans. Reproductive Toxicology 31:4, pages 574-584.
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Thomas B. Knudsen, Keith A. Houck, Nisha S. Sipes, Amar V. Singh, Richard S. Judson, Matthew T. Martin, Arthur Weissman, Nicole C. Kleinstreuer, Holly M. Mortensen, David M. Reif, James R. Rabinowitz, R. Woodrow Setzer, Ann M. Richard, David J. Dix & Robert J. Kavlock. (2011) Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets. Toxicology 282:1-2, pages 1-15.
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Jane E. Gallagher, Elaine A. Cohen Hubal & Stephen W. Edwards. 2010. Biomarkers. Biomarkers 517 547 .
Kathryn Z. Guyton, Weihsueh A. Chiu, Thomas F. Bateson, Jennifer Jinot, Cheryl Siegel Scott, Rebecca C. Brown & Jane C. Caldwell. (2009) A Reexamination of the PPAR-α Activation Mode of Action as a Basis for Assessing Human Cancer Risks of Environmental Contaminants. Environmental Health Perspectives 117:11, pages 1664-1672.
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George Cruzan, James Bus, Marcy Banton, Ralph Gingell & Gary Carlson. (2009) Mouse specific lung tumors from CYP2F2-mediated cytotoxic metabolism: An endpoint/toxic response where data from multiple chemicals converge to support a mode of action. Regulatory Toxicology and Pharmacology 55:2, pages 205-218.
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Chao W. Chen. (2008) Estimating birth and death rates from cell labeling data. Stochastic Environmental Research and Risk Assessment 23:5, pages 621-626.
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Kathryn Z. Guyton, Amy D. Kyle, Jiri Aubrecht, Vincent J. Cogliano, David A. Eastmond, Marc Jackson, Nagalakshmi Keshava, Martha S. Sandy, Babasaheb Sonawane, Luoping Zhang, Michael D. Waters & Martyn T. Smith. (2009) Improving prediction of chemical carcinogenicity by considering multiple mechanisms and applying toxicogenomic approaches. Mutation Research/Reviews in Mutation Research 681:2-3, pages 230-240.
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Ronald H. White, Ila Cote, Lauren Zeise, Mary Fox, Francesca Dominici, Thomas A. Burke, Paul D. White, Dale B. Hattis & Jonathan M. Samet. (2009) State-of-the-Science Workshop Report: Issues and Approaches in Low-Dose–Response Extrapolation for Environmental Health Risk Assessment. Environmental Health Perspectives 117:2, pages 283-287.
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Stephen W. Edwards & R. Julian Preston. (2008) Systems Biology and Mode of Action Based Risk Assessment. Toxicological Sciences 106:2, pages 312-318.
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Ehi Idahosa, Lesley Rushton & Alan R. Boobis. (2008) Systematic review of epidemiological evidence for use in the framework approach for analysing the human relevance of an animal mode of action. Toxicology 253:1-3, pages 15.
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