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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 34, 2019 - Issue 1
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Research Paper

In vitro anticancer potentiality and molecular modelling study of novel amino acid derivatives based on N1,N3-bis-(1-hydrazinyl-1-oxopropan-2-yl) isophthalamide

Asmaa F. KassemDepartment of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Division, National Research Centre, Giza, Egypt;
,
Gaber O. MoustafaDepartment of Peptide Chemistry, Chemical Industries Research Division, National Research Centre, Cairo, Egypt; Correspondence[email protected]
,
Eman S. NossierDepartment of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt;
,
Hemat S. KhalafDepartment of Chemistry, College of Science and Arts, Jouf University, Al Qurayat, Saudi Arabia; ;Chemical Industries Research Division, Department of Photochemistry, National Research Centre, Cairo, Egypt;
,
Marwa M. MounierPharmaceutical and Drug Industries Research Division, Department of Pharmacognosy, National Research Centre, Giza, Egypt;
,
Suliman A. Al-YousefDepartment of Clinical Laboratory Science, College of Applied Medical Science, University of Hafr Al Batin, Hafr Al Batin, Saudi Arabia;
&
Sabry Y. MahmoudDepartment of Biology, College of Science, University of Hafr Al Batin, Hafr Al Batin, Saudi Arabia
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Pages 1247-1258 | Received 14 Feb 2019, Accepted 23 Apr 2019, Published online: 09 Jul 2019

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Ahmed M Naglah, Gaber O Moustafa, Ahmed A Elhenawy, Marwa M Mounier, Heba El-Sayed, Mohamed A Al-Omar, Abdulrahman A Almehizia & Mashooq A Bhat. (2021) Nα-1, 3-Benzenedicarbonyl-Bis-(Amino Acid) and Dipeptide Candidates: Synthesis, Cytotoxic, Antimicrobial and Molecular Docking Investigation. Drug Design, Development and Therapy 15, pages 1315-1332.
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Hemat S. Khalaf, Hala E. M. Tolan, Mohamed A. A. Radwan, Ashraf M. Mohamed, Hanem M. Awad & Wael A. El-Sayed. (2020) Design, synthesis and anticancer activity of novel pyrimidine and pyrimidine-thiadiazole hybrid glycosides. Nucleosides, Nucleotides & Nucleic Acids 39:7, pages 1036-1056.
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Nada A. Khaled, Nesreen S. Ahmed, Ahmed Z. Abdelazem, Neama A. Mohamed, Ahmed F. El-Sayed & Sayed A. Ahmed. (2023) Design, synthesis, biological evaluation, in silico ADME prediction and molecular docking of pyrazole-benzamides as multitargeting protien kinase inhibitors. Journal of Molecular Structure 1288, pages 135753.
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Rohith Gattu, Sanjay S. Ramesh, Siddaram Nadigar, Channe Gowda D & Suhas Ramesh. (2023) Conjugation as a Tool in Therapeutics: Role of Amino Acids/Peptides-Bioactive (Including Heterocycles) Hybrid Molecules in Treating Infectious Diseases. Antibiotics 12:3, pages 532.
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Zahra M. Alamshany, Nada Y. Tashkandi, Ismail M.M. Othman, Manal M. Anwar & Eman S. Nossier. (2022) New thiophene, thienopyridine and thiazoline-based derivatives: Design, synthesis and biological evaluation as antiproliferative agents and multitargeting kinase inhibitors. Bioorganic Chemistry 127, pages 105964.
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Said E. Desouky, Mohammed Abu-Elghait, Eman A. Fayed, Samy Selim, Basit Yousuf, Yasuhiro Igarashi, Basel A. Abdel-Wahab, Amnah Mohammed Alsuhaibani, Kenji Sonomoto & Jiro Nakayama. (2022) Secondary Metabolites of Actinomycetales as Potent Quorum Sensing Inhibitors Targeting Gram-Positive Pathogens: In Vitro and In Silico Study. Metabolites 12:3, pages 246.
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Heba E. Hashem, Abd El-Galil E. Amr, Eman S. Nossier, Manal M. Anwar & Eman M. Azmy. (2022) New Benzimidazole-, 1,2,4-Triazole-, and 1,3,5-Triazine-Based Derivatives as Potential EGFR WT and EGFR T790M Inhibitors: Microwave-Assisted Synthesis, Anticancer Evaluation, and Molecular Docking Study . ACS Omega 7:8, pages 7155-7171.
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Amira A. El-Sayed, Eman S. Nossier, Abdulrahman A. Almehizia & Abd El-Galil E. Amr. (2022) Design, synthesis, anticancer evaluation and molecular docking study of novel 2,4-dichlorophenoxymethyl-based derivatives linked to nitrogenous heterocyclic ring systems as potential CDK-2 inhibitors. Journal of Molecular Structure 1247, pages 131285.
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Mindaugas Žukauskas, Birutė Grybaitė, Paulina Jonutė, Rita Vaickelionienė, Paulius Gibieža, Giedrius Vaickelionis, Bertina Dragūnaitė, Kazimieras Anusevičius, Vytautas Mickevičius & Vilma Petrikaitė. (2021) Evaluation of N-aryl-β-alanine derivatives as anticancer agents in triple-negative breast cancer and glioblastoma in vitro models. Bioorganic Chemistry 115, pages 105214.
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Eman A. Abd El-Meguid, Gaber O. Moustafa, Hanem M. Awad, Eman R. Zaki & Eman S. Nossier. (2021) Novel benzothiazole hybrids targeting EGFR: Design, synthesis, biological evaluation and molecular docking studies. Journal of Molecular Structure 1240, pages 130595.
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Gaber O. Moustafa, Ahmed Shalaby, Ahmed M. Naglah, Marwa M. Mounier, Heba El-Sayed, Manal M. Anwar & Eman S. Nossier. (2021) Synthesis, Characterization, In Vitro Anticancer Potentiality, and Antimicrobial Activities of Novel Peptide–Glycyrrhetinic-Acid-Based Derivatives. Molecules 26:15, pages 4573.
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Ashraf S. Hassan, Gaber O. Moustafa, Hanem M. Awad, Eman S. Nossier & Mohamed F. Mady. (2021) Design, Synthesis, Anticancer Evaluation, Enzymatic Assays, and a Molecular Modeling Study of Novel Pyrazole–Indole Hybrids. ACS Omega 6:18, pages 12361-12374.
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Hemat S. Khalaf, Ahmed M. Naglah, Mohamed A. Al-Omar, Gaber O. Moustafa, Hassan M. Awad & Ahmed H. Bakheit. (2020) Synthesis, Docking, Computational Studies, and Antimicrobial Evaluations of New Dipeptide Derivatives Based on Nicotinoylglycylglycine Hydrazide. Molecules 25:16, pages 3589.
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Mohamed S. Hasanin & Gaber O. Moustafa. (2020) New potential green, bioactive and antimicrobial nanocomposites based on cellulose and amino acid. International Journal of Biological Macromolecules 144, pages 441-448.
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