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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 17, 2002 - Issue 5
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Research Article

Some 3-(4-Aminophenyl)pyrrolidine-2,5-diones as All- trans -retinoic Acid Metabolising Enzyme Inhibitors (RAMBAs)

Andrew J. Kirby Pharmacology Division, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK
,
Regis Lelain Pharmacology Division, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK
,
Peter Mason Medicinal Chemistry Division, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK
,
Farshid Maharlouie Medicinal Chemistry Division, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK
,
Paul J. Nicholls Pharmacology Division, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK
,
H. John Smith Medicinal Chemistry Division, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK
&
Claire Simons Medicinal Chemistry Division, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK
 show all
Pages 321-327 | Published online: 30 Sep 2008

Citations (10)

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Read on this site (2)

Peter Mason, Valerie P. Greer, Andrew J. Kirby, Claire Simons, Paul J. Nicholls & H. John Smith. (2003) Some Aryl Substituted 2-(4-Nitrophenyl)-4-oxo-4-phenylbutanoates and 3-(4-Nitrophenyl)-1-phenyl-1,4-butanediols and Related Compounds as Inhibitors of Rat Liver Microsomal Retinoic Acid Metabolising Enzymes. Journal of Enzyme Inhibition and Medicinal Chemistry 18:6, pages 511-528.
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V.P. Greer, P. Mason, A.J. Kirby, H.J. Smith, P.J. Nicholls & C. Simons. (2003) Some 1,2-Diphenylethane Derivatives as Inhibitors of Retinoic Acid—Metabolising Enzymes. Journal of Enzyme Inhibition and Medicinal Chemistry 18:5, pages 431-443.
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Articles from other publishers (8)

Yinjun Xie, Shengmei Guo, Longmin Wu, Chungu Xia & Hanmin Huang. (2015) Metal Bridging for Directing and Accelerating Electron Transfer as Exemplified by Harnessing the Reactivity of AIBN. Angewandte Chemie International Edition 54:20, pages 5900-5904.
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Yinjun Xie, Shengmei Guo, Longmin Wu, Chungu Xia & Hanmin Huang. (2015) Metal Bridging for Directing and Accelerating Electron Transfer as Exemplified by Harnessing the Reactivity of AIBN. Angewandte Chemie 127:20, pages 5998-6002.
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Fengrong Li, Dongmei Zhao, Jinhong Ren, Feiyue Hao, Guyue Liu, Shengfei Jin, Yongkui Jing & Maosheng Cheng. (2013) 2-(2-Methylfuran-3-carboxamido)-3-phenylpropanoic acid, a potential CYP26A1 inhibitor to enhance all-trans retinoic acid-induced leukemia cell differentiation based on virtual screening and biological evaluation. Bioorganic & Medicinal Chemistry 21:11, pages 3256-3261.
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Vincent C.O. Njar, Lalji Gediya, Puranik Purushottamachar, Pankaj Chopra, Tadas Sean Vasaitis, Aakanksha Khandelwal, Jhalak Mehta, Carlic Huynh, Aashvini Belosay & Jyoti Patel. (2006) Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases. Bioorganic & Medicinal Chemistry 14:13, pages 4323-4340.
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Sook Wah Yee, Moray J. Campbell & Claire Simons. (2006) Inhibition of Vitamin D3 metabolism enhances VDR signalling in androgen-independent prostate cancer cells. The Journal of Steroid Biochemistry and Molecular Biology 98:4-5, pages 228-235.
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Sook Wah YeeLaetitia JarnoMohamed Sayed GomaaCarole ElfordLi-Ling OoiMichael P. CooganRichard McClellandRobert Ian NicholsonBronwen A. J. EvansAndrea BrancaleClaire Simons. (2005) Novel Tetralone-Derived Retinoic Acid Metabolism Blocking Agents:  Synthesis and in Vitro Evaluation with Liver Microsomal and MCF-7 CYP26A1 Cell Assays. Journal of Medicinal Chemistry 48:23, pages 7123-7131.
Crossref
Jyoti B. PatelCarlic K. HuynhVenkatesh D. HandrattaLalji K. GediyaAngela M. H. BrodieOlga G. GoloubevaOmoshile O. ClementIvo P. NanneDianne Robert SopranoVincent C. O. Njar. (2004) Novel Retinoic Acid Metabolism Blocking Agents Endowed with Multiple Biological Activities Are Efficient Growth Inhibitors of Human Breast and Prostate Cancer Cells in Vitro and a Human Breast Tumor Xenograft in Nude Mice. Journal of Medicinal Chemistry 47:27, pages 6716-6729.
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Sook Wah Yee & Claire Simons. (2004) Synthesis and CYP24 inhibitory activity of 2-substituted-3,4-dihydro-2H-naphthalen-1-one (tetralone) derivatives. Bioorganic & Medicinal Chemistry Letters 14:22, pages 5651-5654.
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