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Expert Review of Molecular Diagnostics Volume 18, 2018 - Issue 8
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Review

Digital microfluidics comes of age: high-throughput screening to bedside diagnostic testing for genetic disorders in newborns

David MillingtonDepartment of Pediatrics, Duke University Medical Center, Durham, NC, USACorrespondence[email protected]
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,
Scott NortonBaebies, Inc, Durham, NC, USAView further author information
,
Raj SinghBaebies, Inc, Durham, NC, USAView further author information
,
Rama SistaBaebies, Inc, Durham, NC, USAView further author information
,
Vijay SrinivasanBaebies, Inc, Durham, NC, USAView further author information
&
Vamsee PamulaBaebies, Inc, Durham, NC, USAView further author information
Pages 701-712 | Received 30 Mar 2018, Accepted 27 Jun 2018, Published online: 13 Jul 2018

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Alberto B. Burlina & Vincenza Gragnaniello. (2022) Newborn screening of mucopolysaccharidosis type I. Critical Reviews in Clinical Laboratory Sciences 59:4, pages 257-277.
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Malik Al-Lababidi & Mohamed Abdelgawad. (2023) Minimum movable droplet volume in digital microfluidics depends on the grounding scheme in addition to electrode size. Sensors and Actuators A: Physical 355, pages 114299.
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S. Amir, A. Arathi, S. Reshma & P.V. Mohanan. (2023) Microfluidic devices for the detection of disease-specific proteins and other macromolecules, disease modelling and drug development: A review. International Journal of Biological Macromolecules 235, pages 123784.
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Ren Shen, A'man Lv, Shuhong Yi, Ping Wang, Pui-In Mak, Rui P. Martins & Yanwei Jia. (2023) Nucleic acid analysis on electrowetting-based digital microfluidics. TrAC Trends in Analytical Chemistry 158, pages 116826.
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Genaro Castillon, Shun-Chiao Chang & Yola Moride. (2022) Global Incidence and Prevalence of Gaucher Disease: A Targeted Literature Review. Journal of Clinical Medicine 12:1, pages 85.
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A. Dardis, H. Michelakakis, P. Rozenfeld, K. Fumic, J. Wagner, E. Pavan, M. Fuller, S. Revel-Vilk, D. Hughes, T. Cox & J. Aerts. (2022) Patient centered guidelines for the laboratory diagnosis of Gaucher disease type 1. Orphanet Journal of Rare Diseases 17:1.
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Rahul Eswar, C. Harrison Brodie & Christopher M. Collier. (2022) Lock-In Amplified Fluorescence Spectroscopy in a Digital Microfluidic Configuration for Antibiotic Detection of Ciprofloxacin in Milk. Journal of Microelectromechanical Systems 31:6, pages 927-934.
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Seungmin Lee, Daeyoung Lee, Minsuk Choi & Sang Kug Chung. (2022) AC EWOD-induced asymmetric droplet oscillation and manipulation. Sensors and Actuators A: Physical 347, pages 113910.
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Roy W.A. Peake. 2022. Lysosomal Storage Disorders. Lysosomal Storage Disorders 51 58 .
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Filip Pančík, Zuzana Pakanová, Filip Květoň & Peter Baráth. (2022) Diagnostics of lysosomal storage diseases by mass spectrometry: a review. Chemical Papers 76:7, pages 3995-4004.
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Mollie A. Minear, Megan N. Phillips, Alice Kau & Melissa A. Parisi. (2022) Newborn screening research sponsored by the NIH : From diagnostic paradigms to precision therapeutics . American Journal of Medical Genetics Part C: Seminars in Medical Genetics 190:2, pages 138-152.
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Kuan-Lun Ho, Hong-Yu Liao, Helene Minyi Liu, Yen-Wen Lu, Pin-Kuan Yeh, Justin Yu Chang & Shih-Kang Fan. (2022) Digital Microfluidic qPCR Cartridge for SARS-CoV-2 Detection. Micromachines 13:2, pages 196.
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Shivani Sathish & Amy Q. Shen. (2021) Toward the Development of Rapid, Specific, and Sensitive Microfluidic Sensors: A Comprehensive Device Blueprint. JACS Au 1:11, pages 1815-1833.
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Zhanwei Zhong, Tung-Che Liang & Krishnendu Chakrabarty. (2021) Enhancing the Reliability of MEDA Biochips Using IJTAG and Wear Leveling. IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems 40:10, pages 2063-2076.
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Melissa P. Wasserstein, Joseph J. Orsini, Aaron Goldenberg, Michele Caggana, Paul A. Levy, Margo Breilyn & Michael H. Gelb. (2021) The future of newborn screening for lysosomal disorders. Neuroscience Letters 760, pages 136080.
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Kerri Bosfield, Debra S. Regier, Sarah Viall, Rebecca Hicks, Natasha Shur & Christina L. Grant. (2020) Mucopolysaccharidosis type I newborn screening: Importance of second tier testing for ethnically diverse populations. American Journal of Medical Genetics Part A 185:1, pages 134-140.
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Peipei Zhou, Jinxu He, Lu Huang, Ziming Yu, Zhenning Su, Xuetao Shi & Jianhua Zhou. (2020) Microfluidic High-Throughput Platforms for Discovery of Novel Materials. Nanomaterials 10:12, pages 2514.
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Gowtham Sathyanarayanan, Markus Haapala & Tiina Sikanen. (2020) Digital Microfluidics-Enabled Analysis of Individual Variation in Liver Cytochrome P450 Activity. Analytical Chemistry 92:21, pages 14693-14701.
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Jon Washburn & David S. Millington. (2020) Digital Microfluidics in Newborn Screening for Mucopolysaccharidoses: A Progress Report. International Journal of Neonatal Screening 6:4, pages 78.
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Varun B. Kothamachu, Sabrina Zaini & Federico Muffatto. (2020) Role of Digital Microfluidics in Enabling Access to Laboratory Automation and Making Biology Programmable. SLAS Technology 25:5, pages 411-426.
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Dong Liu, Zhenghuan Yang, Luyang Zhang, Minglun Wei & Yuan Lu. (2020) Cell-free biology using remote-controlled digital microfluidics for individual droplet control. RSC Advances 10:45, pages 26972-26981.
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Mohamed Abdelgawad. (2020) Digital Microfluidics: Automating Microscale Liquid Handling. IEEE Nanotechnology Magazine 14:3, pages 6-23.
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Jia Li & Chang-Jin “CJ” Kim. (2020) Current commercialization status of electrowetting-on-dielectric (EWOD) digital microfluidics. Lab on a Chip 20:10, pages 1705-1712.
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Francyne Kubaski, Fabiano de Oliveira Poswar, Kristiane Michelin-Tirelli, Maira Graeff Burin, Diana Rojas-Málaga, Ana Carolina Brusius-Facchin, Sandra Leistner-Segal & Roberto Giugliani. (2020) Diagnosis of Mucopolysaccharidoses. Diagnostics 10:3, pages 172.
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Francyne Kubaski, Fabiano de Oliveira Poswar, Kristiane Michelin-Tirelli, Ursula da Silveira Matte, Dafne D. Horovitz, Anneliese Lopes Barth, Guilherme Baldo, Filippo Vairo & Roberto Giugliani. (2020) Mucopolysaccharidosis Type I. Diagnostics 10:3, pages 161.
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Yiqiang Fan, Xiaopeng Kong, Dongping Chai, Bin Wei & Yajun Zhang. (2020) Low‐cost and flexible film‐based digital microfluidic devices. Micro & Nano Letters 15:3, pages 163-165.
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Donald B. BaileyJrJr, Lisa M. Gehtland, Megan A. Lewis, Holly Peay, Melissa Raspa, Scott M. Shone, Jennifer L. Taylor, Anne C. Wheeler, Michael Cotten, Nancy M. P. King, Cynthia M. Powell, Barbara Biesecker, Christine E. Bishop, Beth Lincoln Boyea, Martin Duparc, Blake A. Harper, Alex R. Kemper, Stacey N. Lee, Rebecca Moultrie, Katherine C. Okoniewski, Ryan S. Paquin, Denise Pettit, Katherine Ackerman Porter & Scott J. Zimmerman. (2019) Early Check: translational science at the intersection of public health and newborn screening. BMC Pediatrics 19:1.
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Urice N. Tohgha, Ernest L. Alvino, Clark C. Jarnagin, Scott T. Iacono & Nicholas P. Godman. (2019) Electrowetting Behavior and Digital Microfluidic Applications of Fluorescent, Polymer-Encapsulated Quantum Dot Nanofluids. ACS Applied Materials & Interfaces 11:31, pages 28487-28498.
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Feng, Shirani & Inglis. (2019) Droplets for Sampling and Transport of Chemical Signals in Biosensing: A Review. Biosensors 9:2, pages 80.
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Zipeng Li, Krishnendu Chakrabarty, Tsung-Yi Ho & Chen-Yi LeeZipeng Li, Krishnendu Chakrabarty, Tsung-Yi Ho & Chen-Yi Lee. 2019. Micro-Electrode-Dot-Array Digital Microfluidic Biochips. Micro-Electrode-Dot-Array Digital Microfluidic Biochips 1 20 .
Philipp Skrinjar, Markus Schwarz, Stefan Lexmüller, Thomas P. Mechtler, Maximilian Zeyda, Susanne Greber-Platzer, Joe Trometer, David C. Kasper & Hannes Mikula. (2018) Rapid and Modular Assembly of Click Substrates To Assay Enzyme Activity in the Newborn Screening of Lysosomal Storage Disorders. ACS Central Science 4:12, pages 1688-1696.
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