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Amyloid
The Journal of Protein Folding Disorders
Volume 12, 2005 - Issue 4
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Original

Quantitative serum free light chain assay in the diagnostic evaluation of AL amyloidosis

Harun Akar Amyloid Treatment and Research Program at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA
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David C. Seldin Amyloid Treatment and Research Program at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA; Stem Cell Transplant Program at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA; Department of Medicine at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA
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Barbarajean Magnani Department of Laboratory Medicine at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA
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Carl O'Hara Amyloid Treatment and Research Program at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA; Department of Laboratory Medicine at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA; Department of Pathology at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA
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John L. Berk Amyloid Treatment and Research Program at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA; Department of Medicine at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA
,
Christopher Schoonmaker Boston University School of Public Health, Boston, MA, 02118, USA
,
Howard Cabral Boston University School of Public Health, Boston, MA, 02118, USA
,
Laura M. Dember Amyloid Treatment and Research Program at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA; Department of Medicine at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA
,
Vaishali Sanchorawala Amyloid Treatment and Research Program at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA; Stem Cell Transplant Program at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA; Department of Medicine at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA
,
Lawreen H. Connors Amyloid Treatment and Research Program at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA; Department of Biochemistry at Boston University School of Medicine, Boston, MA, 02118, USA
,
Rodney H. Falk Amyloid Treatment and Research Program at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA; Department of Medicine at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA
&
Dr Martha Skinner Amyloid Treatment and Research Program at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA; Department of Medicine at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USACorrespondence[email protected]
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Pages 210-215 | Published online: 06 Jul 2009

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Vina P. Nguyen, Allison Rosenberg, Lisa M. Mendelson, Raymond L. Comenzo, Cindy Varga & Vaishali Sanchorawala. (2018) Outcomes of patients with AL amyloidosis and low serum free light chain levels at diagnosis. Amyloid 25:3, pages 156-159.
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Tatiana Prokaeva, Brian Spencer, Fangui Sun, Richard M. O’Hara, David C. Seldin, Lawreen H. Connors & Vaishali Sanchorawala. (2016) Immunoglobulin heavy light chain test quantifies clonal disease in patients with AL amyloidosis and normal serum free light chain ratio. Amyloid 23:4, pages 214-220.
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Julie Abraham, Estelle Desport, Charlotte Rigaud, Benoit Marin, Sébastien Bender, Corinne Lacombe, Stéphane Moreau, Fatima Yagoubi, Dominique Bordessoule, David Lavergne, Frank Bridoux & Arnaud Jaccard. (2015) Hepatocyte growth factor measurement in AL amyloidosis. Amyloid 22:2, pages 112-116.
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Tilmann Bochtler, Ute Hegenbart, Christina Kunz, Axel Benner, Anja Seckinger, Sascha Dietrich, Martin Granzow, Kai Neben, Hartmut Goldschmidt, Anthony D. Ho, Dirk Hose, Anna Jauch & Stefan O. Schönland. (2014) Gain of chromosome 1q21 is an independent adverse prognostic factor in light chain amyloidosis patients treated with melphalan/dexamethasone. Amyloid 21:1, pages 9-17.
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David C. Seldin & Jennifer E. Ward. (2008) Serum Free Light Chain Analysis, 4th Edition. Amyloid 15:2, pages 142-143.
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Articles from other publishers (34)

Ramona M. Absmeier, Georg J. Rottenaicher, Hristo L. Svilenov, Pamina Kazman & Johannes Buchner. (2022) Antibodies gone bad – the molecular mechanism of light chain amyloidosis. The FEBS Journal 290:6, pages 1398-1419.
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Nabamita Halder, Sushma Talegaonkar & Monalisa Mishra. 2022. Drug Delivery Systems for Metabolic Disorders. Drug Delivery Systems for Metabolic Disorders 47 64 .
Jin Seok Kim, Sung-Soo Yoon, Chang-Ki Min, Je-Jung Lee, Dok Hyun Yoon & Kihyun Kim. (2021) Screening Tests for Early Diagnosis of Multiple Myeloma and Related Plasma Cell Disorders. The Korean Journal of Medicine 96:5, pages 371-381.
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Jennifer L.J. Heaney, Felix Ackermann, Michèle Paunet-Bobo, Souad Mehlal, Emilie Jolly, Johanna Hachem, Aurélie Védrenne & Marc Vasse. (2020) Evaluation of two serum free light chain quantitation methods, Freelite and Seralite, in the clinical laboratory with a view to switching immunoassay. Clinica Chimica Acta 510, pages 235-241.
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Morie A. Gertz, Francis K. Buadi, Taimur Sher & Angela Dispenzieri. 2018. Neoplastic Diseases of the Blood. Neoplastic Diseases of the Blood 651 672 .
Ralph C. Budd & David C. Seldin. 2017. Kelley and Firestein's Textbook of Rheumatology. Kelley and Firestein's Textbook of Rheumatology 1973 1982 .
Lutfiye Bilge Caliskan, Tugba Karadeniz, Sumeyye Ekmekci, Banu Yilmaz Avcioglu, Mehmet Tanrisev, Muhammed Ali Kaypak, Hakan Yarkici, Cengiz Ceylan & Harun Akar. (2016) A Case of Multiple Myeloma Diagnosed by Renal Biopsy. BANTAO Journal 14:2, pages 89-91.
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Jason Kidd & Daniel E. Carl. (2016) Renal amyloidosis. Current Problems in Cancer 40:5-6, pages 209-219.
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Brandon T Larsen, Oana M Mereuta, Surendra Dasari, Ahmed U Fayyaz, Jason D Theis, Julie A Vrana, Martha Grogan, Ahmet Dogan, Angela Dispenzieri, William D Edwards, Paul J Kurtin & Joseph J Maleszewski. (2016) Correlation of histomorphological pattern of cardiac amyloid deposition with amyloid type: a histological and proteomic analysis of 108 cases. Histopathology 68:5, pages 648-656.
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Peter Mollee & Giampaolo Merlini. (2016) Free light chain testing for the diagnosis, monitoring and prognostication of AL amyloidosis. Clinical Chemistry and Laboratory Medicine (CCLM) 54:6.
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Heather J. Landau, Morie A. Gertz & Raymond L. Comenzo. 2015. Thomas’ Hematopoietic Cell Transplantation. Thomas’ Hematopoietic Cell Transplantation 724 741 .
John C. Lee, Lawreen H. Connors & Carl J. O’Hara. 2015. Amyloid and Related Disorders. Amyloid and Related Disorders 343 353 .
Vasiliki Papadopoulou, Savvas Ioannou, Georgia Levidou, Eleni Variami, Panagiotis Kouzis & Marina Siakantaris. (2014) Systemic Mastocytosis Accompanied by a Non-Secretory Plasma Cell Dyscrasia and Nephrotic Syndrome-Level Proteinuria in a 76-Year-Old Patient. Acta Haematologica 131:2, pages 78-83.
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Ellen Jenner. (2014) Serum free light chains in clinical laboratory diagnostics. Clinica Chimica Acta 427, pages 15-20.
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Giovanni Palladini & Giampaolo Merlini. (2013) Systemic amyloidoses: What an internist should know. European Journal of Internal Medicine 24:8, pages 729-739.
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Joseph J. Maleszewski, David L. Murray, Angela Dispenzieri, Martha Grogan, Naveen L. Pereira, Sarah M. Jenkins, Daniel P. Judge, Patrizio Caturegli, Julie A. Vrana, Jason D. Theis, Ahmet Dogan & Marc K. Halushka. (2013) Relationship between monoclonal gammopathy and cardiac amyloid type. Cardiovascular Pathology 22:3, pages 189-194.
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D. P. Phillips, D. Talaulikar, C. A. Hawkins & P. E. Hickman. (2012) Utilisation of s FLC assays – how well do we comply with guidelines? . International Journal of Laboratory Hematology 35:2, pages 200-210.
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David C. Seldin & Martha Skinner. 2013. Kelley's Textbook of Rheumatology. Kelley's Textbook of Rheumatology 1889 1897 .
John Cho Lee, Hao Wu, Tatiana B Prokaeva, Carl O'Hara & David C Seldin. (2012) Expression of D-type cyclins in AL amyloidosis plasma cells. Journal of Clinical Pathology 65:11, pages 1052-1055.
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Lauren Stern, Craig E. Gordon & Karim Malek. (2012) Recognition of Monoclonal Proteins in Hospitalized Patients. Hospital Medicine Clinics 1:3, pages e378-e385.
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Sujata Ramamurthy, Lawreen H. Connors & Carl J. O’Hara. 2012. Amyloid and Related Disorders. Amyloid and Related Disorders 283 290 .
Shaji K. Kumar, Angela Dispenzieri, Martha Q. Lacy, Suzanne R. Hayman, Francis K. Buadi, Steven R. Zeldenrust, Tow Tan, Shirshendu Sinha, Nelson Leung, Robert A. Kyle, S. Vincent Rajkumar & Morie A. Gertz. (2011) Changes in serum-free light chain rather than intact monoclonal immunoglobulin levels predicts outcome following therapy in primary amyloidosis. American Journal of Hematology 86:3, pages 251-255.
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Shaji Kumar, Angela Dispenzieri, Jerry A. Katzmann, Dirk R. Larson, Colin L. Colby, Martha Q. Lacy, Suzanne R. Hayman, Francis K. Buadi, Nelson Leung, Steve R. Zeldenrust, Marina Ramirez-Alvarado, Raynell J. Clark, Robert A. Kyle, S. Vincent Rajkumar & Morie A. Gertz. (2010) Serum immunoglobulin free light-chain measurement in primary amyloidosis: prognostic value and correlations with clinical features. Blood 116:24, pages 5126-5129.
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Laura M. Dember. 2010. Amyloidosis. Amyloidosis 129 143 .
Giovanni Palladini, Paola Russo, Tiziana Bosoni, Laura Verga, Gabriele Sarais, Francesca Lavatelli, Mario Nuvolone, Laura Obici, Simona Casarini, Simona Donadei, Riccardo Albertini, Gabriella Righetti, Maddalena Marini, Maria Stella Graziani, Gian Vico Melzi D'Eril, Remigio Moratti & Giampaolo Merlini. (2009) Identification of Amyloidogenic Light Chains Requires the Combination of Serum-Free Light Chain Assay with Immunofixation of Serum and Urine. Clinical Chemistry 55:3, pages 499-504.
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David C. Seldin & Martha Skinner. 2009. Kelley's Textbook of Rheumatology. Kelley's Textbook of Rheumatology 1785 1793 .
Morie A. Gertz & Suzanne R. Hayman. 2009. Treatment of Multiple Myeloma and Related Disorders. Treatment of Multiple Myeloma and Related Disorders 112 128 .
J.-F. Cordier. (2008) Amyloses et dépôts immunoglobuliniques non amyloïdes pulmonaires. Revue des Maladies Respiratoires 25:6, pages 743-765.
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Vaishali Sanchorawala. 2009. Myeloma Therapy. Myeloma Therapy 551 569 .
Umesh Kapur, Kevin Barton, Raoul Fresco, David J. Leehy & Maria M. Picken. (2007) Expanding the Pathologic Spectrum of Immunoglobulin Light Chain Proximal Tubulopathy. Archives of Pathology & Laboratory Medicine 131:9, pages 1368-1372.
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K. L. Morris, J. R. Tate, D. Gill, G. Kennedy, J. Wellwood, P. Marlton, R. Bird, A. K. Mills & P. Mollee. (2007) Diagnostic and prognostic utility of the serum free light chain assay in patients with AL amyloidosis. Internal Medicine Journal 37:7, pages 456-463.
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R P Hasserjian, H J B Goodman, H J Lachmann, A Muzikansky & P N Hawkins. (2007) Bone marrow findings correlate with clinical outcome in systemic AL amyloidosis patients. Histopathology 50:5, pages 567-573.
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Laura M. Dember. (2006) Amyloidosis-Associated Kidney Disease. Journal of the American Society of Nephrology 17:12, pages 3458-3471.
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Vaishali Sanchorawala. (2006) Light-Chain (AL) Amyloidosis: Diagnosis and Treatment. Clinical Journal of the American Society of Nephrology 1:6, pages 1331-1341.
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