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Scandinavian Cardiovascular Journal Volume 37, 2003 - Issue 6
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Article

N‐Acetylcysteine as an additive to crystalloid cardioplegia increased oxidative stress capacity in CABG patients

Antti E. Vento Department of Thoracic and Cardiovascular Surgery, Helsinki University Central Hospital, Helsinki, FinlandCorrespondence[email protected]
,
Arto Nemlander Department of Thoracic and Cardiovascular Surgery, Helsinki University Central Hospital, Helsinki, Finland
,
Juha Aittomäki Department of Thoracic and Cardiovascular Surgery, Helsinki University Central Hospital, Helsinki, Finland
,
Jarmo Salo Department of Thoracic and Cardiovascular Surgery, Helsinki University Central Hospital, Helsinki, Finland
,
Janne Karhunen Department of Thoracic and Cardiovascular Surgery, Helsinki University Central Hospital, Helsinki, Finland
&
O. Juhani Rämö Department of Thoracic and Cardiovascular Surgery, Helsinki University Central Hospital, Helsinki, Finland
Pages 349-355 | Received 31 Jul 2002, Accepted 18 Jun 2003, Published online: 12 Jul 2009

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Su Jin Kang, Young Joon Lee, Byeong Mo Kim, Young Joo Choi & Hai Won Chung. (2011) Cytotoxicity and genotoxicity of titanium dioxide nanoparticles in UVA-irradiated normal peripheral blood lymphocytes. Drug and Chemical Toxicology 34:3, pages 277-284.
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Yuqi Cui, Qiang Zhu, Hong Hao, Gregory C. Flaker & Zhenguo Liu. (2023) N-Acetylcysteine and Atherosclerosis: Promises and Challenges. Antioxidants 12:12, pages 2073.
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Riccardo Giuseppe Abbasciano, Sara Tomassini, Marius A Roman, Angelica Rizzello, Suraj Pathak, Joussi Ramzi, Carla Lucarelli, Georgia Layton, Ayesha Butt, Florence Lai, Tracy Kumar, Marcin J Wozniak & Gavin J Murphy. (2023) Effects of interventions targeting the systemic inflammatory response to cardiac surgery on clinical outcomes in adults. Cochrane Database of Systematic Reviews 2023:10.
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Amirhossein Yazdi, Nakisa Khansari, Maryam Mehrpooya, Younes Mohammadi & Shiva Zareie. (2021) Oral N-acetylcysteine as an adjunct to standard medical therapy improved heart function in cases with stable class II and III systolic heart failure. Irish Journal of Medical Science (1971 -) 191:5, pages 2063-2075.
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Jingtao Zhao, Maowei Li & Chen Tan. (2022) Efficacy of N-acetylcysteine in Preventing Acute Kidney Injury and Major Adverse Cardiac Events After Cardiac Surgery: A Meta-Analysis and Trial Sequential Analysis. Frontiers in Medicine 9.
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José Eduardo G. Pereira, Regina El Dib, Leandro G. Braz, Janaina Escudero, Jason Hayes & Bradley C. Johnston. (2019) N-acetylcysteine use among patients undergoing cardiac surgery: A systematic review and meta-analysis of randomized trials. PLOS ONE 14:5, pages e0213862.
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Richard Eugene Frye. 2019. The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine. The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine 331 348 .
Daniel Fudulu & Gianni Angelini. (2016) Oxidative Stress after Surgery on the Immature Heart. Oxidative Medicine and Cellular Longevity 2016, pages 1-10.
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Mustafa Zakkar, Gustavo Guida, M-Saadeh Suleiman & Gianni D. Angelini. (2015) Cardiopulmonary Bypass and Oxidative Stress. Oxidative Medicine and Cellular Longevity 2015, pages 1-8.
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Mehmet Ozaydin, Oktay Peker, Dogan Erdogan, Selahaddin Akcay, Habil Yucel, Atilla Icli, Betul M. Ceyhan, Recep Sutcu, Bayram A. Uysal, Ercan Varol, Abdullah Dogan & Huseyin Okutan. (2014) Oxidative Status, Inflammation, and Postoperative Atrial Fibrillation With Metoprolol vs Carvedilol or Carvedilol Plus N‐Acetyl Cysteine Treatment. Clinical Cardiology 37:5, pages 300-306.
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Mehmet Ozaydin, Tulay Peker, Selahaddin Akcay, Bayram A. Uysal, Habil Yucel, Atilla Icli, Dogan Erdogan, Ercan Varol, Abdullah Dogan & Huseyin Okutan. (2014) Addition of N-Acetyl Cysteine to Carvedilol Decreases the Incidence of Acute Renal Injury After Cardiac Surgery. Clinical Cardiology 37:2, pages 108-114.
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Richard Hall. (2013) Identification of Inflammatory Mediators and Their Modulation by Strategies for the Management of the Systemic Inflammatory Response During Cardiac Surgery. Journal of Cardiothoracic and Vascular Anesthesia 27:5, pages 983-1033.
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Mehmet Ozaydin, Dogan Erdogan, Habil Yucel, Oktay Peker, Atilla Icli, Selahaddin Akcay, Mustafa Etli, Betul M. Ceyhan, Recep Sutcu, Ercan Varol, Abdullah Dogan & Turhan Yavuz. (2013) N-acetyl cysteine for the conversion of atrial fibrillation into sinus rhythm after cardiac surgery: A prospective, randomized, double-blind, placebo-controlled pilot study. International Journal of Cardiology 165:3, pages 580-583.
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M. Ozaydin, A. Icli, H. Yucel, S. Akcay, O. Peker, D. Erdogan, E. Varol, A. Dogan & H. Okutan. (2012) Metoprolol vs. carvedilol or carvedilol plus N-acetyl cysteine on post-operative atrial fibrillation: a randomized, double-blind, placebo-controlled study. European Heart Journal 34:8, pages 597-604.
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Juliana C. Fantinelli, Luisa F. González Arbeláez, Ignacio A. Pérez Núñez & Susana M. Mosca. (2013) Protective effects of N-(2-mercaptopropionyl)-glycine against ischemia–reperfusion injury in hypertrophied hearts. Experimental and Molecular Pathology 94:1, pages 277-284.
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Mohammed Aldakkak, David F. Stowe, James S. Heisner, Matthias L. Riess & Amadou K. S. Camara. (2011) Adding ROS Quenchers to Cold K + Cardioplegia Reduces Superoxide Emission During 2-Hour Global Cold Cardiac Ischemia . Journal of Cardiovascular Pharmacology and Therapeutics 17:1, pages 93-101.
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Azita Hajhossein Talasaz, Hossein Khalili, Fanak Fahimi & Salarifar Mojtaba. (2011) Potential role of N -acetylcysteine in cardiovascular disorders . Therapy 8:3, pages 237-245.
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Jean-Christophe Charniot, Dominique Bonnefont-Rousselot, Jean-Paul Albertini, Sylvie Dever, Noelle Vignat, Patrick Nataf, Alain Pavie, Jean-Jacques Monsuez, Jacques Delattre & Jean-Yves Artigou. (2010) Oxidative Stress Implication After Prolonged Storage Donor Heart with Blood Versus Crystalloid Cardioplegia and Reperfusion Versus Static Storage. Journal of Surgical Research 160:2, pages 308-314.
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Rajat Sethi, Adriana Adameova, Ken S. Dhalla, Mohsin Khan, Vijayan Elimban & Naranjan S. Dhalla. (2009) Modification of Epinephrine-induced Arrhythmias by N-Acetyl-L-Cysteine and Vitamin E. Journal of Cardiovascular Pharmacology and Therapeutics 14:2, pages 134-142.
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Duminda N. Wijeysundera, Keyvan Karkouti, Vivek Rao, John T. Granton, Christopher T. Chan, Roshan Raban, Jo Carroll, Humara Poonawala & W Scott Beattie. (2009) N-acetylcysteine is associated with increased blood loss and blood product utilization during cardiac surgery*. Critical Care Medicine 37:6, pages 1929-1934.
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Jordan L. Holtzman. 2008. Atherosclerosis and Oxidant Stress. Atherosclerosis and Oxidant Stress 211 239 .
Ismail Koramaz, Zerrin Pulathan, Sefer Usta, S. Caner Karahan, Ahmet Alver, Ersin Yaris, Nuri Ihsan Kalyoncu & Fahri Ozcan. (2006) Cardioprotective Effect of Cold-Blood Cardioplegia Enriched with N-Acetylcysteine During Coronary Artery Bypass Grafting. The Annals of Thoracic Surgery 81:2, pages 613-618.
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H. J. Geissler & U. Mehlhorn. (2006) Cold crystalloid cardioplegia. Multimedia Manual of Cardio-Thoracic Surgery 2006:0109.
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Tomi T Niemi, Edward Munsterhjelm, Reino Pöyhiä, Marja S Hynninen & Markku T Salmenperä. (2006) The effect of N-acetylcysteine on blood coagulation and platelet function in patients undergoing open repair of abdominal aortic aneurysm. Blood Coagulation & Fibrinolysis 17:1, pages 29-34.
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