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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 38, 2023 - Issue 1
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Research Paper

Design, synthesis, and biological evaluation of novel ciprofloxacin derivatives as potential anticancer agents targeting topoisomerase II enzyme

Hadeer K. Swedana Central Administration of Research and Health Development, Ministry of Health, and Population (MoHP), Cairo, Egypt
,
Asmaa E. Kassabb Faculty of Pharmacy, Department of Pharmaceutical Organic Chemistry, Cairo University, Cairo, EgyptCorrespondence[email protected]
,
Ehab M. Gedawyb Faculty of Pharmacy, Department of Pharmaceutical Organic Chemistry, Cairo University, Cairo, Egypt;c Faculty of Pharmacy and Pharmaceutical Industries, Department of Pharmaceutical Chemistry, Badr University in Cairo (BUC), Badr City, Egypt
&
Salwa E. Elmeligieb Faculty of Pharmacy, Department of Pharmaceutical Organic Chemistry, Cairo University, Cairo, Egypt
Pages 118-137 | Received 12 Jun 2022, Accepted 10 Oct 2022, Published online: 28 Oct 2022

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Asmaa H. Mohamed, Mohammed B. Alshammari, Ashraf A. Aly, Kamal U. Sadek, Akil Ahmad, Eman A. Aziz, Amira F. El-Yazbi, Eman J. El-Agroudy & Marwa E. Abdelaziz. (2024) New imidazole-2-thiones linked to acenaphythylenone as dual DNA intercalators and topoisomerase II inhibitors: structural optimization, docking, and apoptosis studies. Journal of Enzyme Inhibition and Medicinal Chemistry 39:1.
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Mahmoud G. Abo Al-Hamd, Haytham O. Tawfik, Omeima Abdullah, Koki Yamaguchi, Masaharu Sugiura, Ahmed B. M. Mehany, Mervat H. El-Hamamsy & Tarek F. El-Moselhy. (2023) Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFRWT, EGFRT790M, and EGFRL858R). Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Yogesh Singh, Neha Bhatia, Avadh Biharee, Swanand Kulkarni, Suresh Thareja & Vikramdeep Monga. (2023) Developing our knowledge of the quinolone scaffold and its value to anticancer drug design. Expert Opinion on Drug Discovery 18:10, pages 1151-1167.
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Articles from other publishers (11)

Neda Pashapour, Mohammad Javad Dehghan-Nayeri, Esmaeil Babaei, Mohammad Khalaj-Kondori & Majid Mahdavi. (2023) The Assessment of Cytotoxicity, Apoptosis Inducing Activity and Molecular Docking of a new Ciprofloxacin Derivative in Human Leukemic Cells. Journal of Fluorescence 34:3, pages 1379-1389.
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Vuyolwethu Khwaza, Sithenkosi Mlala & Blessing A. Aderibigbe. (2024) Advancements in Synthetic Strategies and Biological Effects of Ciprofloxacin Derivatives: A Review. International Journal of Molecular Sciences 25:9, pages 4919.
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Mina E. Adly, Ehab M. Gedawy, Afaf A. El-Malah & Omneya M. Khalil. (2024) Design, synthesis and in vitro anticancer activity of some new lomefloxacin derivatives. Scientific Reports 14:1.
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Sijongesonke Peter & Blessing A. Aderibigbe. (2024) Ciprofloxacin and Norfloxacin Hybrid Compounds: Potential Anticancer Agents. Current Topics in Medicinal Chemistry 24:7, pages 644-665.
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Asmaa E. Kassab. (2024) N-Acylhydrazone Pharmacophore's Analgesic and Anti-inflammatory Profile: Recent Advancements during the Past Ten Years. Current Pharmaceutical Design 30:5, pages 333-351.
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Hadil Faris Alotaibi, El-Sayed Khafagy, Serag Eldin Elbehairi, Ashwag Alanazi, Samar Zuhair Alshawwa, Mohammad Yehia Alfaifi, Jawaher Abdullah Alamoudi, Sarah Salem Alamrani, Rana Saeed Alqahtani, Heba Ahmed Yassin & Fatma Alzahraa Mokhtar. (2024) Enhancing the Anticancer Efficacy of Ciprofloxacin Towards Three Cancer Cell Lines via Avocado Oil Nanoemulsion Formulation. International Journal of Pharmacology 20:1, pages 128-138.
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Mohammed Salah Ayoup, Mohamed Reda Barakat, Hamida Abdel-Hamid, Ehab Emam, Yasair S. Al-Faiyz, Aliaa A. Masoud, Doaa A. Ghareeb, Amr Sonousi & Asmaa E. Kassab. (2024) Design, synthesis, and biological evaluation of 1,2,4-oxadiazole-based derivatives as multitarget anti-Alzheimer agents. RSC Medicinal Chemistry.
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Hiram Hernández‐López, Christian Jairo Tejada‐RodríguezSocorro Leyva‐Ramos, Alberto Pedraza‐Alvarez, Eduardo Alejandro Juárez‐Dorado, Angélica Judith Granados‐López, Yamilé López‐Hernández, Sarah L. McOnie, Kim M. Baines & Jesús Adrián López. (2023) Synthesis and Anticancer Activity of 1‐(Ethyl/Methyl)‐7‐( p ‐Methoxybenzyl Amino) and 7‐Amino‐6‐Fluoroquinolone‐Boron Difluoride Complexes . ChemistrySelect 8:45.
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Hadeer K. Swedan, Asmaa E. Kassab, Ehab M. Gedawy & Salwa E. Elmeligie. (2023) Topoisomerase II inhibitors design: Early studies and new perspectives. Bioorganic Chemistry 136, pages 106548.
Crossref
Nader R. Albujuq, Khalid Althumayri, Reem A. K Alharbi, Ahmed A. Al‐Karmalawy & Mohamed S. Nafie. (2023) Design and Synthesis of Benzenesulfonamides Coupled with Piperidine, Morpholine, and N , N ‐Dimethylethanamine Moieties as Apoptotic Inducers through VEGFR2 and Topoisomerase II Inhibition . ChemistrySelect 8:20.
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Thais Aparecida Sales, Mateus Aquino Gonçalves & Teodorico Castro Ramalho. (2022) Structural Parameters of the Interaction between Ciprofloxacin and Human Topoisomerase-II β Enzyme: Toward New 19F NMR Chemical Shift Probes. Magnetochemistry 8:12, pages 181.
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