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Original Articles

Human Exposure to Endocrine Disrupters and Semen Quality

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Pages 188-220 | Published online: 26 Mar 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (24)

Melanie C Buser, Henry G Abadin, John L Irwin & Hana R Pohl. (2018) Windows of sensitivity to toxic chemicals in the development of reproductive effects: an analysis of ATSDR’s toxicological profile database. International Journal of Environmental Health Research 28:5, pages 553-578.
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Stanislav A. Pshenichnyuk, Alberto Modelli & Alexei S. Komolov. (2018) Interconnections between dissociative electron attachment and electron-driven biological processes. International Reviews in Physical Chemistry 37:1, pages 125-170.
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Mariana T. Farcas, Elena R. Kisin, Autumn L. Menas, Dmitriy W. Gutkin, Alexander Star, Richard S. Reiner, Naveena Yanamala, Kai Savolainen & Anna A. Shvedova. (2016) Pulmonary exposure to cellulose nanocrystals caused deleterious effects to reproductive system in male mice. Journal of Toxicology and Environmental Health, Part A 79:21, pages 984-997.
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Sol-Ji In, Seung-Hee Kim, Ryeo-Eun Go, Kyung-A Hwang & Kyung-Chul Choi. (2015) Benzophenone-1 and Nonylphenol Stimulated MCF-7 Breast Cancer Growth by Regulating Cell Cycle and Metastasis-Related Genes Via an Estrogen Receptor α-Dependent Pathway. Journal of Toxicology and Environmental Health, Part A 78:8, pages 492-505.
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Marciana Sanabria, Alessandra Pessin, Mirella Rossitto Zanutto, Juliana Elaine Perobelli, Marina Trevizan Guerra, Thais Petrochelli Banzato, Cibele dos Santos Borges & Wilma De Grava Kempinas. (2015) Absence of Effects on the Rat Sperm Quality After Subacute Exposure to Low Doses of Fungicide Prochloraz. Journal of Toxicology and Environmental Health, Part A 78:8, pages 481-491.
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Sheng-Yuan Wang, Yu Wang, Fang-Qin Xie, Yan-Xing Li, Xue-Lian Wan, Wei-Wei Ma, De-Cai Wang & Yong-Hui Wu. (2015) Analysis of PAEs in semen of infertile men. International Journal of Occupational and Environmental Health 21:1, pages 40-48.
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Vanessa R. Kay, Michael S. Bloom & Warren G. Foster. (2014) Reproductive and developmental effects of phthalate diesters in males. Critical Reviews in Toxicology 44:6, pages 467-498.
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Marina T. Guerra, Raquel F. Silva, Heloise R. Luchiari, Marciana Sanabria & Wilma De Grava Kempinas. (2014) Perinatal Androgenic Exposure and Reproductive Health Effects Female Rat Offspring. Journal of Toxicology and Environmental Health, Part A 77:7, pages 375-389.
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Maria Anna Bauer, Didac Carmona-Gutiérrez, Christoph Ruckenstuhl, Angela Reisenbichler, Evgenia V. Megalou, Tobias Eisenberg, Christoph Magnes, Helmut Jungwirth, Frank M. Sinner, Thomas R. Pieber, Kai-Uwe Fröhlich, Guido Kroemer, Nektarios Tavernarakis & Frank Madeo. (2013) Spermidine promotes mating and fertilization efficiency in model organisms. Cell Cycle 12:2, pages 346-352.
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Benoit Roig, Wissem Mnif, Aziza Ibn Hadj Hassine, Ines Zidi, Sandrine Bayle, Aghleb Bartegi & Olivier Thomas. (2013) Endocrine Disrupting Chemicals and Human Health Risk Assessment: A Critical Review. Critical Reviews in Environmental Science and Technology 43:21, pages 2297-2351.
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Glaura S. A. Fernandes, Ana Paula A. Favareto, Carla D. B. Fernandez, Fernanda F. Bellentani, Arielle C. Arena, Tony F. Grassi, Wilma G. Kempinas & Luís F. Barbisan. (2012) Effects of Diuron on Male Rat Reproductive Organs: A Developmental and Postnatal Study. Journal of Toxicology and Environmental Health, Part A 75:16-17, pages 1059-1069.
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Thais Petrochelli Banzato, Antonio Francisco Godinho, Elaine Cristina Mathias da Silva Zacarin, Juliana Elaine Perobelli, Carla Dal Bianco Fernandez, Ana Paula Alves Favareto & Wilma De Grava Kempinas. (2012) Sperm Quality in Adult Male Rats Exposed to Cadmium in Utero and Lactation. Journal of Toxicology and Environmental Health, Part A 75:16-17, pages 1047-1058.
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Suresh C. Joshi & Preeti Sharma. (2011) Male reproductive toxicity of organophosphorous compounds: a review. Toxicological & Environmental Chemistry 93:7, pages 1486-1507.
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Jenna T. Haverfield, Seungmin Ham, Kristy A. Brown, Evan R. Simpson & Sarah J. Meachem. (2011) Teasing out the role of aromatase in the healthy and diseased testis. Spermatogenesis 1:3, pages 240-249.
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Bonnie H.Y. Yeung, Hin T. Wan, Alice Y.S. Law & Chris K.C. Wong. (2011) Endocrine disrupting chemicals. Spermatogenesis 1:3, pages 231-239.
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PaolaG. Cormio, Mathias Christmann, Andrew Rastall, Stefanie Grund, Henner Hollert, Ingolf Schuphan & Burkhard Schmidt. (2011) Chlorinated isomers of nonylphenol differ in estrogenic and androgenic activity. Journal of Environmental Science and Health, Part A 46:4, pages 329-336.
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Dangxia Zhou, Jing Zhang, Haixu Wang & Yahong Xue. (2011) Effect of formaldehyde exposure on structure and function of epididymis in adult rats: a histological and biochemical study. Toxicological & Environmental Chemistry 93:1, pages 134-144.
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Seonyoung Choi, So-Young Park, Dongsub Kwak, Sohee Phark, Min Lee, Ji-Youn Lim, Woon-Won Jung & Donggeun Sul. (2010) Proteomic Analysis of Proteins Secreted by HepG2 Cells Treated with Butyl Benzyl Phthalate. Journal of Toxicology and Environmental Health, Part A 73:21-22, pages 1570-1585.
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Tae Sung Kim, Ki Kyung Jung, Soon Sun Kim, Il Hyun Kang, Jung Hee Baek, Hye-Seon Nam, Soon-Keun Hong, Byung Mu Lee, Jin Tae Hong, Ki Wan Oh, Hyung Sik Kim, Soon Young Han & Tae Seok Kang. (2010) Effects of in Utero Exposure to DI(n-Butyl) Phthalate on Development of Male Reproductive Tracts in Sprague-Dawley Rats. Journal of Toxicology and Environmental Health, Part A 73:21-22, pages 1544-1559.
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J. S. Taylor, B. M. Thomson, C. N. Lang, F. Y. T. Sin & E. Podivinsky. (2010) Estrogenic Pyrethroid Pesticides Regulate Expression of Estrogen Receptor Transcripts in Mouse Sertoli Cells Differently From 17β-Estradiol. Journal of Toxicology and Environmental Health, Part A 73:16, pages 1075-1089.
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Juliana Elaine Perobelli, Meire França Martinez, Carla Adriene da Silva Franchi, Carla Dal Bianco Fernandez, João Lauro Viana de Camargo & Wilma De Grava Kempinas. (2010) Decreased Sperm Motility in Rats Orally Exposed to Single or Mixed Pesticides. Journal of Toxicology and Environmental Health, Part A 73:13-14, pages 991-1002.
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Karen P Phillips & Nongnuj Tanphaichitr. (2010) Mechanisms of obesity-induced male infertility. Expert Review of Endocrinology & Metabolism 5:2, pages 229-251.
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Seung Jun Kwack, Kyu-Bong Kim, Hyung Sik Kim, Kyung Sil Yoon & Byung Mu Lee. (2009) Risk Assessment of Soybean-Based Phytoestrogens. Journal of Toxicology and Environmental Health, Part A 72:21-22, pages 1254-1261.
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GunterG. C. Kuhnle, Caterina Dell'Aquila, SueM. Aspinall, ShirleyA. Runswick, AngelaA. Mulligan & SheilaA. Bingham. (2009) Phytoestrogen Content of Cereals and Cereal-Based Foods Consumed in the UK. Nutrition and Cancer 61:3, pages 302-309.
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Matineh Rastegar Panah, Irtaza Tahir, Bibiana Garcia-Bailo, Kirk Lo, Keith Jarvi & Ahmed El-Sohemy. (2023) Ascorbic acid is associated with favourable hormonal profiles among infertile males. Frontiers in Reproductive Health 5.
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Paloma da Cunha de Medeiros, Cinthia C. Nascimento & Juliana E. Perobelli. (2023) Antineoplastic drugs in environmentally relevant concentrations cause endocrine disruption and testicular dysfunction in experimental conditions. Environmental Toxicology and Pharmacology 100, pages 104122.
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Xuelian Zhang, Ming Li, Wenjie Li, Linxiu Yue, Taiyuan Zhang, Qi Tang, Naidan Zhang, Xianyong Lan & Chuanying Pan. (2023) Chlorpyrifos induces male infertility in pigs through ROS and PI3K-AKT pathway. iScience 26:5, pages 106558.
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Anirban Goutam Mukherjee & Abilash Valsala Gopalakrishnan. (2023) Unlocking the mystery associated with infertility and prostate cancer: an update. Medical Oncology 40:6.
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Maxim Kleshchev, Alexander Osadchuk & Ludmila Osadchuk. (2021) Impaired semen quality, an increase of sperm morphological defects and DNA fragmentation associated with environmental pollution in urban population of young men from Western Siberia, Russia. PLOS ONE 16:10, pages e0258900.
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Sayyed Mohammad Hadi Alavi, Sepideh Barzegar-Fallah, Parastoo Rahdar, Mohammad Mahdi Ahmadi, Mina Yavari, Azadeh Hatef, Mahdi Golshan & Otomar Linhart. (2021) A Review on Environmental Contaminants-Related Fertility Threat in Male Fishes: Effects and Possible Mechanisms of Action Learned from Wildlife and Laboratory Studies. Animals 11:10, pages 2817.
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Jana Hlaváčová, Jaroslav Flegr, Karel Řežábek, Pavel Calda & Šárka Kaňková. (2021) Association between latent toxoplasmosis and fertility parameters of men. Andrology 9:3, pages 854-862.
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Mark P. Green, Alexandra J. Harvey, Bethany J. Finger & Gerard A. Tarulli. (2021) Endocrine disrupting chemicals: Impacts on human fertility and fecundity during the peri-conception period. Environmental Research 194, pages 110694.
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Mahdi Golshan & Sayyed Mohammad Hadi Alavi. (2019) Androgen signaling in male fishes: Examples of anti-androgenic chemicals that cause reproductive disorders. Theriogenology 139, pages 58-71.
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Ramy Abou Ghayda, Paige L. Williams, Jorge E. Chavarro, Jennifer B. Ford, Irene Souter, Antonia M. Calafat, Russ Hauser & Lidia Mínguez-Alarcón. (2019) Urinary bisphenol S concentrations: Potential predictors of and associations with semen quality parameters among men attending a fertility center. Environment International 131, pages 105050.
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Alison E Hipwell, Linda G Kahn, Pam Factor-Litvak, Christina A Porucznik, Eva L Siegel, Raina N Fichorova, Richard F Hamman, Michele Klein-Fedyshin & Kim G Harley. (2019) Exposure to non-persistent chemicals in consumer products and fecundability: a systematic review. Human Reproduction Update 25:1, pages 51-71.
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Nicola Zampieri, Simone Patanè, Federica Bianchi, Marta Peretti & Francesco Saverio Camoglio. 2019. Varicocele and Male Infertility. Varicocele and Male Infertility 573 577 .
T. Latif, R. Lindahl-Jacobsen, J. Mehlsen, M. L. Eisenberg, S. A. Holmboe, K. Pors, L. Brinth, S. O. Skouby, N. Jørgensen & T. K. Jensen. (2018) Semen quality associated with subsequent hospitalizations - Can the effect be explained by socio-economic status and lifestyle factors?. Andrology 6:3, pages 428-435.
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Ukpai A. Eze, John Huntriss, Michael N. Routledge & Yun Yun Gong. (2018) Toxicological effects of regulated mycotoxins and persistent organochloride pesticides: In vitro cytotoxic assessment of single and defined mixtures on MA-10 murine Leydig cell line. Toxicology in Vitro 48, pages 93-103.
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Michelle Mostrom & Tim J. Evans. 2018. Veterinary Toxicology. Veterinary Toxicology 817 833 .
Suresh C. Sikka & Ahmet Ayaz. 2018. Bioenvironmental Issues Affecting Men's Reproductive and Sexual Health. Bioenvironmental Issues Affecting Men's Reproductive and Sexual Health 371 386 .
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N.H. Ing, K.O. CurleyJr.Jr., T.H. WelshJr.Jr., L. Johnson & C. Staub. 2018. Comprehensive Toxicology. Comprehensive Toxicology 2 63 .
Tabassam Latif, Tina Kold Jensen, Jesper Mehlsen, Stine Agergaard Holmboe, Louise Brinth, Kirsten Pors, Sven Olaf Skouby, Niels Jørgensen & Rune Lindahl-Jacobsen. (2017) Semen Quality as a Predictor of Subsequent Morbidity: A Danish Cohort Study of 4,712 Men With Long-Term Follow-up. American Journal of Epidemiology 186:8, pages 910-917.
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Younes Aftabi, Abasalt Hosseinzadeh Colagar, Faramarz Mehrnejad, Ensiyeh Seyedrezazadeh & Emadoddin Moudi. (2017) Aryl hydrocarbon receptor gene transitions (c.-742C>T; c.1661G>A) and idiopathic male infertility: a case-control study with in silico and meta-analysis. Environmental Science and Pollution Research 24:25, pages 20599-20615.
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Xiang Li, Jinhao Li, Ya Zhang & Yun Zhou. (2017) Di‐n‐butyl phthalate induced hypospadias relates to autophagy in genital tubercle via the PI3K/Akt/mTOR pathway. Journal of Occupational Health 59:1, pages 8-16.
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Cleber Cremonese, Camila Piccoli, Fabio Pasqualotto, Ruth Clapauch, Rosalina Jorge Koifman, Sergio Koifman & Carmen Freire. (2017) Occupational exposure to pesticides, reproductive hormone levels and sperm quality in young Brazilian men. Reproductive Toxicology 67, pages 174-185.
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Mark Gibson & Ahmad Hammoud. 2017. Clinical Reproductive Medicine and Surgery. Clinical Reproductive Medicine and Surgery 209 226 .
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Rafael Lafuente, Núria García-Blàquez, Bénédicte Jacquemin & Miguel Angel Checa. (2016) Outdoor air pollution and sperm quality. Fertility and Sterility 106:4, pages 880-896.
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Weijun Jiang, Hui Sun, Jing Zhang, Qing Zhou, Qiuyue Wu, Tianfu Li, Cui Zhang, Weiwei Li, Mingchao Zhang & Xinyi Xia. (2015) Polymorphisms in Protamine 1 and Protamine 2 predict the risk of male infertility: a meta-analysis. Scientific Reports 5:1.
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Steven Jones, Annie Boisvert, Sade Francois, Liandong Zhang & Martine Culty. (2015) In Utero Exposure to Di-(2-Ethylhexyl) Phthalate Induces Testicular Effects in Neonatal Rats That Are Antagonized by Genistein Cotreatment1. Biology of Reproduction 93:4.
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Ye-Seul Kim, Kyung-Chul Choi & Kyung-A Hwang. (2015) Genistein suppressed epithelial–mesenchymal transition and migration efficacies of BG-1 ovarian cancer cells activated by estrogenic chemicals via estrogen receptor pathway and downregulation of TGF-β signaling pathway. Phytomedicine 22:11, pages 993-999.
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L. I. Kolesnikova, N. A. Kurashova, L. V. Osadchuk, A. V. Osadchuk, M. I. Dolgikh & B. G. Dashiev. (2015) Parameters of Pro- and Antioxidant Status in Ejaculate of Men of Fertile Age. Bulletin of Experimental Biology and Medicine 159:6, pages 726-728.
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Chuan Wang, Yalan Zhan, Fang Wang, Huaying Li, Liang Xie, Bin Liu, Yifei Li, Dezhi Mu, Hong Zheng, Kaiyu Zhou & Yimin Hua. (2015) Parental Occupational Exposures to Endocrine Disruptors and the Risk of Simple Isolated Congenital Heart Defects. Pediatric Cardiology 36:5, pages 1024-1037.
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Weidong Gan, Ming Zhou, Zou Xiang, Xiaodong Han & Dongmei Li. (2015) Combined Effects of Nonylphenol and Bisphenol A on the Human Prostate Epithelial Cell Line RWPE-1. International Journal of Environmental Research and Public Health 12:4, pages 4141-4155.
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Erin O’Reilly, Marika Sevigny, Kelley-Anne Sabarre & Karen P Phillips. (2014) Perspectives of complementary and alternative medicine (CAM) practitioners in the support and treatment of infertility. BMC Complementary and Alternative Medicine 14:1.
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A. C. Faure, J.-F. Viel, A. Bailly, O. Blagosklonov, C. Amiot & C. Roux. (2014) Evolution of sperm quality in men living in the vicinity of a municipal solid waste incinerator possibly correlated with decreasing dioxins emission levels. Andrologia 46:7, pages 744-752.
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Malgorzata Kotula-Balak, Pawel Grzmil, Katarzyna Chojnacka, Katarzyna Andryka & Barbara Bilinska. (2014) Do photoperiod and endocrine disruptor 4-tert-octylphenol effect on spermatozoa of bank vole (Clethrionomys glareolus)?. General and Comparative Endocrinology 201, pages 21-29.
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Simin Zhang, Qiuqin Tang, Wei Wu, Beilei Yuan, Chuncheng Lu, Yankai Xia, Hongjuan Ding, Lingqing Hu, Daozhen Chen, Jiahao Sha & Xinru Wang. (2014) Association between DAZL polymorphisms and susceptibility to male infertility: systematic review with meta-analysis and trial sequential analysis. Scientific Reports 4:1.
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Riana Bornman & Natalie Aneck-Hahn. 2014. Male Infertility. Male Infertility 193 210 .
Kelley-Anne Sabarre, Zainab Khan, Amanda N Whitten, Olivia Remes & Karen P Phillips. (2013) A qualitative study of Ottawa university students’ awareness, knowledge and perceptions of infertility, infertility risk factors and assisted reproductive technologies (ART). Reproductive Health 10:1.
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Rakesh Sharma, Kelly R Biedenharn, Jennifer M Fedor & Ashok Agarwal. (2013) Lifestyle factors and reproductive health: taking control of your fertility. Reproductive Biology and Endocrinology 11:1.
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D.B. Martinez-Arguelles, E. Campioli, M. Culty, B.R. Zirkin & V. Papadopoulos. (2013) Fetal origin of endocrine dysfunction in the adult: The phthalate model. The Journal of Steroid Biochemistry and Molecular Biology 137, pages 5-17.
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Richard Villemur, Silvia Cristina Cunha dos Santos, Julianne Ouellette, Pierre Juteau, François Lépine & Eric Déziel. (2013) Biodegradation of Endocrine Disruptors in Solid-Liquid Two-Phase Partitioning Systems by Enrichment Cultures. Applied and Environmental Microbiology 79:15, pages 4701-4711.
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Jin‐xia Hu, Yan‐fang Li, Jing Li, Chen Pan, Zhen He, Hong‐yan Dong & Li‐chun Xu. (2011) Toxic effects of cypermethrin on the male reproductive system: with emphasis on the androgen receptor. Journal of Applied Toxicology 33:7, pages 576-585.
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Xiao-Li Feng, Shi-Ying Lu, Dong Liu, Le Li, Xin-Zi Wu, Jie Song, Pan Hu, Yan-Song Li, Feng Tang, Zhao-Hui Li, Guang-Ming Wang, Yu Zhou, Zeng-Shan Liu & Hong-Lin Ren. (2013) Direct competitive immunosorbent assay for detection of MEHP in human urine. Chemosphere 92:1, pages 150-155.
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D. Mortimer, C. L. R. Barratt, L. Bjorndahl, C. de Jager, A. M. Jequier & C. H. Muller. (2013) What should it take to describe a substance or product as 'sperm-safe'. Human Reproduction Update 19:suppl 1, pages i1-i45.
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WCL Ford. (2013) Ignorance but not bliss: too little is known about the determinants of semen quality. Asian Journal of Andrology 15:2, pages 174-178.
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Richard Hampl, Jana Kubátová, Vladimír Sobotka & Jiří Heráček. (2013) Steroids in semen, their role in spermatogenesis, and the possible impact of endocrine disruptors. Hormone Molecular Biology and Clinical Investigation 13:1, pages 1-5.
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D.B. Martinez–Arguelles, M. McIntosh, C.V. Rohlicek, M. Culty, B.R. Zirkin & V. Papadopoulos. (2013) Maternal in utero exposure to the endocrine disruptor di-(2-ethylhexyl) phthalate affects the blood pressure of adult male offspring. Toxicology and Applied Pharmacology 266:1, pages 95-100.
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Mark Gibson & Ahmad O. Hammoud. 2013. Clinical Reproductive Medicine and Surgery. Clinical Reproductive Medicine and Surgery 163 175 .
Julianne Ouellette, Silvia Cristina Cunha dos Santos, François Lépine, Pierre Juteau, Eric Déziel & Richard Villemur. (2013) High absorption of endocrine disruptors by Hytrel: towards the development of a two-phase partitioning bioreactor. Journal of Chemical Technology & Biotechnology 88:1, pages 119-125.
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Philippe Kadhel, Patricia Monnier, Isabelle Boucoiran, Nils Chaillet & William D. Fraser. (2012) Organochlorine Pollutants and Female Fertility: A Systematic Review Focusing on In Vitro Fertilization Studies. Reproductive Sciences 19:12, pages 1246-1259.
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René Glynnis English, Melissa Perry, Mary M. Lee, Elaine Hoffman, Steven Delport & Mohamed Aqiel Dalvie. (2012) Farm residence and reproductive health among boys in rural South Africa. Environment International 47, pages 73-79.
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