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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 35, 2020 - Issue 1
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Research Paper

S-substituted 2-mercaptoquinazolin-4(3H)-one and 4-ethylbenzensulfonamides act as potent and selective human carbonic anhydrase IX and XII inhibitors

Adel S. El-Azaba Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-7197-1515View further author information
ORCID Icon,
Alaa A.-M. Abdel-Aziza Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaORCID Iconhttps://orcid.org/0000-0002-3362-9337View further author information
ORCID Icon,
Silvia Buab Department of Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Florence, ItalyView further author information
,
Alessio Nocentinib Department of Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Florence, ItalyView further author information
,
Nawaf A. AlSaifa Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaView further author information
,
Mohammed M. Alanazia Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaView further author information
,
Manal A. El-Gendya Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaView further author information
,
Hany E. A. Ahmedc Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt;d Pharmacognosy and Pharmaceutical Chemistry Department, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah, Saudi ArabiaView further author information
&
Claudiu T. Supuranb Department of Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Florence, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-4262-0323View further author information
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Pages 733-743 | Received 25 Jan 2020, Accepted 09 Mar 2020, Published online: 19 Mar 2020

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Maan T. Khayat, Hany E. A. Ahmed, Abdelsattar M. Omar, Yosra A. Muhammad, Khadijah A. Mohammad, Azizah M. Malebari, Ahdab N. Khayyat, Ahmed H. Halawa, Hamada S. Abulkhair, Ahmed A. Al-Karmalawy, Mohammed Almaghrabi, Majed Alharbi, Anfal S. Aljahdali & Ahmed M. El-Agrody. (2023) A novel class of phenylpyrazolone-sulphonamides rigid synthetic anticancer molecules selectively inhibit the isoform IX of carbonic anhydrases guided by molecular docking and orbital analyses. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-19.
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Mateusz Kciuk, Adrianna Gielecińska, Somdutt Mujwar, Mariusz Mojzych, Beata Marciniak, Rafał Drozda & Renata Kontek. (2022) Targeting carbonic anhydrase IX and XII isoforms with small molecule inhibitors and monoclonal antibodies. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 1278-1298.
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Articles from other publishers (15)

Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Silvia Bua, Alessio Nocentini, Ahmed H. Bakheit, Hamad M. Alkahtani, Mohamed M. Hefnawy & Claudiu T. Supuran. (2023) Design, synthesis, and carbonic anhydrase inhibition activities of Schiff bases incorporating benzenesulfonamide scaffold: Molecular docking application. Saudi Pharmaceutical Journal 31:12, pages 101866.
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Fereshteh Gandomi, Karim Akbari Dilmaghani, Bakhshali Massoumi & Yasin Sarve Ahrabi. (2023) Synthesis, Characterization and Molecular Docking Study of Novel 1,4-Dihydropyridine Derivatives as Antimicrobial and Anticancer Agents. Russian Journal of Bioorganic Chemistry 49:5, pages 1089-1099.
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Adel S. El-Azab, Hamad M. Alkahtani, Nawaf A. AlSaif, Ibrahim A. Al-Suwaidan, Ahmad J. Obaidullah, Mohammed M. Alanazi, Abdulrahman M. Al-Obaid, Mohamed H.M. Al-Agamy & Alaa A.-M. Abdel-Aziz. (2023) Synthesis, antiproliferative and enzymatic inhibition activities of quinazolines incorporating benzenesulfonamide: Cell cycle analysis and molecular modeling study. Journal of Molecular Structure 1278, pages 134928.
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Reihane Ghomashi, Shakila Ghomashi, Hamidreza Aghaei & Ahmad Reza Massah. (2023) Recent Advances in Biological Active Sulfonamide based Hybrid Compounds Part A: Two-Component Sulfonamide Hybrids. Current Medicinal Chemistry 30:4, pages 407-480.
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Heba T. Abdel‐Mohsen, Mohamed A. Omar, Andrea Petreni & Claudiu T. Supuran. (2022) Novel 2‐substituted thioquinazoline‐benzenesulfonamide derivatives as carbonic anhydrase inhibitors with potential anticancer activity. Archiv der Pharmazie 355:12.
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Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Hazem A. Ghabbour, Silvia Bua, Alessio Nocentini, Hamad M. Alkahtani, Nawaf A. Alsaif, Mohamed H. M. Al-Agamy & Claudiu T. Supuran. (2022) Carbonic Anhydrase Inhibition Activities of Schiff’s Bases Based on Quinazoline-Linked Benzenesulfonamide. Molecules 27:22, pages 7703.
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Heba T. Abdel‐Mohsen, Andrea Petreni & Claudiu T. Supuran. (2022) Investigation of the carbonic anhydrase inhibitory activity of benzenesulfonamides incorporating substituted fused‐pyrimidine tails. Archiv der Pharmazie 355:11.
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Amit Kumar, Kiran Siwach, Claudiu T. Supuran & Pawan K. Sharma. (2022) A decade of tail-approach based design of selective as well as potent tumor associated carbonic anhydrase inhibitors. Bioorganic Chemistry 126, pages 105920.
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Maja Molnar, Mario Komar & Igor Jerković. (2022) Methyl 2-((3-(3-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)thio)acetate. Molbank 2022:3, pages M1434.
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Pengcheng Lv, Yinyi Cai, Jiayi Luo & Kun Chen. (2022) Recent Advances in the Design and Synthesis of Small Molecule Carbonic Anhydrase IX Inhibitors. Current Topics in Medicinal Chemistry 22:7, pages 550-560.
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Mario Komar, Tatjana Gazivoda Kraljević, Igor Jerković & Maja Molnar. (2022) Application of Deep Eutectic Solvents in the Synthesis of Substituted 2-Mercaptoquinazolin-4(3H)-Ones: A Comparison of Selected Green Chemistry Methods. Molecules 27:2, pages 558.
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Ram Karan, Pooja Agarwal, Mukty Sinha & Neelima Mahato. (2021) Recent Advances on Quinazoline Derivatives: A Potential Bioactive Scaffold in Medicinal Chemistry. ChemEngineering 5:4, pages 73.
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Mária Bodnár Mikulová, Dáša Kružlicová, Daniel Pecher, Andrea Petreni, Claudiu T. Supuran & Peter Mikuš. (2021) Synthesis and Inhibition Activity Study of Triazinyl-Substituted Amino(alkyl)-benzenesulfonamide Conjugates with Polar and Hydrophobic Amino Acids as Inhibitors of Human Carbonic Anhydrases I, II, IV, IX, and XII. International Journal of Molecular Sciences 22:20, pages 11283.
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Adel S. El-Azab, Nasr Y. Khalil & Alaa A.-M. Abdel-Aziz. (2021) Remarkable Conversion of 2-Thioxo-2,3-dihydroquinazolin-4(1H)-ones into the Corresponding Quinazoline-2,4(1H,3H)-diones: Spectroscopic Analysis and X-Ray Crystallography. Journal of Chemistry 2021, pages 1-8.
Crossref
Shubham Kumar, Sandeep Rulhania, Shalini Jaswal & Vikramdeep Monga. (2021) Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors. European Journal of Medicinal Chemistry 209, pages 112923.
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