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Expert Opinion on Investigational Drugs Volume 26, 2017 - Issue 10
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Review

Current drug and molecular therapies for the treatment of atrophic age-related macular degeneration: phase I to phase III clinical development

Huiling LiDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, ChinaView further author information
,
Sumana R. ChintalapudiDepartment of Ophthalmology, The Hamilton Eye Institute, The University of Tennessee Health Science Center, Memphis, TN, USA;Department of Anatomy and Neurobiology, The University of Tennessee Health Science Center, Memphis, TN, USAView further author information
&
Monica M. JablonskiDepartment of Ophthalmology, The Hamilton Eye Institute, The University of Tennessee Health Science Center, Memphis, TN, USA;Department of Anatomy and Neurobiology, The University of Tennessee Health Science Center, Memphis, TN, USA;Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, Memphis, TN, USACorrespondence[email protected]
View further author information
Pages 1103-1114 | Received 25 Oct 2016, Accepted 15 Aug 2017, Published online: 24 Aug 2017

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Clemente Capasso & Jean-Yves Winum. (2019) Novel method of treating macular degeneration: a patent evaluation (WO2018/107005). Expert Opinion on Therapeutic Patents 29:10, pages 749-752.
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Articles from other publishers (14)

T. J. Hollingsworth, Xiangdi Wang, Raven N. Simpson, William A. White, Robert W. Williams & Monica M. Jablonski. 2023. Retinal Degenerative Diseases XIX. Retinal Degenerative Diseases XIX 371 376 .
Zhongdi Chu, Yingying Shi, Xiao Zhou, Liang Wang, Hao Zhou, Rita Laiginhas, Qinqin Zhang, Yuxuan Cheng, Mengxi Shen, Luis de Sisternes, Mary K. Durbin, William Feuer, Giovanni Gregori, Philip J. Rosenfeld & Ruikang K. Wang. (2022) Optical Coherence Tomography Measurements of the Retinal Pigment Epithelium to Bruch Membrane Thickness Around Geographic Atrophy Correlate With Growth. American Journal of Ophthalmology 236, pages 249-260.
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Zhongdi Chu, Liang Wang, Xiao Zhou, Yingying Shi, Yuxuan Cheng, Rita Laiginhas, Hao Zhou, Mengxi Shen, Qinqin Zhang, Luis de Sisternes, Aaron Y. Lee, Giovanni Gregori, Philip J. Rosenfeld & Ruikang K. Wang. (2022) Automatic geographic atrophy segmentation using optical attenuation in OCT scans with deep learning. Biomedical Optics Express 13:3, pages 1328.
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Sara Romero-Vazquez, Víctor Llorens, Alba Soler-Boronat, Marc Figueras-Roca, Alfredo Adan & Blanca Molins. (2021) Interlink between Inflammation and Oxidative Stress in Age-Related Macular Degeneration: Role of Complement Factor H. Biomedicines 9:7, pages 763.
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Ho Hin Ma & Rasa Liutkevičienė. (2021) Age-Related Macular Degeneration: What Do We Know So Far?. Acta medica Lituanica 28:1, pages 36-47.
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Sudha Priya Soundara Pandi, J. Arjuna Ratnayaka, Andrew J. Lotery & Jessica L. Teeling. (2021) Progress in developing rodent models of age-related macular degeneration (AMD). Experimental Eye Research 203, pages 108404.
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Alicia Arranz-Romera, Maria Hernandez, Patricia Checa-Casalengua, Alfredo Garcia-Layana, Irene T. Molina-Martinez, Sergio Recalde, Michael J. Young, Budd A. Tucker, Rocío Herrero-Vanrell, Patricia Fernandez-Robredo & Irene Bravo-Osuna. (2021) A Safe GDNF and GDNF/BDNF Controlled Delivery System Improves Migration in Human Retinal Pigment Epithelial Cells and Survival in Retinal Ganglion Cells: Potential Usefulness in Degenerative Retinal Pathologies. Pharmaceuticals 14:1, pages 50.
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Chao Chen, Jingmeng Chen, Yan Wang, Zuguo Liu & Yalin Wu. (2021) Ferroptosis drives photoreceptor degeneration in mice with defects in all-trans-retinal clearance. Journal of Biological Chemistry 296, pages 100187.
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Wenpei Chen, Bingqing Lin, Shichuan Xie, Wei Yang, Junli Lin, Zhaojia Li, Yaxian Zhan, Shuhua Gui & Baoqin Lin. (2021) Naringenin protects RPE cells from NaIO3-induced oxidative damage in vivo and in vitro through up-regulation of SIRT1. Phytomedicine 80, pages 153375.
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Mengling You, Xiaobo Xia, Haibo Li, Jiayu Wu, Rong Rong, Zhou Zeng, Kun Xiong, Jufang Huang, Luosheng Tang, Hetian Lei, Wenyi Wu & Dan Ji. (2020) Normal vitreous promotes angiogenesi via the epidermal growth factor receptor. The FASEB Journal 34:11, pages 14799-14809.
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Marcella Nebbioso, Alessandro Lambiase, Alberto Cerini, Paolo Giuseppe Limoli, Maurizio La Cava & Antonio Greco. (2019) Therapeutic Approaches with Intravitreal Injections in Geographic Atrophy Secondary to Age-Related Macular Degeneration: Current Drugs and Potential Molecules. International Journal of Molecular Sciences 20:7, pages 1693.
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Eveline Kersten, Maartje J. Geerlings, Marc Pauper, Jordi Corominas, Bjorn Bakker, Lebriz Altay, Sascha Fauser, Eiko K. de Jong, Carel B. Hoyng & Anneke I. den Hollander. (2018) Genetic screening for macular dystrophies in patients clinically diagnosed with dry age‐related macular degeneration. Clinical Genetics 94:6, pages 569-574.
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Yanli Wei, Hongxia Liao & Jian Ye. (2018) Therapeutic effects of various therapeutic strategies on non-exudative age-related macular degeneration. Medicine 97:21, pages e10422.
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Charlotte J. Pattison & Viktor I. Korolchuk. 2018. Biochemistry and Cell Biology of Ageing: Part I Biomedical Science. Biochemistry and Cell Biology of Ageing: Part I Biomedical Science 25 47 .

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