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Human Fertility
an international, multidisciplinary journal dedicated to furthering research and promoting good practice
Volume 9, 2006 - Issue 3
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Original

Can ‘abnormally’ fertilized zygotes give rise to viable embryos?

Katie Feenan Newcastle Fertility Centre, Bioscience Centre, International Centre for Life, Times Square, Newcastle upon Tyne, NE1 4EP, UKCorrespondence[email protected]
&
Mary Herbert Newcastle Fertility Centre, Bioscience Centre, International Centre for Life, Times Square, Newcastle upon Tyne, NE1 4EP, UK
Pages 157-169 | Published online: 03 Jul 2009

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Lei Fu, Dapeng Chu, Wenhui Zhou & Yuan Li. (2022) Strictly selected Mono- and non-pronuclear blastocysts could result in appreciable clinical outcomes in IVF cycles. Human Fertility 25:3, pages 470-477.
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. (2012) Association of Clinical Embryologists – Guidelines on Good Practice in Clinical Embryology Laboratories 2012. Human Fertility 15:4, pages 174-189.
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Articles from other publishers (28)

Chelsea Canon, Anabel Thurman, Albert Li, Carlos Hernandez-Nieto, Joseph A. Lee, Rose Marie Roth, Richard Slifkin, Christine Briton-Jones, Daniel Stein & Alan B. Copperman. (2023) Assessing the clinical viability of micro 3 pronuclei zygotes. Journal of Assisted Reproduction and Genetics 40:7, pages 1765-1772.
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Chen Chen, Wenzhi Li, Mingru Yin, Menghui Li, Ling Wu, Jiqiang Si, Leiwen Zhao, Bin Li, Zheng Yan & Qifeng Lyu. (2022) Does the cell number of 0PN embryos on day 3 affect pregnancy and neonatal outcomes following single blastocyst transfer?. BMC Pregnancy and Childbirth 22:1.
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Lei Fu, Wenhui Zhou & Yuan Li. (2021) Development and frozen-thawed transfer of non-pronuclear zygotes-derived embryos in IVF cycles. European Journal of Obstetrics & Gynecology and Reproductive Biology 264, pages 206-211.
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Nuria Soler, Rosa Bautista-Llàcer, Laura Escrich, Andrea Oller, Noelia Grau, Raquel Tena, María Fernanda Insua, Paloma Ferrer, María-José Escribà & Xavier Vendrell. (2021) Rescuing monopronucleated-derived human blastocysts: a model to study chromosomal topography and fingerprinting. Fertility and Sterility 116:2, pages 583-596.
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Alan H. Handyside, Abeo McCollin, Michael C. Summers & Christian S. Ottolini. (2020) Copy number analysis of meiotic and postzygotic mitotic aneuploidies in trophectoderm cells biopsied at the blastocyst stage and arrested embryos. Prenatal Diagnosis 41:5, pages 525-535.
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Ming Li, Jin Huang, Xinjie Zhuang, Shengli Lin, Yujiao Dang, Ying Wang, Dandan Liu, Rong Li, Ping Liu & Jie Qiao. (2021) Obstetric and neonatal outcomes after the transfer of vitrified-warmed blastocysts developing from nonpronuclear and monopronuclear zygotes: a retrospective cohort study. Fertility and Sterility 115:1, pages 110-117.
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Adelle Yun Xin Lim & Colin Soon Soo Lee. (2019) Embryos Arising from Apronuclear (0PN) and Unipronuclear (1PN) Have Similar Euploidy Rates with Those from 2PN and Should be Considered for Transfer. Fertility & Reproduction 01:02, pages 73-77.
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Aspasia Destouni, Eftychia Dimitriadou, Heleen Masset, Sophie Debrock, Cindy Melotte, Kris Van Den Bogaert, Masoud Zamani Esteki, Jia Ding, Thiery Voet, Ellen Denayer, Thomy de Ravel, Eric Legius, Christel Meuleman, Karen Peeraer & Joris R Vermeesch. (2018) Genome-wide haplotyping embryos developing from 0PN and 1PN zygotes increases transferrable embryos in PGT-M. Human Reproduction.
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Bryan Woodward. 2018. Clinical Reproductive Science. Clinical Reproductive Science 291 302 .
Tuğba Kotil, M. Ertan Kervancıoğlu, Gülçin Ekter Kanten, Gülden Tunalı & Seyhun Solakoğlu. (2018) Mitochondrial activity and cytoskeleton organization in three pronuclei oocytes after intracytoplasmic sperm injection. Zygote 26:4, pages 319-325.
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Xiangjin Kang, Wenyin He, Yuling Huang, Qian Yu, Yaoyong Chen, Xingcheng Gao, Xiaofang Sun & Yong Fan. (2016) Introducing precise genetic modifications into human 3PN embryos by CRISPR/Cas-mediated genome editing. Journal of Assisted Reproduction and Genetics 33:5, pages 581-588.
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Antonio Capalbo, Christian S. Ottolini, Darren K. Griffin, Filippo Maria Ubaldi, Alan H. Handyside & Laura Rienzi. (2016) Artificial oocyte activation with calcium ionophore does not cause a widespread increase in chromosome segregation errors in the second meiotic division of the oocyte. Fertility and Sterility 105:3, pages 807-814.e2.
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Jing Liu, Xing Ling Wang, Xiao Zhang, Chun Yan Shen & Zhan Zhang. (2016) Live births resulting from 0PN-derived embryos in conventional IVF cycles. Journal of Assisted Reproduction and Genetics 33:3, pages 373-378.
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Ming Li, Shengli Lin, Yuan Chen, Jinliang Zhu, Ping Liu & Jie Qiao. (2015) Value of transferring embryos that show no evidence of fertilization at the time of fertilization assessment. Fertility and Sterility 104:3, pages 607-611.e2.
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Christine van de Werken, Godfried W. van der Heijden, Cindy Eleveld, Miriam Teeuwssen, Mareike Albert, Willy M. Baarends, Joop S. E. Laven, Antoine H. F. M. Peters & Esther B. Baart. (2014) Paternal heterochromatin formation in human embryos is H3K9/HP1 directed and primed by sperm-derived histone modifications. Nature Communications 5:1.
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Ana Raquel Azevedo, Maria João Pinho, Joaquina Silva, Rosália Sá, Sólveig Thorsteinsdóttir, Alberto Barros & Mário Sousa. (2014) Molecular Cytogenetics of Human Single Pronucleated Zygotes. Reproductive Sciences 21:12, pages 1472-1482.
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Kelly Athayde Wirka, Alice A. Chen, Joe Conaghan, Kristen Ivani, Marina Gvakharia, Barry Behr, Vaishali Suraj, Lei Tan & Shehua Shen. (2014) Atypical embryo phenotypes identified by time-lapse microscopy: high prevalence and association with embryo development. Fertility and Sterility 101:6, pages 1637-1648.e5.
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Deng Lixin, Xiang Zhifeng, He Cong, Zhang Jinzhou & Xie Hongbin. (2013) RETRACTED ARTICLE: Aneuploidy analysis of non-pronuclear embryos from IVF with use of array CGH: a case report. Journal of Molecular Histology 45:3, pages 269-274.
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Bernd Rosenbusch. (2014) The Chromosomal Constitution of Embryos Arising from Monopronuclear Oocytes in Programmes of Assisted Reproduction. International Journal of Reproductive Medicine 2014, pages 1-8.
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Jason E. Swain. (2013) Could time-lapse embryo imaging reduce the need for biopsy and PGS?. Journal of Assisted Reproduction and Genetics 30:8, pages 1081-1090.
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S?bastien Le Cruguel, V?ronique Ferr?-L?H?tellier, Catherine Morini?re, Sophie Lemerle, Pascal Reynier, Philippe Descamps & Pascale May-Panloup. (2013) Early compaction at day 3 may be a useful additional criterion for embryo transfer. Journal of Assisted Reproduction and Genetics 30:5, pages 683-690.
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Xinjie Chen, Yumei Luo, Yong Fan, Lei Yue, Xueshi Wu, Yaoyong Chen & Xiaofang Sun. (2012) Triploid and diploid embryonic stem cell lines derived from tripronuclear human zygotes. Journal of Assisted Reproduction and Genetics 29:8, pages 713-721.
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Catherine M.H. Combelles, William G. Kearns, Janis H. Fox & Catherine Racowsky. (2011) Cellular and genetic analysis of oocytes and embryos in a human case of spontaneous oocyte activation. Human Reproduction 26:3, pages 545-552.
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Lyndsey Craven, Helen A. Tuppen, Gareth D. Greggains, Stephen J. Harbottle, Julie L. Murphy, Lynsey M. Cree, Alison P. Murdoch, Patrick F. Chinnery, Robert W. Taylor, Robert N. Lightowlers, Mary Herbert & Douglass M. Turnbull. (2010) Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease. Nature 465:7294, pages 82-85.
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Qing Huan, Xuan Gao, Yan Wang, Yun Shen, Wu Ma & Zi‐Jiang Chen. (2010) Comparative evaluation of human embryonic stem cell lines derived from zygotes with normal and abnormal pronuclei. Developmental Dynamics 239:2, pages 425-438.
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Bernd E. Rosenbusch. (2009) Selective microsurgical removal of a pronucleus from tripronuclear human oocytes to restore diploidy: disregarded but valuable?. Fertility and Sterility 92:3, pages 897-903.
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Bernd E. Rosenbusch. (2008) Mechanisms giving rise to triploid zygotes during assisted reproduction. Fertility and Sterility 90:1, pages 49-55.
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Nicole Noyes, M Elizabeth Fino, Lewis Krey, Caroline McCaffrey, Alexis Adler & James Grifo. (2008) Embryo biopsy: the fate of abnormal pronuclear embryos. Reproductive BioMedicine Online 17:6, pages 782-788.
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