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Expert Opinion on Therapeutic Patents Volume 30, 2020 - Issue 6
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Review

Microneedles as an alternative technology for transdermal drug delivery systems: a patent review

Monna Lisa Barreto QueirozPost-graduate Program in Pharmaceuticals Sciences, Federal University of Sergipe, São Cristóvão, BrazilORCID Iconhttps://orcid.org/0000-0002-3644-7715View further author information
ORCID Icon,
Saravanan ShanmugamDepartment of Pharmacy, Federal University of Sergipe, São Cristóvão, BrazilORCID Iconhttps://orcid.org/0000-0002-3781-8426View further author information
ORCID Icon,
Lana Naiadhy Silva SantosPost-graduate Program in Pharmaceuticals Sciences, Federal University of Sergipe, São Cristóvão, BrazilORCID Iconhttps://orcid.org/0000-0003-1882-6348View further author information
ORCID Icon,
Caio de Alcântara CamposPost-graduate Program in Pharmaceuticals Sciences, Federal University of Sergipe, São Cristóvão, BrazilView further author information
,
Anamaria Mendonça SantosDepartment of Pharmacy, Federal University of Sergipe, São Cristóvão, BrazilView further author information
,
Mayrton Santos BatistaDepartment of Pharmacy, Federal University of Sergipe, São Cristóvão, BrazilView further author information
,
Adriano Antunes de Souza AraújoPost-graduate Program in Pharmaceuticals Sciences, Federal University of Sergipe, São Cristóvão, Brazil;Department of Pharmacy, Federal University of Sergipe, São Cristóvão, BrazilView further author information
&
Mairim Russo SerafiniPost-graduate Program in Pharmaceuticals Sciences, Federal University of Sergipe, São Cristóvão, Brazil;Department of Pharmacy, Federal University of Sergipe, São Cristóvão, BrazilCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0003-4223-3470View further author information
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Pages 433-452 | Received 27 Jul 2018, Accepted 10 Mar 2020, Published online: 12 Apr 2020

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Pradip Kumar Yadav, Sanjoy Das & Malay K. Das. (2023) 3D-Microneedles: A novel approach for skin directed delivery and its application. Polymer-Plastics Technology and Materials 62:11, pages 1364-1393.
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Srividya Gorantla, Unnati Batra, Samshritha RN  , Eswara Rao Puppala, Tejashree Waghule, V. G. M. Naidu & Gautam Singhvi. (2022) Emerging trends in microneedle-based drug delivery strategies for the treatment of rheumatoid arthritis. Expert Opinion on Drug Delivery 19:4, pages 395-407.
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Emrullah Korkmaz, Stephen C. Balmert, Cara Donahue Carey, Geza Erdos & Louis D. Falo$suffix/text()$suffix/text(). (2021) Emerging skin-targeted drug delivery strategies to engineer immunity: A focus on infectious diseases. Expert Opinion on Drug Delivery 18:2, pages 151-167.
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Articles from other publishers (25)

Quanpeng Li, Xueqing Yu, Xiaoyan Zheng, Jing Yang, Junfeng Hui & Daidi Fan. (2023) Rapid dissolution microneedle based on polyvinyl alcohol/chitosan for local oral anesthesia. International Journal of Biological Macromolecules, pages 128629.
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Vrushali Pathade, Shweta Nene, Shreya Ratnam, Dharmendra Kumar Khatri, Rajeev Singh Raghuvanshi, Shashi Bala Singh & Saurabh Srivastava. (2023) Emerging insights of peptide-based nanotherapeutics for effective management of rheumatoid arthritis. Life Sciences 312, pages 121257.
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Nazia Tabassum, Maria Alba, Li Yan & Nicolas H. Voelcker. (2022) Porous Silicon Microneedles for Enhanced Transdermal Drug Delivery. Advanced Therapeutics 6:1.
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Vaibhavi Meghraj Desai, Sakshi Priya, Srividya Gorantla & Gautam Singhvi. (2022) Revolutionizing Therapeutic Delivery with Microneedle Technology for Tumor Treatment. Pharmaceutics 15:1, pages 14.
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Xinqi Huang, Xuefeng Pan, Xiner Xiong, Zhihe Zhao & Xiao Cen. (2022) Drug delivery systems for treatment of temporomandibular joint osteoarthritis. Frontiers in Pharmacology 13.
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Ziaul Karim, Preeti Karwa & Shobha Rani R. Hiremath. (2022) Polymeric microneedles for transdermal drug delivery- a review of recent studies. Journal of Drug Delivery Science and Technology 77, pages 103760.
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ZULCAIF ZULCAIF, NADIAH ZAFAR, ASIF MAHMOOD & RAI MUHAMMAD SARFRAZ. (2022) TOXICOLOGICAL EVALUATION OF NATURAL AND SYNTHETIC POLYMER BASED DISSOLVABLE MICRONEEDLE PATCHES HAVING VARIABLE RELEASE PROFILES. Cellulose Chemistry and Technology 56:7-8, pages 777-786.
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Mohammed Kanan Alshammari, Jamila Ali Ghazwani, Fahad Owaidh Alsharari, Shahad Saleh Alotaibi, Rahaf Mohammad Alotaibi, Amwaj Abdullah Alsayahani, Rakan Bijad Alosaimi, Atheer Nasser Alotaibi, Mohd Imran & Mohammed Faiz Arshad. (2022) An update on microneedle in insulin delivery: Quality attributes, clinical status and challenges for clinical translation. Journal of Drug Delivery Science and Technology 75, pages 103668.
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Jitong Wang, Jia Zeng, Zhidan Liu, Qin Zhou, Xin Wang, Fan Zhao, Yu Zhang, Jiamiao Wang, Minchen Liu & Ruofei Du. (2022) Promising Strategies for Transdermal Delivery of Arthritis Drugs: Microneedle Systems. Pharmaceutics 14:8, pages 1736.
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Ibrahim A. Aljuffali, Chih-Hung Lin, Shih-Chun Yang, Ahmed Alalaiwe & Jia-You Fang. (2022) Nanoencapsulation of Tea Catechins for Enhancing Skin Absorption and Therapeutic Efficacy. AAPS PharmSciTech 23:6.
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Anna Procopio, Elena Lagreca, Rezvan Jamaledin, Sara La Manna, Brunella Corrado, Concetta Di Natale & Valentina Onesto. (2022) Recent Fabrication Methods to Produce Polymer-Based Drug Delivery Matrices (Experimental and In Silico Approaches). Pharmaceutics 14:4, pages 872.
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Jelle Schoppink & David Fernandez Rivas. (2022) Jet injectors: Perspectives for small volume delivery with lasers. Advanced Drug Delivery Reviews 182, pages 114109.
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Keegan Braz Gomes, Bernadette D'Souza, Sharon Vijayanand, Ipshita Menon & Martin J. D'Souza. (2022) A dual-delivery platform for vaccination using antigen-loaded nanoparticles in dissolving microneedles. International Journal of Pharmaceutics 613, pages 121393.
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Fateme Nazary Abrbekoh, Leila Salimi, Sepideh Saghati, Hassan Amini, Sonia Fathi Karkan, Keyvan Moharamzadeh, Emel Sokullu & Reza Rahbarghazi. (2022) Application of microneedle patches for drug delivery; doorstep to novel therapies. Journal of Tissue Engineering 13, pages 204173142210853.
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Navid Kashaninejad, Ehsanollah Moradi & Hajar Moghadas. 2022. Micro/Nanofluidics and Lab-on-Chip Based Emerging Technologies for Biomedical and Translational Research Applications - Part B. Micro/Nanofluidics and Lab-on-Chip Based Emerging Technologies for Biomedical and Translational Research Applications - Part B 9 39 .
Ishrat Zahoor, Sukhbir Singh, Tapan Behl, Neelam Sharma, Tanveer Naved, Vetriselvan Subramaniyan, Shivkanya Fuloria, Neeraj Kumar Fuloria, Saurabh Bhatia, Ahmed Al-Harrasi, Lotfi Aleya, Shahid Nazir Wani, Celia Vargas-De-La-Cruz & Simona Bungau. (2021) Emergence of microneedles as a potential therapeutics in diabetes mellitus. Environmental Science and Pollution Research 29:3, pages 3302-3322.
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Mayuri Dalvi, Pratik Kharat, Pradip Thakor, Valamla Bhavana, Shashi Bala Singh & Neelesh Kumar Mehra. (2021) Panorama of dissolving microneedles for transdermal drug delivery. Life Sciences 284, pages 119877.
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Zhi Cao, Shengkai Jin, Peiru Wang, Qiumin He, Yuling Yang, Zhengliang Gao & Xiuli Wang. (2021) Microneedle based adipose derived stem cells‐derived extracellular vesicles therapy ameliorates UV ‐induced photoaging in SKH ‐1 mice . Journal of Biomedical Materials Research Part A 109:10, pages 1849-1857.
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Jae Hwan Jung & Sung Giu Jin. (2021) Microneedle for transdermal drug delivery: current trends and fabrication. Journal of Pharmaceutical Investigation 51:5, pages 503-517.
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Merima Sirbubalo, Amina Tucak, Kenan Muhamedagic, Lamija Hindija, Ognjenka Rahić, Jasmina Hadžiabdić, Ahmet Cekic, Derzija Begic-Hajdarevic, Maida Cohodar Husic, Almir Dervišević & Edina Vranić. (2021) 3D Printing—A “Touch-Button” Approach to Manufacture Microneedles for Transdermal Drug Delivery. Pharmaceutics 13:7, pages 924.
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Tsu-Man Chiu, Ping-Chun Hsu, Mohd Yaqub Khan, Cheng-An J. Lin, Chun-Hung Lee, Tsai-Ching Hsu, Min-Hua Chen & Nobutaka Hanagata. (2021) A Perspective on Imiquimod Microneedles for Treating Warts. Pharmaceutics 13:5, pages 607.
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Shailesh Dugam, Rahul Tade, Rani Dhole & Sopan Nangare. (2021) Emerging era of microneedle array for pharmaceutical and biomedical applications: recent advances and toxicological perspectives. Future Journal of Pharmaceutical Sciences 7:1.
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Sajjad Rahmani Dabbagh, Misagh Rezapour Sarabi, Reza Rahbarghazi, Emel Sokullu, Ali K. Yetisen & Savas Tasoglu. (2021) 3D-printed microneedles in biomedical applications. iScience 24:1, pages 102012.
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Chunling Tian, Liu Liu, Mengqiu Xia & Xiao-qin Chu. (2020) The Evaluations of Menthol and Propylene Glycol on the Transdermal Delivery System of Dual Drug–Loaded Lyotropic Liquid Crystalline Gels. AAPS PharmSciTech 21:6.
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Rezvan Jamaledin, Cynthia K.Y. Yiu, Ehsan N. Zare, Li‐Na Niu, Raffaele Vecchione, Guojun Chen, Zhen Gu, Franklin R. Tay & Pooyan Makvandi. (2020) Advances in Antimicrobial Microneedle Patches for Combating Infections. Advanced Materials 32:33.
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