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Amyloid
The Journal of Protein Folding Disorders
Volume 24, 2017 - Issue 1
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Original Article

CSP-1103 (CHF5074) stabilizes human transthyretin in healthy human subjects

Lixia QiangDivision of Respiratory Disease, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China; ;Yamamura Project Laboratory, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Kumamoto, Japan; View further author information
,
Yanxia GuanDivision of Respiratory Disease, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China; View further author information
,
Xiangshun LiDivision of Respiratory Disease, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China; ;Yamamura Project Laboratory, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Kumamoto, Japan; View further author information
,
Li LiuYamamura Project Laboratory, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Kumamoto, Japan; ;Department of Histology and Embryology, Harbin Medical University, Harbin, Heilongjiang, China; View further author information
,
Yanshuang MuYamamura Project Laboratory, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Kumamoto, Japan; View further author information
,
Aki SuganoDivision of Medical Informatics and Bioinformatics, Kobe University Hospital, Kobe, Japan; View further author information
,
Yutaka TakaokaDivision of Medical Informatics and Bioinformatics, Kobe University Hospital, Kobe, Japan; View further author information
,
Toshiyuki SakaedaDepartment of Pharmacokinetics, Kyoto Pharmaceutical University, Kyoto, Japan; View further author information
,
Bruno P. ImbimboResearch and Development, Chiesi Farmaceutici, Parma, ItalyView further author information
,
Ken-Ichi YamamuraYamamura Project Laboratory, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Kumamoto, Japan; View further author information
,
Shoude JinDivision of Respiratory Disease, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China; Correspondence[email protected]
View further author information
&
Zhenghua LiDepartment of Histology and Embryology, Harbin Medical University, Harbin, Heilongjiang, China; Correspondence[email protected]
View further author information
 show all
Pages 42-51 | Received 11 Sep 2016, Accepted 15 Mar 2017, Published online: 10 Apr 2017

Citations (11)

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Madia Lozupone, Vincenzo Solfrizzi, Francesca D’Urso, Ilaria Di Gioia, Rodolfo Sardone, Vittorio Dibello, Roberta Stallone, Angelo Liguori, Chiara Ciritella, Antonio Daniele, Antonello Bellomo, Davide Seripa & Francesco Panza. (2020) Anti-amyloid-β protein agents for the treatment of Alzheimer’s disease: an update on emerging drugs. Expert Opinion on Emerging Drugs 25:3, pages 319-335.
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Morie A. Gertz, Morton Scheinberg, Márcia Waddington-Cruz, Stephen B. Heitner, Chafic Karam, Brian Drachman, Sami Khella, Carol Whelan & Laura Obici. (2019) Inotersen for the treatment of adults with polyneuropathy caused by hereditary transthyretin-mediated amyloidosis. Expert Review of Clinical Pharmacology 12:8, pages 701-711.
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Joel N. Buxbaum. (2019) Treatment of hereditary and acquired forms of transthyretin amyloidosis in the era of personalized medicine: the role of randomized controlled trials. Amyloid 26:2, pages 55-65.
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Articles from other publishers (8)

Yutaka Takaoka, Aki Sugano, Yoshitomo Morinaga, Mika Ohta, Kenji Miura, Haruyuki Kataguchi, Minoru Kumaoka, Shigemi Kimura & Yoshimasa Maniwa. (2022) Prediction of infectivity of SARS-CoV2: Mathematical model with analysis of docking simulation for spike proteins and angiotensin-converting enzyme 2. Microbial Risk Analysis 22, pages 100227.
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Monica Alcantara, Michelle M. Mezei, Steven K. Baker, Ari Breiner, Priya Dhawan, Amanda Fiander, Nowell M. Fine, Christopher Hahn, Hans D. Katzberg, Shahin Khayambashi, Rami Massie, Genevieve Matte, Brendan Putko, Zaeem Siddiqi, Diego Delgado & Vera Bril. (2021) Canadian Guidelines for Hereditary Transthyretin Amyloidosis Polyneuropathy Management. Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 49:1, pages 7-18.
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Bin Zhong, Xianhua Huang, Yizhou Zheng, Xiaohua Guo & Longhuo Wu. (2021) The discovery and development of transthyretin amyloidogenesis inhibitors: what are the lessons?. Future Medicinal Chemistry 13:23, pages 2083-2105.
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Matthew Capustin & William H. Frishman. (2021) Transthyretin Cardiac Amyloidosis and Novel Therapies to Treat This Not-so-rare Cause of Cardiomyopathy. Cardiology in Review 29:5, pages 263-273.
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Christian Bailly & Gérard Vergoten. (2020) Flurbiprofen as a biphenyl scaffold for the design of small molecules binding to PD-L1 protein dimer. Biochemical Pharmacology 178, pages 114042.
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Valentina Loconte, Ilaria Menozzi, Alberto Ferrari, Claudia Folli, Bruno P. Imbimbo, Giuseppe Zanotti & Rodolfo Berni. (2019) Structure-activity relationships of flurbiprofen analogues as stabilizers of the amyloidogenic protein transthyretin. Journal of Structural Biology 208:2, pages 165-173.
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Michael A. Hollas, Manel Ben Aissa, Sue H. Lee, Jesse M. Gordon-Blake & Gregory R.J. Thatcher. (2019) Pharmacological manipulation of cGMP and NO/cGMP in CNS drug discovery. Nitric Oxide 82, pages 59-74.
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Mika Ohta, Aki Sugano, Naoya Hatano, Hirotaka Sato, Hirofumi Shimada, Hitoshi Niwa, Toshiyuki Sakaeda, Hajime Tei, Yoshiyuki Sakaki, Ken-ichi Yamamura & Yutaka Takaoka. (2017) Co-precipitation molecules hemopexin and transferrin may be key molecules for fibrillogenesis in TTR V30M amyloidogenesis. Transgenic Research 27:1, pages 15-23.
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