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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 21, 2006 - Issue 2
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Research Article

Synthesis and anti-inflammatory activity of some selected aminothiophene analogs

Khalid Mohammed Khan University of Karachi, International Center for Chemical Sciences, HEJ Research Institute of Chemistry, Karachi, 75270, Pakistan
,
Zia Nullah University of Paderborn, Faculty of Sciences, Department of Chemistry, Warburger Strasse 100, 33098, Paderborn, Germany
,
Muhammad arif Lodhi University of Karachi, International Center for Chemical Sciences, HEJ Research Institute of Chemistry, Karachi, 75270, Pakistan
,
Saima Jalil University of Karachi, International Center for Chemical Sciences, HEJ Research Institute of Chemistry, Karachi, 75270, Pakistan
,
Muhammad Iqbal Choudhary University of Karachi, International Center for Chemical Sciences, HEJ Research Institute of Chemistry, Karachi, 75270, Pakistan
&
Atta-Ur- Rahman University of Karachi, International Center for Chemical Sciences, HEJ Research Institute of Chemistry, Karachi, 75270, Pakistan
Pages 139-143 | Received 06 Aug 2005, Accepted 22 Oct 2005, Published online: 04 Oct 2008

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Khurshid I. Molvi, Vasudevan Sudarsanam, Madhubhai M. Patel & Navedul Haque. (2008) Design, synthesis and pharmacological evaluation of novel tetrasubstituted thiophene analogues as anti-inflammatory agents. Journal of Enzyme Inhibition and Medicinal Chemistry 23:6, pages 819-828.
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Articles from other publishers (25)

V. Vikram, K. R. Amperayani & P. Umadevi. (2021) 3-(Methoxycarbonyl)thiophene Thiourea Derivatives as Potential Potent Bacterial Acetyl-CoA Carboxylase Inhibitors. Russian Journal of Organic Chemistry 57:8, pages 1336-1345.
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Bilquees Bano, Kanwal, Khalid Mohammed Khan, Almas Jabeen, Aisha Faheem, Muhammad Taha, Syed Moazzam Haider & Shahnaz Perveen. (2021) Sulfonamides and Sulphonyl Ester of Quinolines as Non-Acidic, Non- Steroidal, Anti-inflammatory Agents. Letters in Drug Design & Discovery 18:2, pages 112-120.
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Raghav Mishra, Nitin Kumar & Neetu Sachan. (2021) Synthesis, Pharmacological Evaluation, and In-Silico Studies of Thiophene Derivatives. Oncologie 23:4, pages 493-514.
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Moustafa A. Gouda, Mohammed Al‐Ghorbani & Nabil Al‐Zaqri. (2020) Synthesis and cytotoxic activity of some new heterocycles incorporating cyclohepta[b]thiophene‐3‐carboxamide derivatives. Journal of Heterocyclic Chemistry 57:10, pages 3664-3672.
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Mohammed Al‐Ghorbani & Moustafa A. Gouda. (2020) Synthesis and in vitro anticancer activity of some novel cyclohepta[ b ]thiophene‐3‐carboxamides bearing pyrazole moiety . Journal of Heterocyclic Chemistry 57:8, pages 3213-3221.
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Nadia Y. Megally Abdo, Rafat M. Mohareb & Waleed N. Al-darkazali. (2020) Heterocyclization of 2-Arylidenecyclohexan-1,3-dione: Synthesis of Thiophene, Thiazole, and Isoxazole Derivatives with Potential Antitumor Activities. Anti-Cancer Agents in Medicinal Chemistry 20:3, pages 335-345.
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Ehab Abdel-Latif, Eman M. Keshk, Abdel-Galil M. Khalil, Ali Saeed & Heba M. Metwally. (2018) Utilization of thioacetanilides in the synthesis of new 4-(4-acetamidophenylazo)thiophene scaffolds and evaluating their anti-oxidant activity. Journal of the Iranian Chemical Society 16:3, pages 629-637.
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Arshia, Almas Jabeen, Aisha Faheem, Khalid M. Khan, Shazia Shah & Shahnaz Perveen. (2019) Benzophenone Esters and Sulfonates: Synthesis and their Potential as Antiinflammatory Agents. Medicinal Chemistry 15:2, pages 162-174.
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Giacomo Mari, Lucia De Crescentini, Gianfranco Favi, Stefania Santeusanio & Fabio Mantellini. (2018) 1,2-Diaza-1,3-diene-Based Multicomponent Reactions in Sequential Protocols to Synthesize Arylamino-5-hydrazonothiophene-3-carboxylates. European Journal of Organic Chemistry 2018:46, pages 6548-6556.
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Min Zou, Bo Jin, Yanrong Liu, Huiping Chen, Zhuangli Zhang, Changzheng Zhang, Zhihong Zhao & Liyun Zheng. (2018) Synthesis and Biological Evaluation of Some Novel Thiophene-bearing Quinazoline Derivatives as EGFR Inhibitors. Letters in Drug Design & Discovery 16:2, pages 102-110.
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Rafat M. Mohareb, Fatima Al-Omran & Rehab A. Ibrahim. (2017) The uses of cyclohexan-1,4-dione for the synthesis of thiophene derivatives as new anti-proliferative, prostate anticancer, c-Met and tyrosine kinase inhibitors. Medicinal Chemistry Research 27:2, pages 618-633.
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Bilquees Bano, Khalid M. Khan, Almas Jabeen, Abdul Hameed, Aisha Faheem, Muhammad Taha, Shahnaz Perveen & Sarosh Iqbal. (2017) Aminoquinoline Schiff Bases as Non-Acidic, Non-Steroidal, Anti-Inflammatory Agents. ChemistrySelect 2:31, pages 10050-10054.
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Rangappa S. Keri, Karam Chand, Srinivasa Budagumpi, Sasidhar Balappa Somappa, Siddappa A. Patil & Bhari Mallanna Nagaraja. (2017) An overview of benzo [b] thiophene-based medicinal chemistry. European Journal of Medicinal Chemistry 138, pages 1002-1033.
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Rafat Milad Mohareb, Nermeen Saeed Abbas & Rehab Ali Ibrahim. (2017) Uses of Cyclohexan-1,4-dione for the Synthesis of 2-Amino-4,5-dihydrobenzo[<i>b</i>]thiophen-6(7<i>H</i>)-one Derivatives with Anti-proliferative and Pim-1 Kinase Activities. CHEMICAL & PHARMACEUTICAL BULLETIN Chemical and Pharmaceutical Bulletin 65:12, pages 1117-1131.
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Andreza Conception Véras of Aguiar, Ricardo Olímpio of Moura, Jaime Francisco Bezerra MendonçaJuniorJunior, Hugo Alexandre de Oliveira Rocha, Rafael Barros Gomes Câmara & Manuela dos Santos Carvalho Schiavon. (2016) Evaluation of the antiproliferative activity of 2-amino thiophene derivatives against human cancer cells lines. Biomedicine & Pharmacotherapy 84, pages 403-414.
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Uzma Salar, Khalid Mohammed Khan, Almas Jabeen, Aisha Faheem, Muhammad Imran Fakhri, Syed Muhammad Saad, Shahnaz Perveen, Muhammad Taha & Abdul Hameed. (2016) Coumarin sulfonates: As potential leads for ROS inhibition. Bioorganic Chemistry 69, pages 37-47.
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Gajanan G. Mandawad, Rahul D. Kamble, Shrikant V. Hese, Rahul A. More, Rajesh N. Gacche, Kisan M. Kodam & Bhaskar S. Dawane. (2014) An efficient synthesis of isoxazoline libraries of thiophene analogs and its antimycobacterial investigation. Medicinal Chemistry Research 23:10, pages 4455-4463.
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Khurshed Bozorov, Hai-Rong Ma, Jiang-Yu Zhao, Hai-Qing Zhao, Hua Chen, Khayrulla Bobakulov, Xue-Lei Xin, Burkhon Elmuradov, Khusnutdin Shakhidoyatov & Haji A. Aisa. (2014) Discovery of diethyl 2,5-diaminothiophene-3,4-dicarboxylate derivatives as potent anticancer and antimicrobial agents and screening of anti-diabetic activity: Synthesis and in vitro biological evaluation. Part 1. European Journal of Medicinal Chemistry 84, pages 739-745.
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J. Balzarini, J. Thomas, S. Liekens, S. Noppen, W. Dehaen & R. Romagnoli. (2013) 2-aminothiophene-3-carboxylic acid ester derivatives as novel highly selective cytostatic agents. Investigational New Drugs 32:1, pages 200-210.
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Gajanan G. Mandawad, Bhaskar S. Dawane, Supriya D. Beedkar, Chandrahas N. Khobragade & Omprakash S. Yemul. (2013) Trisubstituted thiophene analogues of 1-thiazolyl-2-pyrazoline, super oxidase inhibitors and free radical scavengers. Bioorganic & Medicinal Chemistry 21:1, pages 365-372.
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Diaa A. Ibrahim, Julie Boucau, Daniel H. Lajiness, Sri Kumar Veleti, Kevin R. Trabbic, Samuel S. Adams, Donald R. Ronning & Steven J. Sucheck. (2012) Design, Synthesis, and X-ray Analysis of a Glycoconjugate Bound to Mycobacterium tuberculosis Antigen 85C. Bioconjugate Chemistry 23:12, pages 2403-2416.
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Luigi Aurelio, Bernard L. Flynn & Peter J. Scammells. (2011) New methodology for the N-alkylation of 2-amino-3-acylthiophenes. Organic & Biomolecular Chemistry 9:13, pages 4886.
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Khalid M. Khan, Abdul Wadood, Muhammad Ali, Zia-Ullah, Zaheer Ul-Haq, M. Arif Lodhi, Momin Khan, Shahnaz Perveen & M. Iqbal Choudhary. (2010) Identification of potent urease inhibitors via ligand- and structure-based virtual screening and in vitro assays. Journal of Molecular Graphics and Modelling 28:8, pages 792-798.
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M. Thankamony, B. Sindhu Kumari, G. Rijulal & K. Mohanan. (2008) Lanthanum(III) chloride complexes with heterocyclic Schiff bases. Journal of Thermal Analysis and Calorimetry 95:1, pages 259-266.
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P. Molina, A. Arques & I. Cartagena. 2008. Comprehensive Heterocyclic Chemistry III. Comprehensive Heterocyclic Chemistry III 625 739 .

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