1,044
Views
45
CrossRef citations to date
0
Altmetric
Review

Effects of phytoestrogens on bone mineral density during the menopause transition: a systematic review of randomized, controlled trials

, ORCID Icon, &
Pages 535-545 | Received 11 Jul 2016, Accepted 15 Sep 2016, Published online: 06 Oct 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Soomin Lim, Hye Jung Ihn, Ju Ang Kim, Jong-Sup Bae, Jung-Eun Kim, Yong Chul Bae, Hong-In Shin, Tae Hoon Kim & Eui Kyun Park. (2023) Suppressive effects of (-)-tubaic acid on RANKL-induced osteoclast differentiation and bone resorption. Animal Cells and Systems 27:1, pages 1-9.
Read now
X.-Y. Yi, Z.-H. Wang & Y. Wang. (2021) Genistein for glycolipid metabolism in postmenopausal women: a meta-analysis. Climacteric 24:3, pages 267-274.
Read now
H. Matsushita, S. Shimizu, N. Morita, K. Watanabe & A. Wakatsuki. (2021) Effects of royal jelly on bone metabolism in postmenopausal women: a randomized, controlled study. Climacteric 24:2, pages 164-170.
Read now
I. J. Rowe & R. J. Baber. (2021) The effects of phytoestrogens on postmenopausal health. Climacteric 24:1, pages 57-63.
Read now
Ángela Peirotén, Daniel Bravo & José M. Landete. (2020) Bacterial metabolism as responsible of beneficial effects of phytoestrogens on human health. Critical Reviews in Food Science and Nutrition 60:11, pages 1922-1937.
Read now

Articles from other publishers (40)

Volker Ziller. (2023) Knochengesundheit in der PostmenopauseBone health in the postmenopause. Journal für Gynäkologische Endokrinologie/Österreich 33:2, pages 73-83.
Crossref
Alexa Barad & Kimberly O. O'Brien. 2023. Encyclopedia of Human Nutrition. Encyclopedia of Human Nutrition 612 621 .
Maryam Noori, Ahmad Jayedi, Tauseef Ahmad Khan, Sajjad Moradi & Sakineh Shab-Bidar. (2022) Mediterranean dietary pattern and bone mineral density: a systematic review and dose-response meta-analysis of observational studies. European Journal of Clinical Nutrition 76:12, pages 1657-1664.
Crossref
S. Swathi Krishna, Beena Briget Kuriakose & P. K. Lakshmi. (2022) Effects of phytoestrogens on reproductive organ health. Archives of Pharmacal Research 45:12, pages 849-864.
Crossref
Saeedeh Hosseini Hooshiar, Mohammad Tobeiha & Sadegh Jafarnejad. (2022) Soy Isoflavones and Bone Health: Focus on the RANKL/RANK/OPG Pathway. BioMed Research International 2022, pages 1-10.
Crossref
Volker Ziller. (2022) Knochengesundheit in der PostmenopauseBone health in the postmenopause. Gynäkologische Endokrinologie 20:3, pages 170-177.
Crossref
Valeria Rodríguez, María Rivoira, Gabriela Picotto, Gabriela Díaz de Barboza, Alejandro Collin & Nori Tolosa de Talamoni. (2022) Analysis of the Molecular Mechanisms by Flavonoids with Potential Use for Osteoporosis Prevention or Therapy. Current Medicinal Chemistry 29:16, pages 2913-2936.
Crossref
. (2022) Management of Postmenopausal Osteoporosis. Obstetrics & Gynecology 139:4, pages 698-717.
Crossref
Jurga Andreja Kazlauskaite, Liudas Ivanauskas, Mindaugas Marksa & Jurga Bernatoniene. (2022) The Effect of Traditional and Cyclodextrin-Assisted Extraction Methods on Trifolium pratense L. (Red Clover) Extracts Antioxidant Potential. Antioxidants 11:2, pages 435.
Crossref
Yong Cui, Hui Cai, Wei Zheng & Xiao‐Ou Shu. (2021) Associations of Dietary Intakes of Calcium, Magnesium, and Soy Isoflavones With Bone Fracture Risk in Men: A Prospective Study. JBMR Plus 6:2.
Crossref
Yong Cui, Hui Cai, Yutang Gao, Qi Dai, Gong Yang, Wei Zheng & Xiao-Ou Shu. (2022) Associations of dietary intakes of calcium, magnesium and soy isoflavones with osteoporotic fracture risk in postmenopausal women: a prospective study. Journal of Nutritional Science 11.
Crossref
Mohammed M. Alshehri, Javad Sharifi-Rad, Jesús Herrera-Bravo, Evelyn L. Jara, Luis A. Salazar, Dorota Kregiel, Yadav Uprety, Muhammad Akram, Mehwish Iqbal, Miquel Martorell, Margalida Torrens-Mas, Daniel Gabriel Pons, Sevgi Durna Daştan, Natália Cruz-Martins, Fethi Ahmet Ozdemir, Manoj Kumar & William C. Cho. (2021) Therapeutic Potential of Isoflavones with an Emphasis on Daidzein. Oxidative Medicine and Cellular Longevity 2021, pages 1-15.
Crossref
Soo In Sohn, Subramani Pandian, Young Ju Oh, Hyeon Jung Kang, Woo Suk Cho & Youn Sung Cho. (2021) Metabolic Engineering of Isoflavones: An Updated Overview. Frontiers in Plant Science 12.
Crossref
Wojciech Słupski, Paulina Jawień & Beata Nowak. (2021) Botanicals in Postmenopausal Osteoporosis. Nutrients 13:5, pages 1609.
Crossref
M. I. Mazitova, I. R. Talipova & R. R. Mardieva. (2021) Phytoestrogens in treatment of climacteric syndrome as an alternative to menopausal hormone therapy. Obstetrics, Gynecology and Reproduction 14:6, pages 685-693.
Crossref
Saioa Gómez-Zorita, Maitane González-Arceo, Alfredo Fernández-Quintela, Itziar Eseberri, Jenifer Trepiana & María Puy Portillo. (2020) Scientific Evidence Supporting the Beneficial Effects of Isoflavones on Human Health. Nutrients 12:12, pages 3853.
Crossref
Daniel L. KrinskyCydney E. McQueen & Katherine Kelly Orr. 2020. Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care, 20th Edition. Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care, 20th Edition.
Chad C. CarrollShivam H. PatelJessica SimmonsBen DH. GordonJay F. OlsonKali ChemelewskiShannon SawTaben M. HaleReuben HowdenArman Sabbaghi. (2020) The Impact of Genistein Supplementation on Tendon Functional Properties and Gene Expression in Estrogen-Deficient Rats. Journal of Medicinal Food 23:12, pages 1266-1274.
Crossref
Ji Eon Kim, Hyeyun Jeong, Soohee Hur, Junho Lee & Oran Kwon. (2020) Efficacy and Safety of Kudzu Flower–Mandarin Peel on Hot Flashes and Bone Markers in Women during the Menopausal Transition: A Randomized Controlled Trial. Nutrients 12:11, pages 3237.
Crossref
K. Sansai, M. Na Takuathung, R. Khatsri, S. Teekachunhatean, N. Hanprasertpong & N. Koonrungsesomboon. (2020) Effects of isoflavone interventions on bone mineral density in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials. Osteoporosis International 31:10, pages 1853-1864.
Crossref
Marta Carnovali, Giuseppe Banfi & Massimo Mariotti. (2020) Liquiritigenin reduces osteoclast activity in zebrafish model of glucocorticoid-induced osteoporosis. Journal of Pharmacological Sciences 143:4, pages 300-306.
Crossref
Amelia K Wesselink, Elizabeth E Hatch, Ellen M Mikkelsen, Ellen Trolle, Sydney K Willis, Susan E McCann, Liisa Valsta, Annamari Lundqvist, Katherine L. Tucker, Kenneth J Rothman & Lauren A Wise. (2020) Dietary phytoestrogen intakes of adult women are not strongly related to fecundability in 2 preconception cohort studies. The Journal of Nutrition 150:5, pages 1240-1251.
Crossref
Sabrina B. Cepeda, Marisa J. Sandoval, María Carla Crescitelli, María Belén Rauschemberger & Virginia L. Massheimer. (2020) The isoflavone genistein enhances osteoblastogenesis: signaling pathways involved. Journal of Physiology and Biochemistry 76:1, pages 99-110.
Crossref
Marijana Tucak, Tihomir Čupić, Daniela Horvat, Svetislav Popović, Goran Krizmanić & Marija Ravlić. (2020) Variation of Phytoestrogen Content and Major Agronomic Traits in Alfalfa (Medicago sativa L.) Populations. Agronomy 10:1, pages 87.
Crossref
Zhao-min Liu, Bailing Chen, Shuyi Li, Guoyi Li, Di Zhang, Suzanne C. Ho, Yu-ming Chen, Jing Ma, Huang Qi & Wen-hua Ling. (2020) Effect of whole soy and isoflavones daidzein on bone turnover and inflammatory markers: a 6-month double-blind, randomized controlled trial in Chinese postmenopausal women who are equol producers. Therapeutic Advances in Endocrinology and Metabolism 11, pages 204201882092055.
Crossref
Emanuele Chisari, Nitin Shivappa & Shraddha Vyas. (2019) Polyphenol-Rich Foods and Osteoporosis. Current Pharmaceutical Design 25:22, pages 2459-2466.
Crossref
Neil Zheng, Evelyn Hsieh, Hui Cai, Liang Shi, Kai Gu, Ying Zheng, Ping-Ping Bao & Xiao-Ou Shu. (2019) Soy Food Consumption, Exercise, and Body Mass Index and Osteoporotic Fracture Risk Among Breast Cancer Survivors: The Shanghai Breast Cancer Survival Study. JNCI Cancer Spectrum 3:2.
Crossref
Evangelia Mareti, Christina Abatzi, Dimitrios Vavilis, Irene Lambrinoudaki & Dimitrios G. Goulis. (2019) Effect of oral phytoestrogens on endometrial thickness and breast density of perimenopausal and postmenopausal women: A systematic review and meta-analysis. Maturitas 124, pages 81-88.
Crossref
Sandrasekaran Naresh, Mei Kying Ong, Kokila Thiagarajah, Norliza Binti Shah Jehan Muttiah, Balakrishnan Kunasundari & Huey Shi Lye. 2019. Non-Alcoholic Beverages. Non-Alcoholic Beverages 329 361 .
Max Norman Tandrup Lambert & Per Bendix Jeppesen. (2018) Isoflavones and bone health in perimenopausal and postmenopausal women. Current Opinion in Clinical Nutrition & Metabolic Care 21:6, pages 475-480.
Crossref
Manoj K. Pandey, Subash C. Gupta, Deepkamal Karelia, Patrick J. Gilhooley, Mehdi Shakibaei & Bharat B. Aggarwal. (2018) Dietary nutraceuticals as backbone for bone health. Biotechnology Advances 36:6, pages 1633-1648.
Crossref
Alison M. Duncan. 2018. Vegetarian Nutrition and Wellness. Vegetarian Nutrition and Wellness 173 190 .
Yunqi Xiao, Shan Zhang, Haibing Tong & Shourong Shi. (2018) Comprehensive evaluation of the role of soy and isoflavone supplementation in humans and animals over the past two decades. Phytotherapy Research 32:3, pages 384-394.
Crossref
Myungsuk Kim, Jisun Lim, Jung-Hee Lee, Kyung-Mi Lee, Suji Kim, Kye Won Park, Chu Won Nho & Yoon Shin Cho. (2018) Understanding the functional role of genistein in the bone differentiation in mouse osteoblastic cell line MC3T3-E1 by RNA-seq analysis. Scientific Reports 8:1.
Crossref
Hiroya KADOKAWA, Kiran PANDEY, Kereilwe ONALENNA & Asrafun NAHAR. (2018) Reconsidering the roles of endogenous estrogens and xenoestrogens: the membrane estradiol receptor G protein-coupled receptor 30 (GPR30) mediates the effects of various estrogens. Journal of Reproduction and Development 64:3, pages 203-208.
Crossref
Juan F. Rodríguez-Landa, Abraham Puga-Olguín, León J. Germán-Ponciano, Oscar J. Olmos-Vázquez & Blandina Bernal-Morales. 2018. 133 159 .
Hubertine M.E. Willems, Ellen G.H.M. van den Heuvel, Ruud J.W. Schoemaker, Jenneke Klein-Nulend & Astrid D. Bakker. (2017) Diet and Exercise: a Match Made in Bone. Current Osteoporosis Reports 15:6, pages 555-563.
Crossref
Da‐Hye Lee, Min Jung Kim, Jiyun Ahn, Sang Hee Lee, Hyunjung Lee, Jin Hee Kim, So‐Hyun Park, Young‐Jin Jang, Tae‐Youl Ha & Chang Hwa Jung. (2017) Nutrikinetics of Isoflavone Metabolites After Fermented Soybean Product (Cheonggukjang) Ingestion in Ovariectomized Mice. Molecular Nutrition & Food Research 61:12, pages 1700322.
Crossref
Valerie Little, Kevin Reed & Kevin Smith. (2017) Variation for Concentrations of Various Phytoestrogens and Agronomic Traits Among a Broad Range of Red Clover (Trifolium pratense) Cultivars and Accessions. Agronomy 7:2, pages 34.
Crossref
Masumeh GhazanfarpourElham AminiTalat KhadivzadehMasoudeh BabakhanianBahareh NouriHassan RakhshandehMaliheh Afiat. (2017) The Effect of Short-term Treatment with Fennel on Bone Density in Postmenopausal Women: A Randomized Controlled Trial. Journal of Menopausal Medicine 23:2, pages 124.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.