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Expert Opinion on Pharmacotherapy Volume 20, 2019 - Issue 1
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Review

Current and emerging medical therapeutic agents for idiopathic male infertility

Ylenia DucaDepartment of Clinical and Experimental Medicine, University of Catania, Catania, ItalyView further author information
,
Aldo E. CalogeroDepartment of Clinical and Experimental Medicine, University of Catania, Catania, ItalyView further author information
,
Rossella CannarellaDepartment of Clinical and Experimental Medicine, University of Catania, Catania, ItalyView further author information
,
Rosita A. CondorelliDepartment of Clinical and Experimental Medicine, University of Catania, Catania, ItalyView further author information
&
Sandro La VigneraDepartment of Clinical and Experimental Medicine, University of Catania, Catania, ItalyCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-7113-2372View further author information
ORCID Icon
Pages 55-67 | Received 02 Jul 2018, Accepted 29 Oct 2018, Published online: 08 Nov 2018

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Sandro La Vignera, Antonio Aversa, Rossella Cannarella, Rosita A. Condorelli, Ylenia Duca, Giorgio I. Russo & Aldo E. Calogero. (2021) Pharmacological treatment of lower urinary tract symptoms in benign prostatic hyperplasia: consequences on sexual function and possible endocrine effects. Expert Opinion on Pharmacotherapy 22:2, pages 179-189.
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Rossella Cannarella, Cristina M.B. Petralia, Rosita A. Condorelli, Antonio Aversa, Aldo E. Calogero & Sandro La Vignera. Investigational follicle-stimulating hormone receptor agonists for male infertility therapy. Expert Opinion on Investigational Drugs 0:0.
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Articles from other publishers (41)

Rossella Cannarella, Rosita A. Condorelli, Carmelo Gusmano, Vincenzo Garofalo, Antonio Aversa, Aldo E. Calogero & Sandro La Vignera. (2023) Predictive role of 17α-hydroxy-progesterone serum levels of response to follicle-stimulating hormone in patients with abnormal sperm parameters. Fertility and Sterility 120:6, pages 1193-1202.
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Lesley Haddock, Erica Gardiner & Sheena E. M. Lewis. 2023. Men's Reproductive and Sexual Health Throughout the Lifespan. Men's Reproductive and Sexual Health Throughout the Lifespan 175 182 .
Neena Ann John & Litty Joseph. (2023) Role of herbal, nutraceutical and synthetic agents in oligoasthenoteratozoospermia: A comparative assessment. Natural Resources for Human Health.
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Margit Rosner, Stefanie Horer, Michael Feichtinger & Markus Hengstschläger. (2023) Multipotent fetal stem cells in reproductive biology research. Stem Cell Research & Therapy 14:1.
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Decheng Bi, Jinfeng Huang, Jue Cao, Lijun Yao, Wushuang Guo, Zhenqing Zhang, Yan Wu, Hong Xu, Zhangli Hu & Xu Xu. (2023) Preparation, characterization and immunomodulatory effects of unsaturated sulfated oligoguluronic acid. Carbohydrate Polymers 301, pages 120370.
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Gunel Talibova, Yesim Bilmez & Saffet Ozturk. (2022) Increased double-strand breaks in aged mouse male germ cells may result from changed expression of the genes essential for homologous recombination or nonhomologous end joining repair. Histochemistry and Cell Biology 159:2, pages 127-147.
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Zhen Wang, Ziyang Zhou, Lijuan Zhang, Xujie Li, Miaoxiu Li, Yankun Pan, Tiyong Jiao, Xiaoyun Shi, Qing Liu, Congan Wang & Yongquan Wang. (2023) Efficacy and safety of nonpharmacological strategies for the treatment of oligoasthenospermia: a systematic review and Bayesian network meta-analysis. European Journal of Medical Research 28:1.
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Deniz Al-Tawalbeh, Roba Bdeir & Joud Al-Momani. (2023) The Use of Medicinal Herbs to Treat Male Infertility in Jordan: Evidence-Based Review. International Journal of Pharmaceutical Research And Allied Sciences 12:1, pages 66-74.
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Xuebao Zhang, Jie Chen, Yuanqing Cui, Yinshan Jin & Xiong Wang. (2022) FSH can improve semen parameters in patients with idiopathic oligoasthenoteratozoospermia: A systematic review and meta‐analysis . Andrologia 54:11.
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Pinelopi G. Ioannidou, Dimitrios A. Papanikolaou, Julia K. Bosdou, Dimitrios G. Goulis, Alexandros F. Lambropoulos, Grigoris F. Grimbizis & Efstratios M. Κolibianakis. (2022) Improvement in sperm quality by oral antioxidant supplementation in infertile men with varicocele who have not undergone surgical repair: Systematic review and meta‐analysis. Andrologia 54:10.
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Zumna Sharif, Muhammad Furqan Akhtar, Hamna Sharif, Ammara Saleem, Muhammad Imran Khan & Amjad Riaz. (2022) Endocrine disruption: Reproductive toxicity of glyceryl trinitrate and isosorbide mononitrate in male Wistar rats. Andrologia 54:8.
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Jian Li, Qi Wu, Ernest Hung Yu Ng, Ben Willem J. Mol, Xiao Ke Wu & Chi Chiu Wang. (2022) Effects of Medicines and Supplements on Spontaneous Pregnancy and Semen Parameters in Male Infertility: A Systematic Review Update and Network Meta-Analysis. Engineering 16, pages 198-209.
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Xue Bai, Zhejun Liu, Tian Tang, Shujun Yu, Dan Liu, Guimin Liu, Xiaolei Fan, Yibo Tang & Zhenquan Liu. (2022) An integrative approach to uncover the components, mechanisms, and functions of traditional Chinese medicine prescriptions on male infertility. Frontiers in Pharmacology 13.
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Vincenzo De Leo, Claudia Tosti, Giuseppe Morgante, Rosetta Ponchia, Alice Luddi, Laura Governini & Paola Piomboni. (2022) Positive Effect of a New Combination of Antioxidants and Natural Hormone Stimulants for the Treatment of Oligoasthenoteratozoospermia. Journal of Clinical Medicine 11:7, pages 1991.
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Matthew Hamilton, Stewart Russell, Sergey Moskovtsev, Stephen A. Krawetz & Clifford Librach. (2022) The developmental significance of sperm-borne ribonucleic acids and their potential for use as diagnostic markers for male factor infertility. F&S Reviews 3:1, pages 11-23.
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Rano Zhankina, Neda Baghban, Manarbek Askarov, Dana Saipiyeva, Almaz Ibragimov, Bakhyt Kadirova, Arezoo Khoradmehr, Iraj Nabipour, Reza Shirazi, Ulanbek Zhanbyrbekuly & Amin Tamadon. (2021) Mesenchymal stromal/stem cells and their exosomes for restoration of spermatogenesis in non-obstructive azoospermia: a systemic review. Stem Cell Research & Therapy 12:1.
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Eva Tvrdá, Filip Benko, Tomáš Slanina & Stefan S. du Plessis. (2021) The Role of Selected Natural Biomolecules in Sperm Production and Functionality. Molecules 26:17, pages 5196.
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Rossella Cannarella, Rosita A. Condorelli, Aldo E. Calogero, Vincenzo Bagnara, Antonio Aversa, Emanuela A. Greco, Antonio Brunetti & Sandro La Vignera. (2021) Effects of Selenium Supplementation on Sperm Parameters and DNA-Fragmentation Rate in Patients with Chronic Autoimmune Thyroiditis. Journal of Clinical Medicine 10:16, pages 3755.
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Konstantinos Pantos, Sokratis Grigoriadis, Penelope Tomara, Ioanna Louka, Evangelos Maziotis, Agni Pantou, Nikolaos Nitsos, Terpsithea Vaxevanoglou, Georgia Kokkali, Ashok Agarwal, Konstantinos Sfakianoudis & Mara Simopoulou. (2021) Investigating the Role of the microRNA-34/449 Family in Male Infertility: A Critical Analysis and Review of the Literature. Frontiers in Endocrinology 12.
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S. La Vignera, R. Cannarella, A. Aversa, R. Rago, R. A. Condorelli & A. E. Calogero. (2020) Leukocytospermia in late adolescents: possible clinical interpretations. Journal of Endocrinological Investigation 44:7, pages 1525-1531.
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Fernando Lopes, Patrícia Pinto‐Pinho, Isabel Gaivão, Ana Martins‐Bessa, Zélia Gomes, Osvaldo Moutinho, Maria Manuel Oliveira, Francisco Peixoto & Rosário Pinto‐Leite. (2021) Sperm DNA damage and seminal antioxidant activity in subfertile men. Andrologia 53:5.
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Federica Barbagallo, Sandro La Vignera, Rossella Cannarella, Andrea Crafa, Aldo E. Calogero & Rosita A. Condorelli. (2021) The Relationship between Seminal Fluid Hyperviscosity and Oxidative Stress: A Systematic Review. Antioxidants 10:3, pages 356.
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Haiyan Lin, Yu Li, Songbang Ou, Xuedan Jiao, Wenjun Wang, Peter Humaidan & Qingxue Zhang. (2021) Role of the total progressive motile sperm count (TPMSC) in different infertility factors in IUI: a retrospective cohort study. BMJ Open 11:2, pages e040563.
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Ashok Agarwal, Manesh Kumar Panner Selvam, Saradha Baskaran, Renata Finelli, Kristian Leisegang, Cătălina Barbăroșie, Peter Natesan Pushparaj, Kathy Amy Robert, Rafael Ambar, Concetta Iovine, Damayanthi Durairajanayagam & Ralf Henkel. (2020) A scientometric analysis of research publications on male infertility and assisted reproductive technology. Andrologia 53:1.
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Rossella Cannarella, Nicolò Musso, Rosita A. Condorelli, Marco MusmeciStefania Stefani, Sandro La Vignera & Aldo E. Calogero. (2021) Combined Effects of the FSHR 2039 A/G and FSHR -29 G/A Polymorphisms on Male Reproductive Parameters . The World Journal of Men's Health 39:3, pages 516.
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Jeremy T Choy & John K Amory. (2020) Nonsurgical Management of Oligozoospermia. The Journal of Clinical Endocrinology & Metabolism 105:12, pages e4194-e4207.
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Ankita Kaushik, Sandhya Anand & Deepa Bhartiya. (2020) Altered Biology of Testicular VSELs and SSCs by Neonatal Endocrine Disruption Results in Defective Spermatogenesis, Reduced Fertility and Tumor Initiation in Adult Mice. Stem Cell Reviews and Reports 16:5, pages 893-908.
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Angela Alamo, Claudia De Luca, Laura M. Mongioì, Federica Barbagallo, Rossella Cannarella, Sandro La Vignera, Aldo E. Calogero & Rosita A. Condorelli. (2020) Mitochondrial Membrane Potential Predicts 4-Hour Sperm Motility. Biomedicines 8:7, pages 196.
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Andrea Delbarba, Nicola Arrighi, Paolo Facondo, Carlo Cappelli & Alberto Ferlin. (2020) Positive effect of nutraceuticals on sperm DNA damage in selected infertile patients with idiopathic high sperm DNA fragmentation. Minerva Endocrinologica 45:2.
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Manuela Simoni, Giulia Brigante, Vincenzo Rochira, Daniele Santi & Livio Casarini. (2020) Prospects for FSH Treatment of Male Infertility. The Journal of Clinical Endocrinology & Metabolism 105:7, pages 2105-2118.
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Daniele Santi, Sara De Vincentis, Patrizia Alfano, Giancarlo Balercia, Aldo E. Calogero, Francesco Cargnelutti, Maria Elisabetta Coccia, Rosita A. Condorelli, Alessandro Dal Lago, Cristina Angelis, Mariagrazia Gallo, Nicola Iannantuoni, Francesco Lombardo, Angelo Marino, Marco Mazzella, Francesco Pallotti, Donatella Paoli, Rosario Pivonello, Rocco Rago, Mariarita Rampini, Gianmaria Salvio & Manuela Simoni. (2020) Use of follicle‐stimulating hormone for the male partner of idiopathic infertile couples in Italy: Results from a multicentre, observational, clinical practice survey. Andrology 8:3, pages 637-644.
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Rossella Cannarella, Rosita A. Condorelli, Laura M. Mongioì, Sandro La Vignera & Aldo E. Calogero. (2020) Molecular Biology of Spermatogenesis: Novel Targets of Apparently Idiopathic Male Infertility. International Journal of Molecular Sciences 21:5, pages 1728.
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Rosita A. Condorelli, Aldo E. Calogero, Giorgio I. Russo & Sandro La Vignera. (2020) From Spermiogram to Bio-Functional Sperm Parameters: When and Why Request Them?. Journal of Clinical Medicine 9:2, pages 406.
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Maria Salomé Bezerra Espinola & Cesare Aragona. (2019) New perspectives on male fertility evaluation: Innovative approach for the qualitative analysis of spermatozoa. Andrologia 52:1.
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Rossella Cannarella, Rosita A. Condorelli, Sandro La Vignera & Aldo E. Calogero. (2020) Terapia medica dell’infertilità maschile. L'Endocrinologo 21:1, pages 11-18.
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Rossella Cannarella, Francesco Lanzafame, Rosita Condorelli, Aldo E. Calogero & Sandro La Vignera. 2020. Male Infertility. Male Infertility 805 816 .
Víctor Blasco, Francisco M. Pinto, Cristina González-Ravina, Esther Santamaría-López, Luz Candenas & Manuel Fernández-Sánchez. (2019) Tachykinins and Kisspeptins in the Regulation of Human Male Fertility. Journal of Clinical Medicine 9:1, pages 113.
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Petr Kluson, Petr Stavarek, Vera Penkavova, Hana Vychodilova, Stanislav Hejda, Natalie Jaklova & Petra Curinova. (2019) Stereoselective synthesis of optical isomers of ethyl 4-chloro-3-hydroxybutyrate in a microfluidic chip reactor. Journal of Flow Chemistry 9:4, pages 221-230.
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Saturnino Luján, Ettore Caroppo, Craig Niederberger, Joan-Carles Arce, Ingrid Sadler-Riggleman, Daniel Beck, Eric Nilsson & Michael K. Skinner. (2019) Sperm DNA Methylation Epimutation Biomarkers for Male Infertility and FSH Therapeutic Responsiveness. Scientific Reports 9:1.
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Sandro La Vignera, Rosita A. Condorelli, Laura Cimino, Rossella Cannarella, Filippo Giacone & Aldo E. Calogero. (2019) Early Identification of Isolated Sertoli Cell Dysfunction in Prepubertal and Transition Age: Is It Time?. Journal of Clinical Medicine 8:5, pages 636.
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R. �. Nykolaichuk. (2018) MALE INFERTILITY AS A RESULT OF GENETIC DISORDERS (REVIEW). Bulletin of Problems Biology and Medicine 2:4, pages 54-.
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