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Expert Opinion on Investigational Drugs Volume 30, 2021 - Issue 11
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Review

Differentiation between emerging non-steroidal and established steroidal mineralocorticoid receptor antagonists: head-to-head comparisons of pharmacological and clinical characteristics

Jonatan Barrera-Chimala Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico;b Unidad de Investigación UNAM-INC, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoView further author information
,
Peter Kolkhofc Heart and Vascular Diseases, R&D Preclinical Research, Bayer AG, GermanyView further author information
,
Ixchel Lima-Posadad Centre de Recherche Des Cordeliers, Sorbonne Université, Université de Paris, Paris, FranceView further author information
,
Joachim Alexandree Normandy University, University of Caen Normandy, Centre Hospitalier Universitaire (CHU) de Caen Normandie, Department of Pharmacology, Ea 4650, Signalisation, Électrophysiologie Et Imagerie Des Lésions d’Ischémie-Reperfusion Myocardique, Caen, FranceView further author information
,
Patrick Rossignolf Université de Lorraine, Inserm, Centre d’Investigations Cliniques Plurithématique - 1433, and Inserm U1116; Chru Nancy; F-crin Ini-crct, Nancy, FranceView further author information
&
Frederic Jaisserd Centre de Recherche Des Cordeliers, Sorbonne Université, Université de Paris, Paris, France;f Université de Lorraine, Inserm, Centre d’Investigations Cliniques Plurithématique - 1433, and Inserm U1116; Chru Nancy; F-crin Ini-crct, Nancy, FranceCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-9051-1901View further author information
ORCID Icon
Pages 1141-1157 | Received 14 Sep 2021, Accepted 02 Nov 2021, Published online: 06 Dec 2021

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Marta Lorente-Ros, Jose S Aguilar-Gallardo, Aayush Shah, Bharat Narasimhan & Wilbert S. Aronow. (2022) An overview of mineralocorticoid receptor antagonists as a treatment option for patients with heart failure: the current state-of-the-art and future outlook. Expert Opinion on Pharmacotherapy 23:15, pages 1737-1751.
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Articles from other publishers (15)

Orly Vardeny & Hailee Houle. (2023) Patient selection for mineralocorticoid receptor antagonists in heart failure with mildly reduced or preserved ejection fraction. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy.
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Ruolin Lv, Lili Xu, Lin Che, Song Liu, Yangang Wang & Bingzi Dong. (2023) Cardiovascular-renal protective effect and molecular mechanism of finerenone in type 2 diabetic mellitus. Frontiers in Endocrinology 14.
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Asadur Rahman, Nourin Jahan, Md Tanvir Rahman & Akira Nishiyama. (2023) Potential Impact of Non-Steroidal Mineralocorticoid Receptor Antagonists in Cardiovascular Disease. International Journal of Molecular Sciences 24:3, pages 1922.
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Qi Chen, Yingnan Liang, Jiaxin Yan, Yiran Du, Mengbi Li, Zhenjie Chen & Jingwei Zhou. (2023) Efficacy and safety of non-steroidal mineralocorticoid receptor antagonists for renal outcomes: A systematic review and meta-analysis. Diabetes Research and Clinical Practice 195, pages 110210.
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Peter J. Fuller, Morag J. Young, Jun Yang & Timothy J. Cole. 2023.
Vincent D. Salvador & George L. Bakris. (2022) Novel antihypertensive agents for resistant hypertension: what does the future hold?. Hypertension Research 45:12, pages 1918-1928.
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Kerstin Folkerts, Aurelie Millier, Beata Smela, Elzbieta Olewinska, Niklas Schmedt, Paul Mernagh & Csaba P. Kovesdy. (2022) Real-world evidence for steroidal mineralocorticoid receptor antagonists in patients with chronic kidney disease. Journal of Nephrology.
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Christoph Wanner, Paola Fioretto, Csaba P. Kovesdy, Jolanta Malyszko, Roberto Pecoits‐Filho, Oliver Schnell & Patrick Rossignol. (2022) Potassium management with finerenone: Practical aspects. Endocrinology, Diabetes & Metabolism 5:6.
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Peter Kolkhof, Robert Lawatscheck, Gerasimos Filippatos & George L. Bakris. (2022) Nonsteroidal Mineralocorticoid Receptor Antagonism by Finerenone—Translational Aspects and Clinical Perspectives across Multiple Organ Systems. International Journal of Molecular Sciences 23:16, pages 9243.
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Aderonke E. Igbekele, George Jia, Michael A. Hill, James R. Sowers & Guanghong Jia. (2022) Mineralocorticoid Receptor Activation in Vascular Insulin Resistance and Dysfunction. International Journal of Molecular Sciences 23:16, pages 8954.
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Panagiotis I. Georgianos & Rajiv Agarwal. (2022) Management of hypertension in advanced kidney disease. Current Opinion in Nephrology & Hypertension 31:4, pages 374-379.
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Jonatan Barrera-Chimal, Casimiro Gerarduzzi, Patrick Rossignol & Frédéric Jaisser. (2022) The non-steroidal mineralocorticoid receptor antagonist finerenone is a novel therapeutic option for patients with Type 2 diabetes and chronic kidney disease. Clinical Science 136:12, pages 1005-1017.
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Toru Iijima, Makoto Katoh, Kei Takedomi, Yasuo Yamamoto, Hidenori Akatsuka, Naritoshi Shirata, Akito Nishi, Misae Takakuwa, Yoshinori Watanabe, Hitomi Munakata, Naomi Koyama, Tomoko Ikeda, Taku Iguchi, Harutoshi Kato, Kohei Kikkawa & Takayuki Kawaguchi. (2022) Discovery of Apararenone (MT-3995) as a Highly Selective, Potent, and Novel Nonsteroidal Mineralocorticoid Receptor Antagonist. Journal of Medicinal Chemistry 65:12, pages 8127-8143.
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Xiao Lin, Muhammad Hasnain Ehsan Ullah, Xiong Wu, Feng Xu, Su-Kang Shan, Li-Min Lei, Ling-Qing Yuan & Jun Liu. (2022) Cerebro-Cardiovascular Risk, Target Organ Damage, and Treatment Outcomes in Primary Aldosteronism. Frontiers in Cardiovascular Medicine 8.
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Qi Chen, Yingnan Liang, Jiaxin Yan, Yiran Du, Mengbi Li, Zhenjie Chen & Jingwei Zhou. (2022) Efficacy and Safety of Non-Steroidal Mineralocorticoid Receptor Antagonists for Renal Outcomes: A Systematic Review and Meta-Analysis. SSRN Electronic Journal.
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