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Research Article

Antidepressant Effect of Baicalin Extracted from the Root of Scutellaria baicalensis. in Mice and Rats

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Pages 503-510 | Accepted 19 Apr 2006, Published online: 07 Oct 2008

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Arval Viji Elango, Sahana Vasudevan, Karthi Shanmugam, Adline Princy Solomon & Prasanna Neelakantan. (2021) Exploring the anti-caries properties of baicalin against Streptococcus mutans: an in vitro study. Biofouling 37:3, pages 267-275.
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Li Tu, Zhuo-Yu Wu, Xiu-Lin Yang, Qian Zhang, Ran Gu, Qian Wang, Tian Tian, Huan Yao, Xiang Qu & Jin-Yong Tian. (2019) Neuroprotective effect and mechanism of baicalin on Parkinson’s disease model induced by 6-OHDA. Neuropsychiatric Disease and Treatment 15, pages 3615-3625.
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Mahalaxmi Mohan, Deepali Attarde, Rehan Momin & Sanjay Kasture. (2013) Antidepressant, anxiolytic and adaptogenic activity of torvanol A: an isoflavonoid from seeds of Solanum torvum. Natural Product Research 27:22, pages 2140-2143.
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Yun-Heng Shen, Yun Zhou, Chuan Zhang, Run-Hui Liu, Juan Su, Xiao-Hua Liu & Wei-Dong Zhang. (2009) Antidepressant effects of methanol extract and fractions of Bacopa monnieri. Pharmaceutical Biology 47:4, pages 340-343.
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Marcelina Chmiel & Monika Stompor-Gorący. (2023) Promising Role of the Scutellaria baicalensis Root Hydroxyflavone–Baicalein in the Prevention and Treatment of Human Diseases. International Journal of Molecular Sciences 24:5, pages 4732.
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Risha Ganguly, Ramesh Kumar & Abhay K Pandey. (2022) Baicalin provides protection against fluoxetine-induced hepatotoxicity by modulation of oxidative stress and inflammation. World Journal of Hepatology 14:4, pages 729-743.
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Xuefei Mao, Zhi Li, Baogang Li & Haiping Wang. (2021) Baicalin regulates mRNA expression of VEGF‐c, Ang‐1/Tie2, TGF‐β and Smad2/3 to inhibit wound healing in streptozotocin‐induced diabetic foot ulcer rats. Journal of Biochemical and Molecular Toxicology 35:11.
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Samar A Rizk, Manal A Elsheikh, Yosra S R Elnaggar & Ossama Y Abdallah. (2021) Novel bioemulsomes for baicalin oral lymphatic targeting: development, optimization and pharmacokinetics. Nanomedicine 16:22, pages 1983-1998.
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Benny Antony, A.P.A. Aravind, Merina Benny, Nishant K. Gupta, Biji Joseph & Anu Sebastian. (2020) Bioactivity Guided Fractionation and Purification of Anti-Depressant Molecule from Ashwagandha (Withania somnifera). Current Bioactive Compounds 16:5, pages 681-686.
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Fiona Limanaqi, Francesca Biagioni, Carla Letizia Busceti, Maico Polzella, Cinzia Fabrizi & Francesco Fornai. (2020) Potential Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea. Antioxidants 9:3, pages 234.
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Esra Küpeli Akkol, Fatma Tuğçe Gürağaç Dereli & Mert Ilhan. (2019) Assessment of Antidepressant Effect of the Aerial Parts of Micromeria myrtifolia Boiss. & Hohen on Mice. Molecules 24:10, pages 1869.
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Kandhasamy Sowndhararajan, Ponnuvel Deepa, Minju Kim, Se Park & Songmun Kim. (2018) Neuroprotective and Cognitive Enhancement Potentials of Baicalin: A Review. Brain Sciences 8:6, pages 104.
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Samira EghbaliFeriz, Akram Taleghani & Zahra Tayarani-Najaran. (2018) Central nervous system diseases and Scutellaria: a review of current mechanism studies. Biomedicine & Pharmacotherapy 102, pages 185-195.
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León Jesús German-Ponciano, Gilberto Uriel Rosas-Sánchez, Eduardo Rivadeneyra-Domínguez & Juan Francisco Rodríguez-Landa. (2018) Advances in the Preclinical Study of Some Flavonoids as Potential Antidepressant Agents. Scientifica 2018, pages 1-14.
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Qi Zhang, Fei Guo, Zhi-wen Fu, Bing Zhang, Cheng-gang Huang & Yang Li. (2015) Timosaponin derivative YY-23 acts as a non-competitive NMDA receptor antagonist and exerts a rapid antidepressant-like effect in mice. Acta Pharmacologica Sinica 37:2, pages 166-176.
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Roodabeh Bahramsoltani, Mohammad Hosein Farzaei, Marzieh Sarbandi Farahani & Roja Rahimi. (2015) Phytochemical constituents as future antidepressants: a comprehensive review. Reviews in the Neurosciences 26:6, pages 699-719.
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Kuo Zhang, Fang Wang, Jing-yu Yang, Li-juan Wang, Huan-huan Pang, Guang-yue Su, Jie Ma, Shao-jiang Song, Zhi-li Xiong & Chun-fu Wu. (2015) Analysis of main constituents and mechanisms underlying antidepressant-like effects of Xiaochaihutang in mice. Journal of Ethnopharmacology 175, pages 48-57.
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Marzieh Sarbandi Farahani, Roodabeh Bahramsoltani, Mohammad Hosein Farzaei, Mohammad Abdollahi & Roja Rahimi. (2015) Plant-derived natural medicines for the management of depression: an overview of mechanisms of action. Reviews in the Neurosciences 26:3.
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Simone Carradori, Melissa D’Ascenzio, Paola Chimenti, Daniela Secci & Adriana Bolasco. (2013) Selective MAO-B inhibitors: a lesson from natural products. Molecular Diversity 18:1, pages 219-243.
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G. Negri, D. Santi & R. Tabach. (2013) Flavonol glycosides found in hydroethanolic extracts from Tilia cordata, a species utilized as anxiolytics. Revista Brasileira de Plantas Medicinais 15:2, pages 217-224.
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Nelson G.M. Gomes, Maria G. Campos, João M.C. Órfão & Carlos A.F. Ribeiro. (2009) Plants with neurobiological activity as potential targets for drug discovery. Progress in Neuro-Psychopharmacology and Biological Psychiatry 33:8, pages 1372-1389.
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Weixing Wang, Xinying Hu, Zhiyu Zhao, Peng Liu, Yuchi Hu, Jianping Zhou, Dongfeng Zhou, Zhibin Wang, Dean Guo & Hongzhu Guo. (2008) Antidepressant-like effects of liquiritin and isoliquiritin from Glycyrrhiza uralensis in the forced swimming test and tail suspension test in mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry 32:5, pages 1179-1184.
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