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Original Article

Testosterone metabolism, dose–response relationships and receptor polymorphisms: selected pharmacological/toxicological considerations on benefits versus risks of testosterone therapy in men

Pages 230-256 | Published online: 06 Jul 2009

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Scott Segal, Ramesh Narayanan & James T Dalton. (2006) Therapeutic potential of the SARMs: revisiting the androgen receptor for drug discovery. Expert Opinion on Investigational Drugs 15:4, pages 377-387.
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Articles from other publishers (21)

Lucas Germain, Camille Lafront, Virginie Paquette, Bertrand Neveu, Jean-Sébastien Paquette, Frédéric Pouliot & Étienne Audet-Walsh. (2023) Preclinical models of prostate cancer — modelling androgen dependency and castration resistance in vitro, ex vivo and in vivo. Nature Reviews Urology 20:8, pages 480-493.
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Andrew Richard McCullough & Mehvish Khan. (2022) Testosterone Replacement Options. Urologic Clinics of North America 49:4, pages 679-693.
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A.S. Meakin & V.L. Clifton. (2019) Review: Understanding the role of androgens and placental AR variants: Insight into steroid-dependent fetal-placental growth and development. Placenta 84, pages 63-68.
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Andrea Camargo Casquero, Jairo Augusto Berti, Laura Lauand Sampaio Teixeira & Helena Coutinho Franco de Oliveira. (2017) Chronic Exercise Reduces CETP and Mesterolone Treatment Counteracts Exercise Benefits on Plasma Lipoproteins Profile: Studies in Transgenic Mice. Lipids 52:12, pages 981-990.
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Michael B. Cook, Frank Z. Stanczyk, Shannon N. Wood, Ruth M. Pfeiffer, Muhannad Hafi, Carmela C. Veneroso, Barlow Lynch, Roni T. Falk, Cindy Ke Zhou, Shelley Niwa, Eric Emanuel, Yu-Tang Gao, George P. Hemstreet, Ladan Zolfghari, Peter R. Carroll, Michael J. Manyak, Isabell A. Sesterhann, Paul H. Levine & Ann W. Hsing. (2017) Relationships between Circulating and Intraprostatic Sex Steroid Hormone Concentrations. Cancer Epidemiology, Biomarkers & Prevention 26:11, pages 1660-1666.
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Esther Imperlini, Annamaria ManciniAndreina AlfieriDomenico Martone, Marianna Caterino, Stefania OrrùPasqualina Buono. (2015) Molecular effects of supraphysiological doses of doping agents on health. Molecular BioSystems 11:6, pages 1494-1506.
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P.S. Rao. 2014. Encyclopedia of Toxicology. Encyclopedia of Toxicology 230 233 .
Wenqing Gao. (2010) Androgen receptor as a therapeutic target. Advanced Drug Delivery Reviews 62:13, pages 1277-1284.
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Esther Imperlini, Annamaria Mancini, Sara Spaziani, Domenico Martone, Andreina Alfieri, Marica Gemei, Luigi Del Vecchio, Pasqualina Buono & Stefania Orrù. (2010) Androgen receptor signaling induced by supraphysiological doses of dihydrotestosterone in human peripheral blood lymphocytes. PROTEOMICS 10:17, pages 3165-3175.
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Michael Kendler, Evgenia Makrantonaki, Jürgen Kratzsch, Ulf Anderegg, Tino Wetzig, Christos Zouboulis & Jan C. Simon. (2010) Elevated sex steroid hormones in great saphenous veins in men. Journal of Vascular Surgery 51:3, pages 639-646.
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James T. Dalton & Wenqing Gao. 2010. Nuclear Receptors. Nuclear Receptors 143 182 .
Susan Kovats, Esther Carreras & Hemant Agrawal. 2010. Sex Hormones and Immunity to Infection. Sex Hormones and Immunity to Infection 53 91 .
Jay R Hoffman, William J Kraemer, Shalender Bhasin, Thomas Storer, Nicholas A Ratamess, G Gregory Haff, Darryn S Willoughby & Alan D Rogol. (2009) Position Stand on Androgen and Human Growth Hormone Use. Journal of Strength and Conditioning Research 23:Supplement 5, pages S1-S59.
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Bruno LunenfeldMichael Oettel. (2009) Therapeutic potential of testosterone gels. Aging Health 5:2, pages 227-245.
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Fabrice Piu, Luis R. Gardell, Thomas Son, Nathalie Schlienger, Birgitte W. Lund, Hans H. Schiffer, Kim E. Vanover, Robert E. Davis, Roger Olsson & Stefania Risso Bradley. (2008) Pharmacological characterization of AC-262536, a novel selective androgen receptor modulator. The Journal of Steroid Biochemistry and Molecular Biology 109:1-2, pages 129-137.
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Wenqing Gao & James T. Dalton. (2007) Expanding the therapeutic use of androgens via selective androgen receptor modulators (SARMs). Drug Discovery Today 12:5-6, pages 241-248.
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Wenqing Gao, Juhyun Kim & James T. Dalton. (2006) Pharmacokinetics and Pharmacodynamics of Nonsteroidal Androgen Receptor Ligands. Pharmaceutical Research 23:8, pages 1641-1658.
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Ryuto NAKAZAWA, Katsuyuki BABA, Masaru NAKANO, Takuyuki KATABAMI, Nobuhiko SAITO, Takesi TAKAHASHI & Teruaki IWAMOTO. (2006) Hormone Profiles after Intramuscular Injection of Testosterone Enanthate in Patients with Hypogonadism. Endocrine Journal 53:3, pages 305-310.
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Wenqing Gao, Casey E. Bohl & James T. Dalton. (2005) Chemistry and Structural Biology of Androgen Receptor. Chemical Reviews 105:9, pages 3352-3370.
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C. Pérez-Martínez, S. Ureta Sánchez, I.B. Vargas Días, L. Gómez, L. Zegarra-Montes, J.F. Uribe-Arcila, R. Fragas-Valdez & R. Szemat. (2005) Proyecto de las recomendaciones de prevención, diagnóstico, tratamiento y seguimiento de la andropausia o hipogonadismo de inicio tardío de la Sociedad Latino Americana para el Estudio del Hombre Maduro (LASSAM). Revista Internacional de Andrología 3:1, pages 38-46.
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Prathibha S. Rao & Harihara M. Mehendale. 2005. Encyclopedia of Toxicology. Encyclopedia of Toxicology 121 125 .

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