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Expert Opinion on Investigational Drugs Volume 26, 2017 - Issue 3
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Drug Evaluation

Strontium ranelate, a promising disease modifying osteoarthritis drug

Weiyu HanDepartment of Orthopaedics, 3rd Affiliated Hospital of Southern Medical University, Guangzhou, China;Academy of Orthopaedics, Guangdong Province, Southern Medical University, Guangzhou, China;Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, AustraliaView further author information
,
Shicai FanDepartment of Orthopaedics, 3rd Affiliated Hospital of Southern Medical University, Guangzhou, China;Academy of Orthopaedics, Guangdong Province, Southern Medical University, Guangzhou, ChinaView further author information
,
Xiaochun BaiDepartment of Orthopaedics, 3rd Affiliated Hospital of Southern Medical University, Guangzhou, China;Academy of Orthopaedics, Guangdong Province, Southern Medical University, Guangzhou, ChinaView further author information
&
Changhai DingAcademy of Orthopaedics, Guangdong Province, Southern Medical University, Guangzhou, China;Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia;Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, AustraliaCorrespondence[email protected]
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Pages 375-380 | Received 22 Sep 2016, Accepted 13 Jan 2017, Published online: 25 Jan 2017

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Xinquan Yang, Peilong Liu, Yan Zhang, Jun Lu & Hongmou Zhao. (2023) Bioprinting-Enabled Biomaterials: A Cutting-Edge Strategy for Future Osteoarthritis Therapy. International Journal of Nanomedicine 18, pages 6213-6232.
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Peihua Cao, Yamin Li, Yujin Tang, Changhai Ding & David J. Hunter. (2020) Pharmacotherapy for knee osteoarthritis: current and emerging therapies. Expert Opinion on Pharmacotherapy 21:7, pages 797-809.
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Sunny Trivedi, William Fang, Ishan Ayyalasomayajula & C. Thomas Vangsness. (2020) Pharmacotherapeutic considerations and options for the management of osteoarthritis in women. Expert Opinion on Pharmacotherapy 21:5, pages 557-566.
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Zhaohua Zhu, Jia Li, Guangfeng Ruan, Guoliang Wang, Cibo Huang & Changhai Ding. (2018) Investigational drugs for the treatment of osteoarthritis, an update on recent developments. Expert Opinion on Investigational Drugs 27:11, pages 881-900.
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Articles from other publishers (26)

Luca M. Sihn, Erick L. Bastos, Marcelo Nakamura, Mayara K. Uchiyama & Henrique E. Toma. (2023) Repurposing the Strontium Ranelate Antiosteoporotic Drug as a New Outstanding Biocompatible Blue Dye. Colorants 2:3, pages 578-590.
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Chao Xie, Qili Sun, Yu Dong, Huiwen Lu, Wenhua Li, Zhaowei Lin, Kai Li, Jinhao Cheng, Zhanpeng Liu, Jie Qi, Bin Tang & Lijun Lin. (2023) Calcitriol-Loaded Multifunctional Nanospheres with Superlubricity for Advanced Osteoarthritis Treatment. ACS Nano 17:13, pages 12842-12861.
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Fangyuan Zeng, Lan Li, Jiaqi Yang, Siqi Liu, Yang Yuan, Chenxu Zhao & Jianguo Wang. (2023) Transcriptomic and Proteomic Analyses Reveal New Insights into Regulatory Mechanisms of Strontium in Bovine Chondrocytes. Animals 13:8, pages 1301.
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Qing Yao, Xiaohao Wu, Chu Tao, Weiyuan Gong, Mingjue Chen, Minghao Qu, Yiming Zhong, Tailin He, Sheng Chen & Guozhi Xiao. (2023) Osteoarthritis: pathogenic signaling pathways and therapeutic targets. Signal Transduction and Targeted Therapy 8:1.
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Binghui Liao, Ming Ding, Yingchun Wang, Hu Xu & Lei Shangguan. (2022) Strontium ion attenuates osteoarthritis through inhibiting senescence and enhancing autophagy in fibroblast-like synoviocytes. Molecular Biology Reports 50:2, pages 1437-1446.
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Shengfa Li, Peihua Cao, Tianyu Chen & Changhai Ding. (2023) Latest insights in disease-modifying osteoarthritis drugs development. Therapeutic Advances in Musculoskeletal Disease 15, pages 1759720X2311698.
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Pengfei Wen, Rui Liu, Jun Wang, Yakang Wang, Wei Song & Yumin Zhang. (2022) Bibliometric insights from publications on subchondral bone research in osteoarthritis. Frontiers in Physiology 13.
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Akira Furukawa & Yasuhito Tanaka. (2022) Conversion of Nastrophites to Fibrous Strontium Apatites and Their Crystallographic Characterization. Crystals 12:12, pages 1705.
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Qianju Wu, Longwei Hu, Ran Yan, Junfeng Shi, Hao Gu, Yuwei Deng, Ruixue Jiang, Jin Wen & Xinquan Jiang. (2022) Strontium-incorporated bioceramic scaffolds for enhanced osteoporosis bone regeneration. Bone Research 10:1.
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Xiao Ma, Dechao Cai, Yakun Zhu, Yao Zhao, Xianbo Shang, Chen Wang, Haotian Zhang, Ashuai Bian, Haoran Yu & Wendan Cheng. (2022) L-G lutamine alleviates osteoarthritis by regulating lncRNA- NKILA expression through the TGF-β1/SMAD2/3 signalling pathway . Clinical Science 136:13, pages 1053-1069.
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Hao Yu, Yan Liu, Xiangwen Yang, Jiajing He, Qun Zhong & Xiaojing Guo. (2022) The anti‑inflammation effect of strontium ranelate on rat chondrocytes with or without IL‑1β in vitro . Experimental and Therapeutic Medicine 23:3.
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Victor V. Dotsenko, Alexander V. Bespalov, Arthur S. Vashurin, Nicolai A. Aksenov, Inna V. Aksenova, Elena A. Chigorina & Sergey G. Krivokolysko. (2021) 2-Amino-4,5-dihydrothiophene-3-carbonitriles: A New Synthesis, Quantum Chemical Studies, and Mannich-Type Reactions Leading to New Hexahydrothieno[2,3-d]pyrimidines. ACS Omega 6:48, pages 32571-32588.
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Hao Yu, Yan Liu, Xiangwen Yang, Jiajing He, Fan Zhang, Qun Zhong & Xiaojing Guo. (2021) Strontium ranelate promotes chondrogenesis through inhibition of the Wnt/β-catenin pathway. Stem Cell Research & Therapy 12:1.
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Yishan Chen, Heng Sun, Xudong Yao, Yeke Yu, Tian Tian, Weiyang Xu, Yujie Zhou & Hongwei Ouyang. (2021) Pharmaceutical therapeutics for articular regeneration and restoration: state-of-the-art technology for screening small molecular drugs. Cellular and Molecular Life Sciences 78:24, pages 8127-8155.
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Akira Furukawa. (2021) The formation of strontium apatites through alkaline hydrolysis of strontium hydrogen phosphate and their crystallographic characterization. Ceramics International 47:15, pages 21848-21861.
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Xiaoyan Cai, Shiwen Yuan, Yanting Zeng, Cuicui Wang, Na Yu & Changhai Ding. (2021) New Trends in Pharmacological Treatments for Osteoarthritis. Frontiers in Pharmacology 12.
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Peilin Hu, Jie Du, Shuai Zhang, Ting Wang, Jun Li, Gang Chen & Guangqian Zhou. (2019) Oral Administration of Strontium Gluconate Effectively Reduces Articular Cartilage Degeneration Through Enhanced Anabolic Activity of Chondrocytes and Chondrogenetic Differentiation of Mesenchymal Stromal Cells. Biological Trace Element Research 193:2, pages 422-433.
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Nujood Ibrahim Alyousef, Yara Khalid Almaimouni, Mashael Abdullah Benrahed, Abdul Samad Khan & Saroash Shahid. 2020. Handbook of Ionic Substituted Hydroxyapatites. Handbook of Ionic Substituted Hydroxyapatites 307 325 .
Toby O. Smith, Andrew Kemp & Michael J. Twigg. (2018) Medication taking in people with hip and knee osteoarthritis: An analysis of the English Longitudinal Study of Ageing. Musculoskeletal Care 16:4, pages 450-457.
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Yamini Krishnan & Alan J. Grodzinsky. (2018) Cartilage diseases. Matrix Biology 71-72, pages 51-69.
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Pierre Maudens, Olivier Jordan & Eric Allémann. (2018) Recent advances in intra-articular drug delivery systems for osteoarthritis therapy. Drug Discovery Today 23:10, pages 1761-1775.
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Zhengping Huang, Changhai Ding, Tianwang Li & Shirley Pei-Chun Yu. (2018) Current status and future prospects for disease modification in osteoarthritis. Rheumatology 57:suppl_4, pages iv108-iv123.
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N. Vordos, G. Drosos, I. Kazanidis, A. Ververidis, P. Ypsilantis, K. Kazakos, C. Simopoulos, A. Ch. Mitropoulos & S. Touloupidis. (2018) Hydroxyapatite Crystal Thickness and Buckling Phenomenon in Bone Nanostructure During Mechanical Tests. Annals of Biomedical Engineering 46:4, pages 627-639.
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Kai Huang, Li-dong Wu & Jia-peng Bao. 2018. Dehydroepiandrosterone. Dehydroepiandrosterone 367 384 .
Dragos C Ilas, Sarah M Churchman, Dennis McGonagle & Elena Jones. (2017) Targeting subchondral bone mesenchymal stem cell activities for intrinsic joint repair in osteoarthritis. Future Science OA 3:4, pages FSO228.
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M. Pilmane, K. Salma-Ancane, D. Loca, J. Locs & L. Berzina-Cimdina. (2017) Strontium and strontium ranelate: Historical review of some of their functions. Materials Science and Engineering: C 78, pages 1222-1230.
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