Design, synthesis and biological evaluation of 4-aminoquinoline derivatives as receptor-interacting protein kinase 2 (RIPK2) inhibitors

Tiantian Fana Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China;b University of Chinese Academy of Sciences, Beijing, P. R. ChinaView further author information

Yinchun Jic Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. ChinaView further author information

Danqi Chena Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. ChinaView further author information

Xia Pengc Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. ChinaView further author information

Jing Aib University of Chinese Academy of Sciences, Beijing, P. R. China;c Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China;d Hangzhou Institute for Advanced Study (UCAS), Hangzhou, P. R. ChinaCorrespondence[email protected]
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Bing Xionga Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China;b University of Chinese Academy of Sciences, Beijing, P. R. ChinaCorrespondence[email protected]
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Lixia Ding, Zhifei Zhu, Xinyue Zhou, Gongming Zhu, Jian-Hua Wang, Shu-Tong Zhu, Bing Hu, Xiao-Na Wang & Junbiao Chang. (2023) Metal-free [2 + 2] and [4 + 2] cycloadditions of N -aryl-substituted ynamides to construct functionalized aminocyclobutenes and 4-aminoquinolines . Organic Chemistry Frontiers 10:16, pages 4043-4054.
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Design, synthesis and biological evaluation of 4-aminoquinoline derivatives as receptor-interacting protein kinase 2 (RIPK2) inhibitors

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Design, synthesis and biological evaluation of 4-aminoquinoline derivatives as receptor-interacting protein kinase 2 (RIPK2) inhibitors

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