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Research Article

Peptidomimetic 2-cyanopyrrolidines as potent selective cathepsin L inhibitors

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Pages 190-197 | Received 05 Jan 2007, Accepted 21 May 2007, Published online: 04 Oct 2008

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Sofia Ferrer​, Michael E. Muratore & Peter Buijnsters. (2022) The intriguing role of USP30 inhibitors as deubiquitinating enzymes from the patent literature since 2013. Expert Opinion on Therapeutic Patents 32:5, pages 523-559.
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Brian W. Moran, Frankie P. Anderson, Deborah M. Ruth, Ciarán Ó. Fágáin, John P. Dalton & Peter T. M. Kenny. (2010) Fluorobenzoyl dipeptidyl derivatives as inhibitors of the Fasciola hepatica cysteine protease cathepsin L1. Journal of Enzyme Inhibition and Medicinal Chemistry 25:1, pages 1-12.
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Articles from other publishers (6)

Aaron D. Krabill, Hao Chen, Sajjad Hussain, Chao Feng, Ammara Abdullah, Chittaranjan Das, Uma K. Aryal, Carol Beth Post, Michael K. Wendt, Paul J. Galardy & Daniel P. Flaherty. (2019) Ubiquitin C‐Terminal Hydrolase L1: Biochemical and Cellular Characterization of a Covalent Cyanopyrrolidine‐Based Inhibitor. ChemBioChem 21:5, pages 712-722.
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Marton Siklos, Manel BenAissa & Gregory R.J. Thatcher. (2015) Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors. Acta Pharmaceutica Sinica B 5:6, pages 506-519.
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G.D. Kishore Kumar, Gustavo E. Chavarria, Amanda K. Charlton-Sevcik, Grace Kim Yoo, Jiangli Song, Tracy E. Strecker, Bronwyn G. Siim, David J. Chaplin, Mary Lynn Trawick & Kevin G. Pinney. (2010) Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L. Bioorganic & Medicinal Chemistry Letters 20:22, pages 6610-6615.
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Donald J. AbrahamPhilippe G. Nantermet, Evan F. Shalen, Shankar Venkatraman, Hong Zhu & Robert J. Mark. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 447 828 .
Gaetano Leto, Maria Vittoria Sepporta, Marilena Crescimanno, Carla Flandina & Francesca Maria Tumminello. (2010) Cathepsin L in metastatic bone disease: therapeutic implications. Biological Chemistry 391:6.
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G.D. Kishore Kumar, Gustavo E. Chavarria, Amanda K. Charlton-Sevcik, Wara M. Arispe, Matthew T. MacDonough, Tracy E. Strecker, Shen-En Chen, Bronwyn G. Siim, David J. Chaplin, Mary Lynn Trawick & Kevin G. Pinney. (2010) Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors. Bioorganic & Medicinal Chemistry Letters 20:4, pages 1415-1419.
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