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Pharmaceutical Biology Volume 54, 2016 - Issue 12
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Research Article

Effects of berberine on the pharmacokinetics of losartan and its metabolite EXP3174 in rats and its mechanism

Hong LiDepartment of Endocrinology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, P.R. China; Correspondence[email protected]
,
Lu LiuDepartment of Endocrinology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, P.R. China;
,
Lei XieBiliary Tract Surgery Department 1, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, P.R. China; ;Ningbo Cancer Hospital, Shanghai Wu Meng Chao Cancer Center, Ningbo City, Zhejiang Province, P.R. China;
,
Dongmei GanDepartment of Paediatrics, Ningbo Women and Children’s Hospital, Ningbo, Zhejiang Province, P.R. China
&
Xiaoqing JiangBiliary Tract Surgery Department 1, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, P.R. China; Correspondence[email protected]
Pages 2886-2894 | Received 05 Sep 2015, Accepted 12 May 2016, Published online: 21 Jun 2016

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Yingying Huang & Minglei Xue. (2023) Combination of losartan and puerarin induced pharmacokinetic interaction in hypertension rats enhances the antihypertensive effect of losartan. Xenobiotica 53:3, pages 201-206.
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Jie Zhang, Lu Liu, Hong Li & Bin Zhang. (2021) Pharmacokinetic study on the interaction between pachymic acid and bavachin and its potential mechanism. Pharmaceutical Biology 59:1, pages 1254-1257.
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Guiying Zhang, Yanping Zhang, Xianjie Ma, Xin Yang, Yuyan Cai & Wenli Yin. (2021) Pogostone inhibits the activity of CYP3A4, 2C9, and 2E1 in vitro. Pharmaceutical Biology 59:1, pages 530-534.
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Haihua Shang, Ze Wang, Hong Ma, Yinghui Sun, Xiaoyan Ci, Yuan Gu, Changxiao Liu & Duanyun Si. (2021) Influence of verapamil on the pharmacokinetics of rotundic acid in rats and its potential mechanism. Pharmaceutical Biology 59:1, pages 198-206.
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Abdul Ahad, Mohammad Raish, Yousef A. Bin Jardan, Mohd Aftab Alam, Abdullah M. Al-Mohizea & Fahad I. Al-Jenoobi. (2020) Effect of Hibiscus sabdariffa and Zingiber officinale on the antihypertensive activity and pharmacokinetic of losartan in hypertensive rats. Xenobiotica 50:7, pages 847-857.
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Jianling Yang, Yuanyuan Li, Yang Li, Xueqi Rui, Meiqing Du & Zengfu Wang. (2020) Effects of atorvastatin on pharmacokinetics of amlodipine in rats and its potential mechanism. Xenobiotica 50:6, pages 685-688.
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Kai Wang, Qing Gao, Tingting Zhang, Jinqiu Rao, Liqin Ding & Feng Qiu. (2020) Inhibition of CYP2C9 by natural products: insight into the potential risk of herb-drug interactions. Drug Metabolism Reviews 52:2, pages 235-257.
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Yang Liu, Jiaqi Zhang, Di Wu & Liran Cui. (2020) Pharmacokinetic interaction study between ligustrazine and valsartan in rats and its potential mechanism. Pharmaceutical Biology 58:1, pages 1299-1302.
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Xiuyuan Han, Haixia Zhang, Huihui Hao, Hangao Li, Xichun Guo & Dong Zhang. (2019) Effect Of epigallocatechin-3-gallate on the pharmacokinetics of amlodipine in rats. Xenobiotica 49:8, pages 970-974.
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Qingling Zhao, Jinlan Wei & Hongying Zhang. (2019) Effects of quercetin on the pharmacokinetics of losartan and its metabolite EXP3174 in rats. Xenobiotica 49:5, pages 563-568.
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Tonghui Li, Jijun Liu, Yingying Zheng, Shengchang Yang, Xun Liu & Xuejing Li. (2019) Effects of triptolide on pharmacokinetics of fenofibrate in rats and its potential mechanism. Xenobiotica 49:2, pages 211-215.
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Wei Liu, Guozhi Liu & Jing Liu. (2019) Effects of astragaloside IV on the pharmacokinetics of omeprazole in rats. Pharmaceutical Biology 57:1, pages 449-452.
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Qun Zhao, Yingli Wang, Hongqin Wang & Lichun Feng. (2018) Effects of glycyrrhizin on the pharmacokinetics of puerarin in rats. Xenobiotica 48:11, pages 1157-1163.
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Baiping Dong, Suowei Yuan, Jinsheng Hu & Yanzhen Yan. (2018) Effects of Ginkgo leaf tablets on the pharmacokinetics of losartan and its metabolite EXP3174 in rats and its mechanism. Pharmaceutical Biology 56:1, pages 333-336.
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Zengfu Wang, Dali Chen & Zhongwei Wang. (2018) Effects of diclofenac on the pharmacokinetics of celastrol in rats and its transport. Pharmaceutical Biology 56:1, pages 269-274.
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Ling Guo, Ying Cui & Kaijun Hao. (2018) Effects of glycyrrhizin on the pharmacokinetics of asiatic acid in rats and its potential mechanism. Pharmaceutical Biology 56:1, pages 119-123.
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Xianming Wang, Xin Zhang, Fei Liu, Minghai Wang & Shiyong Qin. (2017) The effects of triptolide on the pharmacokinetics of sorafenib in rats and its potential mechanism. Pharmaceutical Biology 55:1, pages 1863-1867.
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Yuzhen Jia, Binger Xu & Jisen Xu. (2017) Effects of type 2 diabetes mellitus on the pharmacokinetics of berberine in rats. Pharmaceutical Biology 55:1, pages 510-515.
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Articles from other publishers (10)

Fan Wu, Mingyu Cui, Siwen Wang, Chao Yu, Weihong Yin, Jiao Li & Xueying Yan. (2023) Effect of Berberine on Pharmacokinetics and Pharmacodynamics of Atorvastatin in Hyperlipidemia Rats. Xenobiotica, pages 1-27.
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Wenhao Cheng, Kexin Xia, Siyang Wu & Yingfei Li. (2023) Herb-Drug Interactions and Their Impact on Pharmacokinetics: An Update. Current Drug Metabolism 24:1, pages 28-69.
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Ayesha Tanveer, Khalid Hussain, Hirra Tasneem, Iqra Arif, Memoona Rashid, Nasir Abbas, Rahat Shamim, Pervaiz A. Shah & Nadeem Irfan Bukhari. (2022) Prediction of CYP-mediated silybin A-losartan pharmacokinetic interactions using physiological based pharmacokinetic modeling. Journal of Pharmacokinetics and Pharmacodynamics 49:3, pages 311-323.
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Guofei Li, Mingming Zhao & Limei Zhao. (2022) The drug interaction potential of berberine hydrochloride when co-administered with simvastatin, fenofibrate, gemfibrozil, metformin, glimepiride, nateglinide, pioglitazone and sitagliptin in beagles. Arabian Journal of Chemistry 15:2, pages 103562.
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Maria D. Auxtero, Susana Chalante, Mário R. Abade, Rui Jorge & Ana I. Fernandes. (2021) Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction. Pharmaceutics 13:1, pages 124.
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Abdul Ahad, Mohammad Raish, Yousef A. Bin Jardan, Mohd Aftab Alam, Abdullah M. Al-Mohizea & Fahad I. Al-Jenoobi. (2020) Potential pharmacodynamic and pharmacokinetic interactions of Nigella Sativa and Trigonella Foenum-graecum with losartan in L-NAME induced hypertensive rats. Saudi Journal of Biological Sciences 27:10, pages 2544-2550.
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Krishna Sriram & Paul A. Insel. (2020) Risks of ACE Inhibitor and ARB Usage in COVID‐19: Evaluating the Evidence. Clinical Pharmacology & Therapeutics 108:2, pages 236-241.
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Jian-Qi Zhang, Guo-Hong Yang, Xin Zhou, Jun-Xiang Liu, Rui Shi, Yan Dong, Shao-Bo Chen & Yu-Ming Li. (2019) Effects of allisartan isoproxil on blood pressure and target organ injury in patients with mild to moderate essential hypertension. Medicine 98:12, pages e14907.
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Beth Buchanan, Qingfang Meng, Mathieu-Marc Poulin, Jonathan Zuccolo, Chike Godwin Azike, Joseph Gabriele & David Charles Baranowski. (2018) Comparative pharmacokinetics and safety assessment of transdermal berberine and dihydroberberine. PLOS ONE 13:3, pages e0194979.
Crossref
Nilanjan Ghosh, Rituparna C. Ghosh, Anindita Kundu & Subhash C. Mandal. 2018. Natural Products and Drug Discovery. Natural Products and Drug Discovery 467 490 .

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