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Archives of Physiology and Biochemistry
The Journal of Metabolic Diseases
Volume 115, 2009 - Issue 4: Special Issue: Adipose Tissue Function and Dysfunction: Organ Cross-Talk and Metabolic Risk
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Review Article

PRAS40: Target or modulator of mTORC1 signalling and insulin action?

Emmani B.M. NascimentoDepartment of Molecular Cell Biology, Section Signal Transduction and Ageing, Leiden University Medical Centre, Leiden, The Netherlands
&
D. Margriet OuwensDepartment of Molecular Cell Biology, Section Signal Transduction and Ageing, Leiden University Medical Centre, Leiden, The NetherlandsCorrespondence[email protected]
Pages 163-175 | Received 14 Apr 2009, Accepted 21 Apr 2009, Published online: 28 May 2009

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Qun Zhou, Shengsong Tang, Xianhui Zhang & Linxi Chen. (2021) Targeting PRAS40: a novel therapeutic strategy for human diseases. Journal of Drug Targeting 29:7, pages 703-715.
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SubbaRao V. Madhunapantula & Gavin P. Robertson. (2017) Targeting protein kinase-b3 (akt3) signaling in melanoma. Expert Opinion on Therapeutic Targets 21:3, pages 273-290.
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Uyanga Chuluunbaatar & Ian Mohr. (2011) A herpesvirus kinase that masquerades as Akt. Cell Cycle 10:13, pages 2064-2068.
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Articles from other publishers (23)

Zaid I. I. Al-Luhaibi, Áron Dernovics, György Seprényi, Ferhan Ayaydin, Zsolt Boldogkői, Zoltán Veréb & Klára Megyeri. (2021) IL-36α and Lipopolysaccharide Cooperatively Induce Autophagy by Triggering Pro-Autophagic Biased Signaling. Biomedicines 9:11, pages 1541.
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Hui Yi Chew, Priscila O. De Lima, Jazmina L. Gonzalez Cruz, Blerida Banushi, Godwins Echejoh, Lingbo Hu, Shannon R. Joseph, Benedict Lum, James Rae, Jake S. O’Donnell, Lilia Merida de Long, Satomi Okano, Brigid King, Rachael Barry, Davide Moi, Roberta Mazzieri, Ranjeny Thomas, Fernando Souza-Fonseca-Guimaraes, Matthew Foote, Adam McCluskey, Phillip J. Robinson, Ian H. Frazer, Nicholas A. Saunders, Robert G. Parton, Riccardo Dolcetti, Katharine Cuff, Jennifer H. Martin, Benedict Panizza, Euan Walpole, James W. Wells & Fiona Simpson. (2020) Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies. Cell 180:5, pages 895-914.e27.
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F Hu, X Deng, X Yang, H Jin, D Gu, X Lv, C Wang, Y Zhang, X Huo, Q Shen, Q Luo, F Zhao, T Ge, F Zhao, W Chu, H Shu, M Yao, J Fan & W Qin. (2015) Hypoxia upregulates Rab11-family interacting protein 4 through HIF-1α to promote the metastasis of hepatocellular carcinoma. Oncogene 34:49, pages 6007-6017.
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Janani Panneerselvam, Manish Shanker, Jiankang Jin, Cynthia D. Branch, Ranganayaki Muralidharan, Yan D. Zhao, Sunil Chada, Anupama Munshi & Rajagopal Ramesh. (2015) Phosphorylation of interleukin (IL)-24 is required for mediating its anti-cancer activity. Oncotarget 6:18, pages 16271-16286.
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J J Havel, Z Li, D Cheng, J Peng & H Fu. (2014) Nuclear PRAS40 couples the Akt/mTORC1 signaling axis to the RPL11-HDM2-p53 nucleolar stress response pathway. Oncogene 34:12, pages 1487-1498.
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Xiangmin Zhang, Danjun Ma, Michael Caruso, Monique Lewis, Yue Qi & Zhengping Yi. (2014) Quantitative phosphoproteomics reveals novel phosphorylation events in insulin signaling regulated by protein phosphatase 1 regulatory subunit 12A. Journal of Proteomics 109, pages 63-75.
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Claudia Wiza, Emmani B.M. Nascimento, Margot M.L. Linssen, Françoise Carlotti, Daniella Herzfeld de Wiza, Gerard C.M. van der Zon, J. Antonie Maassen, Michaela Diamant, Bruno Guigas & D. Margriet Ouwens. (2013) Proline-rich Akt substrate of 40-kDa contains a nuclear export signal. Cellular Signalling 25:9, pages 1762-1768.
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Wanyeon Kim, HyeSook Youn, TaeWoo Kwon, JiHoon Kang, EunGi Kim, Beomseok Son, Hee Jung Yang, Youngmi Jung & BuHyun Youn. (2013) PIM1 kinase inhibitors induce radiosensitization in non-small cell lung cancer cells. Pharmacological Research 70:1, pages 90-101.
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Yanqing Xu, Amanda Parmar, Emmanuelle Roux, Alejandro Balbis, Victor Dumas, Stephanie Chevalier & Barry I. Posner. (2012) Epidermal Growth Factor-induced Vacuolar (H+)-ATPase Assembly. Journal of Biological Chemistry 287:31, pages 26409-26422.
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Claudia Wiza, Emmani B. M. Nascimento & D. Margriet Ouwens. (2012) Role of PRAS40 in Akt and mTOR signaling in health and disease. American Journal of Physiology-Endocrinology and Metabolism 302:12, pages E1453-E1460.
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Di Wu, Jessica R. Chapman, Lifu Wang, Thurl E. Harris, Jeffrey Shabanowitz, Donald F. Hunt & Zheng Fu. (2012) Intestinal Cell Kinase (ICK) Promotes Activation of mTOR Complex 1 (mTORC1) through Phosphorylation of Raptor Thr-908. Journal of Biological Chemistry 287:15, pages 12510-12519.
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Lin Huang, Yuji Nakai, Iku Kuwahara & Ken Matsumoto. (2012) PRAS40 Is a Functionally Critical Target for EWS Repression in Ewing Sarcoma. Cancer Research 72:5, pages 1260-1269.
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Christiane Fuchs, Margit Rosner, Helmut Dolznig, Mario Mikula, Nina Kramer & Markus Hengstschläger. (2012) Tuberin and PRAS40 are anti-apoptotic gatekeepers during early human amniotic fluid stem-cell differentiation. Human Molecular Genetics 21:5, pages 1049-1061.
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Mashiko Setshedi, Lisa Longato, Dennis R. Petersen, Martin Ronis, William C. Chen, Jack R. Wands & Suzanne M. de la Monte. (2011) Limited Therapeutic Effect of N-Acetylcysteine on Hepatic Insulin Resistance in an Experimental Model of Alcohol-Induced Steatohepatitis. Alcoholism: Clinical and Experimental Research 35:12, pages 2139-2151.
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Shuai Chen, Silvia Synowsky, Michele Tinti & Carol MacKintosh. (2011) The capture of phosphoproteins by 14-3-3 proteins mediates actions of insulin. Trends in Endocrinology & Metabolism 22:11, pages 429-436.
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Michael Haidinger, Johannes Werzowa, Thomas Weichhart & Marcus D. Säemann. (2011) Targeting the dysregulated mammalian target of rapamycin pathway in organ transplantation: killing 2 birds with 1 stone. Transplantation Reviews 25:4, pages 145-153.
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Wanyeon Kim, HyeSook Youn, Ki Moon Seong, Hee Jung Yang, Young Ju Yun, TaeWoo Kwon, Young Ha Kim, Ji Young Lee, Young-Woo Jin & BuHyun Youn. (2011) PIM1-Activated PRAS40 Regulates Radioresistance in Non-small Cell Lung Cancer Cells through Interplay with FOXO3a, 14-3-3 and Protein Phosphatases. Radiation Research 176:5, pages 539.
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X. Wang & C. G. Proud. (2010) mTORC1 signaling: what we still don't know. Journal of Molecular Cell Biology 3:4, pages 206-220.
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E E Vincent, D J E Elder, E C Thomas, L Phillips, C Morgan, J Pawade, M Sohail, M T May, M R Hetzel & J M Tavaré. (2011) Akt phosphorylation on Thr308 but not on Ser473 correlates with Akt protein kinase activity in human non-small cell lung cancer. British Journal of Cancer 104:11, pages 1755-1761.
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Abid A. Kazi, Anne M. Pruznak, Robert A. Frost & Charles H. Lang. (2011) Sepsis-Induced Alterations in Protein-Protein Interactions Within mTOR Complex 1 and the Modulating Effect of Leucine on Muscle Protein Synthesis. Shock 35:2, pages 117-125.
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Emmani B.M. Nascimento, Marieke Snel, Bruno Guigas, Gerard C.M. van der Zon, Jan Kriek, J. Antonie Maassen, Ingrid M. Jazet, Michaela Diamant & D. Margriet Ouwens. (2010) Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1. Cellular Signalling 22:6, pages 961-967.
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Coby B. Carlson, Michael J. Mashock & Kun Bi. (2010) BacMam-Enabled LanthaScreen® Cellular Assays for PI3K/Akt Pathway Compound Profiling in Disease-Relevant Cell Backgrounds. SLAS Discovery 15:3, pages 327-334.
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Aurelio A. Teleman. (2009) Molecular mechanisms of metabolic regulation by insulin in Drosophila . Biochemical Journal 425:1, pages 13-26.
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